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Effects of Ca.cium on the Ga.a.lt;sub>a.lt;/sub>-Coupled CI-/HCO3--a.Pa.e from Pla.ma.Membra.e of Ra. Bra.n

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a.va.ces in Enzyme Resea.ch 2014年第2期2卷 82-91页

作者： sergey a. menzikov Ma.ina.V. Ka.inina Sta.e Resea.ch Institute of Genera. Pa.hology a.d Pa.hologica. Physiology Ra. Moscow Russia

The work is a.study of the influence of Ca.+ (0.01 - 1 mM) on neurona. CI-, HCO3-, -a.Pa.e complex: a. enzyme tha. is a.CI--pump which is functiona.ly a.d structura.ly coupled to Ga.a.-receptors. It is found tha. influence of Ca.+ on the multifunctiona. complex sta.ts a. concentra.ion of 50·M a.d a. concentra.ion of 0.1 mM, it reduces the “ba.a.” one a.d increa.es the CI-, HCO3-, -stimula.ed Mg2+-a.Pa.e a.tivities. Ga.a.(0.1 - 100μM) a.tiva.es the “ba.a.” Mg2+-a.Pa.e a.tivity in the a.-sence of ca.cium. The effect of Ga.a.on the enzyme in the presence of 0.01 ·M Ca.+ does not cha.ge. a. the sa.e time, 1 mM Ca.+elimina.es the Ga.a.effect on the “ba.a.” Mg2+-a.Pa.e a.tivity. Competitive blocker of Ga.a.-receptors bicuculline (5 - 20 μM) in the a.sence of Ca.+ ions elimi-na.es the stimula.ion of the “ba.a.” Mg2+-a.Pa.e by a.ions. When 0.25 mM Ca.+ is a.ded to the in-cuba.ion medium the inhibitory bicuculline effect on the enzyme does not a.pea.. We found tha. 0.1 mM o-va.a.a.e (protein tyrosine phospha.a.e blocker) reduces the Ga.a.a.tiva.ed a.Pa.e a.tivity. a. the sa.e time, 0.1 mM genistein (a.protein tyrosine kina.e blocker) ha. no effect on enzyme a.tivity. In the presence of Ca.+ (0.25 mM), the effect of o-va.a.a.e on the “ba.a.” a.d CI-, HCO3-, -a.Pa.e a.tivities does not a.pea.. It is shown for the first time tha. high concentra.ions of Ca.+prevent the a.tion of Ga.a.-ergic liga.ds on the study a.Pa.e. It is a.sumed tha. there is the involvement of protein kina.es a.d protein phospha.a.es in the modula.ion of the enzyme a.tivity by ca.cium. The observed effect of ca.cium on the a.Pa.e ma. pla. a. importa.t role in the study of the mecha.isms of epileptogenesis a.d seizure a.tivity.

关键词： Mg2+-a.Pa.e Chloride Bica.bona.e Ca.cium Ra. Bra.n Pla.ma Membra.es Ga.a.-Ergic Drugs o-Va.a.a.e Genistein

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Ga.a.lt;sub>a.lt;/sub>-Coupled Cl-/ HCO3--a.Pa.e from Pla.ma.Membra.e of the Ra. Bra.n: Role of HCO3-in the Enzyme a.tiva.ion

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a.va.ces in Enzyme Resea.ch 2015年第1期3卷 9-18页

作者： sergey a. menzikov Ma.ga.ita.N. Ka.pova.La.a.V. Kuznetsova.Na.a.ya.Y. Klishina Federa. Sta.e Scientific Institution “Resea.ch Institute of Genera. Pa.hology a.d Pa.hophysiology” Moscow Russia

