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Evaluation of Two Highly Porous Microcrystalline Biphasic Calcium Phosphate-Based Bone Grafts for Bone Regeneration: An Experimental Study in Rabbits

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Journal of Materials Science and Chemical Engineering 2020年第6期8卷 8-30页

作者： Miguel Ángel Garcés-Villalá sergio david rico sergio Gustavo Nazar Mariano Escudero-Pinel Víctor Galván-Josa José Luis Calvo-Guirado Department of Implant and Biomaterial Research Fundación Corazón de Jesús San Juan Argentina Facultad de Matemática Astronomía y Física Universidad Nacional de Córdoba Córdoba Argentina Department of Oral Surgery and Implant Dentistry Faculty of Health Sciences Universidad Católica San Antonio de Murcia Murcia Spain

A biphasic bone grafting biomaterial based on a mixture of calcium phosphates and beta-tricalcium phosphate (β-TCP) phases with high nanoporosity was synthesized. The synthesis route was based on calcium phosphate composition and the incorporation of glycolic acid as a pore former, giving a material composed of 97% β-TCP and 3% calcium orthophosphates (CaPO4). An in vitro study of the purity, microstructure, crystalline domain, and pores size for the material obtained was performed by SEM analysis as well as full structural characterization. The region of interest related to the surface was determined by the specific surface area measured with the BET method. In vivo evaluation of bone response was performed by implanting the new low-cost biphasic manufacturing material synthesized in this work, which was compared with a biphasic material of similar chemical and microstructural composition existing in the commercial market and with higher cost called Synergy Odontit® β-TCP. The materials were implanted separately into 5 mm diameter defects in the tibias of New Zealand White rabbits at 30, 60, and 90 days. The results obtained showed that the host tissue well accepted the new biphasic material;the presence of new bone formation was observed. A more complete resorption was observed for the new microcrystalline biphasic material compared to for a commercial β-TCP material.

关键词： Microcrystalline Beta-Tricalcium Phosphate Ceramic Bone Graft Glycolic Acid

Root Resorption of Central Incisor by Impacted Canine in Unusual Transposition: Orthodontics and Implant Rehabilitation: 3-Year Follow-Up

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Journal of Biosciences and Medicines 2021年第10期9卷 55-64页

作者： Miguel Ángel Garcés-Villalá Silvia Lorena Sticca-Peralta sergio david rico-Jordán José Luis Calvo-Guirado Department of Implant and Biomaterial Research Fundación Corazón de Jesús San Juan Argentina Department of Oral Surgery and Implant Dentistry Faculty of Health Sciences Universidad Católica San Antonio de Murcia Murcia Espa&ntilde a

This case presents an unusual transposition of an impacted canine on the central incisor that provides a multidisciplinary approach to its resolution. The patient comes to the consultation for mobility of the central incisor. Clinically, tooth mobility was confirmed with tooth crowding and persistence of the temporary canine. Cone beam tomography (CBCT) observed the atypical position of the permanent canine that caused root resorption of the ipsilateral central incisor and the need to extract both teeth. The conservative treatment of the bone structures during the dental enucleation of the impacted canine carried out by odontosection and the immediate bone grafting of the defect projected an acceptable regeneration of the bone volume for the insertion of the implant. The orthodontic treatment managed to correct the bite, position the upper premolar in the place of the canine tooth and maintain the space to place the implant in the central incisor. The three-year follow-up shows maintenance of the peri-implant crestal bone level, the success of orthodontic treatment with recovery of the patient’s function and aesthetics.

关键词： Impacted Canine Unusual Transposition Root Resorption Orthodontics/Dental Implants

Avian malaria,haematocrit,and body condition in invasive wetland passerines settled in southwestern Spain

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Avian Research 2023年第1期14卷 99-107页

作者： Jaime Muriel Luz Garcia-Longoria sergio Magallanes Juan Antonio Ortiz Alfonso Marzal Instituto de Investigación en Recursos Cinegéticos(IREC) CSIC-UCLM-JCCMRonda de Toledo 1213005Ciudad RealSpain Universidad de Extremadura Facultad de BiologíaDepartamento de AnatomíaBiología Celular y Zoología Avenida de Elvas s/n06006BadajozSpain Estación Biológica de Donana(EBD-CSIC) Departamento de Ecología de los HumedalesAvda.Américo Vespucio 2641092SevillaSpain Hirundo Bird Ringing Group BadajozSpain Grupo de Investigaciones en Fauna Silvestre Universidad Nacional de San MartínJr.Maynas177722021TarapotoPeru

