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现代生物医学进展 2017年第27期17卷 I0004-I0004页

作者： Chi a.Ma. Yua. Zha.g, Micha.l a.Weinreich, Jona.ha. J Lyons, Celeste G Nelson, Thoma. DiMa.gio, Kelly D Stone, Joshua.D Milner Jeffrey R Stinson, Elisa.Ruffo, Ba.sukh Dorjba., Swa.hinya.a.juna.a.a. Kelsey Voss, a.drew L Snow Jorda. K a.bott, Pia.J Ha.k, Pa.l R Reynolds, Erwin W Gelfa.d Elisa.Ruffo Sa.omé Gla.zy, Na.suko Ya.a.a.a. Eric Meffre Jennifer Stodda.d, Julie Niemela. sergio D Rosenzweig Yu Zha.g, Helen F Ma.thews Joshua.J McElwee Nina.Jones a.eja.dro Pa.ma. Ma.ía. Olea.tro, Emma.Prieto, a.drea.R Berna.coni, Geronimo Dubra. Silvia.Da.ielia., Jona.ha. Za.a., Ma.celo a.Ma.ti Bria. Kim Mega. a.Cooper Neil Romberg La.ora.ory of a.lergic Disea.es National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda Maryland USA Depa.tment of Pha.ma.ology a.d Molecula. Thera.eutics Uniformed Services University of the Health Sciences Bethesda Maryland USA Immunodeficiency Dia.nosis a.d Trea.ment Progra. Department of Pediatrics National Jewish Health Denver Colorado USA Depa.tment of Tra.sla.iona. Medicine University of Piemonte Orientale Novara Italy Depa.tment of Immunobiology Yale University School of Medicine New Haven Connecticut USA Immunology Service Department of Laboratory Medicine NIH Clinical Center National Institutes of Health Bethesda Maryland USA Huma. Immunologica. Disea.e Section National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda Maryland USA Merck Resea.ch La.ora.ories Merck and Co. Inc. Boston Massachusetts USA Clinica. Resea.ch Directora.e/Clinica. Monitoring Resea.ch Progra. Leidos Biomedical Research Inc. NCI Campus at Frederick Frederick Maryland USA Servicio de Immunología.y Reuma.ología Hospital Nacional de Pediatría Prof. Dr. Juan P. Garrahan Buenos Aires Argentina Division of Derma.ology Department of Medicine Washington University School of Medicine St. Louis Missouri USA Depa.tment of Pedia.rics Division of Rheumatology and Department of Pathology and Immunology Washington University School of Medicine St. Louis Missouri USA Depa.tment of Pedia.rics Children’s Hospital of Philadelphia Philadelphia Pennsylvania USA.

最近，研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变：Ca.Dll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析，发现了这一导致疾病产生的基因、

关键词：过敏性皮炎基因突变 Na. 神经性皮炎血缘关系研究所传染病 NIH

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嘉稳斋

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世界建筑导报 2020年第3期35卷 6-11页

作者：无景进正宋承熙张淑容金吉妍辛恩金金贤金辛宇森塞尔吉奥·皮罗内(摄影) 金正恩(摄影) 郑锡门(摄影) 履露斋金孝晩建筑师事务所不详

纪念性场地大约20年前,韩国政府在江南举办了“房博会”,建造了这座低层住宅的“世博小镇”,小镇的每一处建筑都是由当时韩国著名的建筑师精心设计的。“Ga.On Ja.(嘉稳斋)”曾是“博览城”之一。新主人购买了该地的老房子后,将它拆除,... 详细信息

纪念性场地大约20年前,韩国政府在江南举办了“房博会”,建造了这座低层住宅的“世博小镇”,小镇的每一处建筑都是由当时韩国著名的建筑师精心设计的。“Ga.On Ja.(嘉稳斋)”曾是“博览城”之一。新主人购买了该地的老房子后,将它拆除,重新建造了新房子。客户要求-最大程度上利用土地空间,赋予生态化“最大程度上利用土地空间,赋予生态化”是房主的重点要求,因为他认为被拆毁的老房子的外部空间狭窄、无用且内部空间呈蓝黑色。

关键词：低层住宅外部空间土地空间生态化老房子内部空间博览城纪念性场地

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The enha.ced X-ra. Timing a.d Pola.imetry mission—eXTP

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Science China.Physics,Mecha.ics & a.tronomy) 2019年第2期62卷 3-27页

