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COVID-19 Vaccine Priority Access for Adults and Children with Congenital Heart Disease: A Statement of the Italian Society of Pediatric Cardiology

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Congenital Heart Disease 2021年第5期16卷 427-431页

作者： Gabriele Egidy Assenza Biagio Castaldi serena Flocco Giovanni Battista Luciani Giovanni Meliota Gabriele Rinelli Ugo Vairo Silvia Favilli Board of the Italian Society of Pediatric Cardiology Department of Cardio-Thoracic and Vascular Medicine IRCCS Azienda Ospedaliero-Universitaria di BolognaBolognaItaly Department of Women’s and Children’s Health University of PadovaPadovaItaly Health Professions Research and Development Unit IRCCS Policlinico San DonatoMilanoItaly Department of Surgery DentistryPediatrics and GynecologyUniversity of VeronaVeronaItaly Pediatric Cardiology ‘Giovanni XXIII’Pediatric HospitalBariItaly Department of Pediatric Cardiology and Cardiac Surgery ‘Ospedale Pediatrico Bambino Gesu’RomaItaly Pediatric Cardiology ‘A.Meyer’Pediatric HospitalFirenzeItaly 不详

COVID-19 pandemic continues to strike across the world with increasing number of infected patients,severe morbidity and mortality,social life and economy *** access to vaccine prophylaxis will be pivotal in controlling this infection and providing individual level ***,mismatch between vaccine request and vaccine availability,as well as constraints in logistics of vaccine campaign is creating a transition phase of progressive but still incomplete inclusion of group of individuals in the vaccination *** patients living with chronic and multisystemic disease may present increased propensity of adverse outcome,should Sars-Cov-2 infection *** these patients,expedite access to COVID-19 vaccination may be *** Italian Society of Pediatric Cardiology National Board is providing a viewpoint to inform policy makers and public authorities during vaccine allocation strategies development,to consider higher priority and expedite access for selected groups of patients living with congenital heart disease.

关键词： COVID-19 vaccine congenital heart disease

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Chemical Bromatological Evaluation of Biomass for Silage of the Winter Cereals

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Journal of Chemistry and Chemical Engineering 2017年第4期11卷 152-156页

作者： Carlos Eugenio Fortes Teixeira Renato serena Fontaneli Tecnico em Mecdnica Engenharia Mecanica IFSul Campus Passo Fundo Passo Fundo RS Brazil Agronomia ppgAgro UPF Universidade de Passo Fundo Pesquisador EMBRAPA TRIGO Passo Fundo RS Brazil

Winter cereals are cultivated in order to produce grain for food and feed, green forage and haylage for cattle. The objectives of this study are to assay the production and chemical characteristics bromatological of winter cereal forages. The factorial arrangement of treatments 5 × 2 （5 cultivars and two cutting heights--low 7-10 cm and 20 cm from the soil surface） harvested when the grain was at the dough stage. Genetic materials tested were rye BRS Serrano, wheat BRS Umbu and BRS Pastoreio, triticale BRS Saturno, barley BRS Aliensa and Brevis oats BRS Centauro. The experimental design was a randomized complete block design with four replications. The assay carried out to forage, BRS Centauro showed oat forage yield higher than the other genotypes. Barley BRS Aliensa stood out for DMD （dry matter digestibility） and CP （crude protein） for the two tested cutting heights. BRS Pastoreio wheat had lower NDF （neutral detergent fiber） concentration than BRS Serrano rye.

关键词： Cellular content assay physiologic production forage.

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Insight into the role of lactic acid bacteria in the development of a novel fermented pistachio(Pistacia vera L.)beverage

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Food Bioscience 2023年第3期53卷 2782-2791页

作者： Tiziana Di Renzo Andrea Osimani serena Marulo Federica Cardinali Gianfranco Mamone Cecilia Puppo Antonela G.Garzón Silvina R.Drago Carmine Laurino Anna Reale Institute of Food Sciences National Research Council(CNR-ISA)Via Roma 6483100AvellinoItaly Dipartimento di Scienze Agrarie Alimentari ed Ambientali(D3A)Università Politecnica delle Marchevia Brecce Bianche60131AnconaItaly CIDCA-UNLP-CONICET 47 y 116 s/n1900La PlataArgentina Instituto de Tecnología de Alimentos CONICETFacultad de Ingeniería Química–Univerisdad Nacional del Litoral1°de Mayo 32503000Santa FeArgentina

