检索结果-南通市图书馆

Previous hepatitis b viral infection–an underestimated cause of pancreatic cancer

World Journal of Gastroenterology 2022年第33期28卷 4812-4822页

作者： sergey batskikh sergey Morozov Alexey Dorofeev Zanna borunova Dmitry Kostyushev sergey brezgin Anastasiya Kostyusheva Vladimir Chulanov Department of Hepatology Moscow Clinical Scientific Center N.A.A.S.LoginovMoscow 111123Russia Department of Gastroenterology Hepatology and NutritionFederal Research Center of NutritionBiotechnology and Food SafetyMoscow 115446Russia Department of Scientific and Clinical Laboratory Research Moscow Clinical Scientific Center N.A.A.S.LoginovMoscow 111123Russia Laboratory of Genetic Technologies Sechenov UniversityMoscow 119435Russia Division of biotechnology Scientific Center for Genetics and Life SciencesSirius University of Science and TechnologySochi 354340Russia Laboratory of Genetic Technologies and Translational Research National Medical Research Center for Tuberculosis and Infectious Diseases of Ministry of Health of RussiaMoscow 127994Russia

bACKGROUND The etiology of pancreatic cancer remains unclear. This limits the possibility of prevention and effective treatment. Hepatitis b virus(HbV) is responsible for the development of different types of cancer, but its role in pancreatic cancer is still being *** To assess the prevalence of previous HbV infection and to identify viral biomarkers in patients with pancreatic ductal adenocarcinoma(PDAC) to support the role of the virus in etiology of this *** The data of 130 hepatitis b surface antigen-negative subjects were available for the final analysis,including 60 patients with PDAC confirmed by cytology or histology and 70 sex-and age-matched controls. All the participants were tested for HbV biomarkers in blood [antibody to hepatitis b core antigen(anti-Hbc), antibody to hepatitis b surface antigen(anti-Hbs) and HbV DNA], and for those with PDAC, biomarkers in resected pancreatic tissues were tested(HbV DNA, HbV pregenomic RNA and covalently closed circular DNA). We performed immunohistochemistry staining of pancreatic tissues for hepatitis b virus X antigen and Ki-67 protein. Non-parametric statistics were used for the *** Anti-Hbc was detected in 18/60(30%) patients with PDAC and in 9/70(13%) participants in the control group(P = 0.029). Accordingly, the odds of PDAC in anti-Hbc-positive subjects were higher compared to those with no previous HbV infection(odds ratio: 2.905, 95% confidence interval: 1.191-7.084, standard error 0.455). HbV DNA was detected in 8 cases of PDAC and in 6 of them in the pancreatic tumor tissue samples only(all patients were anti-Hbc positive). blood HbV DNA was negative in all subjects of the control group with positive results of the serum anti-Hbc test. Among 9 patients with PDAC, 5 revealed signs of replicative competence of the virus(covalently closed circular DNA with or without pregenomic RNA) in the pancreatic tumor tissue samples. Hepatitis b virus X antigen expression and active cell

关键词： Hepatitis b virus Previous hepatitis b Occult hepatitis b virus infection Pancreatic cancer Pancreatic ductal adenocarcinoma

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mitochondrial complex Ⅰ as a therapeutic target for Alzheimer’s disease

引用

Acta Pharmaceutica Sinica b 2022年第2期12卷 483-495页

作者： Eugenia Trushina sergey Trushin Md Fayad Hasan Department of Neurology Mayo ClinicRochesterMN 55905USA Department of Molecular Pharmacology and Experimental Therapeutics Mayo ClinicRochesterMN 55905USA

Alzheimer’s disease(AD),the most prominent form of dementia in the elderly,has no *** focused on the reduction of amyloid beta or hyperphosphorylated Tau protein have largely failed in clinical *** therapeutic targets and strategies are urgently *** data suggest that in response to environmental stress,mitochondria initiate an integrated stress response(ISR)shown to be beneficial for healthy aging and ***,we review data that implicate mitochondrial electron transport complexes involved in oxidative phosphorylation as a hub for small molecule-targeted therapeutics that could induce beneficial mitochondrial ***,partial inhibition of mitochondrial complex I has been exploited as a novel strategy for multiple human conditions,including AD,with several small molecules being tested in clinical *** discuss current understanding of the molecular mechanisms involved in this counterintuitive *** this strategy has also been shown to enhance health and life span,the development of safe and efficacious complex Ⅰ inhibitors could promote healthy aging,delaying the onset of age-related neurodegenerative diseases.

