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Clustering-Aided Supervised Malware Detection with Specialized Classifiers and Early Consensus

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计算机、材料和连续体（英文） 2023年第4期75卷 1235-1251页

作者： Murat Dener sercan Gulburun Information Security Engineering Graduate School of Natural and Applied SciencesGazi UniversityAnkara06560Turkey

One of the most common types of threats to the digital world is malicious *** is of great importance to detect and prevent existing and new malware before it damages information *** learning approaches are used effectively for this *** this study,we present a model in which supervised and unsupervised learning algorithms are used *** is used to enhance the prediction performance of the supervised *** aim of the proposed model is to make predictions in the shortest possible time with high accuracy and f1 *** the first stage of the model,the data are clustered with the k-means *** the second stage,the prediction is made with the combination of the classifier with the best prediction performance for the related *** choosing the best classifiers for the given clusters,triple combinations of ten machine learning algorithms(kernel support vector machine,k-nearest neighbor,naive Bayes,decision tree,random forest,extra gradient boosting,categorical boosting,adaptive boosting,extra trees,and gradient boosting)are *** selected triple classifier combination is positioned in two *** prediction time of the model is improved by positioning the classifier with the slowest prediction time in the second *** selected triple classifier combination is positioned in two *** prediction time of the model is improved by positioning the classifier with the highest prediction time in the second *** is seen that clustering before classification improves prediction performance,which is presented using Blue Hexagon Open Dataset for Malware Analysis(BODMAS),Elastic Malware Benchmark for Empowering Researchers(EMBER)2018 and Kaggle malware detection *** model has 99.74%accuracy and 99.77%f1 score for the BODMAS dataset,99.04%accuracy and 98.63%f1 score for the Kaggle malware detection dataset,and 96.77%accuracy and 96.77%f1 score for the EMBER 2018 *** addition,the tiered posi

关键词： Malware detection ensemble learning classification clustering specialized classifier early consensus

Comparison of numbers of interneurons in three thalamic nuclei of normal and epileptic rats

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Neuroscience Bulletin 2014年第3期30卷 451-460页

作者： Safiye avdar Hüsniye Hacioglu Bay sercan D.Yildiz Dilek Akakin Serap Sirvanci Filiz Onat Department of Anatomy School of Medicine Ko University Department of Anatomy School of Medicine Marmara University Department of Histology and Embryology School of Medicine Marmara University Department of Pharmacology and Clinical Pharmacology School of Medicine Marmara University

The inhibitory sources in the thalamic nuclei are local interneurons and neurons of the thalamic reticular nucleus. Studies of models of absence epilepsy have shown that the seizures are associated with an excess of inhibitory neurotransmission in the thalamus. In the present study, we used light- microscopic gamma-aminobutyric acid （GABA） immunocytochemistry to quantify the interneurons in the lateral geniculate （LGN）, ventral posteromedial （VPM）, and ventral posterolateral （VPL） thalamic nuclei, and compared the values from normal Wistar rats and genetic absence epilepsy rats from Strasbourg （GAERS）. We found that in both Wistar rats and GAERS, the proportion of interneurons was significantly higher in the LGN than in the VPM and VPL. In the LGN of Wistar rats, 16.4% of the neurons were interneurons and in the GAERS, the value was 15.1%. In the VPM, the proportion of interneurons was 4.2% in Wistar and 14.9% in GAERS; in the VPL the values were 3.7% for Wistar and 11.1% for the GAERS. There was no significant difference between Wistar rats and the GAERS regarding the counts of interneurons in the LGN, whereas the VPM and VPL showed significantly higher counts in GAERS. Comparison of the mean areas of both relay cells and interneuronal profiles showed no significant differences between Wistar rats and GAERS. These findings show that in the VPL and the VPM there are relatively more GABAergic interneurons in GAERS than in Wistar rats. This may represent a compensatory response of the thalamocortical circuitry to the absence seizures or may be related to the production of absence seizures.

