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Conservation genomic investigation of an endangered conifer,Thuja sutchuenensis,reveals low genetic diversity but also low genetic load

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Plant Diversity 2024年第1期46卷 78-90页

作者： Tongzhou Tao Richard iMilne Jialiang Li Heng Yang Shiyang Wang Sihan Chen Kangshan Mao Key Laboratory for Bio-Resource and Eco-Environment of Ministry of Education&Sichuan Zoige Alpine Wetland Ecosystem National Observation and Research Station College of Life ScienceSichuan UniversityChengduChina institute of Molecular Plant Science School of Biological ScienceUniversity of EdinburghEdinburgh EH93BFUK College of Science Tibet UniversityLhasa 850000Xizang Autonomous RegionPR China

Endangered species generally have small populations with low genetic diversity and a high genetic *** sutchuenensis is an endangered conifer endemic to southwestern *** was once considered extinct in the wild,but in 1999 was ***,little is known about its genetic *** collected 67 individuals from five wild,isolated *** populations,and used 636,151 SNPs to analyze the level of genetic diversity and genetic load in *** to delineate the conservation units of ***,based on whole transcriptome sequencing data,as well as target capture sequencing *** found that populations of *** could be divided into three *** groups had low levels genetic diversity and were moderately genetically *** findings also indicate that *** suffered two severe bottlenecks around the Last Glaciation Period and Last Glacial *** Thuja species,*** presented the lowest genetic load and hence might have purged deleterious mutations efficiently through purifying ***,distribution of fitness effects analysis indicated a high extinction risk for *** lines of evidence identified three management units for *** *** possesses a low genetic load,low genetic diversity,suboptimal fitness,and anthropogenic pressures all present an extinction risk for this rare *** might also hold true for many endangered plant species in the mountains all over the world.

关键词： Sichuan Arborvitae Genetic load Deleterious mutations Demographic history Conservation genomics

Structure and dielectric properties of (1-x)Na_(0.5)Bi_(0.5)TiO_(3-x)Na_(0.5)K_(0.5)NbO_(3)

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Journal of Advanced Dielectrics 2024年第1期14卷 82-88页

作者： E.V.Glazunova L.A.Shilkina A.S.Chekhova A.V.Nazarenko i.A.Verbenko L.A.Reznichenko Research institute of Physics Southern Federal University Rostov-on-Don344090Russia Faculty of Physics Southern Federal University Rostov-on-Don344090Russia Southern Scientific Center of the Russian Academy of Sciences Rostov-on-Don 344006Russia

The solid solutions of the(1-x)Na_(0.5)Bi_(0.5)TiO_(3-x)Na_(0.5)K_(0.5)NbO_(3) system were produced by the conventional ceramic technology using mechanical activation of the synthesized *** was found that in the(1-x)Na_(0.5)Bi_(0.5)TiO_(3-x)Na_(0.5)K_(0.5)NbO_(3) system at room temperature,a number of morphotropic phase transitions occur:rhombohedral!cubic!tetragonal!monoclinic *** introduction of a small amount of Na_(0.5)K_(0.5)NbO_(3) leads to an increase in the temperature stability of the dielectric properties of ceramics.A change in the relaxor properties of the solid solutions of the(1-x)Na_(0.5)Bi_(0.5)TiO_(3-x)Na_(0.5)K_(0.5)NbO_(3) system was *** increase in energy density and energy efficiency was found at additive 10 mol.%of Na_(0.5)K_(0.5)NbO_(3).

关键词： Ceramics lead-free materials mechanical activation dielectric properties energy storage

Hypergonadotrophic Hypogonadism with Cerebellar Ataxia in a Twenty-Six-Year-Old Female: A Case Report

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Open Journal of Modern Neurosurgery 2024年第1期14卷 83-90页

作者： Bibiana i. Oti Geoffrey Okorie Peter Chime Ethel Chime Birinus Ezeala-Adikaibe Casmir Orjioke Fintan Ekochin Michael C. Abonyi Enugu State University Teaching Hospital Enugu Nigeria University of Nigeria Teaching Hospital Ituku-Ozalla Nigeria

Gordon Holmes Syndrome is a rare inherited disease characterized by both neurological and reproductive signs and symptoms. Most patients develop neurologic challenges in early adulthood and cerebellar ataxia occurs as the disease progresses. in the majority of patients, hypogonadism is hypogonadotropic but rarely hypergonadotropic. We report a case of a 26-year-old female in Nigeria, with hypergonadotropic hypogonadism and cerebellar atrophy from a non-consanguineous marriage and no family history.

