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Developing Project Duration Models in Software Engineering

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Journal of Computer Science & Technology 2007年第3期22卷 348-357页

作者： pierre Bourque serge Oligny Alain Abran Bertrand Fournier cole de Technologie Supérieure Montréal QuébecCanada Bell Canada Montréal QuébecCanada Université du Québec à Montréal Montréal QuébecCanada

Based on the empirical analysis of data contained in the International Software Benchmarking Standards Group （ISBSG） repository, this paper presents software engineering project duration models based on project effort. Duration models are built for the entire dataset and for subsets of projects developed for personal computer, mid-range and mainframe platforms. Duration models are also constructed for projects requiring fewer than 400 person-hours of effort and for projects requiring more than 400 person-hours of effort. The usefulness of adding the maximum number of assigned resources as a second independent variable to explain duration is also analyzed. The opportunity to build duration models directly from project functional size in function points is investigated as well.

关键词： international software benchmarking standards group (ISBSG) project duration models project scheduling models schedule and organizational issues software engineering time estimation

New opportunities of dendrimers for theranostic approaches to personalized medicine

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Science China Materials 2018年第11期61卷 1365-1366页

作者： Jean-pierre Majoral Xiangyang Shi serge Mignani Laboratoire de Chimie de Coordination Centre National de la Recherche Scientifique Toulouse France College of Chemistry Chemical Engineering and Biotechnology Donghua University Shanghai China CQM-Centro de Quimica da Madeira MMRG Universidade da Madeira Campus da Penteada 9020-105 Funchal Portugal

Theranostic nanomedicine paradigm, a combination of specific molecular diagnostic tests and specific targeted therapy, involves two topics:therapeutic product efficacies and diagnosis. The first topic concerns identified patients to be treated, whereas the second is to select patients for personalized medicine. Generally, nanotechnology allows developing theranostic strategy

关键词：特定分子诊断测试定向治疗发展现状医疗卫生行业

Multiplexing technology for in vitro diagnosis of pathogens： the key contribution of phosphorus dendrimers

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Science China Materials 2018年第11期61卷 1454-1461页

作者： Jean pierre Majoral Jean Marie Francois Richard Fabre Alice Senescau serge Mignani Anne-Marie Caminade Laboratoire de Chimie de Coordination du CNRS 31077 Toulouse Cedex 4France LCC-CNRS Universit6 de Toulouse CNRSToulouseFrance Dendris 31670 LabegeFrance LISBP UMR CNRS 5504 INRA 79231077 Toulouse Cedex 04France Universite Paris Descartes PRES Sorbonne Paris Cite CNRS-UMR 860Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicolgique75006 ParisFrance

After the microbiology based on Pasteur's method and polymerase chain reaction(PCR), the diagnosis company named Dendris has proposed a third-generation of diagnosis enabling the search of a broad range of pathogens with strong sensitivity and specificity. This extraordinary profile was possible thanks to the use of phosphorus dendrimers for which various techniques of deposition on a given support were investigated and described and analyzed in this report.

关键词： phosphorus dendrimers diagnosis DNA arrays multiplexing technology

Flow fields and particle trajectories beneath a tidal bore:A numerical study

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International Journal of Sediment Research 2018年第3期33卷 351-370页

作者： Adrien Berchet Bruno Simon Anthony Beaudoin pierre Lubin Germain Rousseaux serge Huberson Institut Pprime Université de Bordeaux

Tidal bores may appear in some estuaries when the tides quickly reach a high level. This phenomenon is rare but has a strong impact during its short duration: i.e. the river bed is significantly eroded and sediments are then transported. In this paper, the trajectories of suspended particles induced by this flow are numerically studied. Four undular bores with Froude numbers between 1.1 and 1.2 are *** similar Froude numbers, various initial flow conditions were selected to produce or not an inversion of the flow direction during the bore passage. The particle trajectories associated with each distinct flow configuration are presented and analyzed. These trajectories, estimated by solving the Maxey-Riley equation, appear to be very different even though the Froude numbers of flows are *** observations are important because the Froude number is often used to characterize a tidal bore as it describes well the free surface, however, it cannot describe the sediment transport. Finally, Chen’s model of wave-current interactions is adapted to fit the cases studied and is applied to the four bores simulated. The results highlight that this latter model can reproduce the observed trajectories and dissociate their different components. From this model, it is shown that the inertial and Basset history effects can be neglected compared to the gravity and flow entrainment effects due to the viscous drag when one wants to determine the long-term trajectories of suspended particles.

