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Targeting harmful effects of non-excitatory amino acids as an alternative therapeutic strategy to reduce ischemic damage

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Neural Regeneration Research 2025年第9期20卷 2454-2463页

作者： Victoria Jiménez Carretero IrisÁlvarez-Merz Jorge Hernández-Campano sergei A.Kirov Jesús M.Hernández-Guijo Department of pharmacology and Therapeutic School of MedicineUniv.Autónoma de MadridMadridSpain Ramón y Cajal Institute for Health Research(IRYCIS) Neurobiology-Research ServiceHospital Ramón y CajalMadridSpain Institute of Neurobiology Faculty of Mathematics and Natural SciencesHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neuroscience and Regenerative Medicine&Department of Neurosurgery Medical College of Georgia at Augusta UniversityAugustaGAUSA

The involvement of the excitatory amino acids glutamate and aspartate in ce rebral ischemia and excitotoxicity is ***,the role of non-excitatory amino acids in brain damage following a stroke or brain trauma remains largely *** release of amino acids by necrotic cells in the ischemic core may contribute to the expansion of the *** findings indicated that the reversible loss of field excitato ry postsynaptic potentials caused by transient hypoxia became irreversible when exposed to a mixture of just four non-excitatory amino acids(L-alanine,glycine,L-glutamine,and L-serine)at their plasma *** amino acids induce swelling in the somas of neurons and astrocytes during hypoxia,along with permanent dendritic damage mediated by N-methyl-D-aspartate *** N-methyl-D-aspartate receptors prevented neuronal damage in the presence of these amino acids during *** is likely that astroglial swelling caused by the accumulation of these amino acids via the alanine-serine-cysteine transporter 2 exchanger and system N transporters activates volume-regulated anion channels,leading to the release of excitotoxins and subsequent neuronal damage through N-methyl-D-aspartate receptor ***,previously unrecognized mechanisms involving non-excitatory amino acids may contribute to the progression and expansion of brain injury in neurological emergencies such as stroke and traumatic brain *** these pathways co uld highlight new therapeutic targets to mitigate brain injury.

关键词： cell swelling N-methyl-D-aspartate receptor non-excitatory amino acids stroke synaptic transmission

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The Global Soil Mycobiome consortium dataset for boosting fungal diversity research

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Fungal Diversity 2021年第6期111卷 573-588页