作者： Shua.gNa. Zha.g a.drea.Sa.ta.gelo Ma.co Feroci YuPeng Xu Fa.gJun Lu Yong Chen Hua.Feng Shu Zha.g Sφren Bra.dt Ma.ga.ita.Herna.z Luca.Ba.dini Enrico Bozzo Ricca.do Ca.pa.a.a.essa.dra.De Rosa.YongWei Dong Yuri Eva.gelista.Vla.imir Ka.a. Norbert Meidinger a.ine Meuris Kirpa. Na.dra.Teng Pa. Giova.ni Pa.eschi Piotr Orlea.ski QiuShi Hua.g Stepha.e Scha.ne Giorgia.Sironi Da.iele Spiga.Jiri Svoboda.Gia.piero Ta.lia.erri Christoph Tenzer a.drea.Va.chi Silvia.Za.e Da.e Wa.ton Zha.Sha. Wa.g Berend Winter Xin Wu Jea. J.M.in't Za.d Ma.di a.a.ga.ia.a.ha.i Giova.ni a.brosi Filippo a.brosino Ma.co Ba.bera.Stefa.o Ba.so Jörg Ba.er Rona.do Bella.zini Pierluigi Bellutti Bruna.Bertucci Giuseppe Bertuccio Gia.omo Borghi XueLei Ca. Fra.ck Ca.oux Fra.cesco Cera.do Tia.Xia.g Chen Yu Peng Chen Jerome Chevenez Ma.ta.Civita.i Wei Cui WeiWei Cui Thoma. Da.ser Ettore Del Monte sergio Di Cosimo Seba.tia. Diebold Victor Doroshenko Micha. Dovcia. Yua.Yua. Du Lorenzo Ducci QingMei Fa. Ya.nick Fa.re Fa.io Fuschino JoséLuis Ga.lvez Min Ga. MingYu Ge Olivier Gevin Ma.co Gra.si Qua.Ying Gu YuDong Gu Da.ei Ha. Bin Hong Wei Hu Long Ji ShuMei Jia.WeiChun Jia.g Thoma. Kennedy Ingo Kreykenbohm Irfa. Kuvvetli Cla.dio La.a.ti Luca.La.ronico Ga.g Li Ma.Shun Li Xia. Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu Xia.Jing Liu Bo Lu Ta. Luo Da.iele Ma.era.Piero Ma.cova.i a.ria. Ma.tinda.e Ma.gorza.a.Micha.ska.Bin Meng Ma.simo Minuti a.fredo Morbidini Fa.io Muleri Stepha.e Pa.ta.i Ema.uele Perina.i a.tonino Picciotto Cla.dio Piemonte JinLu Qu a.exa.dre Ra.hevski Irina.Ra.hevska.a.Jerome Rodriguez Thoma. Scha.z ZhengXia.g Shen LiZhi Sheng Jia.gBo Song LiMing Song Ca.melo Sgro Lia.g Sun Ying Ta. Phil Uttley Bo Wa.g Dia.Long Wa.g GuoFeng Wa.g Jua. Wa.g La.gPing Wa.g YuSa.Wa.g a.na.L.Wa.ts Xia.gYa.g Wen Jörn Wilms Sha.Lin Xiong Jia.ei Ya.g Sheng Ya.g Ya.Ji Ya.g Nia. Yu WenDa.Zha.g Gia.luigi Za.pa.Nicola.Za.pa.a.drzej a.Zdzia.ski a.Mei Zha.g ChengMo Zha.g Fa. Zha.g Long Zha.g Tong Zha.g Yi Zha.g Xia.Li Zha.g ZiLia.g Zha.g Ba.Sheng Zha. ShiJie Zheng Yu Peng Zhou Key La.ora.ory for Pa.ticle a.trophysics Institute of High Energy PhysicsChinese Academy of Sciences Institut für a.tronomie und a.trophysik Eberhard Karls Universität INa.-Istituto di a.trofisica.e Pla.etologia.Spa.ia.i INFN-Roma.Tor Verga.a Via della Ricerca Scientifica 1 Depa.tment of Engineering Physics a.d Center for a.trophysics Tsinghua University DTU Building 327DK-2800 Kongens Institute of Spa.e Sciences 08193 Cerdanyola del Valles Institut d’Estudis Espa.ia.s de Ca.a.unya Sezione di Pisa Istituto Nazionale di Fisica NucleareLargo Bruno Pontecorvo3 Depa.tment of a.tronomy University of Genevachemin d’Ecogia 16 Osserva.orio di a.trofisica.e Scienza.Dello Spa.io di Bologna Istituto Nazionale di Astofisica a.tronomica. Institute Czech Academy of Sciences Ma. Pla.ck Institute for Extra.errestria. Physics Giessenbachstr.1 CEa.Pa.is-Sa.la./IRFU Beijing Institute of Spa.ecra.t System Engineering CAST Osserva.orio a.tronomico di Brera Istituto Nazionale di Astofisica Spa.e Resea.ch Center Polish Academy of Sciences Key La.ora.ory of a.va.ced Ma.eria. Microstructure of Educa.ion Ministry of China Institute of Precision Optical EngineeringSchool of Physics Science and EngineeringTongji University Depa.tment of Physics a.d Center for a.trophysics Tsinghua University Universita.degli Studi di Udine Via delle Scienze 206 Mulla.d Spa.e Science La.ora.ory University College London Depa.tment of Nuclea. a.d Pa.ticle Physics University of Geneva SRON Netherla.ds Institute for Spa.e Resea.ch Politecnico di Mila.o Sezione di Perugia Istituto Nazionale di Fisica Nucleare Dipa.timento di Fisica.e Chimica Fonda.ione Bruno Kessler Dr.Ka.l Remeis-Observa.ory a.d Erla.gen Centre for a.tropa.ticle Physics Universität Erlangen-Nürnberg University of Pa.ia Department of ElectronicsInformation and Biomedical Engineering and INFN Pavia Sezione di Torino Istituto Nazionale di Fisica NucleareVia Pietro Giuria1 Depa.tment of Physics a.d a.tronomy University of Leicester Sezione di Trieste Istituto Nazionale di Fisica Nucleare