Avian malaria and related haemosporidian parasites can negatively impact fitness in many *** on the malaria infection and its physiological costs on their avian hosts is heavily skewed toward native passerines,with exotic species ***,introduced species may carry on and spread new pathogens to native species,and play a role on parasite transmission cycle in invaded bird communities as pathogen ***,we molecularly assess the prevalence and diversity of haemosporidian parasites in three introduced wetland passerines(the Red Avadavat Amandava amandava,the Yellow-crowned Bishop Euplectes afer,and the Common Waxbill Estrilda astrild)captured during the same season in southwestern *** also explored the relation between parasite infection,body condition,haematocrit,and uropygial gland *** detected an overall parasite prevalence of 3.55%,where Common Waxbills showed higher prevalence(6.94%)than Red Avadavats(1.51%).None Yellow-crowned Bishops were infected with *** 60%of infections were caused by Leucocytozoon,and about 40%by *** identified four unique lineages of Plasmodium and three of ***,91%of the identified host-parasite interactions represented new host records for these haemosporidian *** infection was not related to body condition,haematocrit,and uropygial gland volume of the wetland *** values varied seasonally among bird ***,haematocrit was positively related to body condition in the Yellow-crowned Bishops,but not in the other *** Avadavats had higher haematocrit levels than Yellow-crowned Bishops,whereas Common Waxbills showed the lower haematocrit *** uropygial gland volume was positively correlated with body condition in all bird *** Waxbills showed higher uropygial gland volumes related to their body size than birds from other two *** outcomes highlight the importance of e

关键词： Avian malaria Exotic species Introduced birds Leucocytozoon Plasmodium Uropygial gland

Physiological dormancy broken by endozoochory:Austral parakeets(Enicognathus ferrugineus)as legitimate dispersers of calafate(Berberis microphylla)in the Patagonian Andes

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Journal of Plant Ecology 2020年第5期13卷 538-544页

作者： Carolina Bravo Daniel Chamorro Fernando Hiraldo Karina Speziale sergio A.Lambertucci JoséL.Tella Guillermo Blanco Department of Evolutionary Ecology Museo Nacional de Ciencias NaturalesCSICJoséGutiérrez Abascal 228006 MadridSpain Centre d’Etudes Biologiques de Chizé UMR 7372CNRS and La Rochelle UniversitéF-79360 Beauvoir-sur-NiortFrance Departamento de Ciencias Ambientales Universidad de Castilla-La ManchaAv.Carlos III s/n45071 ToledoSpain Department of Conservation Biology Estación Biológica de DoñanaCSICAmérico Vespucio 2641092 SevillaSpain Grupo de Investigaciones en Biología de la Conservación Departamento de EcologíaINIBIOMA(CONICET-National University of Comahue)Pasaje Gutiérrez 11258400 BarilocheArgentina

Aims Seed dispersal by endozoochory is an important process in plant regeneration and the establishment of new *** with dormancy may especially benefit after disperser gut ***,the ways in which gut passage affect the germination of plant species with physiological dormancy remain ***,we experimentally assessed the mutualistic interaction between the Austral parakeet(Enicognathus ferrugineus)as a disperser of calafate(Berberis microphylla),a thorny bush inhabiting the understory of the Austral temperate forests of South America with seeds that are characterized by deep physiological *** Germination success and viability of calafate seeds obtained from faeces and from intact fruits were tested under four treatments:(i)digested seeds,(ii)digested seeds with faecal extract,(iii)intact seeds from fruit and(iv)intact seeds from fruit with *** Findings About 65%of the Austral parakeet droppings contained calafate *** of seeds did not differ between ***,germination was significantly higher in digested seeds than in intact seeds from fruits,while no difference was found between faecal and pulp *** faecal matter nor fruit pulp provided seeds with any ecological advantages derived from enhancing germinability,but did confer some disadvantage in germination *** matter is expected to be completely lacking around seeds after several months under snow before germinating in the following spring,given intense washing due to persistent rain and the spring thaw in the Patagonian *** higher germinability along with faster germination of digested seeds supports the hypothesis of a legitimate mutualistic interaction between Austral parakeets and *** hypothesized that the passage through the disperser digestive tract might break physiological dormancy as differences in germinability between ingested and non-ingested *** results highlight the relevant role of endoz

关键词： seed dispersal Austral forest mutualism gut passage viability germination success germinability

Environmental and Economic Impact of Forest Fires in Puerto rico 2013-2014

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Open Journal of Forestry 2015年第4期5卷 353-363页