This work exa.ines the influence of Cl- (2.5 - 125 mM) a.d HCO3- (2 - 30 mM) on the Cl-/HCO3- - a.Pa.e complex of the neurona. membra.e a.d this enzyme is a.Cl--pump tha. is coupled to Ga.a. receptors. The grea.est (44%) a.tiva.ing effect on the enzyme is found with HCO3- (20 - 30 mM), while the ma.imum a.tivity occurs in the presence of a.ra.io of ~25 mM HCO3- /~5mM Cl-. Blockers of the Ga.a. receptor, na.ely bicuculline (10 - 50 μM) a.d picrotoxin (50 - 100 μM), inhibit this a.ion a.tiva.ion, wherea. the HCO3- -a.Pa.e a.tivity is not sensitive to these liga.ds. a.tora.iogra.hic a.a.ysis of the spectrum of the pa.tia.ly purified enzyme phosphoryla.ed with [γ-32P]a.P a.lowed us to distinguish three ma.or 32P-la.eled protein whose molecula. weight a.e a.out 57, 53, a.d 48 kDa. In the presence of 5 mM Cl-/25mM HCO3- a.d 100 μM picrotoxin, the intensity of the phosphoryla.ion of ba.ds significa.tly decrea.ed, thereby confirming the a.sumption a.out coupled of binding sites for a.ions a.d Ga.a.-ergic liga.ds. It wa. suggested scheme of Cl--tra.sport through the pla.ma.membra.e by utilizing neurona. Cl-/ -HCO3- a.Pa.e in the low (5 mM) Cl- a.d high (25 mM) HCO3- concentra.ions. The da.a.demonstra.ed for the first time tha. the Ga.a.-coupled Cl-/ HCO3- -a.Pa.e from ra. bra.n neurona. membra.es is ma.ima.ly a.tiva.ed a. a.Cl-/HCO3- ra.io of 1:5 a.d it rema.ns sta.le a. high concentra.ions of substra.e a.d buffer.

关键词： Ra. Bra.n Pla.ma Membra.e Mg2+-a.Pa.e Chloride Bica.bona.e Mg2+-a.P Picrotoxin Bicuculline a.tora.iogra.hy Molecula. Weight Subunits

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Influence of non-equilibrium rea.tions on the optimiza.ion of a.rothrust a.roa.sisted ma.euver with orbita. cha.ge

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Chinese Journa. of a.rona.tics 2020年第8期33卷 2133-2145页

作者： Nikola. a.LISOV sergey a.SHKOV Igor a.OMa.a.Va.entin GSHa.HOV Depa.tment of Spa.e Engineering Samara National Research UniversitySamara 443086Russia Inter-University Depa.tment of Spa.e Resea.ch Samara National Research UniversitySamara 443086Russia Depa.tment of a.rcra.t Construction a.d Design Samara National Research UniversitySamara 443086Russia

The spa.epla.e is perspective vehicle due to wide ma.euvera.ility in compa.ison with a.spa.e ca.sule. Its ma.euvera.ility is expressed by the la.ger flight ra.ge a.d a.so by a.possibility to rota.e orbita. inclina.ion in the a.mosphere by the a.rodyna.ic a.d thrust forces. Orbita. pla.e a.mospheric rota.ion ma.euvers ca. significa.tly reduce fuel costs compa.ed to rocket-dyna.ic non-copla.a. ma.euver. However, this ma.euver occurs a. Ma.h numbers a.out 25, a.d such velocities lea. to non-equilibrium chemica. rea.tions in the shock wa.e. Such rea.tions cha.ge a.physicochemica. a.r property, a.d it a.fects a.rodyna.ic coefficients. This pa.er investiga.es the influence of non-equilibrium rea.tions on the a.rothrust a.roa.sisted ma.euver with orbita. *** a.proa.h is to solve a. optimiza.ion problem using the differentia. evolution a.gorithm with a.tempera.ure limita.ion. The spa.epla.e a.rodyna.ic coefficients a.e determined by the numerica. solution of the Reynolds-a.era.ed Na.ier-Stokes equa.ions. The a.rodyna.ic ca.cula.ions a.e conducted for the ca.es of perfect a.d non-equilibrium ga.es. a.compa.ison of optima. tra.ectories,control la.s, a.d fuel costs is ma.e between models of perfect a.d non-equilibrium ga.es. The effect of a.chemica.ly rea.ting ga. on the finite pa.a.eters is a.so eva.ua.ed using control la.s obta.ned for a.perfect ga..

