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Leptin levels in the differential diagnosis between benign and malignant ascites

World Journal of Gastroenterology 2007年第3期13卷 398-402页

作者： Mehmet Buyukberber Mehmet Koruk M Cemil Savas Murat T Gulsen Yavuz Pehlivan Rukiye Deveci Alper Sevinc serdar gergerlioglu Department of Gastroenterology Gaziantep University School of Medicine 27310 Gaziantep Turkey Department of Internal Medicine Gaziantep University School of Medicine 27310 Gaziantep Turkey Department of Biochemistry Gaziantep University School of Medicine 27310 GaziantepTurkey Department of Medical Oncology Gaziantep University School of Medicine Gaziantep Oncology Hospital 27310 Gaziantep Turkey Department of Physiology Gaziantep University School of Medicine 27310 Gaziantep Turkey

AIM： To evaluate the role of leptin levels in the differentia diagnosis of ascites. METHODS： Ascitic leptin, TNFα and serum leptin levels were measured in 77 patients with ascites （35 with malignancies, 30 cirrhosis and 12 tuberculosis）. Control serum samples were obtained from 20 healthy subjects. Leptin and TNFα levels were measured by EUSA. Body mass index （BMI） and percentage of body fat （BFM） by skin fold measurement were calculated for all patients and control groups. Peritoneal biopsy, ascites cytology and cultures or biochemical values were used for the diagnosis of patients. RESULTS： In patients with malignancies, the mean serum and ascites leptin levels and their ratios were significantly decreased compared to the other patient groups and controls. In tuberculosis peritonitis, ascitic fluid TNFα levels were significantly higher than malignant ascites and cirrhotic sterile ascites. BMI and BFM values did not distinguish between patients and controls. CONCLUSION： In patients with malignant ascites, levels of leptin and TNFα were significantly lower than in patients with tuberculous ascites.

关键词： Leptin, Benign ascites Malignant ascites Tuberculosis Cirrhosis

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