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Disease modifying treatment of spinal cord injury with directly reprogrammed neural precursor cells in non-human primates

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World Journal of Stem Cells 2021年第5期13卷 452-469页

作者： vladimir P Baklaushev Oleg v Durov vladimir A Kalsin Eugene v Gulaev sergey v kim Ilya L Gubskiy veronika A Revkova Ekaterina M Samoilova Pavel A Melnikov Dzhina D Karal-Ogly sergey v Orlov Alexander v Troitskiy vladimir P Chekhonin Alexander v Averyanov Jan-Eric Ahlfors Biomedical Research Federal Research and Clinical Center of Specialized Medical Care and Medical TechnologiesFMBA of RussiaMoscow 115682MoskvaRussia Department of Neurosurgery Federal Research and Clinical Center of Specialized Medical Care and Medical TechnologiesFMBAMoscow 115682MoskvaRussia Department of Anesthesiology N.N.Blokhin Russian Cancer Research CentreMoscow 115478MoskvaRussia Radiology and Clinical Physiology Scientific Research Center Federal center of brain research and neurotechnologies of the Federal Medical Biological AgencyMoscow 117997Russia Department of Neurobiology Serbsky National Medical Research Center for Psychiatry and NarcologyMoscow 119992MoskvaRussia Department of Primatology Russian Acad Med SciResearch Institute of Medical PrimatologySochi 119992SochiRussia Department of vascular Surgery Federal Research and Clinical Center of Specialized Medical Care and Medical TechnologiesFMBA of RussiaMoscow 115682MoskvaRussia Department of Basic and Applied Neurobiology V.P.Serbsky Federal Medical Research Center for Psychiatry and NarcologyRussia Department of Medical Nanobiotechnology Pirogov Russian National Research Medical University(RNRMU)Moscow 115682MoskvaRussia New World Laboratories Laval H7V 4A7QuebecCanada

BACKGROUND The development of regenerative therapy for human spinal cord injury(SCI)is dramatically restricted by two main challenges:the need for a safe source of functionally active and reproducible neural stem cells and the need of adequate animal models for preclinical *** reprogramming of somatic cells into neuronal and glial precursors might be a promising solution to the first *** use of non-human primates for preclinical studies exploring new treatment paradigms in SCI results in data with more translational relevance to human *** To investigate the safety and efficacy of intraspinal transplantation of directly reprogrammed neural precursor cells(drNPCs).METHODS Seven non-human primates with verified complete thoracic SCI were divided into two groups:drNPC group(n=4)was subjected to intraspinal transplantation of 5 million drNPCs rostral and caudal to the lesion site 2 wk post injury,and lesion control(n=3)was injected identically with the equivalent volume of *** Follow-up for 12 wk revealed that animals in the drNPC group demonstrated a significant recovery of the paralyzed hindlimb as well as recovery of somatosensory evoked potential and motor evoked potential of injured *** resonance diffusion tensor imaging data confirmed the intraspinal transplantation of drNPCs did not adversely affect the morphology of the central nervous system or cerebrospinal fluid *** immunohistochemical analysis showed that drNPCs maintained SOX2 expression characteristic of multipotency in the transplanted spinal cord for at least 12 wk,migrating to areas of axon growth *** Our data demonstrated that drNPC transplantation was safe and contributed to improvement of spinal cord function after acute SCI,based on neurological status assessment and neurophysiological recovery within 12 wk after *** functional improvement described was not associated with neuronal differentiation of th

关键词： Direct cell reprogramming Neural precursor cells Directly reprogrammed neural precursor cells Spinal cord injury Nonhuman primates Regenerative therapy,Evoked potentials

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Pyrrole and Pyrimidine Derivatives as Possible Electron Donors for Colored Charge-Transfer Complexes with a Weakly Electrophilic Energetic Material,FOX-7:A Theoretical Study

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火炸药学报 2023年第5期46卷 390-398,I0002-I0008页

作者： sergey v.Bondarchuk Department of Chemistry and Nanomaterials Science Bogdan Khmelnitsky Cherkasy National Universityblvd.Shevchenko 8118031 CherkasyUkraine

A number of electron-rich heterocycles are studied as potential reagents for visual colorimetric detection of FOX-7 due to colored charge-transfer complexes *** obtained results suggest that pyrrole and pyrimidine derivatives can form such complexes playing the role of electron donors despite a low electrophilicity of *** functional theory calculations,as well as quantum theory of atoms in molecules analysis,suggest stacking binding mode as the most preferable one with the binding energy of about 21-36 kJ/*** the complexes demonstrate a clear single charge-transfer absorption band in the visible region and the expected colors of the complexes are varying from violet and blue to red and *** calculations of the crystalline state of the studied complexes indicate high lattice energies,which are higher than that of pure FOX-7 and are close to the recently reported hydrogen-bonded complex of FOX-7 with 1,*** analysis of the studied charge-transfer complexes using properties based on density difference grids clearly suggests the acceptor role of FOX-7 in the *** analysis can be effectively applied to identify the nature of other possible complexes of FOX-7,in which its role is unclear because of the specific reactivity,namely,both weak electrophilic and nucleophilic properties at the same time.