In this pa.er we present the enha.ced X-ra. Timing a.d Pola.imetry mission—eXTP. eXTP is a.spa.e science mission designed to study funda.enta. physics under extreme conditions of density, gra.ity a.d ma.netism. The mission a.ms a. determining the equa.ion of sta.e of ma.ter a. supra.nuclea. density, mea.uring effects of QED, a.d understa.ding the dyna.ics of ma.ter in strong-field gra.ity. In a.dition to investiga.ing funda.enta. physics, eXTP will be a.very powerful observa.ory for a.trophysics tha. will provide observa.ions of unprecedented qua.ity on a.va.iety of ga.a.tic a.d extra.a.a.tic objects. In pa.ticula., its wide field monitoring ca.a.ilities will be highly instrumenta. to detect the electro-ma.netic counterpa.ts of gra.ita.iona. wa.e *** pa.er provides a.deta.led description of:(1) the technologica. a.d technica. a.pects, a.d the expected performa.ce of the instruments of the scientific pa.loa.;(2) the elements a.d functions of the mission, from the spa.ecra.t to the ground segment.

关键词： X-ra. instrumenta.ion X-ra. pola.imetry X-ra. timing spa.e mission:eXTP

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Notes for genera.a.comycota

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Funga. Diversity 2017年第5期86卷 1-594页

作者： Na.in N.Wija.a.a.dene Kevin D.Hyde Kunhira.a. C.Ra.eshkuma. Da.id L.Ha.ksworth Hugo Ma.rid Pa.l M.Kirk Uwe Bra.n Ra.shree V.Singh Pedro W.Crous Ma.tin Kukwa.Robert Lücking Cletus P.Kurtzma. a.drey Yurkov Da.ny Ha.lewa.ers a.dre´a.troot H.Thorsten Lumbsch Eina. Timda. Da.ien Ertz Ja.ier Eta.o a.a. J.L.Phillips Joha.nes Z.Groenewa.d Moslem Pa.iza.eh La.ra.Selbma.n Monika.C.Da.a.a.hne Gotha.ie Weera.oon E.B.Ga.eth Jones Sa.inee Suetrong Qing Tia. Ra.a.l F.Ca.ta.da.Ruiz a.i H.Ba.ka.i Ka.La. Pa.g Ka.ua.i Ta.a.a.Dong Qin Da. Ja.iya.Sa.a.a.oj Ma.tina.Hujslová Lorenzo Lomba.d Belle D.Shenoy a.e Suija.Sa.eewa.S.N.Ma.a.a.hchikumbura.Ka.un M.Tha.buga.a.Dha.ushka.N.Wa.a.inghe Bha.a.i O.Sha.ma.Subha.h Ga.kwa. Ga.gee Pa.dit La.ra.Zucconi Silva.o Onofri Eleonora.Egidi Huzefa.a.Ra.a.Ra.pa. Kodsueb Ma.cela.E.S.Ca.eres sergio Perez-Ortega.Pa.rícia.O.Fiuza.Josia.e Sa.ta.a.Monteiro La.issa.N.Va.ilyeva.Roger G.Shiva. Ma.ia.Prieto Ma.s Wedin Iba. Ola.ia.a.a.ebola.a.eez La.eef Ya.ini a.ra.a. Seyed a.olha.sa. Sha.za.eh Fa.eli Moha.ma. a.i a.oozega. Guo Zhu Zha. Wa.ter P.Pfliegler Gunja. Sha.ma.Ma.da.ena.Oset Moha.ed a.a.del-Wa.a. Susumu Ta.a.a.su Konsta.ze Bensch Nima.i Indeewa.i de Silva.a.dréDe Kesel a.uruddha.Ka.una.a.hna.Sa.a.ya.ha. Boonmee Dona.d H.Pfister Yong-Zhong Lu Zong-Long Luo Na.ta.ut Boonyuen Dinusha.i a.Da.a.a.a.a.Indunil C.Sena.a.a.e Suba.hini C.Ja.a.iri Mila. C.Sa.a.a.oon Xia.g-Yu Zeng Mingkwa. Doilom Luis Quija.a.Sillma.Ra.pa.a.a.h Ga.riela.Heredia.a.ha.J.Dissa.a.a.e Ruvishika.S.Ja.a.a.da.a.Rekha.i H.Perera.Li Zhou Ta.g Cha.a.a.d Phukha.sa.da.Ma.ga.ita.Herna.dez-Restrepo Xia.ya.Ma.Sa.wa.uck Tibpromma.Luis F.P.Gusma. Da.sha.i Weera.ewa.Sa.a.tha.C.Ka.una.a.hna Key La.ora.ory for Pla.t Diversity a.d Biogeogra.hy of Ea.t a.ia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China Center of Excellence in Funga. Resea.ch Mae Fah Luang UniversityChiang Rai 57100Thailand World a.roforestry Centre East and Central AsiaKunming 650201YunnanPeople’s Republic of China Mushroom Resea.ch Founda.ion 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Mai 50150Thailand Na.iona. Funga. Culture Collection of India.NFCCI) Biodiversity and Palaeobiology(Fungi)GroupAgharkar Research InstitutePuneMaharashtra 411004India Roya. Bota.ic Ga.dens KewRichmondSurrey TW93DSUK Depa.tment of Life Sciences The Natural History MuseumCromwell RoadLondon SW75BDUK Jilin a.ricultura. University Changchun 130118JilinPeople’s Republic of China Centro de Geno´mica.y Bioinforma.tica Facultad de CienciasUniversidad Mayor de ChileCamino La Pira´mide 5750HuechurabaSantiagoChile Ma.tin-Luther-Universita.t Institut fu¨r BiologieBereich Geobotanik und Botanischer GartenHerbariumNeuwerk 2106099 Halle(Saale)Germany Westerdijk Funga. Biodiversity Institute Uppsalalaan 83584 CT UtrechtThe Netherlands Depa.tment of Pla.t Ta.onomy a.d Na.ure Conserva.ion Faculty of BiologyUniversity of Gdan´skWita Stwosza 5980-308 Gdan´skPoland Bota.ic Ga.den a.d Bota.ica. Museum Königin-Luise-Str.6-814195 BerlinGermany Mycotoxin Prevention a.d a.plied Microbiology Resea.ch Unit National Center for Agricultural Utilization ResearchAgricultural Research ServiceU.S.Department of AgriculturePeoriaIL 61604USA Leibniz Institute DSMZ-Germa. Collection of Microorga.isms a.d Cell Cultures Inhoffenstraße 7B38124 BrunswickGermany Fa.low Reference Libra.y a.d Herba.ium of Cryptoga.ic Bota.y Harvard University22 Divinity AvenueCambridgeMA 02138USA Depa.tment of Orga.ismic a.d Evolutiona.y Biology Harvard University22 Divinity AvenueCambridgeMA 02138USA a.L Herba.ium G.v.d.Veenstraat 1073762 XK SoestThe Netherlands Science&Educa.ion The Field Museum1400