关键词： Mitochondria Mitochondria signaling ComplexⅠinhibitors Alzheimer’s disease Integrated stress response Neuroprotection Mitochondria targeted therapeutics Healthy aging

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Fe Nanoclusters on the Ge（001） Surface Studied by Scanning Tunneling Microscopy, Density Functional Theory Calculations and X-Ray Magnetic Circular Dichroism

引用

Nano Research 2011年第10期4卷 971-978页

作者： Olaf LUbben sergey A. Krasnikov Alexei b. Preobrajenski barry E. Murphy Igor V. Shvets Centre for Research on Adaptive Nanostructures and Nanodevices （CRANN） School of Physics Trinity College Dublin Dublin 2 Ireland MAX-lab Lund University Box 118. 22100 Lund Sweden

The growth of Fe nanoclusters oN the Ge（001） surface has been studied using low-temperature scanning tunneling microscopy （STM） and density functional theory （DFT） calculations. STM results indicate that Fe nucleates on the Ge（001） surface, forming well-ordered nanoclusters of uniform size. Depending on the preparation conditions, two types of nanoclusters were observed having either four or sixteen Fe atoms within a nanocluster. The results were confirmed by DFT calculations. Annealing the nanoclusters at 420 K leads to the formation of nanorow structures, due to cluster mobility at such temperature. The Fe nanoclusters and nanorow structures formed on the Ge（001） surface show a superparamagnetic behaviour as measured by X-ray magnetic circular dichroism.

关键词： Ge(001) iron nanoclusters self-assembly scanning tunnelling microscopy X-ray magnetic circular dichroism density functional theory calculations

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatitis b virus markers in hepatitis b surface antigen negative patients with pancreatic cancer:Two case reports

引用

World Journal of Hepatology 2022年第7期14卷 1512-1519页

作者： sergey batskikh sergey Morozov Dmitry Kostyushev Department of Hepatology Moscow Clinical Research Center named after A.S.LoginovMoscow 111123Russia Department of Gastroenterology Hepatology and NutritionFederal Research Center of Nutrition and BiotechnologyMoscow 115446Russia Laboratory of Genetic Technologies Martsinovsky Institute of Medical ParasitologyTropical and Vector-Borne DiseasesFirst Moscow State Medical University(Sechenov University)Moscow 119991Russia Division of biotechnology Sirius University of Science and TechnologySochi 354340Russia

bACKGROUND Hepatitis b virus(HbV)is a known carcinogen that may be involved in pancreatic cancer *** of HbV biomarkers[especially expression of HbV regulatory X protein(Hbx)]within the tumor tissue may provide direct support for ***,there is still a lack of such reports,particularly in non-endemic regions for HbV *** we present two cases of patients with pancreatic ductal adenocarcinoma,without a history of viral hepatitis,in whom the markers of HbV infection were detected in blood and in the resected pancreatic *** SUMMARY The results of examination of two patients with pancreatic cancer,who gave informed consent for participation and publication,were the source for this *** standards of care,special examination to reveal occult HbV infection was *** included blood tests for HbsAg,anti-Hbc,anti-Hbs,HbV DNA,and pancreatic tissue examinations with polymerase chain reaction for HbV DNA,pregenomic HbV RNA(pgRNA HbV),and covalently closed circular DNA HbV(cccDNA)and immunohistochemistry staining for HbxAg and *** subjects were operated on due to pancreatic ductal adenocarcinoma and serum HbsAg was not ***,in both of them anti-Hbc antibodies were detected in blood,although HbV DNA was not *** of the resected pancreatic tissue gave positive results for HbV DNA,expression of Hbx,and active cellular proliferation by Ki-67 index in both ***,HbV pgRNA and cccDNA were detected only in case *** These cases may reflect potential involvement of HbV infection in the development of pancreatic cancer.