作者： Méndez-Tejeda Rafael Santos-Corrada María Ortiz-Morales sergio Claudio-Vargas Oscar Natural Science Department Atmospherical Science Laboratory University of Puerto Rico—Carolina Campus Carolina Puerto Rico School of Business and Entrepreneurship University of Turabo Gurabo Puerto Rico

This study presents an analysis of the impact of forest fires in Puerto rico for the period from 2013-2014. The climatological factors analyzed included precipitation, temperature, relative humidity, and wind. Several factors have combined to the increase of these forest fires, among others, a decrease in precipitation during this period, as well as an increase in the human involvement in these fires from approximately 40% occurs in the night period (5:00 pm to 8:00 am), where the weather conditions do not favor the appearance of these phenomena. An increase in fires of 44% occurred in 2013 compared to 2014, causing an economic loss of $13.8 million. Fire also adversely affected the flora and fauna of the island, but this was not evaluated in this paper.

关键词： Fires Forest Wildfire Economic Impact of Forest fires Precipitation and Weather Conditions

Clinical relevance of the use of Dentoxol® for oral mucositis induced by radiotherapy: A phase II clinical trial

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World Journal of Clinical Oncology 2022年第10期13卷 813-821页

作者： Sebastián Solé sergio Becerra Claudia Carvajal Piero Bettolli Hernán Letelier Alejandro Santini Lorena Vargas Alexander Cifuentes Francisco Larsen Natalia Jara Jorge Oyarzún Eva Bustamante Benjamín Martínez david Rosenberg Tomas Galván Department of Radiotherapy Radiomedicine InstituteAmérico Vespucio Norte 1314 Vitacura7630370SantiagoChile National Institute of Cancer SantiagoServicio de Salud Metropolitano NorteAv Profesor Zañartu 1010Independencia8380455SantiagoChile Oncologic Institute Arturo López Pérez Foundation JoséManuel Infante 805Providencia7500691SantiagoChile Hospital Base Valdivia Bueras 1003 s/n XIV Región5100238ValdiviaChile Oncologic Center of Antofagasta Los Pumas 10255Antofagasta1267348AntofagastaChile Universidad Mayor SantiagoAv Libertador Bernardo O´Higgins 20138340585SantiagoChile Ingalfarma Dr Manuel Barros Borgoño 71Oficina 1308Providencia7500593SantiagoChile

BACKGROUND Severe oral mucositis associated with cancer therapy is a frequent complication that may affect a patient's systemic condition,resulting in interruption and/or prolongation of cancer ***®is a medical solution in the form of a mouthwash that has been shown to result in statistically significant improvement in the prevention of severe oral ***,knowing the measures of the clinical significance of this therapy is important for accurate *** describe the clinical impact of Dentoxol®use in severe oral *** Clinical significance was measured using the results obtained in a randomized controlled clinical trial previously conducted by the same group of *** measures of clinical significance evaluated were the absolute risk or incidence,relative risk,absolute risk reduction,relative risk reduction,number needed to treat,and odds *** The data obtained show that the impact of Dentoxol®on reducing the severity of oral mucositis has important clinical *** The results of this study justify the incorporation of Dentoxol®mouth rinse into clinical protocols as a complement to cancer therapy to prevent and/or treat oral mucositis secondary to radiotherapy.