This study aimed to assess the fermentability of a pistachio-based *** effects of lactic acid fermen-tation on the odor profile and the stability of the beverage were also *** this end,a procedure for obtaining a pistachio beverage was developed,and the nutritional composition of the beverage was *** beverage was characterized by a high content of fiber(2.9%),fat(4.6%),and protein(2%),and contained high amounts of K and *** the experiment,43 cultures of the following lactic acid bacteria were used:Companilactibacillus paralimentarius,Companilactibacillus kimchi,Levilactibacillus brevis,Lactiplantibacillu pentosus,Lactiplantibacillus plantarum,Lactiplantibacillus paraplantarum,Latilactobacillus curvatus,Leuconostoc pseudome-senteroides,and Furfurilactobacillus *** cultures were evaluated for the following technological charac-teristics:i)growth and acidifying activity,ii)production of exopolysaccharides;iii)presence of histidine decarboxylase(hdcA)gene;iv)antimicrobial activity against Listeria *** cultures were used in model pistachio-based fermentations to assess their ability to grow and *** odor profile of the beverage after 24 h fermentation was assessed using an electronic nose system(E-nose).The pistachio-based beverage resulted an optimal substrate for lactic acid bacteria that reached loads between 8 and 10 log CFU/mL and acidified the beverage to pH values between 4 and *** the beverage,viable counts of all cultures remained above 8 log CFU/mL after 30 days of storage at 4℃.The E-nose analysis represented a valid screening method to evaluate the effects of the fermentative activity of microbial starters on the qualitative characteristics of this novel food matrix.

关键词： Pistachio of Bronte E-nose Volatile compounds EPS Food fermentation

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Impact of contrast-enhanced ultrasound in patients with renal function impairment

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World Journal of Radiology 2017年第1期9卷 10-16页

作者： Rossano Girometti Tiziano Stocca Elena serena Antonio Granata Michele Bertolotto Institute of Diagnostic Radiology Department of Medical and Biological SciencesUniversity of UdineUniversity Hospital 'S. Maria della Misericordia' S.O.C. Radiologia San Giovanni di Dio Hospital Department of Radiology University of TriesteCattinara Hospital UOC di Nefrologia-Dialisi 'San Giovanni di Dio' Hospital

AIMTo investigate the role of contrast enhanced ultrasound (CEUS) in evaluating patients with renal function impairment (RFI) showing: (1) acute renal failure (ARF) of suspicious vascular origin; or (2) suspicious renal *** retrospectively evaluated patients addressed to CEUS over an eight years period to rule-out vascular causes of ARF (first group of 50 subjects) or assess previously found suspicious renal lesions (second group of 41 subjects with acute or chronic RFI). After preliminary grey-scale and color Doppler investigation, each kidney was investigated individually with CEUS, using 1.2-2.4 mL of a sulfur hexafluoride-filled microbubble contrast agent. Image analysis was performed in consensus by two readers who reviewed digital clips of CEUS. We calculated the detection rate of vascular abnormalities in the first group and performed descriptive statistics of imaging findings for the second *** the first group, CEUS detected renal infarction or cortical ischemia in 18/50 patients (36%; 95%CI: 23.3-50.9) and 1/50 patients (2%; 95%CI: 0.1-12), respectively. The detection rate of infarction was significantly higher (P = 0.0002; McNemar test) compared to color Doppler ultrasonography (10%). No vascular causes of ARF were identified in the remaining 31/50 patients (62%). In the second group, CEUS detected 41 lesions on 39 patients, allowing differentiation between solid lesions (21/41; 51.2%) vs complex cysts (20/41; 48.8%), and properly addressing 15/39 patients to intervention when feasible based on clinical conditions (surgery and cryoablation in 13 and 2 cases, respectively). Cysts were categorized Bosniak II, IIF, III and IV in 8, 5, 4 and 3 cases, respectively. In the remaining two patients, CEUS found 1 pseudolesion and 1 subcapsular *** showed high detection rate of renal perfusion abnormalities in patients with ARF, influencing the management of patients with acute or chronic RFI and renal masses throughout t

关键词： Contrast-enhanced ultrasonography Renal function impairment Acute renal failure Renal infarction Renal lesions Renal cysts Bosniak classification

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Applications of artificial intelligence in lung ultrasound:Review of deep learning methods for COVID-19 fighting

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Artificial Intelligence in Medical Imaging 2022年第2期3卷 42-54页

作者： Laura De Rosa serena L'Abbate Claudia Kusmic Francesco Faita Institute of Clinical Physiology Consiglio Nazionale delle RicerchePisa 56124Italy