作者： Leho Tedersoo Vladimir Mikryukov Sten Anslan Mohammad Bahram Abdul Nasir Khalid Adriana Corrales Ahto Agan Aída-M.Vasco-palacios Alessandro Saitta Alexandre Antonelli Andrea C.Rinaldi Annemieke Verbeken Bobby p.Sulistyo Boris Tamgnoue Brendan Furneaux Camila Duarte Ritter Casper Nyamukondiwa Cathy Sharp César Marín D.Q.Dai Daniyal Gohar Dipon Sharmah Elisabeth Machteld Biersma Erin K.Cameron Eske De Crop Eveli Otsing Evgeny A.Davydov Felipe E.Albornoz Francis Q.Brearley Franz Buegger Genevieve Gates Geoffrey Zahn Gregory Bonito Indrek Hiiesalu Inga Hiiesalu Irma Zettur Isabel C.Barrio Jaan pärn Jacob Heilmann-Clausen Jelena Ankuda John Y.Kupagme Joosep Sarapuu Jose G.Maciá-Vicente Joseph Djeugap Fovo József Geml Juha M.Alatalo Julieta Alvarez-Manjarrez Jutamart Monkai Kadri põldmaa Kadri Runnel Kalev Adamson Kari A.Bråthen Karin pritsch Kassim I.Tchan Kęstutis Armolaitis Kevin D.Hyde Kevin K.Newsham Kristel panksep Lateef A.Adebola Louis J.Lamit Malka Saba Marcela Eda Silva Cáceres Maria Tuomi Marieka Gryzenhout Marijn Bauters Miklós Bálint Nalin Wijayawardene Niloufar Hagh-Doust Nourou S.Yorou Olavi Kurina peter E.Mortimer peter Meidl RHenrik Nilsson Rasmus puusepp Rebeca Casique-Valdés Rein Drenkhan Roberto Garibay-Orijel Roberto Godoy Saleh Alfarraj Saleh Rahimlou sergei põlme Sergey V.Dudov Sunil Mundra Talaat Ahmed Tarquin Netherway Terry W.Henkel Tomas Roslin Vladimir E.Fedosov Vladimir G.Onipchenko WAErandi Yasanthika Young Woon Lim Meike piepenbring Darta Klavina Urmas Kõljalg Kessy Abarenkov Mycology and Microbiology Center University of TartuTartuEstonia Institute of Ecology and Earth Sciences TartuEstonia Department of Ecology Swedish University of Agricultural SciencesUppsalaSweden Department of Botany University of the PunjabQuaid-e-Azam CampusLahorePakistan Centro de Investigaciones en Microbiología y Biotecnología-UR(CIMBIUR) Facultad de Ciencias NaturalesUniversidad del RosarioBogotáColombia Grupo de Microbiología Ambiental y BioMicro Escuela de MicrobiologíaUniversidad de Antioquia UdeAMedellínColombia Department of Agricultural Food and Forest SciencesUniversity of PalermoPalermoItaly Royal Botanic Gardens SurreyUK Department of Biomedical Sciences University of CagliariCagliariItaly Research Group Mycology Department of BiologyGhent UniversityGhentBelgium Department of Biomedicine Indonesia International Institute for Life SciencesJakartaIndonesia plant pathology and Agricultural Zoology Research Unit Department of Plant ProtectionFaculty of Agronomy and Agricultural SciencesUniversity of DschangDschangCameroon Department of Ecology and Genetics Uppsala UniversityUppsalaSweden Eukaryotic Microbiology University of Duisburg-EssenEssenGermany Department of Biological Sciences and Biotechnology Botswana International University of Science and TechnologyPalapyeBotswana Natural History Museum of Zimbabwe BulawayoZimbabwe Institute of Botany Czech Academy of SciencesPrůhoniceCzech Republic Center for Yunnan plateau Biological Resources protection and Utilization College of Biological Resource and Food EngineeringQujing Normal UniversityQujingPeople’s Republic of China Department of Botany Jawaharlal Nehru Rajkeeya MahavidyalayaPondicherry UniversityPort BlairIndia British Antarctic Survey NERCCambridgeUK Natural History Museum of Denmark University of CopenhagenCopenhagenDenmark Department of Environmental Science Saint Mary’s UniversityHalifaxNSCanada Altai State University BarnaulRussia CSIRO Land and Water WembleyWAAustralia Department of N

Fungi are highly important biotic components of terrestrial ecosystems,but we still have a very limited understanding about their diversity and *** data article releases a global soil fungal dataset of the Global Soil Mycobiome consortium(GSMc)to boost further research in fungal diversity,biogeography and *** dataset comprises 722,682 fungal operational taxonomic units(OTUs)derived from pacBio sequencing of full-length ITS and 18S-V9 variable regions from 3200 plots in 108 countries on all *** plots are supplied with geographical and edaphic *** OTUs are taxonomically and functionally assigned to guilds and other functional *** entire dataset has been corrected by excluding chimeras,index-switch artefacts and potential *** dataset is more inclusive in terms of geographical breadth and phylogenetic diversity of fungi than previously published *** GSMc dataset is available over the plutoF repository.