Knowledge of the rela.ionships a.d thus the cla.sifica.ion of fungi,ha. developed ra.idly with increa.ingly widesprea. use of molecula. techniques,over the pa.t 10–15 yea.s,a.d continues to *** genera.ha.e been found to be polyphyletic,a.d their generic concepts ha.e subsequently been *** na.es ha.e thus been introduced for species which a.e phylogenetica.ly distinct from the type species of pa.ticula. *** ending of the sepa.a.e na.ing of morphs of the sa.e species in 2011,ha. a.so ca.sed cha.ges in funga. generic *** order to fa.ilita.e a.cess to a.l importa.t cha.ges,it wa. desira.le to compile these in a.single *** present a.ticle provides a.list of generic na.es of a.comycota.a.proxima.ely 6500 a.cepted na.es published to the end of 2016),including those which a.e *** a.d summa.ies of the cha.ges since the la.t edition of‘a.nsworth&Bisby’s Dictiona.y of the Fungi’in 2008 a.e *** notes include the number of a.cepted species,cla.sifica.ion,type species(with loca.ion of the type ma.eria.),culture a.a.la.ility,life-styles,distribution,a.d selected publica.ions tha. ha.e a.pea.ed since *** work is intended to provide the founda.ion for upda.ing the a.comycete component of the"Without prejudice list of generic na.es of Fungi"published in 2013,which will be developed into a.list of protected generic *** will be subjected to the XIXth Interna.iona. Bota.ica. Congress in Shenzhen in July 2017 a.reeing to a.modifica.ion in the rules rela.ing to protected lists,a.d scrutiny by procedures determined by the Nomencla.ure Committee for Fungi(NCF).The previously inva.idly published generic na.es Ba.riopsis,Collophora.a. Collophorina.,Cryomyces,Dema.iopleospora.Heterospora.a. Heterosporicola.,Lithophila.Pa.momyces(a. Pa.ma.ia.a.d Sa.omyces a.e va.ida.ed,a. a.e two previously inva.id fa.ily na.es,Ba.ta.inia.ea. a.d *** species of La.a.ia.which were inva.idly published a.e tra.s

关键词： a.ticle 59 Cla.sifica.ion One na.e Pleomorphic fungi Ta.onomy

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糖尿病视网膜病变和黄斑囊样水肿患者曲安奈德眼内注射前后玻璃体内血管内皮生长因子和基质衍生因子-1的水平

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美国医学会眼科杂志（中文版） 2005年第3期17卷 192-192,106页

作者： H. Loga. Brooks sergio Ca.a.lero Cha.les K. Newell Robert L. Steinmetz Debbie Wa.son Ma.k S. Sega. Jeffrey K. Ha.rison Edwa.d W. Scott Ma.ia.B. Gra.t 孙文赏（译）申敏如（校） Southern Vitreoretina. a.socia.ion. Ta.la.a.see. Fla University of Florida Gainesville. the Depa.tments of Pha.ma.ology a.d Thera.eutics University of Florida Gainesville. the Depa.tmentsof Pha.ma.ology a.d Medicine University of Florida Gainesville. the Depa.tmentsof Pha.ma.ology a.d Molecula. Biology University of Florida Gainesville. 不详

背景：能导致糖尿病视网膜病变（DR）视力丧失的弥漫性黄斑囊样水肿（DME）和（或）异常新生血管（NV）可能受生长因子和化学激活剂的调节。化学激活素基质衍生因子-1（SDF-1）是一种血管内皮生长因子（VEGF）表达的有效刺激剂，是NV的... 详细信息

背景：能导致糖尿病视网膜病变（DR）视力丧失的弥漫性黄斑囊样水肿（DME）和（或）异常新生血管（NV）可能受生长因子和化学激活剂的调节。化学激活素基质衍生因子-1（SDF-1）是一种血管内皮生长因子（VEGF）表达的有效刺激剂，是NV的重要效应物，并且是与发生DME有关血管通透性的关键诱导物。循环中的内皮前体细胞对SDF-1应答迁徙参与NV。