关键词： immunohistochemistry interneuron relay neuron thalamus GABA

A novel model of retinopathy of prematurity in normobaric hyperoxic conditions

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International Journal of Ophthalmology(English edition) 2016年第9期9卷 1265-1270页

作者： Taner Ozgurtas sercan Tekin Fatih Yesildal Umut Karaca Fevzi Nuri Aydin Muhammed Talha Ugurlu Mehmet Ozler Hakan Durukan Department of Medical Biochemistry Gulhane Military Medical Academy Ankara 06010 Turkey School of Medicine Gulhane Military Medical AcademyAnkara 06010 Turkey Department of Medical Biochemistry Diyarbakir Military Hospital Diyarbakir 21100 Turkey Department of Ophthalmology Isparta Military HospitalIsparta 32040 Turkey Department of Biochemistry Sirnak Military HospitalSimak 73000 Turkey Department of Physiology Gulhane Military Medical Academy Ankara 06010 Turkey Department of Ophthalmology Gulhane Military Medical Academy Ankara 06010 Turkey

AIM：To examine changes in retinal vasculature after treatment with different oxygen concentrations from common retinopathy of prematurity（ROP） models and to determine a novel and practical ROP ***：A sample of 14 newborn Sprague-Dawley rats was *** study group（n=7） was exposed to95%oxygen for 4h per day followed by normoxic laboratory conditions for 20 *** cycle was repeated for 14 *** control group（n=7） was subjected to normobaric normoxic *** postnatal day 14（P14）,the two groups were placed in room air for *** P21,the two groups were examined using indirect *** eyes were enucleated for immunofluorescence（IF） staining of the vasculature of retinas and analysis of vascular endothelial growth factor（VEGF）,hypoxia inducible factor-1 alpha（HIF-1α）,placental growth factor（PLGF） in vitreous humor,and then the rats were sacrificed by *** procedures were repeated using another litter of 14 ***：In the study group and under normobaric hyperoxic conditions,retinal neovascularization and peripheral avascular retina were determined in 85%of the rats through indirect ophthalmoscopic *** IF staining of retina of the study group showed retarded peripheral vascular *** difference between the two groups for VEGF,HIF-1α and PLGF concentrations of vitreous humor was statistically significant（P=0.003,0.007,0.027 respectively）.CONCLUSION：Fluctuating oxygen concentrations are primarily responsible for retinal *** new ROP model is practical and applicable for all retinal neovascularization studies,considering the laboratory procedures.

关键词： retinopathy of prematurity vascular endothelial growth factor hypoxia inducible factor-1 alpha placental growth factor fundoscopy retina staining

An Analysis on Efficiency and Equity of Fixed-Time Ramp Metering

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Journal of Transportation Technologies 2013年第2期3卷 48-56页

作者： Ali sercan Kesten Murat Ergün Tetsuo Yai Department of Built Environment Tokyo Institute of Technology Tokyo Japan Department of Civil Engineering Istanbul Technical University Istanbul Turkey

Various traffic management strategies have been developed to alleviate the congestion on freeways. The equity issue has been considered as one of the major challenges for the implementation of some traffic control strategies, especially ramp metering. This paper presents a comparative evaluation of the efficiency and equity performance of a traffic control strategies namely Fixed Time Ramp Metering (FTRM). Instead of focusing on a single equity measure and/or indicator, different approaches to the equity concept are discussed and various equity measures are examined. The equity and efficiency performance of traffic control strategies are compared and evaluated by incorporating them into the simulated corridor. The Bosporus Bridge of Istanbul O-1 Freeway, Turkey is used as a test-bed for the simulation model and the control strategy is employed through microscopic traffic flow simulation software, VISSIM AG. The findings from the simulations show that the equity and efficiency properties of the network vary with the measures and indicators taken into account. The results also suggest that the trade-off between equity and efficiency can be observed for some measures, whereas regarding to other measures the trade-off is not validated.

关键词： Traffic Control Strategies Traffic Flow Micro-simulation Equity in Traffic Control Efficiency and Equity Trade-Off

Hepatitis C virus reactivation in cancer patients in the era of targeted therapies

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World Journal of Gastroenterology 2014年第22期20卷 6716-6724页

作者： Ozan Yazici Mehmet Ali Nahit ?endur sercan Aksoy Department of Medical Oncology Ankara Numune Education and Research HospitalAnkara 06100Turkey Department of Medical Oncology Hacettepe University Cancer InstituteAnkara 06100Turkey

