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World Journal of Methodology 2024年第2期14卷 75-87页

作者： Maria Papaioannou Evdoxia Vagiana serafeim-chrysovalantis kotoulas Maria Sileli Katerina Manika Alexandros Tsantos Nikolaos Kapravelos 1^(st)Intensive Care Unit G Papanikolaou General HospitalExohiThessaloniki 57010Greece 2^(nd)Intensive Care Unit G Papanikolaou General HospitalExohiThessaloniki 57010Greece Intensive Care Unit Hippokration General HospitalThessaloniki 54642Greece Department of Pulmonary Medical SchoolAristotle University of ThessalonikiG.Papanikolaou General HospitalExohiThessaloniki 57010Greece 2^(nd)Department of Internal Medicine General Hospital of Thessaloniki“Ippokration”Thessaloniki 54642Greece

BACKGROUND Tracheostomy is commonly used in intensive care unit(ICU)patients who are expected to be on long-term mechanical ventilation or suffer from emergency upper airway ***,some studies have conflicting findings regarding the optimal technique and its timing and *** To provide evidence of practice,characteristics,and outcome concerning tracheostomy in an ICU of a tertiary care *** This was a retrospective cohort study including adult critical care patients in a single ICU for two consecutive ***’demographic characteristics,severity of illness(APACHE II score),level of consciousness[Glasgow Coma Scale(GCS)],comorbidities,timing and type of tracheostomy procedure performed and outcome were *** defined late as tracheostomy placement after 8 days or no *** Data of 660 patients were analyzed(median age of 60 years),median APACHE II score of 19 and median GCS score of 12 at *** was performed in 115 patients,of whom 63 had early and 52 late *** tracheostomy was mainly executed in case of altered level of consciousness and severe critical illness polyneuromyopathy,however there were no significant statistical results(47.6%vs 36.5%,P=0.23)and(23.8%vs 19.2%,P=0.55)*** the method selected,early surgical tracheostomy(ST)was conducted in patients with maxillofacial injuries(50.0%vs 0.0%,P=0.033),whereas late surgical tracheostomy was selected for patients with goiter(44.4%vs 0.0%P=0.033).Patients with early tracheostomy spent significantly fewer days on mechanical ventilation(15.3±8.5 vs 22.8±9.6,P<0.001)and in ICU in general(18.8±9.1 vs 25.4±11.5,P<0.001).Percutaneous dilatation tracheostomy(PDT)vs ST was preferable in older critical care patients in the case of Central Nervous System underlying cause of admission(62.5%vs 26.3%,P=0.004).ST was the method of choice in compromised airway(31.6%,vs 7.3%P=0.008).A large proportion of patients(88/115)with t

关键词： Tracheostomy Early tracheostomy Late tracheostomy Percutaneous dilatation tracheostomy Surgical tracheostomy Weaning Survival Mechanical ventilation

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Is there a correlation between the changes in airway inflammation and the changes in respiratory mechanics after vaping in patients with asthma?

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World Journal of Methodology 2024年第2期14卷 127-133页

作者： serafeim-chrysovalantis kotoulas Kalliopi Domvri Alexandros Tsantos Ioanna Papagiouvanni Anastasia Michailidou Dionisios G Spyratos Konstantinos Porpodis Ioanna Grigoriou Despina Papakosta Athanasia Pataka Intensive Care Unit Hippokration General HospitalThessaloniki 54642Greece Pulmonary Department-Oncology Unit Aristotle University of ThessalonikiThessaloniki 57010Greece 2nd Department of Internal Medicine General Hospital of Thessaloniki‘’Ippokration’’Thessaloniki 54642Greece Fourth Department of Internal Medicine Aristotle University of ThessalonikiThessaloniki 54642ThessalonikiGreece 2nd Propaedeutic Department of Internal Medicine General Hospital of Thessaloniki“Ippokration”Thessaloniki 54642Greece Department of Pulmonary Aristotle University of ThessalonikiThessaloniki 57001Greece Respiratory Failure Clinic Papanikolaou General HospitalThessloniki 57001Greece Department of Respiratory Medicine Aristotle Univ ThessalonikiSch MedG Papanikolaou HospResp Failure UnitAristotle University of ThessalonikiThessaloniki 57001Greece

BACKGROUND Electronic cigarettes(ECs)have been promoted as alternatives to traditional *** investigate ECs’effects on respiratory system,especially in patients with respiratory *** We randomly selected 25 smokers with stable moderate asthma and matched them with 25 healthy *** were subjucted to pulmonary function tests(PFTs),impulse oscillometry(IOS),fraction exhaled Nitric Oxide(FeNO),exhaled breathe condensate(EBC)and biomarker measurements before and after vaping one nicotinecontaining *** The increase in FeNO 30 minutes after EC,reflecting airway inflammation,significantly correlated with increase of residual volume(RV),total lung capacity,respiratory impedance at 5 Hz(Z5Hz)and respiratory resistance at 5 and 20 Hz(R5Hz and R20Hz).No significant correlations were found between EBC biomarkers'changes and respiratory *** This is the first study demonstrating that the changes in airway inflammation caused by EC have direct effects in respiratory mechanics of asthmatic patients.

