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Neural Networks and the Study of Time Series： An Application in Engineering Education

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Journal of Mechanics Engineering and Automation 2015年第3期5卷 153-160页

作者： Jose Tarcisio franco de Camargo Estefano Vizconde Veraszto Gilmar Barreto sergio Ferreira do Amaral Department of Computer Engineering Regional Universitary Center of E. S. do PinhaL E. S. do Pinhal 13990-000 Brazil Department of Natural Sciences Mathematics and Education Federal University of Sao Carlos Araras 13604-900 Brazil School of Electrical and Computing Engineering State University of Campinas Campinas 13083-852 Brazil School of Education University of Campinas Campinas 13084-865 Brazil

Time series are an important object of study in sciences, engineering and business, especially in cases where it is expected to know, predict and optimize behaviors. In this context, we intend to show the feasibility of using artificial neural networks in the study of several time series in an engineering course, especially those that have no overt behavior or are not able to be modeled mathematically in a simple way and have direct application in the education of future engineers.

关键词： Engineering education time series mathematical modeling.

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山脚下的慢时光萨拉戈萨EA住宅

室内设计与装修 2023年第8期 70-75页

作者： [西班牙]sergio Sebastián franco 沙漏(编译) 不详

西班牙小镇利塔卡郊区的这栋住宅展现了建筑与周围环境的完美融合。它沿着一片纵向的地块延伸,向西望去,能够眺望壮丽的蒙卡约山。这条山脉不仅定义了该地区的美丽景观,还塑造了这片区域自然公园的特色。住宅在山脉和小镇之间建立了一... 详细信息

西班牙小镇利塔卡郊区的这栋住宅展现了建筑与周围环境的完美融合。它沿着一片纵向的地块延伸,向西望去,能够眺望壮丽的蒙卡约山。这条山脉不仅定义了该地区的美丽景观,还塑造了这片区域自然公园的特色。住宅在山脉和小镇之间建立了一种特殊的视觉关系,仿佛在进行一场富有诗意的对话。

关键词：周围环境萨拉戈萨住宅诗意的对话完美融合西班牙山脉

Alpha-rhythm stimulation using brain entrainment enhances heart rate variability in subjects with reduced HRV

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World Journal of Neuroscience 2013年第4期3卷 213-220页

作者： Francesco Casciaro Vincenza Laterza sergio Conte Maria Pieralice Antonio Federici Orlando Todarello franco Orsucci Elio Conte Department of Biomedical Sciences and Oncology TIRES Center of Innovative Technologies for Signal Detection and Processing University of Bari Bari Italy Department of Neurological Sciences Center of Innovative Technologies for Signal Detection and Processing University of Bari Bari Italy Division of Psychology and Language Sciences University College London UK School of Advanced International Studies on Applied Theoretical and Non Linear Methodologies of Physics Bari Italy School of Advanced International Studies on Applied Theoretical and Non Linear Methodologies of Physics Bari Italy&ISPA-CNR Bari Italy

In the present research, we have used the brain entrainment (BWE) treatment simultaneously recording time series data of R-R intervals of the ECG during rest condition. In detail, we have used alpha brain stimulation and we have found that it induces an enhancement of HRV, particularly in Total Variability and Vagal Modulation activities. The experiment has been performed by us on ten subjects with age ranging from 20 to 70 years old. The risk induced from low HRV is by this time well known in literature. Therefore, the obtained result promises to be of valuable interest not only in terms of the basic neurological investigation but also because it delineates new possibilities in terms of clinical application.

关键词： Brain Entrainment Alpha Rhythm Brain Stimulation HRV Analysis Fast Fourier Transform Analysis of Time Series Data

Hepatitis C virus-associated neurocognitive and neuropsychiatric disorders:Advances in 2015

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World Journal of Gastroenterology 2015年第42期21卷 11974-11983页

作者： Salvatore Monaco Sara Mariotto sergio Ferrari Massimiliano Calabrese Gianluigi Zanusso Alberto Gajofatto Domenico Sansonno franco Dammacco Department of Neurological and Movement Sciences University of Verona Neurologia B Azienda Ospedaliera Universitaria Integrata Department of Internal Medicine and Clinical Oncology University of Bari Medical School