关键词： a.mospheric entry Bounda.y va.ue problem Computa.iona. fluid dyna.ics Differentia. evolution Flight mecha.ics Non-equilibrium flow Spa.epla.e

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Ra.ia.ion of a.TM mode from a. open end of a.three-la.er dielectric ca.illa.y

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Chinese Physics B 2024年第7期33卷 311-318页

作者： sergey NGa.ya.in a.exa.dr Ma.tma.k St.Petersburg Sta.e University 7/9Universitetskayanab.St.Petersburg 199034Russia St.Petersburg Electrotechnica. University“LETI” 5ProfessoraPopovaSt.Petersburg 197022Russia

Modern trends in bea.-driven ra.ia.ion sources include the intera.tion of Cherenkov wa.efields in open-ended circula. wa.eguides with complica.ed dielectric linings, with a.three-la.er dielectric ca.illa.y recently proposed to reduce ra.ia.ion divergence being a.representa.ive exa.ple [Opt. Lett. 45 5416(2020)]. We present a.rigorous a.proa.h tha. a.lows for a. a.a.ytica. description of the electroma.netic processes tha. occur when the structure is excited by a.single wa.eguide TM mode. In other words, the corresponding ca.onica. wa.eguide diffra.tion problem is solved in a.rigorous formula.ion. This is a.continua.ion of our previous pa.ers which considered simpler ca.es with a.homogeneous or two-la.er dielectric filling. Here we use the sa.e a.a.ytica. a.proa.h ba.ed on the Wiener–Hopf–Fock technique a.d dea. with the more complica.ed ca.e of a.three-la.er dielectric lining. Using the obta.ned rigorous solution, we discuss the possibility of ma.ipula.ing the fa.-field ra.ia.ion pa.tern using a.third la.er ma.e of a.low permittivity ma.eria..

关键词： diffra.tion ra.ia.ion open-ended wa.eguide Wiener–Hopf technique Cherenkov ra.ia.ion

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a.a.ytica. solution of a.isymmetric conta.t problem a.out indenta.ion of a.circula. indenter into a.soft functiona.ly gra.ed ela.tic la.er

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a.ta.Mecha.ica.Sinica 2013年第2期29卷 196-201页

作者： sergey Volkov sergey a.zikovich Yue-Sheng Wa.g Igor Fedotov Resea.ch a.d Educa.ion Center "Ma.eria.s" Don State Technical University South Federa. University Research Institute of Mechanics and Applied Mathematics Institute of Engineering Mecha.ics Beijing Jiaotong University Depa.tment of Ma.hema.ica. Technology Tshwane University of Technology

The pa.er a.dresses a.conta.t problem of the theory of ela.ticity,i.e.,the penetra.ion of a.circula. indenter with a.fla. ba.e into a.soft functiona.ly gra.ed ela.tic *** ela.tic properties of a.functiona.ly gra.ed la.er a.bitra.ily va.y with depth,a.d the founda.ion is a.sumed to be ela.tic,yet much ha.der tha. a.*** a.a.ytica. solution is constructed,a.d it is shown tha. the solutions a.e a.ymptotica.ly exa.t both for la.ge a.d sma.l va.ues of cha.a.teristic dimensionless geometrica. pa.a.eter of the *** exa.ples a.e a.a.yzed for the ca.es of monotonic a.d nonmonotonic va.ia.ions of ela.tic *** results for the ca.e of homogeneous la.er a.e compa.ed with the results for nondeforma.le founda.ion.

关键词： Conta.t problems·Indenta.ion·Functiona.ly gra.ed la.er

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Upda.ed Kimura.Ta.emoto cla.sifica.ion of a.rophic ga.tritis

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World Journa. of Clinica. Ca.es 2021年第13期9卷 3014-3023页

作者： sergey M Kotelevets sergey a.Chekh sergey Z Chukov Depa.tment of Thera.y Medical InstituteNorth Caucasus State Academy for Humanities and TechnologiesCherkessk 369000Russia Depa.tment of Softwa.e Development Institute of Applied Mathematics and Information TechnologyNorth Caucasus State Academy of Humanities and TechnologiesCherkessk 369000Russia Depa.tment of Ma.hema.ics Institute of Applied Mathematics and Information TechnologyNorth Caucasus State Academy of Humanities and TechnologiesCherkessk 369000Russia Depa.tment of Pa.hologica. a.a.omy Stavropol State Medical UniversityStavropol 355017Russia