关键词： Tidal bores Sediment transport Trajectories Physical modeling Numerical modeling

Brain delivery of fibronectin through bioactive phosphorous dendrimers for Parkinson’s disease treatment via cooperative modulation of microglia

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Bioactive Materials 2024年第8期38卷 45-54页

作者： Waicong Dai Mengsi Zhan Yue Gao Huxiao Sun Yu Zou Regis Laurent serge Mignani Jean-pierre Majoral Mingwu Shen Xiangyang Shi State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative MedicineCollege of Biological Science and Medical EngineeringDonghua UniversityShanghai201620PR China Laboratoire de Chimie de Coordination du CNRS 205 Route de NarbonneCEDEX 431077ToulouseFrance Universit´e Toulouse 118 Route de NarbonneCEDEX 431077ToulouseFrance CQM-Centro de Química da Madeira Universidade da MadeiraCampus Universit´ario da Penteada9020-105FunchalPortugal

Effective treatment of Parkinson’s disease(PD),a prevalent central neurodegenerative disorder particularly affecting the elderly population,still remains a huge *** present here a novel nanomedicine formulation based on bioactive hydroxyl-terminated phosphorous dendrimers(termed as AK123)complexed with fibronectin(FN)with anti-inflammatory and antioxidative *** created optimized AK123/FN nanocomplexes(NCs)with a size of 223 nm display good colloidal stability in aqueous solution and can be specifically taken up by microglia through FN-mediated *** show that the AK123/FN NCs are able to consume excessive reactive oxygen species,promote microglia M2 polarization and inhibit the nuclear factor-kappa B signaling pathway to downregulate inflammatory *** the abundant dendrimer surface hydroxyl terminal groups,the developed NCs are able to cross blood-brain barrier(BBB)to exert targeted therapy of a PD mouse model through the AK123-mediated anti-inflammation for M2 polarization of microglia and FN-mediated antioxidant and anti-inflammatory effects,thus reducing the aggregation ofα-synuclein and restoring the contents of dopamine and tyrosine hydroxylase to normal levels in *** developed dendrimer/FN NCs combine the advantages of BBB-crossing hydroxyl-terminated bioactive per se phosphorus dendrimers and FN,which is expected to be extended for the treatment of different neurodegenerative diseases.

关键词： Phosphorous dendrimers Fibronectin Parkinson’s disease Blood brain barrier Combination therapy

Paracetamol Sensitive Cellulose-Based Electrochemical Sensors

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Journal of Renewable Materials 2018年第3期6卷 242-250页

作者： Maxime Pontie serge Foukmeniok Mbokou Jean-Philippe Bouchara Bienvenue Razafimandimby Sylvie Egloff Ornella Dzilingomo pierre-Yves Pontalier Ignas Kenfack Tonle Host-Pathogen Interaction Study Group(GEIHP EA 3142)UNIV AngersUNIV BrestBretagne Loire UniversityInstitute of Health Biology-IRISCHU4 rue Larrey49933 AngersFrance Electrochemistry and Chemistry of Materials Department of ChemistryUniversity of DschangP.O.Box 67 DschangCameroon Toulouse University INP-ENSIACETLCA(Laboratory of Agro-industrial Chemistry)31030 Toulouse France