BACKGROUND The pandemic outbreak of the novel coronavirus disease(COVID-19)has highlighted the need to combine rapid,non-invasive and widely accessible techniques with the least risk of patient’s cross-infection to achieve a successful early detection and surveillance of the *** this regard,the lung ultrasound(LUS)technique has been proved invaluable in both the differential diagnosis and the follow-up of COVID-19 patients,and its potential may be destined to ***,indeed,LUS has been empowered through the development of automated image processing *** To provide a systematic review of the application of artificial intelligence(AI)technology in medical LUS analysis of COVID-19 patients using the preferred reporting items of systematic reviews and meta-analysis(PRISMA)*** A literature search was performed for relevant studies published from March 2020-outbreak of the pandemic-to 30 September *** articles were included in the result synthesis of this *** As part of the review,we presented the main characteristics related to AI techniques,in particular deep learning(DL),adopted in the selected articles.A survey was carried out on the type of architectures used,availability of the source code,network weights and open access datasets,use of data augmentation,use of the transfer learning strategy,type of input data and training/test datasets,and *** Finally,this review highlighted the existing challenges,including the lack of large datasets of reliable COVID-19-based LUS images to test the effectiveness of DL methods and the ethical/regulatory issues associated with the adoption of automated systems in real clinical scenarios.

关键词： Lung ultrasound Deep learning Neural network COVID-19 pneumonia Medical imaging

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太阳照在南窗台上

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花木盆景(花卉园艺) 2016年第12期 19-24页

作者： serena

我从小就喜欢花花草草,记得小时候家里露台摆满了各种各样的花。每个仲夏的夜晚,我们都会围坐在露台听父亲讲故事,那时周围经常散发着茉莉淡淡的清香,沁人心脾,至今令我难以忘怀。温暖的父爱和清香无比的茉莉,成为了我童年美好的记忆。... 详细信息

我从小就喜欢花花草草,记得小时候家里露台摆满了各种各样的花。每个仲夏的夜晚,我们都会围坐在露台听父亲讲故事,那时周围经常散发着茉莉淡淡的清香,沁人心脾,至今令我难以忘怀。温暖的父爱和清香无比的茉莉,成为了我童年美好的记忆。我的花园刚好一岁。去年9月底我无意在网上看到一张组合多肉图片,立即被多肉美丽的色

关键词：花花草草阳台玻璃窗花儿民歌

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Influence of Alternating and Static Magnetic Fields on Drug Release from Hybrid Hydrogels Containing Magnetic Nanoparticles

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Journal of Biomaterials and Nanobiotechnology 2014年第2期5卷 116-127页

作者： Marianna Uva Daniela Pasqui Lorenzo Mencuccini serena Fedi Rolando Barbucci Department of Biotechnology Chemistry and Pharmacy University of Siena Via Aldo Moro 2 Siena Italy Interuniversity Research Centre for Advanced Medical Systems (C.R.I.S.M.A.) Viale Giacomo Matteotti Colle di Val d’Elsa Siena Italy

Hybrid hydrogels of carboxymethylcellulose (CMC), containing two different amounts of CoFe2O4 magnetic nanoparticles (50% and 70% in relation to the quantity of the polymer) as crosslinkers, were prepared. The hybrid hydrogels were chemically and morphologically characterized and their viscoelastic properties and swelling degrees were analyzed. The hydrogels were tested as controlled drug delivery systems by applying one static and two different alternating magnetic fields. The application of the two alternating magnetic fields (AMF) to the hybrid hydrogels induced a higher release of methylene blue (MB), used as a model drug, than without the application of any magnetic field, especially at low frequency (4 Hz) and high magnetic intensity (0.5 T). In contrast, when the hybrid hydrogels were exposed to a static magnetic field (SMF) the release of MB was slowed down. Furthermore the two different amounts of magnetic nanoparticles induce different responses to the magnetic field. The greater number of nanoparticles in the CMC-NP-70 hydrogel leads to the formation of some NPs clusters limiting the drug release;conversely, the CMC-NP-50 hydrogel, containing a lower amount of nanoparticles, shows a higher release of MB vs. time. In conclusion, we were able to get a potential system for modulation of the drug delivery: the release behaviour of hybrid hydrogels can be modulated by applying alternating and static magnetic fields cyclically. A possible explanation for the release mechanism is about the structural modification of the polymeric chains that occurs when the hybrid hydrogels are exposed to the magnetic fields.

