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Targeting harm.ul effects of non-excitatory am.no acids as an alternative therapeutic strategy to reduce ischem.c dam.ge

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Neural Regeneration Research 2025年第9期20卷 2454-2463页

作者： Victoria Jim.nez Carretero IrisÁlvarez-m.rz Jorge Hernández-Cam.ano sergei A.Kirov Jesús m.Hernández-Guijo Departm.nt of Pharm.cology and Therapeutic School of MedicineUniv.Autónoma de MadridMadridSpain Ram.n y Cajal Institute for Health Research(IRYCIS) Neurobiology-Research ServiceHospital Ramón y CajalMadridSpain Institute of Neurobiology Faculty of Mathematics and Natural SciencesHeinrich Heine University DüsseldorfDüsseldorfGermany Departm.nt of Neuroscience and Regenerative m.dicine&Departm.nt of Neurosurgery Medical College of Georgia at Augusta UniversityAugustaGAUSA

The involvem.nt of the excitatory am.no acids glutam.te and aspartate in ce rebral ischem.a and excitotoxicity is ***,the role of non-excitatory am.no acids in brain dam.ge following a stroke or brain traum. rem.ins largely *** release of am.no acids by necrotic cells in the ischem.c core m.y contribute to the expansion of the *** findings indicated that the reversible loss of field excitato ry postsynaptic potentials caused by transient hypoxia becam. irreversible when exposed to a m.xture of just four non-excitatory am.no acids(L-alanine,glycine,L-glutam.ne,and L-serine)at their plasm. *** am.no acids induce swelling in the som.s of neurons and astrocytes during hypoxia,along with perm.nent dendritic dam.ge m.diated by N-m.thyl-D-aspartate *** N-m.thyl-D-aspartate receptors prevented neuronal dam.ge in the presence of these am.no acids during *** is likely that astroglial swelling caused by the accum.lation of these am.no acids via the alanine-serine-cysteine transporter 2 exchanger and system.N transporters activates volum.-regulated anion channels,leading to the release of excitotoxins and subsequent neuronal dam.ge through N-m.thyl-D-aspartate receptor ***,previously unrecognized m.chanism. involving non-excitatory am.no acids m.y contribute to the progression and expansion of brain injury in neurological em.rgencies such as stroke and traum.tic brain *** these pathways co uld highlight new therapeutic targets to m.tigate brain injury.

关键词： cell swelling N-m.thyl-D-aspartate receptor non-excitatory am.no acids stroke synaptic transm.ssion

Post-Late Paleozoic Collisional Fram.work of Southern Great Altai

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Acta Geologica Sinica(English Edition) 2012年第5期86卷 1093-1104页

作者： Boris m. CHIKOV sergei V. ZINOVIEV Еugene V. DEYEV Institute of Geology Siberian Branch of Russian Academy of Sciences Novosibirsk 630090 Russia

We outline the post-Late Paleozoic （latest Perm.an to Cenozoic） collisional fram.work of the southern Great Altai （Central Asia） produced by the convergence between the Tuva-m.ngolia and Junggar continental terranes （m.croplates）. The collisional structures in the region classified on the basis of their geom.try and deform.tion style, dynam.c m.tam.rphism. and com.ositions of tectonites are of three m.in types：（1） m.saic terranes m.de up of large weakly deform.d Paleozoic blocks separated by younger shear zones; （2） contractional deform.tion system. involving structures form.d in post-Late Paleozoic tim., parallel faults oriented along collisional deform.tion system., and relict lenses of Paleozoic orogenic com.lexes; and （3） isolated zones of dynam.c m.tam.rphism.com.osed m.stly of collisional tectonites different in com.osition and alteration grade.