关键词： FOX-7 charge-transfer colorimetric analysis detection of explosives quantum-chemical calculation

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Protective Composite Coatings Formed on Mg Alloy Surface by PEO Using Organofluorine Materials

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Journal of Materials Science & Technology 2017年第7期33卷 661-667页

作者： Dmitry v. Mashtalyar Konstantine v. Nadaraia sergey L. Sinebryukhov sergey v. Gnedenkov Institute of Chemistry Far Eastern BranchRussian Academy of SciencesVladivostok 690022Russia Far Eastern Federal University Vladivostok 690950Russia

The results of the surface modification of magnesium alloys by plasma electrolytic oxidation（PEO） and subsequent treatment in suspension of the superdispersed polytetrafluoroethylene（SPTFE） or telomeric solution of tetrafluoroethylene（TFE） are presented. Composite coatings have been obtained by dipping with subsequent heat treatment. Electrochemical, tribological properties and wettability of protective composite coatings have been investigated. Composite coatings formed on PEO-layer by fourfold treatment of samples in SPTFE suspension possess best protective properties. The obtained coatings decrease the corrosion current density（5.4 × 10^（-11） A cm^（-2）） and wear（7.6 × 10^（-7）mm^3（Nm）^（-1））, and increase the polarisation resistance（1.7 × 10~9 cm^2） and impedance modulus（1.9 × 10~9 cm^2） by orders of magnitude in comparison with unprotected magnesium alloy and base PEO-coating. The highest value of contact angle（CA） has been obtained for coatings with triple application in telomeric solution. CA for such composite coatings attains（171 ± 2）？, as the result of multimodal roughness of the composite coating＇s surface.

关键词： Mg-Mn-Ce alloy Corrosion PEO-coatings Composite coatings Wear Hydrophobicity

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Refractory lipoatrophy treated with autologous whole blood injection:A case report

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World Journal of Clinical Cases 2025年第2期13卷 33-38页

作者： Wonnam kim Jun Su Park En Hyung kim Department of Pharmacology School of Korean MedicinePusan National UniversityYangsan 50612GyeongnamSouth Korea Department of Dermatology College of MedicineChungbuk National UniversityCheongju 28644ChungbukSouth Korea Department of Dermatology Chungbuk National University HospitalCheongju 28644ChungbukSouth Korea

BACKGROUND Intramuscular corticosteroid injection may cause adverse effects such as dermal and/or subcutaneous atrophy,alopecia,hypopigmentation,and *** cutaneous atrophy can spontaneously resolve,several treatment options have been suggested for this *** SUMMARY In this paper,we report a case of corticosteroid injection induced lipoatrophy treated with autologous whole blood(AWB)injection,as the condition had been unresponsive to fractional laser therapy.A 29-year-old female patient visited the dermatology clinic complaining of skin depression on her right buttock area,which had appeared six months *** had been only subtle improvement at the margins after fractional CO_(2) laser treatment;therefore,after obtaining informed consent from the patient,AWB treatment was *** month after the first AWB injection,the size and depth of the lesion had noticeably improved,and a slight improvement was also observed in *** Close observation is the initial treatment of choice for steroid induced skin atrophy;however,for patients in need of immediate cosmetic improvement,AWB injection may be a safe and cost-effective alternative.

关键词： Atrophy Corticosteroid Subcutaneous fat Autologous whole blood injection Laser therapy Case report

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Analysis of natural vibration of truncated conical shells partially filled with fluid

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International Journal of Mechanical System Dynamics 2024年第2期4卷 142-152页

作者： sergey A.Bochkarev sergey v.Lekomtsev Laboratory of Functional Materials Institute of Continuous Media MechanicsUral Branch of Russian Academy of SciencesPermRussian Federation

In this paper,we study the vibrational behavior of shells in the form of truncated cones containing an ideal compressible *** sloshing effect on the free surface of the fluid is *** dynamic behavior of the elastic structure is investigated based on the classical shell theory,the constitutive relations of which represent a system of ordinary differential equations written for new *** fluid vibrations are described in terms of acoustic approximation using the wave equation for hydrodynamic pressure written in spherical *** transformation into the system of ordinary differential equations is carried out by applying the generalized differential quadrature *** formulated boundary value problem is solved by Godunov's orthogonal sweep *** frequencies of shell vibrations are calculated using the stepwise procedure and the Muller *** accuracy and reliability of the obtained results are estimated by making a comparison with the known numerical and analytical *** dependencies of the lowest frequency on the fluid level and cone angle of shells under different combinations of boundary conditions(simply supported,rigidly clamped,and cantilevered shells)have been studied *** conical straight and inverted shells,a numerical analysis has been performed to estimate the possibility of finding configurations at which the lowest natural frequencies exceed the corresponding values of the equivalent cylindrical shell.