Electrochemical determination of paracetamol(PCT)was successfully performed using carbon paste electrodes(CPEs)modified with treated coffee husks(CHt)or cellulose powder(Ce).Scanning electron microscopy was used to characterize unmodified or modified CPEs prior to their *** electrochemical oxidation of PCT was investigated using square wave voltammetry(SWV)and cyclic voltammetry(CV).The oxidation current density of PCT was two-fold higher with the CPE-CHt sensor and 30%higher with CPE-Ce in comparison with the unmodified CPE,and this correlated with the higher hydrophilicity of the modified *** SWV for the electrochemical analysis of PCT,carbon paste electrode modified with raw coffee husks(CPE-CHr)showed the presence of impurities at+0.27 V/SCE,showing the interest in using pure cellulose for the present analytical ***,CPE-Ce presented a higher real area compared to CPE-CHr,which explains the increase in the limit of saturation from 400 mg/L to 950 mg/*** better saturation limit exhibited by CPE-Ce justifies its choice for electroanalysis of PCT in commercialized *** proposed method was successfully applied in the determination of PCT in commercialized tablets(DolipraneR 500)with a recovery rate close to 100%,and no interference with the excipients contained in the tablets analyzed was *** novel sensor opens the way for sustainable development of electroanalytical control of drugs sold individually in developing countries.

关键词： Paracetamol carbon paste electrode coffee husks cellulose fibers square wave voltammetry electroanalysis

Electrical Resistivity Contrasts and High Flow Rates Discontinuous Aquifers Identification in a Sheared Crystallophyllian Basement Zone at Boniérédougou (North-Central Côte d’Ivoire)

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Journal of Geoscience and Environment Protection 2022年第11期10卷 35-49页

作者： Simon pierre Djroh Kouamelan serge Kouamelan Yacouba Ouattara serge Pacome Dégine Gnoleba Applied Geophysics Research Team Laboratory Mineral and Energy Resources (LGRME) Faculty of Earth Science and Mineral Resources Félix Houphou&#235 t Boigny University Abidjan C&#244 te d’Ivoire Ministry of Mines and Geology Yamoussoukro C&#244 te d’Ivoire

This study proposes an alternative approach to the investigation of high flow hydrogeological fractures within the basement in the Dabakala region of north-central Côte d’Ivoire. The used approach consists of exploring the subsurface by measuring electrical resistivity contrasts along the main shear direction within crystallophyllian rocks. Electrical resistivity profiling and vertical electrical sounding techniques, coupled with boreholes monitoring, have identified fractured aquifers whose best flow rates are around 96 and 116 m3/h. These aquifers mostly hosted in granodiorite have an average strength of 10 meters and are located at depth of around 100 meters. They are associated with open fractures created by tangential shear stresses that have affected the Dabakala volcano-sedimentary trench formations. The search for fractured aquifers along the main shear direction offers great perspective for obtaining high flow rates.

关键词： Shear Fractured Aquifer High Flow Rate Côte d’Ivoire

冲绳海槽200ka的孢粉记录及冰期-间冰期旋回古环境重建

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中国科学：地球科学 2013年第10期43卷 1231-1248页

作者：郑卓黄康有邓韫曹玲珑余少华 Jean-pierre SUC serge BERNE Francois GUICHARD 中山大学地球科学系广州510275 Paleoenvironnements et Paleobiosphere Universite Claude Bernard-Lyonl Villeurbanne 69622 France 国家海洋局南海海洋工程勘察与环境研究院广州510300 Institut des Sciences de la Terre Paris Université P. et M. Curie Pads 75005 France Université de Perpignan Via Domitia Perpignan 66860 France Laboratoire des Sciences du Climat et de l'Environnement Gif-sur-Yvette 91191 France

本文对冲绳海槽中部MD982194钻孔29.78m近200kaBP的岩芯进行了孢粉研究.结果表明,孢粉组合主要表现为裸子植物与草本植物花粉之间的交替.带气囊类的松属、铁杉在间冰期的1,3,5和7氧同位素期显著增高,而草本则在冰期阶段占优,两者的含量... 详细信息