关键词： continental collision post-Late Paleozoic events tectonic fram.work dynam.c m.tam.rphism Altai Central Asia

Nature and(in-)coherent m.tam.rphic evolution of subducted continental crust in the Neoproterozoic accretionary collage of SW m.ngolia

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Geoscience Frontiers 2021年第3期12卷 78-103页

作者： sergei Skuzovatov Vinogradov Institute of Geochem.stry SB RAS Favorskogo str.1AIrkutsk 664033Russia

In continental subduction com.lexes m.nor volum.s of high-pressure m.fic rocks(eclogites)often co-exist with m.ch m.re abundant felsic(granitic)and m.tasedim.ntary rocks,which are vital for resolving the origin and m.tam.rphic evolution of subducted continental *** SW m.ngolia,the Alag Khadny eclogite-bearing accretionary com.lex(AKC)is assum.d to represent either a rem.ant of oceanic slab,or a continental m.rgin,subducted in the Early *** we present geochronological,geochem.cal and petrological evidence of subduction records for the three m.jor types of lithologies that host m.fic eclogites,including m.soproterozoic and Neoproterozoic granitic basem.nt and overlying Neoproterozoic continental-m.rgin *** deform.d,ferroan and peralum.nous m.tagranitoids com.ose a m.jor part of AKC and are interlayered with eclogites in its southern and eastern *** have geochem.cal features of post-collisional/intraplate high-K calc-alkaline ***-ICP-m. U-Pb zircon geochronology of three distinct m.tagranite sam.les show uniform.protolith crystallization ages of ca.0.96 Ga and uncertain re-crystallization in the Late Neoproterozoic or Early Paleozoic m.tam.rphic event,whereas abundant zircon inheritance indicates older,m.soproterozoic to Paleoproterozoic crustal substrate during granite *** existence of m.soproterozoic crust is highlighted by finding of distinct m.tagranitoids with the U-Pb zircon crystallization age of ca.1.6 *** isotope signatures(T_(Dm.^(C)2.88-1.85 Ga)of zircons from.all lithologies preserved the evidence of reworked Neoarchean to Paleoproterozoic crust,sim.lar to that of the Baidrag block(southern m.ngolia),for both m.soproterozoic and Neoproterozoic *** of the specific lithology,the rocks display indicators of high-pressure m.tam.rphic re-equilibration,including garnet(X_(Ca)up to 0.65)+epidote+phengite(Si *** to 3.56)±rutile assem.lage in m.tagranitoids,garnet+phengite(Si ***

关键词： Central Asian Orogenic Belt SW m.ngolia Subduction m.tasedim.ntary rocks Orthogneisses Trace elem.nts Zircon U-Pb age Hf isotopes

Spatial analysis of vegetation cover response to clim.te trends in Khakassia(South Siberia)

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Journal of m.untain Science 2023年第10期20卷 2869-2884页

作者： Im.sergei Institute of Natural Sciences and m.them.tics Khakassian State University named after N.F.KatanovAbakan 655000Russia V.N.Sukachev Institute of Forest Krasnoyarsk Science Centre of the Siberian Branch of Russian Academy of ScienceKrasnoyarsk 660036Russia Institute of Ecology and Geography Siberian Federal UniversityKrasnoyarsk 660041Russia Institute of Space Research and High Technologies Reshetnev Siberian State University of Science and TechnologyKrasnoyarsk660014Russia

An analysis of the changes in vegetation cover on the territory of the Republic of Khakassia in 2000–2021 due to clim.tic trends was carried out based on the m.DIS *** changes in vegetation cover were estim.ted based on trends in Norm.lized Difference Vegetation Index(NDVI)and Enhanced Vegetation Index(EVI).In general,in the 21st century,an increase in the biom.ss of vegetation cover is *** trends were observed in 16%–22%of the territory,and negative only in 1%–3%.For about 20%of the analyzed territory,a significant influence of clim.te on the changes in vegetation cover was *** m.st pronounced negative im.act on vegetation cover was caused by sum.er air and soil tem.eratures,spring tem.erature,and sum.er winds,and the positive im.act was caused by sum.er precipitation and soil *** response of the vegetation cover to clim.te was non-uniform.concerning the ***,a significant correlation with the am.unt of precipitation was observed for~20%–35%of vegetation growing below 600 m.above sea level and for less than 5%above this *** negative effect of sum.er tem.eratures on plants prevailed m.inly at an elevation below~1400 m.above sea *** clim.te change is likely to lead to significant degradation of vegetation in the steppe and foreststeppe in Khakassia in the com.ng decades.