关键词： classical shell theory conical shell Godunov's orthogonal sweep method ideal compressible fluid generalized differential quadrature method natural vibrations

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Flash Lamps as Ignition and Initiation Sources of the vS-2 Pyrotechnic Composition

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含能材料 2022年第4期30卷 370-378页

作者： sergey I.Gerasimov Mikhail A.Ilyushin sergey M.Putis sergey A.Dushenok Irina v.Shugalei Andrey M.Sudarikov Russian Federal Nuclear Center‑All‑Russian Research Institute of Experimental Physics SarovRussia Sarov Institute of Physics and Technology is a Branch of the Scientific Research Nuclear University MEPhI SarovRussia Nizhny Novgorod State Technical University Named after R.E.Alekseev Nizhny NovgorodRussia RAS Institute for Studying Problems in Mechanical Engineering ‑is a Branch of the RAS Applied Physics InstituteNizhny NovgorodRussia "Technologist"Special Design and Technological Bureau St.PetersburgRussia Saint‑Petersburg State Institute of Technology(Technical University) St.PetersburgRussia Russian State Hydro‑meteorological University St.PetersburgRussia

In the present work it is found that the pyrotechnic composition vS⁃2 can be initiated with flash lamps IFC⁃500 and ***⁃2 pyrotechnic composition contains 90%of mercury(Ⅱ)5⁃hydrazinotetrazolate perchlorate and 10%of optically trans⁃parent copolymer of 2⁃methyl⁃5⁃vinyltetrazole and methacrylic acid(PvMT).We have found that the flash lamps make it possi⁃ble to initiate combustion of vS⁃2 composition with its transition to detonation both in cylindrical charges placed in brass caps of 5 mm diameter and 2 mm high,and film charges with 10 mm×80 mm in size and surface weights of 60 mg·cm^(-2)and 90 mg·cm^(-2),showing ignition delay times 10μs and 3μs,*** also measured detonation velocities for vS⁃2 composition film charges,which were 4375-4505 m·s^(-1)(of the charge being surface mass 60 mg·cm^(-2))and 4221-4281 m·s^(-1)(of the charge be⁃ing surface mass 90 mg·cm^(-2))and their blasting action on the aluminum *** depths of the normal shock wave imprints at the charge⁃barrier interface were 0.6-0.7 mm(for surface mass of the film charges 60 mg·cm^(-2))and 1.2-1.3 mm(for surface mass of the film charges 90 mg·cm^(-2))

关键词： vS⁃2 pyrotechnic composition flash lamps ignition transition of combustion to detonation blasting action

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Phase-matched third-harmonic generation via doubly resonant optical surface modes in 1D photonic crystals

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Light(Science & Applications) 2016年第1期5卷 424-429页

作者： valery N Konopsky Elena v Alieva sergey Yu Alyatkin Alexey A Melnikov sergey v Chekalin vladimir M Agranovich Institute of Spectroscopy Fizicheskaya5TroitskMoscow 142190Russia Moscow Institute of Physics and Technology Institutskiy per.9Dolgoprudny 141700Russia

Efficient nonlinear conversion requires that interacting optical waves maintain a consistent phase relationship when traveling in a medium despite its *** phase-matching,which is often used to compensate for the dispersion,is not applicable to optically isotropic nonlinear ***,we present a one-dimensional photonic crystal structure that allows the propagation of optical surface waves,both at the fundamental and third-harmonic frequencies,as an efficient medium for phasematched third-harmonic generation.A unique advantage of this structure is that the effective refractive indices for the surface waves are similar to the refractive index of air at both *** allows phase-matching between the first and third harmonics,and a visible collinear beam of the third harmonic is produced at the prism-coupled ***,these optical surface waves propagate over long distances even if a lossy nonlinear nanofilm is deposited onto the photonic crystal *** provide experimental results for third-harmonic generation at a wavelength of 410 nm for a bare dielectric Ta2O5/SiO2 multilayer structure and for the same structure coated with a 15-nm GaAs film.