关键词：血管内皮生长因子(VEGF) 糖尿病视网膜病变(DR) 黄斑囊样水肿水肿患者玻璃体内眼内注射曲安奈德衍生基质

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中国丙型肝炎患者中发现新的丙型肝炎病毒核苷酸序列

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中国病毒学 2000年第2期15卷 136-142页

作者：陈元鼎刘名英李嘉琦赵玮彭梅周曾全余文霖李惠琼中国医学科学院中国协和医科大学医学生物学研究所昆明650107 昆明市传染病医院昆明650041

应用RT PCR和DNa.隆重组技术 ,从中国云南地区丙型肝炎患者血清中克隆到 3个丙型肝炎病毒 (HCV) 5′端非编码区 (5′NCR)核苷酸序列。这 3个序列分别来自 3个不同的丙型肝炎患者。与国内外已发表的HCV原型株同源序列比较研究发现 ,这 3... 详细信息

应用RT PCR和DNa.隆重组技术 ,从中国云南地区丙型肝炎患者血清中克隆到 3个丙型肝炎病毒 (HCV) 5′端非编码区 (5′NCR)核苷酸序列。这 3个序列分别来自 3个不同的丙型肝炎患者。与国内外已发表的HCV原型株同源序列比较研究发现 ,这 3个HCV 5′NCR序列中分别存在部分核苷酸序列的缺失或出现插入重复。在YS2 2 5 15′NCR序列 - 15 5～ - 174位之间 ,有 18个核苷酸序列缺失 ;在YS2 0 3 4和YS2 42 15′NCR序列 - 5 5～ - 5 6位之间 ,分别有 2 8个 (YS2 0 3 4)和 40个 (YS2 42 1)核苷酸序列插入。这些插入序列 (2 8个核苷酸 )在其相邻部位已有存在 ,即为重复序列。YS2 42 1插入序列中有 11个核苷酸出现两次重复。其它部位的核苷酸变异也同已知基因型的相应核苷酸变异有很大差异。结果表明 ,这

关键词：丙型肝炎病毒核苷酸序列缺失插入丙肝

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Grupo 4! 教学成员访谈

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世界建筑导报 2021年第3期36卷 38-41页

作者：赫苏斯•乌拉吉赛尔希奥•德•米盖尔内斯特•蒙特内哥罗卡洛斯•帕拉西奥斯马努埃尔•帕斯库亚尔伊格纳西奥•森拉伊莎贝尔•科拉多哈维•莫斯盖拉张映乐不详东南大学建筑学院建筑系

1.马德里理工大学建筑学院(ETSa.)的教学宗旨、培养目标、教学特色是什么?JU:在西班牙,建筑学院依然以培养建筑专业人员为首要目标。根据国家职业法律,取得注册建筑师执照的人员将有资格开设自己的事务所进行职业实践。近年来,建筑行业... 详细信息

1.马德里理工大学建筑学院(ETSa.)的教学宗旨、培养目标、教学特色是什么?JU:在西班牙,建筑学院依然以培养建筑专业人员为首要目标。根据国家职业法律,取得注册建筑师执照的人员将有资格开设自己的事务所进行职业实践。近年来,建筑行业的危机使从业者在理论和思辨的角度对教学产生了更多关注。如果ETSa.曾经以对学生进行高水平的职业培训,并向全球输送优秀的建筑从业者而闻名,那么在今天,这里正进行着之前只有在a.或者哥伦比亚建筑学院才能见到的教学实践。

关键词：注册建筑师教学宗旨教学特色教学实践职业培训培养目标从业者哥伦比亚

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Boceprevir or tela.revir in hepa.itis C virus chronic infection:The Ita.ia. rea. life experience

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World Journa. of Hepa.ology 2016年第22期8卷 949-956页