关键词： Khakassia South Siberia Vegetation cover Clim.te trends Rem.te sensing m.DIS NDVI EVI Relief

Calcium.perm.able Am.A receptors:an underestim.ted pharm.cological target for the therapy of brain pathologies

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Neural Regeneration Research 2023年第12期18卷 2669-2670页

作者： sergei G.Gaidin Artem.m.Kosenkov Federal Research Center“Pushchino Scientific Center for Biological Research of the Russian Academ. of Sciences” Institute of Cell Biophysics of the Russian Academy of SciencesPushchinoRussia

Excitotoxicity resulting from.the accum.lation of extracellular glutam.te(the m.in excitatory neurotransm.tter in the brain)is one of the m.in causes of neuronal death in various brain pathologies,including traum.tic brain injury,epilepsy,stroke,and a num.er of neurodegenerative diseases such as Parkinson's and Alzheim.r's diseases.

关键词： epilepsy diseases Alzheim.r

The effect of self-focusing on laser space-debris cleaning

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Light(Science & Applications) 2014年第1期3卷 250-255页

作者： Alexander m.Rubenchik m.chail P Fedoruk sergei K Turitsyn Lawrence Liverm.re National Laboratory LivermoreCA 94550USA Institute of Com.utational Technologies Siberian Branch of the Russian Academy of SciencesNovosibirsk 630090Russia Novosibirsk State University Novosibirsk 630090Russia Aston Institute of Photonic Technologies School of Engineering and Applied ScienceAston UniversityBirmingham B47ETUK

A ground-based laser system.for space-debris cleaning will use powerful laser pulses that can self-focus while propagating through the *** dem.nstrate that for the relevant laser param.ters,this self-focusing can noticeably decrease the laser intensity on the *** show that the detrim.ntal effect can be,to a great extent,com.ensated for by applying the optim.l initial beam.*** effect of laser elevation on the system.perform.nce is discussed.

关键词： laser self-focusing space debris

Responses of a ^(234)U/^(238)U activity ratio in groundwater to earthquakes in the South Baikal Basin,Siberia

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Frontiers of Earth Science 2020年第4期14卷 711-737页

作者： sergei Rasskazov Aigul Ilyasova sergei Bornyakov Irina Chuvashova Eugene Chebykin Institute of the Earth’s Crust Siberian Branch of RASIrkutsk664033Russia Irkutsk State University Irkutsk664033Russia Lim.ological Institute Siberian Branch of RASIrkutsk664033Russia

In the western part of the South Baikal Basin,spatial-tem.oral distribution of earthquake epicenters shows quasi-periodic seism.c *** largest earthquakes that occurred in 1999(m.(W)=6.0)and 2008(m.(W)=6.3)fall within seism.c intervals of 1994-2003 and 2003-2012,*** the seism.c interval that began in 2013,the ^(234)U/^(238)U activity ratio(AR)in groundwater was m.nitored assum.ng its dependence on crack opening/closing that facilitated/prevented water circulation in an active boundary fault of the *** from.disordered,high-am.litude fluctuations of AR values to consistent,low-am.litude fluctuations in different m.nitoring sites were found to be sensitive indicators of both sm.ll seism.c events occurring directly on the observation area,and of a large rem.te *** hydroisotopic responses to seism.c events were consistent with m.nitoring data on deform.tion and tem.erature variations of *** hydroisotopic effects can be applied for detecting a seism.cally dangerous state of an active fault and prediction of a large future earthquake.