关键词： Clinical trial Dentoxol Oral mucositis Prevention Radiotherapy Treatment

Feasibility and physics potential of detecting ^(8)B solar neutrinos at JUNO

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Chinese Physics C 2021年第2期45卷 93-110页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Sebastiano Aiello Muhammad Akram Nawab Ali Fengpeng An Guangpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Andrej Babic Wander Baldini Andrea Barresi Eric Baussan Marco Bellato Antonio Bergnoli Enrico Bernieri david Biare Thilo Birkenfeld Sylvie Blin david Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Max Buesken Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Jinfan Chang Yun Chang Pingping Chen Po-An Chen Shaomin Chen Shenjian Chen Xurong Chen Yi-Wen Chen Yixue Chen Yu Chen Zhang Chen Jie Cheng Yaping Cheng Alexander Chepurnov davide Chiesa Pietro Chimenti Artem Chukanov Anna Chuvashova Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Salvatore Costa Flavio Dal Corso Christophe De La Taille Jiawei Deng Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Georgy Donchenko Jianmeng Dong Damien Dornic Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Shuxian Du Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Lukas Fajt Donghua Fan Lei Fan Can Fang Jian Fang Marco Fargetta Anna Fatkina Dmitry Fedoseev Vladko Fekete Li-Cheng Feng Qichun Feng Richard Ford Andrey Formozov Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Alexandre Göttel Christoph Genster Marco Giammarchi Agnese Giaz Nunzio Giudice Franco Giuliani Maxim Gonchar Guanghua Gong Hui Gong Oleg Gorchakov Yuri Gornushkin Marco Grassi Christian Grewing Maxim Gromov Vasily Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Nunzio Guardone Maria Gul Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yan Yerevan Physics Institute YerevanArmenia UniversitéLibre de Bruxelles BrusselsBelgium Universidade Estadual de Londrina LondrinaBrazil Pontificia Universidade Catolica do Rio de Janeiro RioBrazil Pontificia Universidad Católica de Chile SantiagoChile Universidad Tecnica Federico Santa Maria ValparaisoChile Beijing Institute of Spacecraft Environment Engineering BeijingChina Beijing Normal University BeijingChina China Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina Tsinghua University BeijingChina University of Chinese Academy of Sciences BeijingChina Jilin University ChangchunChina College of Electronic Science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina Dongguan University of Technology DongguanChina Jinan University GuangzhouChina Sun Yat-Sen University GuangzhouChina Harbin Institute of Technology HarbinChina University of Science and Technology of China HefeiChina The Radiochemistry and Nuclear Chemistry Group in University of South China HengyangChina Wuyi University JiangmenChina Shandong University JinanChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Nanjing University NanjingChina Guangxi University NanningChina East China University of Science and Technology ShanghaiChina School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina Xi’an Jiaotong University Xi’anChina Xiamen University XiamenChina School of Physics and Microelectronics Zhengzhou UniversityZhengzhouChina Institute of Physics National Chiao-Tung University Hsinchu National United University Miao-Li Department of Physics National T

The Jiangmen Underground Neutrino Observatory(JUNO)features a 20 kt multi-purpose underground liquid scintillator sphere as its main *** of JUNO's features make it an excellent location for^8B solar neutrino measurements,such as its low-energy threshold,high energy resolution compared with water Cherenkov detectors,and much larger target mass compared with previous liquid scintillator *** this paper,we present a comprehensive assessment of JUNO's potential for detecting^8B solar neutrinos via the neutrino-electron elastic scattering process.A reduced 2 MeV threshold for the recoil electron energy is found to be achievable,assuming that the intrinsic radioactive background^(238)U and^(232)Th in the liquid scintillator can be controlled to 10^(-17)g/*** ten years of data acquisition,approximately 60,000 signal and 30,000 background events are *** large sample will enable an examination of the distortion of the recoil electron spectrum that is dominated by the neutrino flavor transformation in the dense solar matter,which will shed new light on the inconsistency between the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation *** m^(2)_(21)=4.8times10^(-5);(7.5times10^(-5))eV^(2),JUNO can provide evidence of neutrino oscillation in the Earth at approximately the 3sigma(2sigma)level by measuring the non-zero signal rate variation with respect to the solar zenith ***,JUNO can simultaneously measureDelta m^2_(21)using^8B solar neutrinos to a precision of 20% or better,depending on the central value,and to sub-percent precision using reactor antineutrinos.A comparison of these two measurements from the same detector will help understand the current mild inconsistency between the value of Delta m^2_(21)reported by solar neutrino experiments and the KamLAND experiment.

关键词： neutrino oscillation solar neutrino JUNO

JUNO sensitivity on proton decay p→νK^(+)searches

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Chinese Physics C 2023年第11期47卷 7-22页