Since its identification in 1989, hepatitis C virus(HCV) has emerged as a worldwide health problem with roughly 185 million chronic infections, representing individuals at high risk of developing cirrhosis and liver cancer. In addition to being a frequent cause of morbidity and mortality due to liver disease, HCV has emerged as an important trigger of lymphoproliferative disorders, owing to its lymphotropism, and of a wide spectrum of extrahepatic manifestations(HCV-EHMs) affecting different organ systems. The most frequently observed HCV-EHMs include mixed cryoglobulinemia and cryoglobulinemic vasculitis, B-cell non-Hodgkin's lymphoma, nephropathies, thyreopathies, type 2 diabetes mellitus, cardiovascular diseases, and several neurological conditions. In addition, neuropsychiatric disorders and neurocognitive dysfunction are reported in nearly 50% of patients with chronic HCV infection, which are independent of the severity of liver disease or HCV replication rates. Fatigue, sleep disturbance, depression and reduced quality of life are commonly associated with neurocognitive alterations in patients with non-cirrhotic chronic HCV infection, regardless of the stage of liver fibrosis and the infecting genotype. These manifestations, which are the topic of this review, typically occur in the absence of structural brain damage or signal abnormalities on conventional brain magnetic resonance imaging(MRI), although metabolic and microstructural changes can be detected by in vivo proton magnetic resonance spectroscopy, perfusion-weighted and diffusion tensorMRI, and neurophysiological tests of cognitive processing. Several lines of evidence, including comparative and longitudinal neuropsychological assessments in patients achieving spontaneous or treatment-induced viral clearance, support a major pathogenic role for HCV in neuropsychiatric and neurocognitive disorders.

关键词： Extra-hepatic manifestations Hepatitis C virus syn

Aortic valve stenosis provides complementary information to bleeding risk scores in non-valvular atrial fibrillation patients initiating anticoagulation

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Journal of Geriatric Cardiology 2020年第3期17卷 141-148,I0005-I0007页

作者： Gines Elvira-Ruiz Cesar Caro-Martinez Pedro JoseFlores-Blanco Juan JoseCerezo-Manchado Helena Albendin-Iglesias Alejandro Lova-Navarro Francisco Arregui-Montoya Francisca Maria Munoz-franco Natalia Garcia-Iniesta Arcadio Garcia-Alberola JoseLuis Bailen-Lorenzo Domingo Andres Pascual-Figal sergio Manzano-Fernández Department of Cardiology University Hospital Virgen de la ArrixacaMurciaSpain Instituto Murciano de Investigación en Biomedicina(IMIB) MurciaSpain Department of Cardiology University Hospital Morales MeseguerMurciaSpain Department of Hematology University Hospital Virgen de la ArrixacaMurciaSpain Department of Internal Medicine University Hospital Virgen de la ArrixacaMurciaSpain School of Medicine University of MurciaMurciaSpain Department of Cardiology Hospital Vega BajaAlicanteSpain

Background The identification of modifiable bleeding risk factors may be of *** aim is to evaluate if aortic stenosis(AS)provides additional information to bleeding risk scores for predicting major bleeding(MB)in non-valvular atrial fibrillation(AF).Methods We designed a retrospective multi-center study including 2880 consecutive non-valvular AF patients initiating oral anticoagulation between January 2013 and December *** was defined as moderate or severe according to European echocardiography guidelines ***,ATRIA and ORBIT scores were used to evaluate the bleeding *** was defined according to the International Society on Thrombosis and Haemostasia criteria and registered at 18 months of *** 168(5.8%)patients had *** with AS had higher risk for MB compared to those without AS(HR=2.13,95%CI:1.40-3.23,P<0.001).Patients without AS and low-intermediate bleeding risk(0 points)showed the lowest MB rate,whereas the MB rate observed among patients with AS and high bleeding risk(2 points)was the highest *** and reclassification analyses showed that AS provided additional information to bleeding risk scores for predicting MB at 18 months of *** In this population,AS was associated with an increased risk for MB at midterm *** three scoring systems showed a moderate discriminatory ability for ***,the addition of AS was associated with a significant improvement in their predictive *** suggest that the presence of this valvulopathy should be taken into account for bleeding risk assessment.

