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Effect of Mushroom Extract Hericium erinaceus on Spatial Memory and Morphology of Neurons in the CA1 and CA3 Regions of the Hippocampus in Ovariectomized Rats

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Open Journal of Veterinary Medicine 2024年第7期14卷 163-179页

作者： Lucia Garcia-Delgado Mariana Monserrath Verdía-Venegas Jacinto Bañuelos-Pineda Esther Albarrán-Rodríguez Guillermo Nolasco-Rodriguez José Ricardo Cuellar-Pérez sergio fausto-guerra Manuel Rosales-Cortés Master in Behavioral Sciences Institute of Neurosciences University of Guadalajara Zapopan Mexico Department of Veterinary Medicine Division of Veterinary Sciences CUCBA University of Guadalajara Zapopan Mexico Botany and Zoology Laboratory CUCBA University of Guadalajara Zapopan Mexico

Various studies indicate that low levels of estradiol negatively impact cognitive abilities. Extracts from the fungus Hericium erinaceus (HE) contain bioactive components that promote the proper functioning of the nervous system and potential effects on protection against neurodegenerative diseases, including dementia and motor dysfunctions. The objective was to evaluate the effects of the administration of the HE mushroom extract on visuospatial memory and morphology of neurons in the CA1 and CA3 regions of the hippocampus in ovariectomized rats. 40 young Wistar rats weighing 90 ± 10 g BW were used, which were distributed into four groups of 10 animals;Control Group, non-ovariectomized and untreated rats;Group E2, ovariectomized rats treated with estradiol (2 μg/kg/body weight);Group HE, ovariectomized rats treated with the extract of the fungus Hericium erinaceus (0.5 mg/kg body weight) and Group Ovx/ST, ovariectomized rats, without treatment. The animals were tested in the Barnes and Open Field maze, then they were sacrificed, and their brains were obtained to perform a histological analysis of neuronal morphology in the CA1 and CA3 areas of the hippocampus. The most outstanding results showed that the Ovx/ST group recorded the longest time to arrive at the escape box and stay in the Barnes maze. A correlation was observed between neuronal damage and function;in the groups that did not present satisfactory performance in the maze tests, morphological alterations were identified such as the presence of some neuronal somata with degeneration characteristics such as pyknosis, nuclear basophilia and shrinkage of the cells. Its soma, as well as a decrease in the nuclear area of CA1 and CA3 neurons. It is concluded that the fungus Hericium erinaceus exerted a neuroprotective effect on the neuronal bodies of the hippocampus, associated with better performance in the visuospatial recognition memory test.

关键词： Ovariectomized Rats Ovarian Hypofunction Estradiol Hericium erinaceus Barnes Circular Labyrinth Open Field Labyrinth

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Protective and Regenerative Effect of the Extract of Kombucha and the Fungus Ganoderma sichuanense on the Islets of Langerhans of Diabetic Rats

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Open Journal of Veterinary Medicine 2023年第10期13卷 173-185页

作者： Pedro Hinojosa-Gómez sergio fausto-guerra Guillermo Nolasco-Rodríguez Lucia García-Delgado Víctor Barragán-Cano Manuel Rosales-Cortés Esther Albarrán-Rodríguez José Ricardo Cuéllar-Pérez Department of Veterinary Medicine University Center for Agricultural Biological Sciences University of Guadalajara Jalisco Mexico Doctorate of Sciences in Ecophysiology and Genetic Resources University Center for Agricultural Biological Sciences University of Guadalajara Jalisco Mexico Department of Botany and Zoology University Center for Agricultural Biological Sciences University of Guadalajara Jalisco Mexico

Objective: The present study consisted of challenging the extract of kombucha and the fungus Ganoderma reported as hypoglycemic and used as alternative treatments against diabetes on the number and morphology of islets of Langerhans. Material and Methods: 64 Wistar rats were used in 4 groups: one control, three experimental, streptozotocin, Kombucha y Ganoderma induced diabetes with streptozotocin. Divided into four post-induction stages at 2, 15, 30 and 45 days of treatment, sacrificing 4 rats at each stage, to perform the morphological analysis of the pancreas. Results: A decrease in the islets of Langerhans in size, volume and the number of cells within them was identified for the streptozotocin group from the second stage until almost disappearing due to diabetes, in the groups of Kombucha y Ganoderma the same was observed but they were recovered with the extract treatments and the average number of islets was similar in these groups, the group of Ganoderma. Conclusion: Under the conditions of this work, a protective and regenerative effect of both extracts is identified.