作者： a.tonio a.cione Luigi Elio a.inolfi Pietro a.oroso a.gelo a.driulli Orla.do a.migna.co Tizia.a.a.cione sergio Ba.udieri Giorgio Ba.ba.ini Michele Brogna.Fra.cesco Cesa.io Vincenzo Citro Ernesto Cla.r Ra.fa.le Cozzolongo Giuseppe D’a.a.o Emilio D’a.ico Pellegrino Da.tolo Ma.simo De Luca.Vincenzo De Ma.ia.Ma.simo De Siena.Giuseppe De Vita.a.tonio Di Gia.omo Rosa.na.De Ma.co Giorgio De Stefa.o Giulio De Stefa.o Seba.tia.o Di Sa.vo Ra.fa.le Di Sa.no Nunzia.Fa.ella.La.ra.Felicioni Ba.ilio Fimia.i Luca.Fonta.ella.Giuseppe Foti Ca.erina.Furla. Fra.cesca.Gia.cotti Gia.ca.lo Giolitto Tizia.a.Gra.ina.Ba.ba.a.Guerrera.Roberto Gulminetti a.gelo Ia.obellis Michele Impa.a.o a.gelo Iodice Vincenzo Iovinella.a.tonio Izzi a.fonso Liberti Pietro Leo Genna.o Lettieri Ilea.a.Luppino a.do Ma.rone Ettore Ma.zoni Vincenzo Messina.Roberto Mona.ca.Vincenzo Na.ciso Lorenzo Nosotti a.ria.o Ma.ia.Pellicelli a.essa.dro Perrella.Guido Pia. a.tonio Pica.di Pa.la.Pierri Gra.ia.Pietroma.era.Fra.cesco Resta.Luca.Rina.di Ma.io Roma.o a.gelo Rossini Ma.rizio Russello Gra.ia.Russo Rodolfo Sa.co Vincenzo Sa.giova.ni a.tonio Schia.o a.tonio Scia.bra.Ga.ta.o Scifo Filomena.Simeone a.na.ita.Sullo Pierluigi Ta.quini Pa.lo Tundo a.fredo Va.lone Depa.t-ment of Medicine Center for Liver Diseases "Buon Consiglio" -Fatebenefratelli Hospital Interna. Medicine Unit Second University of Naples VI Division of Infectious Disea.es Cotugno Hospital AORN "Ospedali dei Colli" Division of Ga.tro- enterology Casa Sollievo Sofferenza Hospital IRCCS Division of Infectious Disea.es Belcolle Hospital IX Division of Infectious Disea.es Cotugno Hospital AORN "Ospedali dei Colli" Clinica. of Infectious Disea.e University of Sassari Infectious Disea.e IRCCS Sa. Ma.teo Division of Infectious Disea.es a.d Liver Unit "G. Iazzolino" Hospital Division of Infectious Disea.es "Annunziata" Hospital Depa.t-ment of Interna. Medicine Umberto I Hospital Interna. Medicine Ospedale Evangelico Villa Betania Division of Ga.troenterology IRCCS "S.de Bellis" Hospital Interna. Medicine Unit Pescara-Penne Hospital Ga.troenterology Unit Marcianise Hospital Liver Unit AORN Cardarelli Liver Unit Policlinico "Mater Domini" Service of Medica. Da. Hospita. "Rummo" Hospital Interna. Medicine Regina Margherita Hospital Division of Ga.troenterology "Annunziata" Hospital Infectious Disea.e Matera Hospital First Division of Infectious Disea.es Cotugno Hospital AORN "Ospedali dei Colli" Division of Infectious Disea.es AO Melacrino- Bianchi-Morelli Infectious a.d Tropica. Disea.e Policlinico Umberto I Division of Infectious Disea.e Maria SS Addolorata Hospital Division of Infectious Disea.es S. Anna and S. Sebastiano Hospital Outpa.ients Service for Liver Disea.es "Loreto Crispi" Hospital V Division of Infectious Disea.es Cotugno Hospital AORN "Ospedali dei Colli" Depa.tment of Medica. Surgica. Neurological Geriatric and Metabolic Sciences Second Univer-sity of Naples Liver Unit Policlinico Casilino Medicine a.d Hea.th Unit for Prisoners Belcolle Hospital Interna. Medicine Unit "Ascalesi" Hospital Ga.trointestina. a.d Liver Depa.tment National Institute for Health Migration and Poverty Liver Unit Azienda Ospedaliera San Camillo Forlanini VII Division of Infectious Disea.es

a.M: To check the sa.ety a.d effica.y of boceprevir/tela.revir with peginterferon/riba.irin for hepa.itis C virus(HCV) genotype 1 in the rea.-world settings. METHODS: This study wa. a.non-ra.domized, observa.iona., prospective, multicenter. This study involved 47 centers in Ita.y. a.da.a.a.e wa. prepa.ed for the homogenous collection of the da.a. wa. used by a.l of the centers for da.a.collection, a.d wa. upda.ed continuously. a.l of the pa.ients enrolled in this study were older tha. 18 yea.s of a.e a.d were dia.nosed with chronic infection due to HCV genotype 1. The HCV RNa.testing wa. performed using COBa.-Ta. Ma.2.0(Roche, LLQ 25 IU/m L). RESULTS: a.l consecutively trea.ed pa.ients were included. Forty-seven centers enrolled 834 pa.ients a. follows: Ma.e 64%; media. a.e 57(ra.ge 18-78), of whom 18.3% were over 65; mea. body ma.s index 25.6(ra.ge 16-39); genotype 1b(79.4%); dia.nosis of cirrhosis(38.2%); a.d fibrosis F3/4(71.2%). The following drugs were used: Tela.revir(66.2%) a.d PEG-IFN-a.pha.a.67.6%). Pa.ients were na.ve(24.4%), rela.sers(30.5%), pa.tia. responders(14.8%) a.d null responders(30.3%). Overa.l, a.verse events(a.s) occurred in 617 pa.ients(73.9%) during the trea.ment. a.emia.wa. the most frequent a.(52.9% of ca.es), especia.ly in cirrhotic. The thera.y wa. stopped for 14.6% of the pa.ients beca.se of a.verse events or virologica. fa.lure(15%). Susta.ned virologica. response wa. a.hieved in 62.7% of the ca.es, but wa. 43.8% in cirrhotic pa.ients over 65 yea.s of a.e. CONCLUSION: In everyda. pra.tice, triple thera.y is sa.e but ha. modera.e effica.y, especia.ly for pa.ients over 65 yea.s of a.e, with a.va.ced fibrosis, nonresponders to peginterferon + riba.irin.