关键词： nonlinear optics optical surface waves photonic crystals

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GIS-based cost distribution analysis of new consumer connections to an urban power grid

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Geo-Spatial Information Science 2015年第4期18卷 183-192页

作者： sergey v.KOSYAKOv Artur M.SADYKOv Department of Software Engineering Ivanovo State Power Engineering UniversityIvanovoRussia Department of Geographical Information Systems Ivanovo State Power Engineering UniversityIvanovoRussia

In this paper,we propose a method of cost distribution analysis of new consumer connections to a city power grid by accounting for spatial restrictions and characteristics of existing *** practice,the calculation of connection costs for each new consumer includes the network design and financial *** suggest that connection costs should be calculated for the whole city based on the normative parameters at the stage when the object location is selected by investors and when power grid development is planned by power *** proposed method enables the modeling of new power line connection routes from every parcel of city land to possible points of connection to the operating networks based on the raster design of the *** optimal path is chosen by one criterion consisting of two components:the costs of both laying new power lines and providing sufficient power reserve in the chosen network connection *** as a computer program,the method has been used to calculate the costs of connections to low-voltage power lines.

关键词： GIS least-cost path analysis grid-connections urban power grid

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Growth of carbon nanotube arrays on various CtxMey alloy films by chemical vapour deposition method

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Journal of Materials Science & Technology 2018年第3期34卷 472-480页

作者： Pawel Mierczynski sergey v.Dubkov sergey v.Bulyarskii Alexander A.Pavlov sergey N.Skorik Alexey Yu Trifonov Agnieszka Mierczynska Eugene P.Kitsyuk sergey A.Gavrilov Tomasz P.Maniecki Dmitry G.Gromov Institute of General and Ecological Chemistry Lodz University of TechnologyZeromskiego 116Lodz 90-924Poland National Research University of Electronic Technology Shokin SquareZelenogradMoscow 124498Russia Institute of Nanotechnology of Microelectronics of the RAS INMEMoscow 11-9991Russia Scientific-Manufacturing Complex'Technological Center' ZelenogradMoscow 124498Russia Scientific Research Institute of Physical Problems named after F v.Lukin Proezd 4806.6ZelenogradMoscow 124460Russia The Australian Wine Research Institute Waite PrecinctHartley Grove cnr Paratoo RoadUrrbrae AdelaideSA 5064Australia

Carbon nanotube （CNT） arrays were fabricated on Ct-Me-N-（O） alloys with content of Ct in the range of 6-40 at.% by chemical vapour deposition. The Ct was a catalytic metal from the group of the following elements： Ni, Co, Fe, Pd, while Me was a transition metal from the group of Iv-vII of the periodic table （where Me=Ti, v, Cr, Zr, Nb, Mo, Ta, W, Re）. Carbon nanotubes were found to grow efficiently on the alloy surface with its composition containing Ti, v, Cr, Zr, Hf, Nb or Ta. The growth of CNTs was not observed when the alloy contained W or Re. Additions of oxygen and nitrogen in the alloy facilitated the formation of oxynitrides and catalyst extrusion on the alloy surface. Replacement of the metals in alloy composition affected the diameter of the resulting CNTs. The obtained results showed that the alloy films of varying thickness （10-500 nm） may be used for the CNTs growth. The resulting CNT material was highly homogenous and its synthesis reproducible.

关键词： Carbon nanotubes Amorphous alloys Chemical vapour deposition Catalytic processes Thin films

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BER Performance of Finite in Time Optimal FTN Signals for the viterbi Algorithm

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Journal of Electronic Science and Technology 2020年第1期18卷 42-51页

作者： sergey B.Makarov Ilya I.Lavrenyuk Anna S.Ovsyannikova sergey v.Zavjalov Higher School of Applied Physics and Space Technologies Peter the Great St.Petersburg Polytechnic UniversitySt.Petersburg 195251

In this article, we consider the faster than Nyquist(FTN) technology in aspects of the application of the viterbi algorithm(vA). Finite in time optimal FTN signals are used to provide a symbol rate higher than the "Nyquist barrier" without any encoding. These signals are obtained as the solutions of the corresponding optimization problem. Optimal signals are characterized by intersymbol interference(ISI). This fact leads to significant bit error rate(BER) performance degradation for "classical" forms of signals. However, ISI can be controlled by the restriction of the optimization problem. So we can use optimal signals in conditions of increased duration and an increased symbol rate without significant energy losses. The additional symbol rate increase leads to the increase of the reception algorithm complexity. We consider the application of vA for optimal FTN signals reception. The application of vA for receiving optimal FTN signals with increased duration provides close to the potential performance of BER,while the symbol rate is twice above the Nyquist limit.

关键词： Bit error rate(BER)performance faster than Nyquist(FTN) Nyquist limit optimal signals viterbi algorithm(vA)

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