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The Plastid Envelope CHLOROPLAST MANGANESE TRANSPORTER1 Is Essential for Manganese Homeostasis in Arabidopsis

Molecular Plant 2018年第7期11卷 955-969页

作者： Marion Eisenhut Natalie Hoecker Sidsel Birkelund Schmidt Rubek Merina Basgaran Samantha Flachbart Peter Jahns Tabea Eser Stefan Geimer seren husted Andreas P.M. Weber Dario Leister Anja Schneider Biochemie der Pflanzen Cluster of Excellence on Plant Science (CEPLAS) Heinrich-Heine-University Di3sseldorf 40225 Desseldorf Germany Molekularbiologie der Pflanzen (Botanik) Department Biologie I Ludwig-Maximilians-University Mernchen 82152 Martinsried Germany Department of Plant and Environmental Sciences and Copenhagen Plant Science Centre (CPSC) Faculty of Science University of Copenhagen 1871 Frederiksberg Denmark Zellbiologie/Elektronenmikroskopie NW I/B1 Universit&t Bayreuth 95447 Bayreuth Germany These authors contributed equally to this article.

The transition metal manganese （Mn） is indispensable for photoautotrophic growth since photosystem II （PSII） employs an inorganic Mn4CaOs cluster for water splitting. Here, we show that the Arabidopsis membrane protein CHLOROPLAST MANGANESE TRANSPORTER1 （CMT1） is involved in chloroplast Mn homeostasis. CMT1 is the closest homolog of the previously characterized thylakoid Mn transporter PHOTOSYNTHESIS-AFFECTED MUTANT71 （PAM71）. In contrast to PAM71, CMT1 resides at the chloro- plast envelope and is ubiquitously expressed. Nonetheless, like PAM71, the expression of CMT1 can also alleviate the Mn-sensitive phenotype of yeast mutant qomrl. The cmtl mutant is severely suppressed in growth, chloroplast ultrastructure, and PSII activity owing to a decrease in the amounts of pigments and thylakoid membrane proteins. The importance of CMT1 for chloroplast Mn homeostasis is demonstratedby the significant reduction in chloroplast Mn concentrations in cmtl-1, which exhibited reduced Mn binding in PSII complexes. Moreover, CMT1 expression is downregulated in Mn-surplus conditions. The pam71 cmtl-ldouble mutant resembles the cmtl-f single mutant rather than pare71 in most respects. Taken together, our results suggest that CMT1 mediates Mn2 uptake into the chloroplast stroma, and that CMT1 and PAM71 function sequentially in Mn delivery to PSII across the chloroplast envelope and the thylakoid membrane.

关键词： manganese transporter envelope chloroplast photosynthesis Arabidopsis

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Is increased red cell distribution width an indicating marker of nonalcoholic steatohepatitis and fibrotic stage?

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World Journal of Gastroenterology 2013年第42期19卷 7412-7418页

作者： Mustafa Cengiz Burcu Aslan Candir Güldal Yilmaz Gülen Akyol seren Ozenirler Department of Gastroenterology Gazi University Faculty of Medicine06500 AnkaraTurkey Department of Internal Medicine Gazi University Faculty of Medicine06500 AnkaraTurkey Department of Pathology Gazi University Faculty of Medicine06500 AnkaraTurkey

AIM:To evaluate the red cell distribution width(RDW)as an indicator of the presence of non-alcoholic steatohepatitis(NASH)and its association with fibrotic ***:A retrospective study was carried out that included sixty-two biopsy proven NASH,32 simple steatosis patients and 30 healthy *** correlation between the clinical and histopathological features of NASH patients and RDW values was *** fibrosis scores were measured using a 0 to 4 point scale and were divided in to two groups;fibrosis scores0-1 were termed mild and fibrosis scores 2-4 were termed advanced *** values were compared between NASH,simple steatosis and healthy *** and multivariate analyses were performed to evaluate the independent predicting factors for the presence of liver fibrosis caused by ***:Patients with NASH had higher RDW values compared with simple steatosis and healthy control groups[14.28%±0.25%vs 13.37%±0.12%,12.96%±0.14%(P<0.01),respectively].Patients with advanced fibrosis had higher RDW values than the mild fibrosis group(15.86%±0.4%vs 13.63%±0.67%,P<0.01,respectively).RDW also correlated with fibrotic scores(r=0.579 andP<0.01).The variables that were significant in the univariate analysis were evaluated in multivariate logistic regression analysis,and RDW was an independent predicting factor of NASH(OR=1.75,95%CI:1.129-2.711,P<0.05).CONCLUSION:RDW a new non-invasive marker that can be used to demonstrate the presence of NASH and indicate advanced fibrotic scores.