Ba.KGROUND The Upda.ed Sydney system for visua. eva.ua.ion of ga.tric mucosa. a.rophy via.ndoscopic observa.ion is subject to sa.pling error a.d interobserver *** Kimura.Ta.emoto cla.sifica.ion system wa. developed to overcome *** compa.e the morphologica. cla.sifica.ion of a.rophic ga.tritis between theKimura.Ta.emoto system a.d the Upda.ed Sydney *** tota. of 169 pa.ients with a.rophic ga.tritis were selected a.cording to dia.nosisby the visua. endoscopic Kimura.Ta.emoto method. Following the Upda.edKimura.Ta.emoto cla.sifica.ion system, one a.trum biopsy a.d five ga.triccorpus biopsies were ta.en a.cording to the visua. sta.es of the Kimura.Ta.emoto system. The Upda.ed Kimura.Ta.emoto cla.sifica.ion system wa. thena.plied to ea.h a.d showed 165 to ha.e histologica. mucosa. a.rophy;therema.ning 4 pa.ients ha. no histologica. evidence of a.rophy in a.y biopsy. The Upda.ed Kimura.Ta.emoto cla.sifica.ion wa. verified a. a.referencemorphologica. method a.d a.plied for the dia.nosis of a.rophic ga.tritis. a.dingone more biopsy from the a.trum to the six biopsies a.cording to the Upda.ed Kimura.Ta.emoto cla.sifica.ion, constitutes the upda.ed combined Kimura.Ta.emoto cla.sifica.ion a.d Sydney *** sensitivity for degree of mucosa. a.rophy a.sessed by the Upda.ed Sydneysystem wa. 25% for mild, 36% for modera.e, a.d 42% for severe, when compa.edwith the Upda.ed Kimura.Ta.emoto cla.sifica.ion of a.rophic ga.tritis formorphologica. dia.nosis. Four types of multifoca. a.rophic ga.tritis wereidentified: sequentia. uniform (type 1;in 28%), sequentia. non-uniform (type 2;in7%), diffuse uniform (type 3;in 23%), diffuse non-uniform (type 4;in 24%), a.d"a.terna.ing a.rophic – non-a.rophic" (type 5;in 18%). The pa.tern of the sprea. ofa.rophy, sequentia.ly from the a.trum to the ca.dia. segment of the stoma.h,which wa. described by the Upda.ed Kimura.Ta.emoto system, wa.histologica.ly confirmed in 82% of ca.es ***

关键词： Upda.ed Sydney system Kimura.Ta.emoto cla.sifica.ion Prevention Ga.tric ca.cer a.rophic ga.tritis Morphology

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Rea.tiva.ion of hepa.itis B virus infection – a. importa.t a.pect of multifa.eted problem

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World Journa. of Ga.troenterology 2024年第26期30卷 3193-3197页

作者： sergey Morozov sergey Ba.skikh Depa.tment of Ga.troenterology Hepatology and NutritionFederal Research Center of NutritionBiotechnology and Food SafetyMoscow 115446Russia Depa.tment of Hepa.ology Moscow Clinical Scientific Center N.A.A.S.LoginovMoscow 111123Russia

In this editoria. we comment on the a.ticle published in the recent issue of the W orld Journa. of *** focus specifica.ly on the problem of occult hepa.itis B virus(HBV)infection,tha. is a.result of previous hepa.itis B(PHB)a.d a.source for rea.tiva.ion of *** preva.ence of PHB is underestima.ed due to the la.k of popula.ion testing ***,this condition not only com-plica.e a.tica.cer trea.ment,but ma. be responsible for the development of other disea.es,like ca.cer or a.toimmune *** we unveil possible mecha.nisms responsible for rea.iza.ion of these processes a.d suggest pra.tica. a.proa.ches for dia.nosis a.d trea.ment.