关键词： Anticoagulants Aortic stenosis Atrial fibrillation Major bleeding Valvular disease

High Resolution Mass Spectrometry Elucidation of Captopril’s Ozonation and Chlorination By-Products

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American Journal of Analytical Chemistry 2017年第4期8卷 264-279页

作者： Frederico Jehar Oliveira Quintao Geraldo Celio Brandao Silvana de Queiroz Silva sergio Francisco Aquino Robson Jose de Cassia franco Afonso Programa de Pos-Graduacao em Engenharia Ambiental(ProAmb) Universidade Federal de Ouro PretoOuro PretoBrazil Programa de Pos-Graduacao em Ciencias Farmaceuticas(CiPharma) Universidade Federal de Ouro PretoOuro PretoBrazil

The article evaluated the degradation of the captopril in aqueous solution after ozonation and chlorination. The process was continuously monitored focusing on the identification, mass spectrometry and elucidation of its by-products by applying direct infusion and high performance liquid chromatography, electrospray ionization high resolution mass spectrometry, in the negative ion mode. The cytotoxicity of its by-products solutions were evaluated with 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. It was observed through that after 30 min of ozonation and chlorination, there was complete oxidation of captopril, i.e., 100% removal efficiency. At these conditions, the rate of mineralization, by total organic carbon, was only 7.63% for ozonation and 6.40% for chlorination, evidencing the formation of degradation by-products. Ten captopril by-products were identified and their respective chemical structures elucidations are proposed. The treated samples and their by-products were nontoxic to HepG2 cells by MTT assay.

关键词： Chlorination Ozonation Captopril High-Resolution Mass Spectrometry Liquid Chromatography Characterization of By-Products MTT Assay

The Transcutaneous Vagus Nerve Stimulation Output of the NuCalm Device of Solace Lifesciences Is Found to Be a Multifractal and Therefore It Is Indicated in the Treatment of Heart Rate Variability in the Dysfunction of Autonomic Nervous System in Anxiety, Depression and Stress

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Journal of Behavioral and Brain Science 2017年第11期7卷 532-543页

作者： sergio Conte Fang Wang Nicoletta Sala Francesco Losito Casciaro franco Orsucci Giuseppe Serafini Ferda Kaleagasioglu Leonardo Mendolicchio Rich Norman Elio Conte School of Advanced International Studies on Applied Theoretical and Non Linear Methodologies of Physics Bari Italy College of Science/Agricultural Mathematical Modeling and Data Processing Center Hunan Agricultural University Changsha China University of Lugano ISSI/Cerfim Lugano Swizerland Department of Biomedical Sciences and Human Oncology University of Bari Bari Italy Division of Psychology University College London England Tor Vergata University Rome Italy Faculty of Medicine Near East University North Nicosia Turkish Republic of Northern Cyprus Clinic Villa Miralago ASL Varese Italy

We have investigated the Nu Calm Transcutaneous Vagus Nerve Stimulation device of the NuCalm Solace Lifesciences founding that it gives a multifractal output. A diminishing fractal/multifractal HRV is consistently reported in literature as related to a serious Autonomic Nervous System (ANS) dysfunction that of course we observe in several psychological and psychiatric disorders. Therefore, we suggest the investigators to apply such a device in subjects affected from anxiety, depression and stress using the method of inducing tVNS stimulation.

关键词： Depression Anxiety Stress Transcutaneous Vagus Nerve Stimulation Neuromodulation Heart Rate Variablity Multifractals

Renal function and physical fitness after 12-mo supervised training in kidney transplant recipients

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World Journal of Transplantation 2018年第1期8卷 13-22页