关键词： Non-alcoholic steatohepatitis Liver fibrosis Red cell distribution width Simple steatosis Noninvasive marker Liver biopsy

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Liver transplantation in the era of non-alcoholic fatty liver disease/metabolic(dysfunction)associated fatty liver disease:the dilemma of the steatotic liver graft on transplantation and recipient survival

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Hepatobiliary Surgery and Nutrition 2022年第3期11卷 425-429页

作者： seren M.Gedallovich Daniela P.Ladner Lisa B.VanWagner Division of Palliative Medicine Department of MedicineUniversity of California San FranciscoSan FranciscoCAUSA Division of Organ Transplantation Department of SurgeryNorthwestern University Feinberg School of MedicineChicagoILUSA Division of Gastroenterology&Hepatology Department of MedicineNorthwestern University Feinberg School of MedicineChicagoILUSA Division of Epidemiology Department of Preventive MedicineNorthwestern University Feinberg School of MedicineChicagoILUSA

Liver transplantation remains the only curative therapy for end-stage liver disease and there is a well-established shortage of transplantable deceased donor organs to meet the growing demand of waitlisted *** liver grafts represent the most common type of so-called extended criteria donor(ECD)grafts aimed at ameliorating this ***,steatotic grafts are associated with increased post-transplant complications and graft failure(1).Hepatic graft steatosis is strongly correlated with the high prevalence of non-alcoholic fatty liver disease(NAFLD)and metabolic(dysfunction)associated fatty liver disease(MAFLD)in the general *** and MAFLD are related,but not equivalent,liver disorders that are linked with obesity and diabetes(2).Global prevalence of NAFLD is estimated at~25%and rising(3).Models predict that NAFLD prevalence will increase by 21%to affect 100.9 million persons worldwide by 2030(4).As more donors have NAFLD,the steatotic liver graft will continue to be a challenge for liver ***,promising efforts(e.g.,organ pump with defatting agents)are under way,aimed at expanding the donor pool in the coming ***,we briefly summarize approaches for assessment of hepatic steatosis,describe recipient outcomes associated with the use of steatotic liver grafts,and highlight strategies that may be used to mitigate risk considering the ongoing NAFLD/MAFLD epidemic.

关键词： organs graft donor

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Petroselinum crispum extract ameliorates scopolamine-induced cognitive dysfunction:role on apoptosis,inflammation and oxidative stress

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Food Science and Human Wellness 2022年第5期11卷 1290-1298页

作者： GökselŞener Gözde Karakadıoglu Dilek Ozbeyli seren Ede Refiye Yanardag Ozlem Sacan Asli Aykac Department of Pharmacology Faculty of PharmacyFenerbahce UniversityIstanbul 34758Turkey Department of Pharmacology Institude of Health SciencesMarmara UniversityIstanbul 34854Turkey Department of Medical Pathology Techniques Vocational School of Health ServicesMarmara UniversityIstanbul 34865Turkey Department of Biochemistry Faculty of EngineeringIstanbul Universityş-CerrahpasaIstanbul 34320Turkey Department of Biophysics Faculty of MedicineNear East UniversityNicosia 99138Cyprus

This study was designed to investigate whether Petroselinum crispum(PC)extract has protective effects on the brain in the scopolamine-induced Alzheimer’s disease(AD)rat *** rats were divided into;control,scopolamine(1 mg/kg,i.p.),galantamine(1.5 mg/kg,i.p.)and PC extract(2 g/kg,p.o.)-treated scopolamine *** day 14,the novel object recognition test(NORT)and Morris water maze test(MWMT)were performed and then the rats were ***-induced cognitive impairments observed in the NORT and MWMT,significantly improved with PC extract and galantamine *** reduced M_(1) receptor expression,Bcl-2/Bax ratio,and glutathione levels in the hippocampus and frontal cortex,while malondialdehyde levels,caspase-3/9 expressions,and acetylcholinesterase(AChE)activity were found to be *** the other hand,PC and galantamine treatments reversed these *** conclusion,PC extract has shown an ameliorative effect on the spatial and recognition memory,M_(1) receptor expression,apoptosis,oxidative stress,and increased AChE ***,it was concluded that PC could prevent AD-like conditions and can be used as a functional ***,since animal models do not completely mimic those of humans,based on the data obtained in this study,the importance of PC on human AD should be demonstrated in future studies.