关键词： Soil fungi Global dataset pacBio sequencing Fungal richness

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Using multi-agent simulation to predict natural crossing points for pedestrians and choose locations for mid-block crosswalks

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Geo-Spatial Information Science 2020年第4期23卷 362-374页

作者： Egor Smirnov sergei Dunaenko sergei Kudinov Institute for Design and Urban Studies ITMO UniversitySaint PetersburgRussia

When arranging the pedestrian infrastructure,one of the most important components that make a tangible contribution to the safety of pedestrians is to organize the safe road *** cities,pedestrians often cross a road in the wrong place due to established routes or inadequate location of *** with the participation of pedestrians who crossed the road neglecting the traffic rules,make up a significant part of the total amount of road *** this paper,we propose a method that allows us,on the basis of the results of a computer simulation of pedestrian traffic,to obtain predicted routes for road crossing and to indicate optimal locations for crosswalks that take into account established pedestrian routes and increase their *** work describes an extension for the existing AntRoadplanner simulation algorithm,which searches for and clusters points where pedestrians cross the roadway and suggests locations for new *** method was tested on the basis of a comparative simulation of several territories before and after its application,as well as on the basis of a field study of the *** developed algorithm can also be used to search for other potentially dangerous places for pedestrians on plans of districts,for example,crossings in places with limited visibility.

关键词： Agent-based modeling computer simulation pedestrian traffic simulation ant road planner pedestrian infrastructure crosswalks pedestrian safety

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Conservation utility of botanic garden living collections:Setting a strategy and appropriate methodology

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plant Diversity 2017年第6期39卷 365-372页

作者： sergei Volis Key Laboratory for plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of Sciences

In the realities of the modern world, when the natural habitat is rapidly disappearing and the number of imperiled plants is constantly growing, ex situ conservation is gaining importance. To meet this challenge, botanic gardens need to revise both their strategic goals and their methodologies to achieve the new goals. This paper proposes a strategy for the management of threatened plants in living collections,which includes setting regional conservation priorities for the species, creation of genetically representative collections for the high priority species, and usage of these collections in in situ actions. In this strategy, the value of existing and future species living collections for conservation is determined by the species' conservation status and how well the accessions represent their natural genetic variation.

关键词： Biodiversity Threatened plants Ex situ Living collections Conservation strategy Integrated conservation management

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Nature and(in-)coherent metamorphic evolution of subducted continental crust in the Neoproterozoic accretionary collage of SW Mongolia

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Geoscience Frontiers 2021年第3期12卷 78-103页

作者： sergei Skuzovatov Vinogradov Institute of Geochemistry SB RAS Favorskogo str.1AIrkutsk 664033Russia

In continental subduction complexes minor volumes of high-pressure mafic rocks(eclogites)often co-exist with much more abundant felsic(granitic)and metasedimentary rocks,which are vital for resolving the origin and metamorphic evolution of subducted continental *** SW Mongolia,the Alag Khadny eclogite-bearing accretionary complex(AKC)is assumed to represent either a remnant of oceanic slab,or a continental margin,subducted in the Early *** we present geochronological,geochemical and petrological evidence of subduction records for the three major types of lithologies that host mafic eclogites,including Mesoproterozoic and Neoproterozoic granitic basement and overlying Neoproterozoic continental-margin *** deformed,ferroan and peraluminous metagranitoids compose a major part of AKC and are interlayered with eclogites in its southern and eastern *** have geochemical features of post-collisional/intraplate high-K calc-alkaline ***-ICp-MS U-pb zircon geochronology of three distinct metagranite samples show uniform protolith crystallization ages of ca.0.96 Ga and uncertain re-crystallization in the Late Neoproterozoic or Early paleozoic metamorphic event,whereas abundant zircon inheritance indicates older,Mesoproterozoic to paleoproterozoic crustal substrate during granite *** existence of Mesoproterozoic crust is highlighted by finding of distinct metagranitoids with the U-pb zircon crystallization age of ca.1.6 *** isotope signatures(T_(DM)^(C)2.88-1.85 Ga)of zircons from all lithologies preserved the evidence of reworked Neoarchean to paleoproterozoic crust,similar to that of the Baidrag block(southern Mongolia),for both Mesoproterozoic and Neoproterozoic *** of the specific lithology,the rocks display indicators of high-pressure metamorphic re-equilibration,including garnet(X_(Ca)up to 0.65)+epidote+phengite(Si *** to 3.56)±rutile assemblage in metagranitoids,garnet+phengite(Si ***

关键词： Central Asian Orogenic Belt SW Mongolia Subduction Metasedimentary rocks Orthogneisses Trace elements Zircon U-pb age Hf isotopes