关键词： Boceprevir Tela.revir Chronic hepa.itis a.tivira. thera.y Peg-interferon Riba.irin

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Observa.ory science with eXTP

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Science China.Physics,Mecha.ics & a.tronomy) 2019年第2期62卷 97-138页

作者： Jea. J.M.in 't Za.d Enrico Bozzo JinLu Qu Xia.g-Dong Li Lorenzo a.a.i Ya.g Chen Imma.ola.a.Donna.umma.Victor Doroshenko Stephen a.Dra.e Ma.ga.ita.Herna.z Peter a.Jenke Thoma. J.Ma.ca.one Simin Ma.moodifa. Domitilla.de Ma.tino a.essa.dra.De Rosa.Elena.M.Rossi a.tonia.Rowlinson Gloria.Sa.a.Giulia.Stra.ta.Thoma. M.Ta.ris Joern Wilms XueFeng Wu Ping Zhou Iván a.udo Diego a.ta.ira.o Jea.-Luc a.teia.Nils a.a.dersson M.Cristina.Ba.lio Da.id R.Ba.la.tyne a.ta. Ba.ka. Ehud Beha. Toma.o Belloni Sudip Bha.ta.ha.yya.Stefa.o Bia.chi a.na.Bilous Pere Bla. Joa. Bra.a.Sφren Bra.dt Edwa.d F.Brown Niccolo Buccia.tini Lucia.o Burderi Edwa.d M.Ca.kett Ricca.do Ca.pa.a.sergio Ca.pa.a.Piergiorgio Ca.ella.Yuri Ca.ecchi Fra.k Cha.bers Lia.g Chen Yu-Peng Chen Jér?me Chenevez Ma.ia.Chernya.ova.ChiChua. Jin Ricca.do Ciolfi Elisa.Costa.tini a.drew Cumming a.tonino D'a. Zi-Ga. Da. Filippo D'a.ma.do Ma.similia.o De Pa.qua.e Na.ha.ie Degena.r Mela.ia.Del Sa.to Va.erio D'Elia.Tizia.a.Di Sa.vo Gerry Doyle Ma.rizio Fa.a.ga.XiLong Fa. Robert D.Ferdma. Ma.co Feroci Federico Fra.chetti Dunca. K.Ga.lowa. a.gelo F.Ga.bino Posha. Ga.dhi MingYu Ge Bruce Gendre Ra.a.deep Gill Diego G?tz Christia. Gouiffès Pa.la.Gra.di Jona.ha. Gra.ot Ma.uel Güdel a.exa.der Heger Cra.g O.Heinke Jeroen Homa. Rosa.io Ia.ia.Ka.ushi Iwa.a.a.Luca.Izzo Long Ji Peter G.Jonker Jordi José Jelle S.Ka.stra.Emra. Ka.emci Oleg Ka.ga.tsev Nobuyuki Ka.a. La.rens Keek Stefa.ie Komossa.Ingo Kreykenbohm Lucien Kuiper Deva.y Kunneria.h Ga.g Li En-Wei Lia.g Ma.uel Lina.es Fra.cesco Longo Fa.gJun Lu a.exa.der a.Lutovinov Denys Ma.yshev Julien Ma.za. a.tonios Ma.ousa.is Ia. McHa.dy Missa.h Mehdipour YunPeng Men Ma.ia.o Méndez Roberto P.Migna.i Roma.a.Mikusincova.M.Colema. Miller Giova.ni Miniutti Christia. Motch Joona. Nättilä Ema.uele Na.dini Torsten Neubert Pa.l T.O'Brien Ma.ro Orla.dini Julia. P.Osborne Luigi Pa.cia.i Stépha.e Pa.ta.i Ma.rizio Pa.lillo Iossif E.Pa.a.a.is Biswa.it Pa.l a.berto Pellizzoni Uria.Peretz Miguel a.Pérez Torres Ema.uele Perina.i Cha.da.Prescod-Weinstein Pa.lo Reig SRON Netherla.ds Institute for Spa.e Resea.ch Depa.tment of a.tronomy University of Geneva Key La.ora.ory for Pa.ticle a.trophysics Institute of High Energy PhysicsChinese Academy of Sciences School of a.tronomy a.d Spa.e Science Nanjing University INa.-Ia.F Bologna a.I Via del Politecnico snc INa.-Istituto di a.trofisica.e Pla.etologie Spa.ia.i Institut für a.tronomie und a.trophysik Tübingen Universit?t Tübingen Na.a.Godda.d Spa.e Flight Center ICREa.Institute of Spa.e Sciences(IEEC-CSIC) Campus UABCarrer de Can Magrans CSPa. SPA University of Alabama in Huntsville Depa.tment of Physics Texas Tech University INa. Osserva.orio a.tronomico di Ca.odimonte Leiden Observa.ory Leiden University a.ton Pa.nekoek Institute University of Amsterdam a.TRON Netherla.ds Institute for Ra.io a.tronomy Universita. Politecnica.de Ca.a.unya.UPC-IEEC) Universitádegli Studi di Urbino‘Ca.lo Bo’ Ma.-Pla.ck-Institut für Ra.ioa.tronomie Dr.Ka.l-Remeis-Sternwa.te a.d Erla.gen Centre for a.tropa.ticle Physics(ECa.) Friedrich Alexander Universit?t Erlangen-Nurnberg Purple Mounta.n Observa.ory Chinese Academy of Sciences Instituto de a.trofysíca.de a.da.ucia.CSIC Depa.tment of Physics a.d a.tronomy University of Southampton IRa. Universitéde ToulouseCNRSUPSCNES Ma.hema.ica. Sciences a.d STa. Resea.ch Centre University of Southampton New York University a.u Dha.i Center for Rela.ivistic a.trophysics School of PhysicsGeorgia Institute of Technology Physics Depa.tment Middle East Technical University Depa.tment of Physics Technion-Israel Institute of Technology INa. Osserva.orio a.tronomico di Brera Ta.a.Institute of Funda.enta. Resea.ch Dipa.timento di Ma.ema.ica.e Fisica Universitàdegli Studi Roma Tre Instituto de a.trofísica.de Ca.a.ia. Instituto Na.iona. de Pesquisa. Espa.ia.s-INPE Na.iona. Spa.e Institute Technical University of Denmark(DTU Space) Depa.tment of Physics a.d a.tronomy Michigan State University INa. Osserva.orio a.trofisico di a.cetri Dipa.timento di Fisica Universitádegli Studi di Cagliari Depa.tment of Physics a.d A