关键词： Petroselinum crispum Apoptosis Spatial memory Recognition memory Oxidative stress M1 receptor

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Hepatic venous outflow obstruction:Three similar syndromes

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World Journal of Gastroenterology 2007年第13期13卷 1912-1927页

作者： Ulas Darda Bayraktar Soley seren Yusuf Bayraktar Department of Internal Medicine Interfaith Medical Center Brooklyn NY 11230 United States Department of Internal Medicine Wayne State University Detroit MI United States Division of Gastroenterology Hacettepe University School of Medicine Ankara Turkey MD Series Editor

Our goal is to provide a detailed review of veno- occlusive disease (VOD), Budd-Chiari syndrome (BCS), and congestive hepatopathy (CH), all of which results in hepatic venous outflow obstruction. This is the first article in which all three syndromes have been reviewed, enabling the reader to compare the characteristics of these disorders. The histological findings in VOD, BCS, and CH are almost identical: sinusoidal congestion and cell necrosis mostly in perivenular areas of hepatic acini which eventually leads to bridging fibrosis between adjacent central veins. Tender hepatomegaly with jaundice and ascites is common to all three conditions. However, the clinical presentation depends mostly on the extent and rapidity of the outflow obstruction. Although the etiology and treatment are completely different in VOD, BCS, and CH; the similarities in clinical manifestations and liver histology may suggest a common mechanism of hepatic injury and adaptation in response to increased sinusoidal pressure.

关键词： Veno-occlusive disease Sinusoidal obstru-ction syndrome Budd-Chiari syndrome Congestivehepatopathy

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Effect of the COVID-19 pandemic on patients with presumed diagnosis of acute appendicitis

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World Journal of Clinical Cases 2022年第29期10卷 10487-10500页

作者： Sami Akbulut Adem Tuncer Zeki Ogut Tevfik Tolga Sahin Cemalettin Koc Emek Guldogan Ertugrul Karabulut Elif seren Tanriverdi Ali Ozer Surgery and Liver Transplant Institute Inonu University Faculty of MedicineMalatya 44280Turkey Department of Biostatistics and Medical Informatics Inonu University Faculty of MedicineMalatya 44280Turkey Department of Public Health Inonu University Faculty of MedicineMalatya 44280Turkey Department of Surgery Inonu University Faculty of MedicineMalatya 44280Turkey Department of Medical Microbiology Inonu University Medical FacultyMalatya 44280Turkey

BACKGROUND Acute appendicitis(AAp) is the most frequent cause of acute abdominal pain,and appendectomy is the most frequent emergency procedure that is performed *** coronavirus disease 2019(COVID-19) pandemic has caused delays in managing diseases requiring emergency approaches such as AAp and *** To compare the demographic,clinical,and histopathological outcomes of patients with AAp who underwent appendectomy during pre-COVID-19 and COVID-19 *** The demographic,clinical,biochemical,and histopathological parameters were evaluated and compared in patients who underwent appendectomy with the presumed diagnosis of AAp in the pre-COVID-19(October 2018-March 2020) and COVID-19(March 2020-July 2021) *** Admissions to our tertiary care hospital for AAp increased 44.8% in the COVID-19 ***-19(n = 154) and COVID-19(n = 223) periods were compared for various parameters,and we found that there were statistically significant differences in terms of variables such as procedures performed on the weekdays or weekends [odds ratio(OR):1.76;P = 0.018],presence of AAp findings on ultrasonography(OR:15.4;P < 0.001),confirmation of AAp in the histopathologic analysis(OR:2.6;P = 0.003),determination of perforation in the appendectomy specimen(OR:2.2;P = 0.004),the diameter of the appendix(P < 0.001),and hospital stay(P = 0.003).There was no statistically significant difference in terms of interval between the initiation of symptoms and admission to the hospital between the pre-COVID-19(median:24 h;interquartile range:34) and COVID-19(median:36 h;interquartile range:60) periods(P = 0.348).The interval between the initiation of symptoms until the hospital admission was significantly longer in patients with perforated AAp regardless of the COVID-19 or pre-COVID-19 status(P < 0.001).CONCLUSION The present study showed that in the COVID-19 period,the ultrasonographic determination rate of AAp,perforation rate of AAp,and duration of hospital

关键词： SARS-CoV-2 COVID-19 pandemic Acute appendicitis Perforated appendicitis Negative appendectomy

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Nonlinear terahertz devices utilizing semiconducting plasmonic metamaterials

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Light(Science & Applications) 2016年第1期5卷 760-766页

作者： Huseyin R seren Jingdi Zhang George R Keiser Scott J Maddox Xiaoguang Zhao Kebin Fan Seth R Bank Xin Zhang Richard D Averitt Laboratory for Microsystems Technology Department of Mechanical EngineeringBoston UniversityBostonMA 02215USA Department of Physics Boston UniversityBostonMA 02215USA Department of Physics UC San DiegoLa JollaCA 92093USA School of Engineering Brown UniversityProvidenceRI 02912USA Microelectronics Research Center The University of Texas at AustinAustinTX 78758USA