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Spatial analysis of vegetation cover response to climate trends in Khakassia(South Siberia)

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Journal of Mountain Science 2023年第10期20卷 2869-2884页

作者： IM sergei Institute of Natural Sciences and Mathematics Khakassian State University named after N.F.KatanovAbakan 655000Russia V.N.Sukachev Institute of Forest Krasnoyarsk Science Centre of the Siberian Branch of Russian Academy of ScienceKrasnoyarsk 660036Russia Institute of Ecology and Geography Siberian Federal UniversityKrasnoyarsk 660041Russia Institute of Space Research and High Technologies Reshetnev Siberian State University of Science and TechnologyKrasnoyarsk660014Russia

An analysis of the changes in vegetation cover on the territory of the Republic of Khakassia in 2000–2021 due to climatic trends was carried out based on the MODIS *** changes in vegetation cover were estimated based on trends in Normalized Difference Vegetation Index(NDVI)and Enhanced Vegetation Index(EVI).In general,in the 21st century,an increase in the biomass of vegetation cover is *** trends were observed in 16%–22%of the territory,and negative only in 1%–3%.For about 20%of the analyzed territory,a significant influence of climate on the changes in vegetation cover was *** most pronounced negative impact on vegetation cover was caused by summer air and soil temperatures,spring temperature,and summer winds,and the positive impact was caused by summer precipitation and soil *** response of the vegetation cover to climate was non-uniform concerning the ***,a significant correlation with the amount of precipitation was observed for~20%–35%of vegetation growing below 600 m above sea level and for less than 5%above this *** negative effect of summer temperatures on plants prevailed mainly at an elevation below~1400 m above sea *** climate change is likely to lead to significant degradation of vegetation in the steppe and foreststeppe in Khakassia in the coming decades.

关键词： Khakassia South Siberia Vegetation cover Climate trends Remote sensing MODIS NDVI EVI Relief

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Complementarities of two existing intermediate conservation approaches

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plant Diversity 2017年第6期39卷 379-382页

作者： sergei Volis Key Laboratory for plant Diversity and Biogeography of East Asia Kunming Institute of Botany Chinese Academy of Sciences

The need for integration of ex situ and in situ approaches in conservation of plants has long been recognized. However, ex situ collections have numerous limitations that reduce their utility for conservation, necessitating the introduction of new, more appropriate, flexible and less costly *** new approaches that can be called "intermediate" between in situ and ex situ, and bridging them in some way have been proposed over the last two decades. In these approaches material collected in natural populations is planted and maintained outside the original location, but with a different *** the purpose of the inter situs approach is reintroduction, the concern of the quasi in situ approach is long-term storage of species genetic diversity. I view these two approaches as complementary and necessary components of conservation-oriented restoration. In restoration of a degraded habitat using threatened species(i.e. inter situs), quasi in situ collections can serve an important role in providing longterm preservation of these species' genetic diversity and production of seeds needed for restoration.

关键词： Biodiversity Threatened plants In situ Ex situ Quasi in situ Conservation strategy Conservation guidelines

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FungalTraits:a user-friendly traits database of fungi and fungus-like stramenopiles

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Fungal Diversity 2020年第6期105卷 I0001-I0016页