关键词： Gordon Holmes Syndrome Hypergonadotrophic Hypogonadism Cerebellar Ataxia Neuroendocrine Disorder

基于完整儿童立场的小学语文课堂教学样态重塑

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小学语文教学 2024年第3期 11-14页

作者：文i章荣耀章荣耀作者单位:江苏省无锡师范学校附属小学江苏省无锡师范学校附属小学

完整儿童立场是基于儿童立场的个体生命的完整性成长,既指个体的全面和谐发展,也指个体的整体性建构,归根结底是最适合儿童自身需求,且适合社会需要的教育成长。2022年版课标背景下的语文课堂教学的根本目标聚焦立德树人.

关键词：儿童立场立德树人语文课堂教学全面和谐发展自身需求个体生命适合儿童

基于非局部增强塑性损伤微平面模型的装配式梁柱节点力学性能研究

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混凝土 2024年第8期 151-157页

作者：李汝飞王辉明新疆大学建筑工程学院新疆乌鲁木齐830017

装配式结构梁柱节点是影响结构力学性能的关键部位,为深入全面地探究其非线性力学行为,基于非局部增强塑性损伤微平面模型,运用ANSYS有限元程序,考虑新旧混凝土结合面等构造措施,建立精细化有限元计算模型,以相关试验为基础,比较验证了... 详细信息

装配式结构梁柱节点是影响结构力学性能的关键部位,为深入全面地探究其非线性力学行为,基于非局部增强塑性损伤微平面模型,运用ANSYS有限元程序,考虑新旧混凝土结合面等构造措施,建立精细化有限元计算模型,以相关试验为基础,比较验证了所建有限元模型的可靠性。并以后浇区混凝土强度等级、轴压比、梁上部纵筋配筋率为参数,考察其对装配式节点承载力及延性的影响。结果表明:节点承载力随后浇区混凝土强度等级、轴压比、梁上部纵筋配筋率的增大而增大;节点延性随后浇区混凝土强度等级、梁上部纵筋配筋率的增大而增大,轴压比则对其影响较小。为装配式结构梁柱节点的设计和应用提供了理论依据和参考。

关键词：微平面模型塑性损伤理论装配式梁柱节点力学性能

Boehmeria nivea var. strigosa (Urticaceae), a new variety from Southwest China

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广西植物 2024年第9期44卷 1617-1624,I0001-I0006页

作者： ZHAO Ying Richard i.MiLNE Li Zhipeng Amos KiPKOECH WU Zengyuan Germplasm Bank of Wild Species Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China CAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China University of Chinese Academy of Sciences Beijing 100049China School of Life Sciences Yunnan UniversityKunming 650091YunnanChina institute of Molecular Plant Sciences/School of Biological Sciences University of EdinburghEH93JHEdinburghUK

Boehmeria nivea *** Zeng ***&***,a new variety of ***(Urticaceae)from Southwest China,is here described based on evidence from morphology and molecular *** new variety is mainly characterized by its green abaxial leaf blade,partly connate stipules,and densely patent strigose hairs on stems and *** phylogenetic analysis based on rbc L,nrDNA and rbc L+nrDNA datasets,revealed that all individuals of *** *** formed a monophyletic *** conservation status of *** *** is assessed as“Near Threatened”(NT)according to iUCN evaluation *** discovery of this new variety is not only crucial for the taxonomy of ramie,but also provides reference for the exploration and utilization of ramie.

关键词： Boehmeria nivea morphology molecular phylogeny new variety Southwest China Yunnan

Prevalence and risk factors for impaired renal function among Asian patients with nonalcoholic fatty liver disease

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Hepatobiliary & Pancreatic Diseases international 2024年第3期23卷 241-248页

作者： Chao Sun George Boon-Bee Goh Wan-Cheng Chow Wah-Kheong Chan Grace Lai-Hung Wong Wai-Kay Seto Yi-Hsiang Huang Han-Chieh Lin i-Cheng Lee Hye Won Lee Seung Up Kim Vincent Wai-Sun Wong Jian-Gao Fan Center for Fatty Liver Disease Department of GastroenterologyXinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai Key Lab of Pediatric Gastroenterology and NutritionShanghai 200092China Department of Gastroenterology&Hepatology Singapore General HospitalSingaporeSingapore Gastroenterology and Hepatology Unit Department of MedicineFaculty of MedicineUniversity of MalayaKuala LumpurMalaysia Department of Medicine and Therapeutics and State Key Laboratory of Digestive Disease The Chinese University of Hong KongHong KongChina Department of Medicine The University of Hong KongHong KongChina institute of Clinical Medicine National Yang Ming Chiao Tung University School of MedicineTaipeiTaiwanChina Division of Gastroenterology and Hepatology Taipei Veterans General HospitalTaipeiTaiwanChina Faculty of Medicine National Yang Ming Chiao Tung University School of MedicineTaipeiTaiwanChina Department of internal Medicine Yonsei University College of MedicineSeoulKorea