关键词： Rats Diabetes Streptozotocin Ganoderma Kombucha Pancreas

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Urethroplasty in a post irradiation urethral stricture-a review

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Plastic and Aesthetic Research 2022年第1期9卷 133-139页

作者： Carlos guerra sergio Davila Slavica Pusica Predrag Aleksic Department of Urology Belgrade Center for Genitourinary Reconstructive SurgeryBelgrade 11000Serbia Department of Urology Hospital Universitario“Dr.JoséEleuterio González”MonterreyNuevo Leon 64460Mexico Department of Urology Medical Military AcademyBelgrade 11000Serbia

Radiotherapy-induced urethral strictures(RIUS)decrease quality of life and present a great challenge for surgical reconstruction,especially due to proximal location,compromised vascular supply,and poor wound *** is unclear whether urethroplasty is an option in cases with stricture resulting from exposure to pelvic *** review the pathophysiology,diagnostic workup,and disease-specific aspects of ***,we discuss several management alternatives such as excision and primary anastomosis,as well as techniques for open reconstruction with *** most extensive techniques in the treatment of strictures include,for example,those using gracilis muscle flaps,as they can involve periurethral tissue to provide sufficient vascularity for excellent post-surgery urethral *** brief,RIUS represent a significant *** carefully chosen patients,urethroplasty should be considered as a feasible and durable ***,medical practitioners should always take into consideration that the results of urethroplasty in RIUS are not comparable to urethroplasties without a radiation background.

关键词： Urethra stricture radiotherapy urethroplasty buccal mucosa graft gracilis muscle flap stricture

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Diversity and host assemblage of avian haemosporidians in different terrestrial ecoregions of Peru

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Current Zoology 2022年第1期68卷 27-40页

作者： Luz GARCIA-LONGORIA Jaime MURIEL sergio MAGALLANES Zaira Hellen VILLA-GALARCE Leonila RICOPA Wilson Giancarlo INGA-DIAZ Esteban FONG Daniel VECCO Cesar guerra-SALDANA Teresa SALAS-RENGIFO Wendy FLORES-SAAVEDRA Kathya ESPINOZA Carlos MENDOZA Blanca SALDANA Manuel GONZALEZ-BLAZQUEZ Henry GONZALES-PINEDO Charlene LUJAN-VEGA Carlos Alberto Del AGUILA Yessica VILCA-HERRERA Carlos Alberto PINEDA Carmen REATEGUI Jorge Manuel CARDENAS-CALLIRGOS JoseAlberto IANNACONE Jorge Luis MENDOZA Ravinder NMSEHGAL Alfonso MARZAL Departamento de Anatomia Biologia Celular y ZoologiaUniversidad de ExtremaduraBadajoz E-506071Spain Molecular Ecology and Evolution Lab Department of BiologyLund UniversitySolvegatan 37SE-22362 LundSweden Instituto Pirenaico de Ecologıa-IPE(CSIC) Avda.Nuestra Senora de la Victoria 16Jaca 22700Spain DIRESA Direccion Regional de SaludLoreto 16001Peru Departamento Academico de Microbiologia y Parasitologia.Facultad de Ciencias Biologicas Universidad Nacional de la Amazonia PeruanaIquitos 16001Peru Facultad de Ciencias Agropecuarias Universidad Alas PeruanasLima 15823Peru EverGreen Institute-San Rafael Distrito de IndianaLoreto 16200Peru Observatorio de Aves Loreto(LBO) Distrito de San JuanLoreto 16008Peru Centro Urku de Estudios Amazonicos Tarapoto 22200Peru Servicio Nacional de Areas Naturales Protegidas por el Estado 15036Peru Sanidad Animal-Facultad de Zootecnia Universidad Nacional Agraria La MolinaLima 15012Peru Laboratorio de Microbiologia Facultad de Medicina Veterinaria y ZootecniaUniversidad CientUfica del SurLima 15067Peru Laboratorio de Analisis Clinico Moraleslab SAC MoralesSan Martin 22201Peru Asociacion Ecosistemas Andinos(ECOAN) Cuzco 08002Peru Pharmacology and Toxicology Graduate Group University of CaliforniaDavisDA 95616USA Global Health Initiative Wabash CollegeCrawfordsvilleIN 47933USA Facultad de Ciencias Biologicas Universidad Nacional Mayor de San MarcosLima 15081Peru Facultad de Medicina Veterinaria Universidad Nacional Hermilio ValdizanHuanuco10160Peru Asociacion Peruana de Helmintologia e Invertebrados Afines Lima 15054Peru Laboratorio de Ecologia y Biodiversidad Animal Universidad Nacional Federico VillarrealEl AgustinoLima 15007Peru Laboratorio de Invertebrados Universidad Ricardo Palma-Santiago de SurcoLima 15537Peru Department of Biology San Francisco State UniversitySan FranciscoCA 94132USA