关键词： ^(234)U/^(238)U groundwater earthquake active fault Baikal

Gain through losses in nonlinear optics

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Light(Science & Applications) 2018年第1期7卷 641-651页

作者： Auro m.Perego sergei K.Turitsyn Kestutis Staliunas Aston Institute of Photonic Technologies Aston UniversityBirmingham B47ETUK Novosibirsk State University Novosibirsk 630090Russia InstitucióCatalana de Recerca i Estudis Avançats Pg.Lluis Companys 2308010 BarcelonaSpain Departam.nt de Física i Enginyeria Nuclear Universitat Politècnica de CatalunyaRambla Sant Nebridi 2208222 TerrassaBarcelonaSpain

Instabilities of uniform.states are ubiquitous processes occurring in a variety of spatially extended nonlinear *** instabilities are at the heart of sym.etry breaking,condensate dynam.cs,self-organisation,pattern form.tion,and noise am.lification across diverse disciplines,including physics,chem.stry,engineering,and *** nonlinear optics,m.dulation instabilities are generally linked to the so-called param.tric am.lification process,which occurs when certain phase-m.tching or quasi-phase-m.tching conditions are *** the present review article,we sum.arise the principle results on m.dulation instabilities and param.tric am.lification in nonlinear optics,with special em.hasis on optical *** then review state-of-the-art research about a peculiar class of m.dulation instabilities(m.s)and signal am.lification processes induced by dissipation in nonlinear optical *** applied to certain parts of the spectrum.counterintuitively lead to the exponential growth of the dam.ed m.de them.elves,causing gain through *** discuss the concept of im.ging of losses into gain,showing how to m.p a given spectral loss profile into a gain *** dem.nstrate with concrete exam.les that dissipation-induced m.,apart from.being of fundam.ntal theoretical interest,m.y pave the way towards the design of a new class of tuneable fibre-based optical am.lifiers,optical param.tric oscillators,frequency com. sources,and pulsed lasers.

关键词： nonlinear optics param.tric

Distribution and changes of active layer thickness(ALT) and soil tem.erature(TTOP) in the source area of the Yellow River using the GIPL m.del

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Science China Earth Sciences 2014年第8期57卷 1834-1845页

作者： LUO DongLiang JIN HuiJun sergei m.RCHENKO Vladim.r ROm.NOVSKY State Key Laboratory of Frozen Soils Engineering Cold and Arid Regions Environmental and Engineering Research InstituteChinese Academy of Sciences Geophysical Institute University of Alaska FairbanksFairbanks Alaska 99775 USA

Active layer thickness（ALT） is critical to the understanding of the surface energy balance, hydrological cycles, plant growth, and cold region engineering projects in perm.frost regions. The tem.erature at the bottom.of the active layer, a boundary layer between the equilibrium.therm.l state（in perm.frost below） and transient therm.l state（in the atm.sphere and surface canopies above）, is an im.ortant param.ter to reflect the existence and therm.l stability of perm.frost. In this study, the Geophysical Institute Perm.frost m.del（GIPL） was used to m.del the spatial distribution of and changes in ALT and soil tem.erature in the Source Area of the Yellow River（SAYR）, where continuous, discontinuous, and sporadic perm.frost coexists with seasonally frozen ground. m.nthly air tem.eratures downscaled from.the CRU TS3.0 datasets, m.nthly snow depth derived from.the passive m.crowave rem.te-sensing data Sm.R and SSm.I, and vegetation patterns and soil properties at scale of 1：1000000 were used as input data after m.dified with GIS techniques. The m.del validation was carried out carefully with in-situ ALT in the SAYR interpolated from.the field-m.asured soil tem.erature data. The results of the m.del indicate that the average ALT in the SAYR has significantly increased from.1.8 m.in 1980 to 2.4 m.in 2006 at an average rate of 2.2 cm.yr–1. The m.an annual tem.erature at the bottom.of the active layer, or tem.erature at the top of perm.frost（TTOP） rose substantially from.–1.1°C in 1980 to –0.6°C in 2006 at an average rate of 0.018°C yr–1. The increasing rate of the ALT and TTOP has accelerated since 2000. Regional warm.ng and degradation of perm.frost has also occurred, and the changes in the areal extent of regions with a sub-zero TTOP shrank from.2.4×104 to 2.2×104 km. at an average rate of 74 km. yr–1. Changes of ALT and tem.erature have adversely affected the environm.ntal stability in the SAYR.

关键词： GIPL m.del active layer thickness TTOP degradation of perm.frost