The purpose of this review is to summarize the evidence of hepatitis C reactivation in cancer patients in the era of targeted *** therapies are novel therapeutics frequently used in cancer *** treatment with targeted therapies,viral replication is one of the major problems that can *** PubMed database,ASCO,and ASCO Gastrointestinal Cancer Symposium abstracts were searched up until September 15,2013 using the following search keywords:"targeted therapies,rituximab,alemtuzumab,brentuximab,hepatitis,hepatitis C reactivation,tyrosine kinase inhibitors,imatinib,mammalian target of rapamycin(mTOR)inhibitors,everolimus,anti-HER therapies,trastuzumab,pertuzumab,lapatinib,antiepidermal growth factor receptor therapies,cetuximab,panitumumab,and ipilimumab".Papers considered relevant for the aim of this review were selected by the *** data about rituximab-induced hepatic flare in hepatitis C virus(HCV)positive patients is ***,there is the possibility of life-threatening hepatic flare that can develop after HCV ribonucleic acid(HCV-RNA)viral load *** followup of liver function tests should be *** in high-risk patients,such as those with baseline chronic active hepatitis and cirrhosis,and where there are plans to administer rituximab concomitantly with corticosteroids,it is advised to have close follow-up of HCV viral *** data is insufficient to make accurate statements about the association of alemtuzumab therapy and HCV ***,alemtuzumab may cause deep *** to this,it is better to follow up with liver function tests and HCV RNA levels during alemtuzumab *** has effects on antibody dependent cellular toxicity and may decrease humoral ***,we believe that during brentuximab treatment of HCV infected patients,clinicians may encounter hepatitis C *** have been no reported cases of hepatitis C reactivation with imatini

关键词： Hepatitis C Hepatitis C reactivation Mono-clonal a

Targeted therapies in gastric cancer and future perspectives

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World Journal of Gastroenterology 2016年第2期22卷 471-489页

作者： Ozan Yazici M Ali Nahit Sendur Nuriye Ozdemir sercan Aksoy Department of Medical Oncology Ankara Numune Education and Research HospitalAnkara 06100Turkey Department of Medical Oncology Yildirim Beyazit UniversityAnkara 06100Turkey Department of Medical Oncology Hacettepe University Cancer InstituteAnkara 06100Turkey

Advanced gastric cancer(AGC) is associated with a high mortality rate and, despite multiple new chemotherapy options, the survival rates of patients with AGC remains poor. After the discovery of targeted therapies, research has focused on the new treatment options for AGC. In the last two decades, many targeted molecules were developed against AGC. Currently, two targeted therapy molecules have been approved for patients with AGC. In 2010, trastuzumab was the first molecule shown to improve survival in patients with HER2-positive AGC as part of a first-line combination regimen. In 2014, ramucirumab was the second targeted molecule to improve survival rates and was suggested as treatment for patients with AGC who had progressed after firstline platinum plus fluoropyrimidine with or without anthracycline chemotherapy. Ramucirumab was the first targeted therapy acting as a single agent in patients with advanced gastroesophageal cancers. Although these two molecules were introduced into clinical use, many other promising molecules have been tested in phase Ⅰ-Ⅱ trials. It is obvious that in the near future many different targeted therapies will be in use for treatment of AGC. In this review, the current status of targeted therapies in the treatment of AGC and gastroesophageal junction tumors, including HER(2-3) inhibitors, epidermal growth factor receptor inhibitors, tyrosine kinase inhibitors, antiangiogenic agents, c-MET inhibitors, mammalian target of rapamycin inhibitors, agents against other molecular pathways fibroblast growth factor, Claudins, insulin-like growth factor, heat shock proteins, and immunotherapy, will be discussed.

关键词： Targeted therapies Antibodies Gastriccancer Tyrosine kinase Survival

土耳其中东科技大学孔子学院汉语教学状况调查报告

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土耳其中东科技大学孔子学院汉语教学状况调查报告

作者：塞尔江（sercan Kacar）厦门大学

学位级别：硕士

近年来,中国经济的迅猛发展,使得汉语在国际上越来越受欢迎,开始学习汉语的外国人也越来越多。土耳其作为中国“一带一路”战略沿线重要的国家,也在很大程度上受到了中国的影响,土耳其国内的汉语热也逐渐升温。随着中国国家汉办积极推... 详细信息