Characterizing the diversity and structure of host–parasite communities is crucial to understandingtheir eco-evolutionary *** and related haemosporidian parasites are responsible forfitness loss and mortality in bird species ***,despite exhibiting the greatest ornithologicalbiodiversity,avian haemosporidians from Neotropical regions are quite ***,we analyze the genetic diversity of bird haemosporidian parasites(Plasmodium andHaemoproteus)in 1,336 individuals belonging to 206 bird species to explore for differences in diversityof parasite lineages and bird species across 5 well-differentiated Peruvian *** 70 different haemosporidian lineages infecting 74 bird *** showed that 25 out ofthe 70 haplotypes had not been previously ***,we also identified 81 new host–parasite interactions representing new host records for these haemosporidian *** outcomesrevealed that the effective diversity(as well as the richness,abundance,and Shannon–Weaver index)for both birds and parasite lineages was higher in Amazon basin ***,we also showed that ecoregions with greater diversity of bird species also had highparasite richness,hence suggesting that host community is crucial in explaining parasite *** parasites were found in ecoregions with lower bird diversity,implying that the abundanceand richness of hosts may shape the exploitation strategy followed by haemosporidian *** outcomes reveal that Neotropical region is a major reservoir of unidentified *** studies analyzing host distribution and specificity of these parasites inthe tropics will provide important knowledge about phylogenetic relationships,phylogeography,and patterns of evolution and distribution of haemosporidian parasites.

关键词： Amazonia avian malaria generalist parasite habitat specificity Haemoproteus Plasmodium specialist parasite

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中世纪的村庄

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建筑实践 2015年第1期 6-11页

作者：李莹 Fernando guerra sergio guerra

金色的平原,一望无际,与阳光相连;太阳给予的温暖,带着缓慢而有序的节奏,这就是葡萄牙东南部的阿连特茹(Alentejo),代表自然和生态物质的雄伟软木树,是这里标志性的平原景观,广阔的土地上密密麻麻地布满了软木与橄榄树,掩盖了时间流逝... 详细信息

金色的平原,一望无际,与阳光相连;太阳给予的温暖,带着缓慢而有序的节奏,这就是葡萄牙东南部的阿连特茹(Alentejo),代表自然和生态物质的雄伟软木树,是这里标志性的平原景观,广阔的土地上密密麻麻地布满了软木与橄榄树,掩盖了时间流逝的痕迹。提起“软木”,你的脑海第一时间可能会浮现出一瓶优质的葡萄酒,而葡萄牙正是世界上主要的软木加工生产国,然而,2008年的经济衰退拖累了这一传统老牌工业,而今,葡萄牙的软木种植者们正绞尽脑汁将