作者： sergei põlme Kessy Abarenkov RHenrik Nilsson Björn D.Lindahl Karina Engelbrecht Clemmensen Havard Kauserud Nhu Nguyen Rasmus Kjøller Scott T.Bates petr Baldrian Tobias Guldberg Frøslev Kristjan Adojaan Alfredo Vizzini Ave Suija Donald pfister Hans-Otto Baral Helle Järv Hugo Madrid Jenni Nordén Jian-Kui Liu Julia pawlowska Kadri põldmaa Kadri pärtel Kadri Runnel Karen Hansen Karl-Henrik Larsson Kevin David Hyde Marcelo Sandoval-Denis Matthew E.Smith Merje Toome-Heller Nalin N.Wijayawardene Nelson Menolli Jr Nicole K.Reynolds Rein Drenkhan Sajeewa S.N.Maharachchikumbura Tatiana B.Gibertoni Thomas Læssøe William Davis Yuri Tokarev Adriana Corrales Adriene Mayra Soares Ahto Agan Alexandre Reis Machado Andrés Argüelles-Moyao Andrew Detheridge Angelina de Meiras-Ottoni Annemieke Verbeken Arun Kumar Dutta Bao-Kai Cui C.K.pradeep César Marín Daniel Stanton Daniyal Gohar Dhanushka N.Wanasinghe Eveli Otsing Farzad Aslani Gareth W.Griffith Thorsten H.Lumbsch Hans-peter Grossart Hossein Masigol Ina Timling Inga Hiiesalu Jane Oja John Y.Kupagme József Geml Julieta Alvarez-Manjarrez Kai Ilves Kaire Loit Kalev Adamson Kazuhide Nara Kati Küngas Keilor Rojas-Jimenez Krišs Bitenieks Laszlo Irinyi LászlóGNagy Liina Soonvald Li-Wei Zhou Lysett Wagner M.Catherine Aime MaarjaÖpik María Isabel Mujica Martin Metsoja Martin Ryberg Martti Vasar Masao Murata Matthew pNelsen Michelle Cleary Milan C.Samarakoon Mingkwan Doilom Mohammad Bahram Niloufar Hagh-Doust Olesya Dulya peter Johnston petr Kohout Qian Chen Qing Tian Rajasree Nandi Rasekh Amiri Rekhani Hansika perera Renata dos Santos Chikowski Renato L.Mendes-Alvarenga Roberto Garibay-Orijel Robin Gielen Rungtiwa phookamsak Ruvishika S.Jayawardena Saleh Rahimlou Samantha C.Karunarathna Saowaluck Tibpromma Shawn p.Brown Siim-Kaarel Sepp Sunil Mundra Zhu-Hua Luo Tanay Bose Tanel Vahter Tarquin Netherway Teng Yang Tom May Torda Varga Wei Li Victor Rafael Matos Coimbra Virton Rodrigo Targino de Oliveira Vitor Xavier de Lima Vladimir S.Mikryukov Yongzhong Lu Yosuke Matsuda Yumiko Miyamoto Urm Institute of Ecology and Earth Sciences University of Tartu14A Ravila50411 TartuEstonia Natural History Museum University of Tartu46 Vanemuise Str51003 TartuEstonia Gothenburg Global Biodiversity Centre Box 46140530 GothenburgSweden Department of Biological and Environmental Sciences University of GothenburgGothenburgSweden Department of Soil and Environment Swedish University of Agricultural SciencesBox 701475007 UppsalaSweden Department of Forest Mycology and plant pathology Swedish University of Agricultural SciencesBox 702675007 UppsalaSweden Section for Genetics and Evolutionary Biology(EvoGene) Department of BiosciencesUniversity of OsloP.O.Box 1066BlindernNO-0316 OsloNorway University of Hawaiʻi at Mānoa 3190 Maile WaySt.John 102HonoluluHIUSA Department of Biology University of CopenhagenUniversitetsparken 152100 CopenhagenØDenmark purdue University Northwest WestvilleIN 46391USA Institute of Microbiology Czech Academy of SciencesVidenska 108314220 Praha 4Czech Republic GLOBE Institute University of CopenhagenØster Farimagsgade 5KH7.2.321353 CopenhagenDenmark Dipartimento di Scienze della Vita e Biologia dei Sistemi Universitàdi TorinoViale Mattioli 2510125 TorinoItaly Department of Organismic and Evolutionary Biology and Farlow Library and Herbarium Harvard University22 Divinity AveCambridgeMA 02138USA Blaihofstr.42 72074 TübingenGermany SYNLAB Estonia Veerenni 53aTallinn 11313Estonia Escuela de Tecnología Médica Universidad Santo TomásLos Carreras 753OsornoChile Centro de Genómica y Bioinformática Universidad MayorCamino La Pirámide 5750HuechurabaSantiagoChile Norwegian Institute for Nature Research(NINA) Sognsveien 680855 OsloNorway School of Life Science and Technology University of Electronic Science and Technology of ChinaChengdu 611731People’s Republic of China Evolutionary Biology Faculty of BiologyBiological and Chemical Research CentreUniversity of Warsawul.Zwirki i Wigury 10102-089 WarsawPoland Department of Botany Swedish Museum of