关键词： Pancreatic cancer Pancreatic ductal adenocarcinoma Hepatitis b virus Previous hepatitis b Anti-Hbc Hepatitis b virus X antigen

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Displacement Current in Domain Walls of bismuth Ferrite

引用

npj Computational Materials 2018年第1期3卷 597-605页

作者： sergey Prosandeev Yurong Yang Charles Paillard L.bellaiche Physics Department and Institute for Nanoscience and Engineering University of ArkansasFayettevilleAR 72701USA Institute of Physics and Physics Department of Southern Federal UniversityRostov-na-Donu 344090Russia

In 1861,Maxwell conceived the idea of the displacement current,which then made laws of electrodynamics more complete and also resulted in the realization of devices exploiting such displacement ***,it is presently unknown if such displacement current can result in large intrinsic ac current in ferroic systems possessing domains,despite the flurry of recent activities that have been devoted to domains and their corresponding conductivity in these ***,we report firstprinciples-based atomistic simulations that predict that the transverse(polarization-related)displacement currents of 71°and 109°domains in the prototypical biFeO_(3) multiferroic material are significant at the walls of such domains and in the GHz regime,and,in fact,result in currents that are at least of the same order of magnitude than previously reported dc currents(that are likely extrinsic in nature and due to electrons).Such large,localized and intrinsic ac currents are found to originate from low-frequency vibrations at the domain walls,and may open the door to the design of novel devices functioning in the GHz or THz range and in which currents would be confined within the domain wall.

关键词： currents regime magnitude

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Non-Gaussian statistics of partially coherent light in atmospheric turbulence

引用

Chinese Physics b 2020年第6期29卷 54-59页

作者： Hao Ni Chunhao Liang Fei Wang Yahong Chen sergey APonomarenko Yangjian Cai School of Physical Science and Technology&Collaborative Innovation Center of Suzhou Nano Science and Technology Soochow UniversitySuzhou 215006China Shandong Provincial Engineering and Technical Center of Light Manipulation&Shandong Provincial Key Laboratory of Optics and Photonic Device School of Physics and ElectronicsShandong Normal UniversityJinan 250014China Department of Electrical and Computer Engineering Dalhousie UniversityHalifaxNova ScotiaB3J 2X4Canada Department of Physics and Atmospheric Science Dalhousie UniversityHalifaxNova ScotiaB3H 4R2Canada

We derive theoretically and verify experimentally a concise general expression for the normalized intensity correlations(IC)of partially coherent light in a weak atmospheric turbulence in the fast detector measurement *** derived relation reveals that the medium turbulence acts,in general,as an additional noise source enhancing the IC of partially coherent *** maximum of the beam IC is,in general,enhanced,causing the fields to exhibit super-Gaussian *** the other hand,the relation indicates that turbulence-induced noise is negligible for sufficiently low coherence light,which reveals the condition for the turbulence-free correlation imaging.

关键词： partially coherent beam atmospheric turbulence intensity correlation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Strain control of layer-resolved negative capacitance in superlattices

引用

npj Computational Materials 2020年第1期6卷 127-130页

作者： Raymond Walter sergey Prosandeev Charles Paillard L.bellaiche Department of Physics and Institute for Nanoscience and Engineering University of ArkansasFayettevilleAR 72701USA Department of Mathematical Sciences University of ArkansasFayettevilleAR 72701USA Identity Engineering Kinesso LLCConwayAR 72032USA Institute of Physics and Physics Department of Southern Federal University Rostov-na-Donu 344090Russia Laboratoire Structures Propriétés et Modélisation des SolidesCentraleSupélecUMR CNRS 8580UniversitéParis-Saclay91190 Gif-sur-YvetteFrance

Negative capacitance in baTiO_(3)/SrTiO_(3) superlattices is investigated by Monte Carlo simulations in an atomistic effective Hamiltonian model,using fluctuation formulas for responses to the local macroscopic field that incorporates depolarizing *** show that epitaxial strain can tune the negative capacitance of the baTiO_(3) ferroelectric layer and the overall capacitance of the *** addition,we predict and explain an original switching of the negative capacitance from the baTiO3 layer to the SrTiO_(3) layer at low temperatures for intermediate strains.