本文对冲绳海槽中部MD982194钻孔29.78m近200kaBP的岩芯进行了孢粉研究.结果表明,孢粉组合主要表现为裸子植物与草本植物花粉之间的交替.带气囊类的松属、铁杉在间冰期的1,3,5和7氧同位素期显著增高,而草本则在冰期阶段占优,两者的含量变化显示出对冰期-间冰期环境变化的敏感响应.本钻孔发现莎草科花粉在冰期阶段含量大幅度增加,伴随蒿属、禾本科、菊科、藜科和淡水藻类的显著升高.它们与轨道尺度的海平面变化呈现十分吻合的负相关关系.草本花粉总量的周期性变化可以作为该区域海平面变化的替代性指标.末次盛冰期的海平面下降导致陆地与冲绳海槽的距离大幅缩小,源于长江的物质随河流进入大陆架后因流速急剧降低发生沉降,导致上游物质难以被远距离搬运到海槽.因此,冰期阶段冲绳海槽的孢粉物质可能主体来自于大陆架前缘的地表植被,而间冰期带气囊类花粉的比例增大与海岸距离较远和风力搬运物质的比例增加有关.钻孔的孢粉组分更替与气候变化也有显著的对应关系,反映出氧同位素7,5和1期木本含量高,并与东亚夏季风增强和降雨量增大有关.其中MIS5.3,MIS5.1和MIS3.3段的松属花粉峰值可能与轨道和亚轨道周期的地表太阳辐射和季风增强有密切联系.研究认为,盛冰期的东海陆架平原的气温和降雨量都有较明显的下降,但低海面时期裸露的大陆架平原可能并非由半干旱的地带性草原所覆盖,而是以疏林草地及密布的隐域性植被(河流补给淡水湖沼和湿地)组成.海平面变化引起的海岸距离伸缩和源区气候变化对陆源物质通量和孢粉组分更替起到联合制约的作用,而冲绳海槽冰期-间冰期尺度的海岸线距离变化在孢粉信号中的表现要明显强于陆源区域的气候变化.

关键词：冲绳海槽孢粉分析东海陆架海平面陆源植被气候变化

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Recent therapeutic applications of the theranostic principle with dendrimers in oncology

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Science China Materials 2018年第11期61卷 1367-1386页

作者： serge Mignani Joao Rodrigues Helena Tomas Anne-Marie Caminade Regis Laurent Xiangyang Shi Jean-pierre Majoral Universite Paris Descartes PRES Sorbonne Paris CiteCNRS UMR 860Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologique45rue des Saints Peres75006 ParisFrance CQM-Centro de Quimica da Madeira MMRGUniversidade da MadeiraCampus da Penteada9020-105FunchalPortugal School of Materials Science and Engineering/Center for Nano Energy Materials Northwestern Polytechnical UniversityXi＇an 710072China Laboratoire de Chimie de Coordination du CNRS 205 Route de NarbonneBP 4409931077 Toulouse Cedex 4France Universite de Toulouse UPSINPT31077 Toulouse CedexFrance State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai 201620China

At the intersection between treatment and diagnosis, nanoparticles technologies are strongly impacting the development of both therapeutic and diagnostic ***, the development of novel modalities for concomitant noninvasive therapy and diagnostics known as theranostics as a single platform has gained significant interests. These multifunctional theranostic platforms include carbon-based nanomaterials（e.g., carbon nanotubes）, drug conjugates, aliphatic polymers, micelles, vesicles, core-shell nanoparticles, microbubbles and dendrimers bearing different contrast agents and drugs, such as cytotoxic compounds in the oncology domain. Dendrimers emerged as a new class of highly tunable hyperbranched polymers, and have been developed as useful theranostic platforms. Magnetic resonance imaging, gamma scintigraphy, computed tomography and optical imaging are the main techniques developed with dendrimers in the theranostic domain in oncology. Different imaging agents have been used such as Gd（Ⅲ）,19F, Fe2O3（MRI）,76Br（PET）,111In,88Y,153Gd,188Re,131I（SPECT）,177Lu,gold（CT） and boronated groups, siliconnaphthalocyanines,dialkylcarbocyanines and QDs（optical imaging dyes）.

关键词： theranostic platforms dendrimers magnetic resonance imaging gamma scintigraphy imaging computed tomography imaging optical imaging