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New opportunities of dendrimers for theranostic approaches to personalized medicine

Science China Materials 2018年第11期61卷 1365-1366页

作者： Jean-Pierre Majoral Xiangyang Shi serge mignani Laboratoire de Chimie de Coordination Centre National de la Recherche Scientifique Toulouse France College of Chemistry Chemical Engineering and Biotechnology Donghua University Shanghai China CQM-Centro de Quimica da Madeira MMRG Universidade da Madeira Campus da Penteada 9020-105 Funchal Portugal

Theranostic nanomedicine paradigm, a combination of specific molecular diagnostic tests and specific targeted therapy, involves two topics:therapeutic product efficacies and diagnosis. The first topic concerns identified patients to be treated, whereas the second is to select patients for personalized medicine. Generally, nanotechnology allows developing theranostic strategy

关键词：特定分子诊断测试定向治疗发展现状医疗卫生行业

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Multiplexing technology for in vitro diagnosis of pathogens： the key contribution of phosphorus dendrimers

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Science China Materials 2018年第11期61卷 1454-1461页

作者： Jean Pierre Majoral Jean Marie Francois Richard Fabre Alice Senescau serge mignani Anne-Marie Caminade Laboratoire de Chimie de Coordination du CNRS 31077 Toulouse Cedex 4France LCC-CNRS Universit6 de Toulouse CNRSToulouseFrance Dendris 31670 LabegeFrance LISBP UMR CNRS 5504 INRA 79231077 Toulouse Cedex 04France Universite Paris Descartes PRES Sorbonne Paris Cite CNRS-UMR 860Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicolgique75006 ParisFrance

After the microbiology based on Pasteur's method and polymerase chain reaction(PCR), the diagnosis company named Dendris has proposed a third-generation of diagnosis enabling the search of a broad range of pathogens with strong sensitivity and specificity. This extraordinary profile was possible thanks to the use of phosphorus dendrimers for which various techniques of deposition on a given support were investigated and described and analyzed in this report.

关键词： phosphorus dendrimers diagnosis DNA arrays multiplexing technology

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Recent therapeutic applications of the theranostic principle with dendrimers in oncology

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Science China Materials 2018年第11期61卷 1367-1386页

作者： serge mignani Joao Rodrigues Helena Tomas Anne-Marie Caminade Regis Laurent Xiangyang Shi Jean-Pierre Majoral Universite Paris Descartes PRES Sorbonne Paris CiteCNRS UMR 860Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologique45rue des Saints Peres75006 ParisFrance CQM-Centro de Quimica da Madeira MMRGUniversidade da MadeiraCampus da Penteada9020-105FunchalPortugal School of Materials Science and Engineering/Center for Nano Energy Materials Northwestern Polytechnical UniversityXi＇an 710072China Laboratoire de Chimie de Coordination du CNRS 205 Route de NarbonneBP 4409931077 Toulouse Cedex 4France Universite de Toulouse UPSINPT31077 Toulouse CedexFrance State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai 201620China

At the intersection between treatment and diagnosis, nanoparticles technologies are strongly impacting the development of both therapeutic and diagnostic ***, the development of novel modalities for concomitant noninvasive therapy and diagnostics known as theranostics as a single platform has gained significant interests. These multifunctional theranostic platforms include carbon-based nanomaterials（e.g., carbon nanotubes）, drug conjugates, aliphatic polymers, micelles, vesicles, core-shell nanoparticles, microbubbles and dendrimers bearing different contrast agents and drugs, such as cytotoxic compounds in the oncology domain. Dendrimers emerged as a new class of highly tunable hyperbranched polymers, and have been developed as useful theranostic platforms. Magnetic resonance imaging, gamma scintigraphy, computed tomography and optical imaging are the main techniques developed with dendrimers in the theranostic domain in oncology. Different imaging agents have been used such as Gd（Ⅲ）,19F, Fe2O3（MRI）,76Br（PET）,111In,88Y,153Gd,188Re,131I（SPECT）,177Lu,gold（CT） and boronated groups, siliconnaphthalocyanines,dialkylcarbocyanines and QDs（optical imaging dyes）.

关键词： theranostic platforms dendrimers magnetic resonance imaging gamma scintigraphy imaging computed tomography imaging optical imaging

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