关键词： capacitance layer resolved

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Variations in defect substructure and fracture surface of commercially pure aluminum under creep in weak magnetic field

引用

Chinese Physics b 2017年第12期26卷 427-431页

作者： sergey Konovalov Dmitry Zagulyaev 陈希章 Victor Gromov Yurii Ivanov Samara National Research University Samara 443086 Russia Wenzhou University Wenzhou 325035 China Siberian State Industrial University Novokuznetsk 654007 Russia Institute of High Current Electronics of the Siberian branch of the Russia Academy of Sciences Tomsk 634055 Russia

Commercially pure polycrystalline aluminum of grade A85, as a test material, is investigated. Using scanning and transmission electron microscopy the aluminum fine structure and fracture surface are analyzed. Fractures are studied in the regime of creep with and without a simultaneous effect of 0.3-T magnetic field. It is found that the application of a magnetic field in a linear stage of creep leads to substructure imperfection increasing. Furthermore, the magnetic field effect on aluminum in the process of creep causes the average scalar density of dislocations to increase and induces the process of dislocation loop formation to strengthen. Fractographic investigation of the fracture surface shows that in the fibrous fracture zone the average size of plastic fracture pits decreases more than twice under creep in the condition of external magnetic field compared with in the conventional experimental condition. In a shear zone, the magnetic field causes the average size of fracture pits to decrease. Experimental data obtained in the research allow us to conclude that the magnetic field effect on aluminum in the process of creep leads to the fracture toughness value of the material decreasing, which will affect the state of defect substructure of the volume and surface layer of the material. The influence of the magnetic field is analyzed on the basis of the magneto-plasticity effect.

关键词： aluminum magnetic field creep structure

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Carbon dioxide:A new material for energy storage

引用

Progress in Natural Science:Materials International 2014年第4期24卷 295-304页

作者： Jacques Amouroux Paul Siffert Jean Pierre Massué Simeon Cavadias béatriz Trujillo Koji Hashimoto Phillip Rutberg sergey Dresvin Xianhong Wang Ecole Nationale Supérieure de Chimie de Paris (ENSCP) Université Pierre et Marie Curie ParisFrance 2. European Material Research Society(EMRS)StrasbourgFrance 3. Laboratoire de Génie des Procédés Plasmas et Traitement de Surface(LGPPTS)Université Pierre et Marie Curie ParisFrance 4. Institute Polytechnic National de MéxicoMexico 5. Lab Electrotechnic and Electrophysic State Polytechnical University of St.PetersbourgRussia 6. Tohoku UniversityJapan Tohoku Institute of Technology Japan Plasma Laboratory State Polytechnical University of St.Petersbourg Russia 9. Key Laboratory of Polymer EcomaterialsChangchun Institute of Applied ChemistryCASChina

Though carbon dioxide is the main green house gas due to burning of fossil resource or miscellaneous chemical processes,we propose here that carbon dioxide be a new material for energy *** it can be the key to find the solution for three critical issues facing the world:food ecosystems,the greenhouse issue and energy *** propose to identify the carbon recovery through a circular industrial revolution in the first part,and in the second part we present the starting way of three business plants to do that from industrial *** pointing out all the economic constraints and the hidden competitions between energy,water and food,we try to qualify the phrase "sustainable development" and open the way of a huge circular economy.

关键词： Carbon dioxide Energy storage material Carbon dioxide recovery Chemical utilization Circular economy Sustainable development

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Editorial for special issue on Z-pinches

引用

Matter and Radiation at Extremes 2019年第6期4卷 65-66页

作者： sergey Lebedev R.b.Spielman Xingwen Li blackett Laboratory Department of PhysicsImperial CollegeLondon SW72AZUnited Kingdom Laboratory for Laser Energetics University of RochesterRochesterNew York 14623-1299USA State Key Laboratory of Electrical Insulation and Power Equipment Xi’an Jiaotong UniversityXi’anShaanxi 710049China

Fast Z-pinches,plasma implosions driven by MA-level∼100-ns duration current pulses,are an active research area with applications to a broad range of High Energy Density Physics studies,including investigations of properties of materials at extreme pressures,1 opacities of various plasmas at conditions found in stellar interiors,2 and scaled modelling of astrophysical magnetohydrodynamics.3 The ability of fast Z-pinches to generate extremely bright pulses of X-ray radiation is of significant interest for Inertial Confinement Fusion(ICF)*** highest X-ray powers and yields are achieved using wire-array Z-pinch loads,which are capable of generating 2-MJ,250-TW,boratories(New Mexico,USA).

关键词： interior generating extreme

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：