Background:Nonalcoholic fatty liver disease(NAFLD)is associated with impaired renal function,and both diseases often occur alongside other metabolic ***,the prevalence and risk factors for impaired renal function in patients with NAFLD remain *** objective of this study was to identify the prevalence and risk factors for renal impairment in NAFLD ***:All adults aged 18-70 years with ultrasound-diagnosed NAFLD and transient elastography examination from eight Asian centers were enrolled in this prospective *** fibrosis and cirrhosis were assessed by FibroScan-aspartate aminotransferase(FAST),Agile 3+and Agile 4 *** renal function and chronic kidney disease(CKD)were defined by an estimated glomerular filtration rate(eGFR)with value ofin/1.73 m^(2) andin/1.73 m^(2),respectively,as estimated by the CKD-Epidemiology Collaboration(CKD-EPi)***:Among 529 included NAFLD patients,the prevalence rates of impaired renal function and CKD were 37.4%and 4.9%,*** multivariate analysis,a moderate-high risk of advanced liver fibrosis and cirrhosis according to Agile 3+and Agile 4 scores were independent risk factors for CKD(Pincreased fasting plasma glucose(FPG)and blood pressure were significantly associated with impaired renal function after controlling for the other components of metabolic syndrome(Pith patients with normoglycemia,those with prediabetes[FPG≥5.6 mmol/L or hemoglobin A1c(HbA1c)≥5.7%]were more likely to have impaired renal function(Pions:Agile 3+and Agile 4 are reliable for identifying NAFLD patients with high risk of *** glycemic control in the prediabetic stage might have a potential renoprotective role in these patients.

关键词： Nonalcoholic fatty liver disease impaired renal function Agile 3+ Agile 4 Metabolic syndrome

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装载机铲装运动作业轨迹规划研究

机械设计与制造 2024年第1期395卷 150-153页

作者：温超李冰席亚丽广西科技大学机械与交通工程学院广西柳州545026

装载机正在往智能化、节能化、低能耗趋势发展,为装载机规划一条低能耗、高效率的铲装轨迹尤为重要。现阶段验证装载机轨迹最佳方法未考虑工作环境带来的测量误差,近而规划铲装轨迹不能适用与真实工况的装载机。本文根据经验公式及插入... 详细信息

装载机正在往智能化、节能化、低能耗趋势发展,为装载机规划一条低能耗、高效率的铲装轨迹尤为重要。现阶段验证装载机轨迹最佳方法未考虑工作环境带来的测量误差,近而规划铲装轨迹不能适用与真实工况的装载机。本文根据经验公式及插入深度公式混合计算,结合软件算法设计出比较接近真实工况的一次铲装曲线轨迹和混合铲装轨迹曲线轨迹,并将两条轨迹曲线输入到装载机工作装置试验台分进行测试验证。相比较传统的仿真模拟验证方法,本文采用真实工作台收集数据,还原铲装作业真实环境,引入铲斗满斗率和作业阻力双重标准进行评判。实验结果表明,对于相同作业量、相同时间内混合铲装轨迹法所受的力小于一次铲装轨迹法,且满斗率混合铲装法高于一次铲装法。

关键词：装载机满斗率铲装轨迹节能

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KarXT治疗精神分裂症患者的临床研究

中国临床药理学杂志 2024年第3期40卷 439-439页

作者： KAUL i 戴荣源

Xanomeline-trospium(KarXT)是将占诺美林与外周限制性毒蕈碱受体拮抗药曲司氯铵联合使用,其目的是改善与外周毒蕈碱受体相关的占诺美林相关不良事件。EMERGENT-2试验旨在评估KarXT对患有急性精神分裂症患者的疗效和安全性。

关键词：急性精神分裂症受体拮抗药疗效和安全性精神分裂症患者曲司氯铵毒蕈碱受体占诺美林相关不良事件