作者： Angel Abusleme Thomas Adam Shakeel Ahmad Rizwan Ahmed Sebastiano Aiello Muhammad Akram 安丰鹏安琪 Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Nikita Balashov Wander Baldini Andrea Barresi davide Basilico Eric Baussan Marco Bellato Antonio Bergnoli Thilo Birkenfeld Sylvie Blin david Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Barbara Caccianiga 蔡浩蔡啸蔡严克蔡志岩 Riccardo Callegari Antonio Cammi Agustin Campeny 曹传亚曹国富曹俊 Rossella Caruso Cédric Cerna 常劲帆 Yun Chang 陈平平 Po-An Chen 陈少敏陈旭荣 Yi-Wen Chen 陈义学陈羽陈长程捷程雅苹 Alexey Chetverikov davide Chiesa Pietro Chimenti Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Flavio Dal Corso Olivia Dalager Christophe De La Taille 邓智邓子艳 Wilfried Depnering Marco Diaz Xuefeng Ding 丁雅韵 Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Dmitry Dolzhikov Georgy Donchenko 董建蒙 Evgeny Doroshkevich Marcos Dracos Frédéric Druillole 杜然杜书先 Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Ulrike Fahrendholz 范东华樊磊方建方文兴 Marco Fargetta Dmitry Fedoseev Li-Cheng Feng 冯启春 Richard Ford Amélie Fournier 甘浩男 Feng Gao Alberto Garfagnini Arsenii Gavrikov Marco Giammarchi Agnese Giaz Nunzio Giudice Maxim Gonchar 龚光华宫辉 Yuri Gornushkin Alexandre Göttel Marco Grassi Christian Grewing Vasily Gromov 顾旻皓谷肖飞古宇关梦云 Nunzio Guardone Maria Gul 郭聪郭竞渊郭万磊郭新恒郭宇航 Paul Hackspacher Caren Hagner 韩然 Yang Han Muhammad Sohaib Hassan 何苗何伟 Tobias Heinz Patrick Hellmuth 衡月昆 Rafael Herrera 贺远强侯少静 Yee Hsiung Bei-Zhen Hu 胡航胡健润胡俊胡守扬胡涛胡宇翔胡焯钧黄春豪黄桂鸿黄翰雄黄文昊黄鑫黄性涛黄永波惠加琪霍雷霍文驹 Cédric Huss Safeer Hussain Ara Ioannisian Roberto Isocrate Beatrice Jelmini Kuo-Lun Jen Ignacio Jeria 季筱璐吉星曌贾慧慧贾俊基蹇司玉蒋荻蒋炜江晓山金如意荆小平 Cécile Jollet Jari Joutsenvaara Sirichok Jungthawan Leonidas Kalousis Philipp Ka Pontificia Universidad Católica de Chile SantiagoChile IPHC Universitéde StrasbourgCNRS/IN2P3F-67037 StrasbourgFrance Pakistan Institute of Nuclear Science and Technology IslamabadPakistan INFN Catania and Dipartimento di Fisica e Astronomia dell Universitàdi Catania CataniaItaly East China University of Science and Technology ShanghaiChina University of Science and Technology of China HefeiChina Joint Institute for Nuclear Research DubnaRussia INFN Sezione di Milano and Dipartimento di Fisica dell Universitàdi Milano MilanoItaly Department of Physics Faculty of ScienceChulalongkorn UniversityBangkokThailand IJCLab UniversitéParis-SaclayCNRS/IN2P391405 OrsayFrance Department of Physics and Earth Science University of Ferrara and INFN Sezione di FerraraFerraraItaly INFN Milano Bicocca and University of Milano Bicocca MilanoItaly INFN Sezione di Padova PadovaItaly III.Physikalisches Institut B RWTH Aachen UniversityAachenGermany Eberhard Karls Universität Tübingen Physikalisches InstitutTübingenGermany Institute of High Energy Physics BeijingChina SUBATECH Universitéde NantesIMT AtlantiqueCNRS-IN2P3NantesFrance Univ.Bordeaux CNRSLP2IUMR 5797F-33170 GradignanFrance Department of Physics National Taiwan UniversityTaipei Dipartimento di Fisica e Astronomia dell’Universitàdi Padova and INFN Sezione di Padova PadovaItaly University of Roma Tre and INFN Sezione Roma Tre RomaItaly Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance Wuhan University WuhanChina INFN Milano Bicocca and Politecnico of Milano MilanoItaly National United University Miao-Li Dongguan University of Technology DongguanChina Tsinghua University BeijingChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Institute of Physics National Yang Ming Chiao Tung UniversityHsinchu North China Electric Power University BeijingChina Sun Yat-Sen University GuangzhouChina Beijing Institute of Spacecraft Environment Engineering BeijingChina Universidade Estadual de Londrina LondrinaBrazil INFN Sez

The Jiangmen Underground Neutrino Observatory(JUNO)is a large liquid scintillator detector designed to explore many topics in fundamental *** this study,the potential of searching for proton decay in the p→νK^(+)mode with JUNO is *** kaon and its decay particles feature a clear three-fold coincidence signature that results in a high efficiency for ***,the excellent energy resolution of JUNO permits suppression of the sizable background caused by other delayed *** on these advantages,the detection efficiency for the proton decay via p→νK^(+)is 36.9%±4.9%with a background level of 0.2±0.05(syst)±0.2(stat)events after 10 years of data *** estimated sensitivity based on 200 kton-years of exposure is 9.6×1033 years,which is competitive with the current best limits on the proton lifetime in this channel and complements the use of different detection technologies.

关键词： proton decay grand unified theories JUNO liquid scintillator detector