关键词： Occult hepa.itis B virus infection Hepa.itis B virus rea.tiva.ion Previous hepa.itis B Ca.cer a.toimmune disorders

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a.Note on Tra.sition Kernels for the Most Unfa.oura.leMixed Stra.egies of the Ma.ket

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Journa. of the Opera.ions Resea.ch Society of China 2024年第1期12卷 35-50页

作者： sergey N.Smirnov Fa.ulty of Computa.iona. Ma.hema.ics a.d Cybernetics Lomonosov Moscow State UniversityMoscowRussian Federation 119991

We consider a.deterministic model of ma.ket evolution with tra.ing constra.nts a.da.ply a.ga.e-theoretic a.proa.h to the superhedging *** obta.n sufﬁcientconditions for the ga.e equilibrium a.d prove under these conditions the existenceof a.Borel-mea.ura.le tra.sition kernel describing dependence on price prehistory ofthe most unfa.oura.le mixed stra.egy of the ma.ket.

关键词： Superhedging Gua.a.teed deterministic a.proa.h Optima. mixedstra.egies of the ma.ket Borel-mea.ura.le tra.sition kernel Ga.e equilibrium

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Structura. Sta.ility of the Fina.cia. Ma.ket Model: Continuity of Superhedging Price a.d Model a.proxima.ion

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Journa. of the Opera.ions Resea.ch Society of China 2024年第1期12卷 215-241页

作者： sergey N.Smirnov Fa.ulty of Computa.iona. Ma.hema.ics a.d Cybernetics Lomonosov Moscow State UniversityMoscow119991Russian Federation

The present pa.er continues the topic of our recent pa.er in the sa.e journa.,a.ming to show the role of structura. sta.ility in fina.cia. *** the context of fina.cia. ma.ket modeling,structura. sta.ility mea.s tha. a.specific“no-a.bitra.e”property is una.fected by sma.l(with respect to the Pompeiu–Ha.sdorff metric)perturba.ions of the model’s *** formula.e,ba.ed on our economic interpreta.ion,a.new requirement concerning“no a.bitra.e”properties,which we ca.l the“uncerta.nty principle”.This principle in the ca.e of no-tra.ing constra.nts is equiva.ent to structura. *** demonstra.e tha. structura. sta.ility is essentia. for a.correct model a.proxima.ion(which is used in our numerica. method for superhedging price computa.ion).We a.so show tha. structura. sta.ility is importa.t for the continuity of superhedging prices a.d discuss the sufficient conditions for this continuity.

关键词： Uncerta.nty Structura. sta.ility No a.bitra.e Continuity of superhedging price Compa.t-va.ued multifunction Fina.cia. ma.ket model a.proxima.ion Tra.ing constra.nts

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a.a.ysis of NIR spectroscopic da.a.using decision trees a.d their ensembles

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Journa. of a.a.ysis a.d Testing 2018年第3期2卷 274-289页

作者： sergey Kucherya.skiy Depa.tment of Chemistry a.d Bioscience Aalborg UniversityNiels Bohrs vej8EsbjergDenmark

Decision trees a.d their ensembles beca.e quite popula. for da.a.a.a.ysis during the pa.t *** of the ma.n rea.ons for tha. is current boom in big da.a.where tra.itiona. sta.istica. methods(such a.,e.g.,multiple linea. regression)a.e not very ***,in chemometrics these methods a.e still not very widesprea.,first of a.l beca.se of severa. limita.ions rela.ed to the ra.io between number of va.ia.les a.d *** pa.er presents severa. exa.ples on how decision trees a.d their ensembles ca. be used in a.a.ysis of NIR spectroscopic da.a.both for regression a.d *** will try to consider a.l importa.t a.pects including optimiza.ion a.d va.ida.ion of models,eva.ua.ion of results,trea.ing missing da.a.a.d selection of most importa.t *** performa.ce a.d outcome of the decision tree-ba.ed methods a.e compa.ed with more tra.itiona. a.proa.h ba.ed on pa.tia. lea.t squa.es.

关键词： NIR spectroscopy Decision trees Cla.sifica.ion a.d regression trees Ra.dom forests

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