近年来,中国经济的迅猛发展,使得汉语在国际上越来越受欢迎,开始学习汉语的外国人也越来越多。土耳其作为中国“一带一路”战略沿线重要的国家,也在很大程度上受到了中国的影响,土耳其国内的汉语热也逐渐升温。随着中国国家汉办积极推进海外汉语教学,孔子学院在土耳其也获得了较大的发展。作为土耳其第一家孔子学院,土耳其中东科技大学孔子学院的教学状况便是本文的研究重点。论文以土耳其中东科技大学孔子学院对研究对象,以其汉语教学状况为研究目标,对土耳其中东科技大学孔子学院学院学习背景和学习行为,及孔子学院汉语教学和课堂教学情况开展调查研究。调查研究表明,土耳其中东科技大学学员在汉语教学在与汉语教学相关的课程、师资、教材、教学设施及考试等方面都在逐步取得进展,在班级设置、师资力量和教学设施方面具有一定的优势。但也存在着缺少土耳其本土编写汉语教材,教材使用不统一,课程目标不够具体,不具有操作性等情况;课程类型不够丰富;语言测试不够规范,针对教师的管理和培训不够系统等问题。在最后论文针对这些问题提出了具有建设性的建议和思考。论文的研究有助于帮助人们了解土耳其中东科技大学孔子学院学生汉语的学习情况,了解学校在发展中遇到的一些问题和不足,了解汉语教师在汉语教学过程中反馈的一些问题,收集学生在汉语学习中遇到一些困难和问题,并针对这些问题进行分析,并提出具有建设性的对策和建议。将有助于中国国家汉办了解中东科技大学孔子学院的教学情况,也有助于土耳其教育部门获知其教学发展,并为对土耳其汉语教学发展感兴趣的学者和研究人员提供研究素材和研究基础,进而深化两国间的文化交流和合作,增进两国的民间合作和双方交流。

关键词：土耳其孔子学院汉语教学学习行为

Segmentation of Sinusoids in Hematoxylin and Eosin Stained Liver Specimens Using an Orientation-Selective Filter

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Open Journal of Medical Imaging 2013年第4期3卷 144-155页

作者： Masahiro Ishikawa sercan Taha Ahi Fumikazu Kimura Masahiro Yamaguchi Hiroshi Nagahashi Akinori Hashiguchi Michiie Sakamoto Department of Pathology Graduate School of Medicine Keio University Shinjuku-ku Japan Global Scientific Information and Computing Center Tokyo Institute of Technology Meguroku Japan Global Scientific Information and Computing Center Tokyo Institute of Technology Meguroku Japan Faculty of Health & Medical Care Saitama Medical University Hidaka-shi Japan

The liver comprises cell layers of hepatocytes called trabeculae, which are separated by vascular sinusoids. Under- standing the structure of hepatic trabeculae and liver sinusoids in hematoxylin and eosin (HE)-stained liver specimens is important for the differential diagnosis of liver diseases. In this study, we develop an approach to extracting liver sinusoids from HE-stained images. The proposed approach involves: 1) a new orientation-selective filter (OS filter) for edge enhancement and image denoising, 2) the clustering of image pixels to identify candidate sinusoids, and 3) a classification procedure that discards unlikely candidates and selects the final sinusoid areas. Experimental studies using a database of 16 images with a resolution of 512 × 512 pixels showed that the proposed approach could segment liver sinusoid pixels with 81% of specificity and 94% of sensitivity. A comparison with a method based on bilateral filters showed that this method improved the sensitivity for all images with an average improvement of 4% and no difference in specificity. The results were presented to a group of pathologists and they confirmed that the images were highly representative of the tissue morphology features.

关键词： Histopathological Tissue Images Orientation-Selective Filter Segmentation of Sinusoids

Cytomegalovirus gastritis after rituximab treatment in a nonHodgkln's lymphoma patient

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World Journal of Gastroenterology 2006年第12期12卷 1978-1979页

作者： Ugur Unluturk sercan Aksoy Ozlem Yonem Yusuf Bayraktar Gulten Tekuzman Hacettepe University Faculty of Medicine Department of Internal Medicine Ankara Turkey Hacettepe University Institute of Ontology Ankara Turkey Hacettepe University Faculty of Medicine Department of Internal Medicine Unit of Gastroenterology Ankara Turkey

TO THE EDITORRituximab is a chimeric monoclonal antibody againstCD20 antigen expressed on most B cells and is used forthe treatment of malignant lymphomas expressing theCD20 *** temporarily eliminates normal B-lym-phocytes without a substantial decrease in serum immuno-globulin ***,several serious viral infectionshave been reported in association with rituximab ***-tomegalovirus(CMV)is one of the agents that may be acause of morbidity and mortality in *** the face of exogenous or endogenouscauses of immunosuppression,cytomegalovirus can

关键词：巨细胞病毒胃炎非霍奇金淋巴瘤病理机制临床表现