作者： Giulio sergio Roi Giovanni Mosconi Valentina Totti Maria Laura Angelini Erica Brugin Patrizio Sarto Laura Merlo sergio Sgarzi Michele Stancari Paola Todeschini Gaetano La Manna Andrea Ermolao Ferdinando Tripi Lucia Andreoli Gianluigi Sella Alberto Anedda Laura Stefani Giorgio Galanti Rocco Di Michele franco Merni Manuela Trerotola Daniela Storani Alessandro Nanni Costa Department of Education and Research Isokinetic Medical Group Department of Nephrology and Dialysis Morgagni-Pierantoni Hospital Department of Biomedical & Neuromotor Sciences University of Bologna Associazione Nazionale Emodializzati Dialisi e Trapianto Department of Cardiovascular Sports Medicine Sports Medicine ULSS Company 9 Sports Medicine Regional Hospital of Bologna Department of Nephrology and Dialysis S. Orsola Hospital Sports Medicine Unit DIMED Department of Medicine University of Padua Sports Medicine Regional Hospital of Modena Sports Medicine Regional Hospital of Ravenna Sports Medicine Regional Hospital of Parma Department of Experimental and Clinical Medicine School of Sports Medicine University of Florence Sports Medicine Centre Italian National Transplant Centre

AIM To evaluate the effect of a 12-mo supervised aerobic and resistance training, on renal function and exercise capacity compared to usual care *** Ninety-nine kidney transplant recipients(KTRs) were assigned to interventional exercise(Group A; n = 52) and a usual care cohort(Group B; n = 47). Blood and urine chemistry, exercise capacity, muscular strength, anthropometric measures and health-related quality of life(HRQo L) were assessed at baseline, and after 6 and 12 mo. Group A underwent a supervised training three times per week for 12 mo. Group B received only general recommendations about home-based physical *** Eighty-five KTRs completed the study(Group A, n = 44; Group B, n = 41). After 12 mo, renal function remained stable in both groups. Group A significantly increased maximum workload(+13 W, P = 0.0003), V'O2 peak(+3.1 mL/kg per minute, P = 0.0099), muscular strength in plantar flexor(+12 kg, P = 0.0368), height in the countermovement jump(+1.9 cm, P = 0.0293) and decreased in Body Mass Index(-0.5 kg/m^2, P = 0.0013). HRQo L significantly improved in physical function(P = 0.0019), physical-role limitations(P = 0.0321) and social functioning scales(P = 0.0346). Noimprovements were found in Group *** Twelve-month of supervised aerobic and resistance training improves the physiological variables related to physical fitness and cardiovascular risks without consequences on renal function. Recommendations alone are not sufficient to induce changes in exercise capacity of KTRs. Our study is an example of collaborative working between transplant centres, sports medicine and exercise facilities.

关键词： Kidney transplant recipients Renal function Supervised exercise Aerobic exercise Muscle strength

Neuropathology of Schizophrenia

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Journal of Pharmacy and Pharmacology 2014年第7期2卷 422-431页

作者： Villeda-Hernandez Juana Sanchez Martinez Rodrigo Totxo-Guerrero Sebastian Manzanarez-Colin Mariel Carolina Palacios-Escalona sergio franco-Del Toro Perla Guadalupe Cuevas-Nunez Flora Minerva Alonso-Zuniga Rosa Emma Peralta-Rodriguez Brenda Rembao-Bojorquez Daniel Tristan-Agundis Ma.Francisca Department of Neuropathology National Institute of Neurology and Neurosurgery Distrito Federal 14269 Mexico Faculty of Medicine National Autonomous University of Mexico Distrito Federal 03000 Mexico School of Medicine Guadalajara University Guadalajara 44100 Mexico School of Medicine San Luis Potosi University San Luis Potosi 78000 Mexico Department of Pathology Fray Bernardino Alvarez Psychiatric Hospital Distrito Federal 14000 Mexico

The paper is to study the structural changes in cortex and cerebellum of autopsies of subjects with schizophrenia. In the Pathology Department of the Psychiatric Hospital ＂Fray Bernardino ,Avarez＂, there are 410 autopsy cases with diagnosis of mental disease, from which 52 match schizophrenia. The aim of this work is to describe structural changes in the autopsy material and make markers in order to confirm neurodevelopment alterations. The tissues were preserved in formol, paraffin-embedded; cut into 5-7 μm slices; stained with H-E （Hematoxilin and Eosin）, Bielschowsky, crystal fast of violet. The observed changes were brain asymmetry, cortical dysplasia, neuronal distortion, axon bifurcation, neuronophagia and generalized demyelination. Schizophrenia is the result of several happenings, it is important to devise new treatment strategies for prevention and genetic counseling for population.

关键词： Schizophrenia cortical dysplasia heterotopias migration failure.