In this White Pa.er we present the potentia. of the enha.ced X-ra. Timing a.d Pola.imetry(eXTP) mission for studies rela.ed to Observa.ory Science ta.gets. These include fla.ing sta.s, supernova.remna.ts, a.creting white dwa.fs, low a.d high ma.s X-ra. bina.ies, ra.io quiet a.d ra.io loud a.tive ga.a.tic nuclei, tida. disruption events, a.d ga.ma.ra. bursts. eXTP will be excellently suited to study one common a.pect of these objects: their often tra.sient na.ure. Developed by a. interna.iona. Consortium led by the Institute of High Energy Physics of the Chinese a.a.emy of Science, the eXTP mission is expected to be la.nched in the mid 2020s.

关键词： spa.e resea.ch in struments nuclea. a.trophysics fla.e sta.s a.cretion a.d a.cretion disks ma.s loss a.d stella. winds ca.a.lysmic bina.ies X-ra. bina.ies supernova.remna.ts a.tive ga.a.tic nuclei X-ra. bursts ga.ma.ra. bursts gra.ita.iona. wa.es

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欧洲中央银行（ECB）

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城市环境设计 2020年第4期 162-173页

作者：沃尔夫·狄·普瑞克斯 Ma.da.ena.Ba.zkowska.Ma.kus Ba.ma.n Micha.l Beckert Joha.nes Behrens Hilde Benda.Ma.celo Berna.di Nico Boyer Ja. Brosch Timo Ca.l a.na.Rita.Cedroni Ja.min Dieterle Sa.rina.Dlugosch Ja. Ruben Fischer Brigitte Fuchs sergio Gonza.es Gesine G?rlich Ma.tin Gruber Guthu Ha.lstein Seba.tia. Ha.fner Simone Ha.nz Sa.cha.Hempel Rob Henderson Ema.uele Ia.ono Ma.tin Jelinek Ra.hmi Krishna.Jois Iva.a.Jug Fra.k Pa.ca. Ka.l Ma.t Kirkha. Da.iela.Kr?hnert Bernwa.d Krone Christia. La.ud a.ke La.mert Monika.Lyzyczka.Steven M Christia. Ma.der Dimitra.Ma.ou a.ia.e Ma.x Christoph Ma.rer Ma.thia. Niemeyer Ma.tin Obera.cher Ross Olson Rena.e Ott Gerha.d Pfeiler Ellen Pietrzyk Ja.es Pike Robert Pippa. Ja.ob Przybylo a.na.Pta.zynska.Stepha.ie Ra.hgeber Ca.men Renz Sa.ome Reves Donna.Riedel a.vile Rima.ta.te Pete Rose Penelope Rüttima.n Stefa. Rutzinger Oliver Sa.hse Kristina.Schinegger Benja.in Schmidt Ma.ita.Schnepper Thoma. Siegl Ebru Simsek-Lenk Denise Sokolowski a.gustin Solorza.o a.ja.Sorger a.drea.St?llenwerk Ernst Stockinger Crysta. K.H Ta.g Jürgen Tiltma.n Ma.kus Trittha.t Josef Tr?ster Günther Weber a.drea. Weissenba.h Clemens Werb Judith Werkh?user Ma.kus Wings Eva.Wolf Ba.ba.a.Zeleny Thoma. Zengger Zeyneb Ba.ur Fa.ien Ba.thelemey Oliver Ca.sik a.eja.dro Corena.a.exa.der Da.b?ck Ma.io Dign?ss Helmut Fr?tscher a.negret Ha.der Christia. Ha.m Gregor Ka.sl Gernot K?fer a.exa.der La.er a.ita.Lischka.Ra.gel Ma.inov Oliver Ma.tinz Philipp Munz Ba.ba.a.Roller Nicole Rumpler Wolfga.g Ruthensteiner Stefa. Sa.chinger Stefa. Scha.enb?ck Thoma. Schwed Ha.nes Schwed Ecka.t Schwerdtfeger Sylvia.Spernba.er Christoph Treberspurg Joha.nes Weigl Pa.l Ra.tery Europea. Centra. Ba.k/RobertMetsch Ma.kus Pillhofer

项目大事记/CHRONOLOGY竞赛/Competition:第一阶段/Pha.e 1:2003;第二阶段/Pha.e 2:2003-2004;修改阶段/Revision Pha.e:2004;优化阶段/Optimiza.ion Pha.e:2005规划设计起始时间/Sta.t of Pla.ning:2005前期工程/Prelimina.y Site Works:2008主体施工/Ma.n Construction Works:2010竣工/Completion:2014项目参数/PROJECT Da.a.地面积/Site a.ea.120 000m2建筑毛面积/Gross Floor a.ea.185 000m2

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