The cryptic lifestyle of most fungi necessitates molecular identification of the guild in environmental *** the past decades,rapid development and affordability of molecular tools have tremendously improved insights of the fungal diversity in all ecosystems and ***,in spite of the progress of molecular methods,knowledge about functional properties of the fungal taxa is vague and interpretation of environmental studies in an ecologically meaningful manner remains *** order to facilitate functional assignments and ecological interpretation of environmental studies we introduce a user friendly traits and character database FungalTraits operating at genus and species hypothesis *** the information from previous efforts such as FUNGuild and FunFun together with involvement of expert knowledge,we reannotated 10,210 and 151 fungal and Stramenopila genera,*** resulted in a stand-alone spreadsheet dataset covering 17 lifestyle related traits of fungal and Stramenopila genera,designed for rapid functional assignments of environmental *** order to assign the trait states to fungal species hypotheses,the scientific community of experts manually categorised and assigned available trait information to 697,413 fungal ITS *** the basis of those sequences we were able to summarise trait and host information into 92,623 fungal species hypotheses at 1%dissimilarity threshold.

关键词： Fungal traits Trophic modes Function Guild Bioinformatics High-throughput sequencing Community ecology

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The effect of self-focusing on laser space-debris cleaning

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Light(Science & Applications) 2014年第1期3卷 250-255页

作者： Alexander M Rubenchik Michail p Fedoruk sergei K Turitsyn Lawrence Livermore National Laboratory LivermoreCA 94550USA Institute of Computational Technologies Siberian Branch of the Russian Academy of SciencesNovosibirsk 630090Russia Novosibirsk State University Novosibirsk 630090Russia Aston Institute of photonic Technologies School of Engineering and Applied ScienceAston UniversityBirmingham B47ETUK

A ground-based laser system for space-debris cleaning will use powerful laser pulses that can self-focus while propagating through the *** demonstrate that for the relevant laser parameters,this self-focusing can noticeably decrease the laser intensity on the *** show that the detrimental effect can be,to a great extent,compensated for by applying the optimal initial beam *** effect of laser elevation on the system performance is discussed.

关键词： laser self-focusing space debris

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Securing a future for China's plant biodiversity through an integrated conservation approach

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plant Diversity 2018年第3期40卷 91-105页

作者： sergei Volis Key Laboratory for plant Diversity and Biogeography of East Asia Kunming Institute of Botany Chinese Academy of Sciences

The severely threatened Chinese flora urgently needs a new, well adapted to China and properly formulated conservation strategy. The present review provides a detailed conservation methodology that complements previously described guidelines for preservation of plant species with extremely small populations(pSESp) in China. This review adds to the above concept in several aspects, making it relevant to all threatened Chinese plant species. The proposed integral conservation strategy has the following crucial components:-ecoregional basis for conservation planning and implementation;-a unified scoring system that is used in regional systematic planning for reserve design,monitoring and assessment of efficiency of a reserve network, and creation of seed banks and living collections;-a focus on population demography and the presence of naturally occurring regeneration as the key criteria for defining the conservation status of a species and the appropriate major focus of the species recovery plan;-creation of multi-species living collections that preserve species genetic variation and provide material for in situ actions;-experimental translocation of threatened species into multiple locations within and outside their known *** and implementing these strategies successfully and more fully in China requires that the country changes pA legislation and improves pA management, the National Science Foundation of China(NSFC) re-prioritizes the type of research that receives research funds, and local scientists improve their approach toward information sharing.

关键词： Biodiversity Threatened plants Conservation guidelines Chinese plant conservation Nature reserves protected areas

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