关键词： Magnetic Hydrogels Alternating Magnetic Field Static Magnetic Field Controlled Release Cobalt Ferrite Nanoparticles

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Targeted approaches for HER2 breast cancer therapy: News from nanomedicine?

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World Journal of Pharmacology 2014年第4期3卷 72-85页

作者： serena Mazzucchelli Marta Truffi Luisa Fiandra Luca Sorrentino Fabio Corsi "L. Sacco" University Hospital 20157 Milan Italy Department of Biomedical and Clinical Sciences "L. Sacco" University of Milan 20157 Milan Italy Surgery Division "Luigi Sacco" Hospital 20157 Milan Italy

About 30% of human breast cancers are human epidermal growth factor receptor 2 （HER2）＋. This particular biological portrait is characterized by the overexpression of HER2 receptor with the subsequent deregulation of downstream pathways, which control cellular survival and proliferation. The most effective treatment for HER2＋ cancer is represented by therapy with HER2-targeted agents. Anti-HER2 therapy dramatically improves clini-cal outcomes, although it shows some limitations in achieving a proper treatment. These drawbacks of HER2-targeted therapy may be overcome with the develop-ment of HER2-targeted drug delivery nanodevices. These nanoparticles possess an internal three-dimensional com-partimentalization, which allows to combine the specifc target recognition with their capability to act as a drug reservoir for the selective delivery of chemotherapics to tumor sites. Moreover, nanoparticles useful in photo-thermal ablation or in photodynamic therapy have been functionalized in order to match specifcity in tumor cell recognition and suitable chemical properties. Here, we summarize the state of the art concerning the HER2＋ breast cancer and anti-HER2 therapy, in particular deep-ening the contribution of the nanomedicine. Description of preclinical studies performed with HER2-targeted nanoparticles for HER2＋ breast cancer therapy will be preceded by an overview on HER2-targeting molecules and nano-conjugation strategies. Further investigation will be necessary to introduce these nano-drugs in clinical prac-tice; however promising results encourage an upcoming translation of this research for the next future.

关键词： Human epidermal growth factor receptor 2 Human epidermal growth factor receptor 2^+-breast cancer Nanomedicine Nanoparticle Targeted-therapy

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彩色小威

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网球大师 2008年第10期 58-65页

作者： serena

在离天美网冠军领奖台72个月之后,在离开世界第一的宝座61个月之后,小威廉姆斯终于完成了一次漂亮的回归,九月的网球场成为小威的天下。和九月的网球场一样,九月的秀场也是小威一个人的舞台。在法拉盛夺魁之后,小威一袭红衣来到时代广... 详细信息

在离天美网冠军领奖台72个月之后,在离开世界第一的宝座61个月之后,小威廉姆斯终于完成了一次漂亮的回归,九月的网球场成为小威的天下。和九月的网球场一样,九月的秀场也是小威一个人的舞台。在法拉盛夺魁之后,小威一袭红衣来到时代广场展示自己的第9个大满贯奖怀;在纽约时装周上,小威一身素净惊艳全场。从黑到白,从红到绿。

关键词：网球场彩色回归冠军红衣法拉夺魁舞台世界广场

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在洒满阳光的阳台上做一个花园梦

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花木盆景(花卉园艺) 2020年第3期 46-51页

作者： serena

大约三年前,我的阳台还是空荡荡的,和大多城市里的青年人一样,平时只有晒个衣服才会去趟阳台。直到某天无意中在网上看到一张种满多肉植物的阳台图片,人生就好像打开了另一扇门,藏在我心里多年的花园梦就这样开启了。养花的起初走了很... 详细信息

大约三年前,我的阳台还是空荡荡的,和大多城市里的青年人一样,平时只有晒个衣服才会去趟阳台。直到某天无意中在网上看到一张种满多肉植物的阳台图片,人生就好像打开了另一扇门,藏在我心里多年的花园梦就这样开启了。养花的起初走了很多弯路,付出了不少心血,都打了水漂。比如担心台风太大,花儿们经不住摧残,又怕冬天太冷影响我赏花,于是请人给阳台封上了双层隔音玻璃,结果通风光照不足每盆花都生病了,那一刻才认识到养花通风特别重要。为了种上更多喜欢的花儿,我又请来师傅把家里的窗户全部改成凸窗。改成凸窗后,每天睡觉醒来就能看到充满阳光的向日葵,心里美美滴。

关键词：凸窗瓷砖建筑陶瓷

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