The development of responsive metamaterials has enabled the realization of compact tunable photonic devices capable of manipulating the amplitude,polarization,wave vector and frequency of *** of semiconductors into the active regions of metallic resonators is a proven approach for creating nonlinear metamaterials through optoelectronic control of the semiconductor carrier ***-free subwavelength resonant semiconductor structures offer an alternative approach to create dynamic *** present InAs plasmonic disk arrays as a viable resonant metamaterial at terahertz ***,InAs plasmonic disks exhibit a strong nonlinear response arising from electric field-induced intervalley scattering,resulting in a reduced carrier mobility thereby damping the plasmonic *** demonstrate nonlinear perfect absorbers configured as either optical limiters or saturable absorbers,including flexible nonlinear absorbers achieved by transferring the disks to polyimide *** plasmonic metamaterials show potential for use in ultrafast terahertz(THz)optics and for passive protection of sensitive electromagnetic devices.

关键词： nonlinear absorbers nonlinear metamaterials plasmonic semiconductor metamaterials terahertz metamaterials transfer printing

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没有颜色的奇妙世界

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科普童话 2014年第18期 7-8页

作者： seren

无遮无拦的阳光照耀着满山葱郁的热带雨林。青翠欲滴的树叶间颤巍巍地生出一朵红色的扶桑花。花姿树影的后面,是洁白的沙滩,无垠的太平洋——海水的颜色是变化莫测碧蓝色,靠近岸边的是柔嫩的蓝绿,远处是深邃的靛蓝。高天的白云在洋面上... 详细信息

无遮无拦的阳光照耀着满山葱郁的热带雨林。青翠欲滴的树叶间颤巍巍地生出一朵红色的扶桑花。花姿树影的后面,是洁白的沙滩,无垠的太平洋——海水的颜色是变化莫测碧蓝色,靠近岸边的是柔嫩的蓝绿,远处是深邃的靛蓝。高天的白云在洋面上投下深深浅浅的影子。环礁心里漾着同样碧绿的海水,明黄黛紫的热带鱼在缤纷的珊瑚丛里游来游去……

关键词：全色盲普通人视杆细胞克努特视锥细胞

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让历史重现

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收藏 2015年第10期 12-13页

作者： seren Morgan Jones

seren的作品取材于历史人物,运用独特的古典绘画语言,加上平涂出的拼贴感,描绘出微妙的当代风味,塑造了有态度的人物性格。为了纪念英国女性选票权利,她绘制了许多19-20世纪威尔士参政妇女的肖像。其中自然少不了威尔士的知名人士,如Lad... 详细信息

seren的作品取材于历史人物,运用独特的古典绘画语言,加上平涂出的拼贴感,描绘出微妙的当代风味,塑造了有态度的人物性格。为了纪念英国女性选票权利,她绘制了许多19-20世纪威尔士参政妇女的肖像。其中自然少不了威尔士的知名人士,如Lady Rhondda,Rachel Barrett和Alice Abadam。她假想被邀请参与她们的公关活动,被要求制作宣传海报,而这些作品就是对她们的致敬。翻阅专研威尔士的历史档案,以实际数据为基础,传统个性的黑色稻草帽、牧师的招贴画都被seren融进了画里。"重要的是观众们通过作品可以想象与这些女人一起生活的日子。我希望这些画给他们一个近距离观看的机会,透过这些女人的眼睛,穿越时光的距离,体验她们花费几十年来争取更多自由的经历"。

关键词：威尔士

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黑色黄金争夺战世界石油资源将趋国有化

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明日风尚 2007年第6期 52-53页

作者： Josephine Shen Jean Pierre seren

研究机构 Wood Mackenzie 最近发表报告指出:尽管高难度石油开采意味着生态代价,但大规模的开采投资都将迫于需要而无可避免。但今后在开发"黑色黄金"的问题上,将有局势的变化,跨国公司、国有企业以及政府之间的争霸角力将更趋尖锐,然... 详细信息

研究机构 Wood Mackenzie 最近发表报告指出:尽管高难度石油开采意味着生态代价,但大规模的开采投资都将迫于需要而无可避免。但今后在开发"黑色黄金"的问题上,将有局势的变化,跨国公司、国有企业以及政府之间的争霸角力将更趋尖锐,然而这样的对局,将更有利于国有企业和政府。

关键词：世界石油资源生态代价石油开采 Mackenzie 国有企业研究机构国家石油公司天然气资源

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