关键词：天然软木埃武拉建筑师克鲁兹

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一座19世纪旧建筑的全新面目

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设计家 2009年第6期 70-77页

作者： Pedro Domingos Fernando guerra sergio guerra 余丹 Pedro Domingos Arquitectos

本项目是对位于葡萄牙里斯本的Lapa/Prazeres区域的一座19世纪建筑的改造工程。建筑物的一边本来面向的是一个花园,因长久弃置而成了一个杂乱的废物堆积场,另一边则面向一条街道,地势略向下倾斜。原建筑是一个功能已经严重退化的大楼。

关键词：里斯本旧建筑改造工程葡萄牙废物堆建筑物功能性新面目世纪设计师

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“火山之巅”

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建筑实践 2014年第10期 34-39页

作者：徐会玲 FG+SG—Fernando guerra sergio guerra

为了在福戈岛上建造一座标志性建筑,并且改善对福戈岛受保护区域的管理,德国和当地政府决定合作兴建福戈岛自然公园总部,其中德国复兴信贷银行提供95%以上的资金支持,其余的由佛得角政府资助。葡萄牙的OTO Arquitectos最终接受委任,为... 详细信息

为了在福戈岛上建造一座标志性建筑,并且改善对福戈岛受保护区域的管理,德国和当地政府决定合作兴建福戈岛自然公园总部,其中德国复兴信贷银行提供95%以上的资金支持,其余的由佛得角政府资助。葡萄牙的OTO Arquitectos最终接受委任,为这座自然公园设计了一个总部管理处。自然公园总部管理处主要为附近的chadas caldeiras村庄提供服务。这一村庄坐落在福戈岛海拔1800米处的火山口,居民在火山喷发期间撤离。这一合法性有待考验的社区占据着国家的土地,为大约1200名居民提供了栖身之地。村庄孤零零的坐落在西非海岸,这一地区主要依靠农产品维持生计。

关键词：自然公园管理处图书馆设计师

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新型金刚石磨具提高石材磨削率的方法

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石材 2005年第3期 39-43页

作者： P.M.Amaral L.guerra Rosa sergio Pinto Pavid Pozo 谈耀麟桂林矿产地质研究院广西桂林541004

金属制成的复合材料或者新近的聚合物粘结剂以及作为研磨(切削)介质的金刚石粒的应用,正在迅速改变着磨削工具的未来,并已导致高性能研磨工具的发展。使用此类工具除了更为直接的优势如较高的使用寿命和较高的生产率之外,也更为有利于... 详细信息

金属制成的复合材料或者新近的聚合物粘结剂以及作为研磨(切削)介质的金刚石粒的应用,正在迅速改变着磨削工具的未来,并已导致高性能研磨工具的发展。使用此类工具除了更为直接的优势如较高的使用寿命和较高的生产率之外,也更为有利于环境保护,而且与传统的磨料相比,对磨削来说金属粘结的和树脂粘结的金刚石磨具要经济得多,即使其生产成本高得多。证明这一点并不难。目前,加工过程经过优化之后,几乎只用金刚石磨具来完成全部磨削工作是有可能的。

关键词：磨削金刚石磨具金属切削磨料工具研磨石材粘结剂树脂

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新罕布什尔休闲寓所美国新罕布什

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世界建筑导报 2018年第2期33卷 90-93页

作者： nader tehrani katherine faulkner ryan murphy sergio verrillo marta guerra tim wong tom beresford lisa lacharité john houser alda black laura williams wes hiatt 不详 AIA

新罕布什尔休闲寓所位于白山总统山脉北麓中．由一系列的独立房间组成——每个房间都是一幅画，捕捉周围山顶的景色。新罕布什尔休闲寓所采用按线性顺序展开，一端用于卧室套房，另一端用于服务区域的方案。

关键词：布什休闲美国服务区域房间景色山顶套房

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