关键词： Asthma Electronic cigarette Airway inflammation Lung function Impulse oscillometry FeNO

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COVID-19 and liver injury: An ongoing challenge

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World Journal of Gastroenterology 2023年第2期29卷 257-271页

作者： Ioanna Papagiouvanni serafeim-chrysovalantis kotoulas Athanasia Pataka Dionisios G Spyratos Konstantinos Porpodis Afroditi K Boutou Georgios Papagiouvannis Ioanna Grigoriou Christos Vettas Ioannis Goulis Fourth Department of Internal Medicine Aristotle University of ThessalonikiThessaloniki 54642ThessalonikiGreece Intensive Care Unit Hippokration General HospitalThessaloniki 54642Greece Department of Respiratory Medicine G Papanikolaou HospitalResp Failure UnitAristotle University of ThessalonikiThessaloniki 57001Greece Pulmonary Department Aristotle University of ThessalonikiThessaloniki 57001Greece Pulmonary Department G Papanikolaou HospitalResp Failure UnitAristotle University of ThessalonikiThessaloniki 54642Greece Department of Pharmacy School of Health SciencesFrederick UniversityNicosia 1036Cyprus Respiratory Failure Clinic Papanikolaou General HospitalThessloniki 57001Greece Fourth Department of Internal Medicine Hippokration General HospitalThessaloniki 54642Greece

The new coronavirus severe acute respiratory syndrome coronavirus 2(SARSCoV-2)was identified in December 2019,in Wuhan,*** virus was rapidly spread worldwide,causing coronavirus disease 2019(COVID-19)*** COVID-19 is presented,usually,with typical respiratory symptoms(i.e.,dyspnea,cough)and fever,extrapulmonary manifestations are also *** injury is a common feature in patients with COVID-19 and ranges from mild and temporary elevation of liver enzymes to severe liver injury and,even,acute liver *** pathogenesis of liver damage is not clearly defined;multiple mechanisms contribute to liver disorder,including direct cytopathic viral effect,cytokine storm and immune-mediated hepatitis,hypoxic injury,and druginduced liver *** with underlying chronic liver disease(i.e.,cirrhosis,non-alcoholic fatty liver disease,alcohol-related liver disease,hepatocellular carcinoma,etc.)may have greater risk to develop both severe COVID-19 and further liver deterioration,and,as a consequence,certain issues should be considered during disease *** aim of this review is to present the prevalence,clinical manifestation and pathophysiological mechanisms of liver injury in patients with SARS-CoV-2 ***,we overview the association between chronic liver disease and SARS-CoV-2 infection and we briefly discuss the management of liver injury during COVID-19.

关键词： COVID-19 Liver injury Cytokine storm Hypoxic hepatitis Drug-induced liver injury Chronic liver disease

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Hepatic ischemia-reperfusion syndrome and its effect on the cardiovascular system: The role of treprostinil, a synthetic prostacyclin analog

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世界胃肠外科杂志:英文版(电子版) 2023年第9期15卷 1858-1870页

作者： Christina Mouratidou Efstathios T Pavlidis Georgios Katsanos serafeim-chrysovalantis kotoulas Eleni Mouloudi Georgios Tsoulfas Ioannis N Galanis Theodoros E Pavlidis Intensive Care Unit Hippokration General HospitalThessaloniki 54642Greece 2^(nd)Propedeutic Department of Surgery Hippokration General HospitalSchool of MedicineAristotle University of ThessalonikiThessaloniki 54642Greece Department of Transplantation Hippokration General HospitalSchool of MedicineAristotle University of ThessalonikiThessaloniki 54642Greece

Hepatic ischemia-reperfusion syndrome has been the subject of intensive study and experimentation in recent decades since it is responsible for the outcome of several clinical entities,such as major hepatic resections and liver *** addition to the organ’s post reperfusion injury,this syndrome appears to play a central role in the dysfunction of distant tissues and ***,continuous research should be directed toward finding effective therapeutic options to improve the outcome and reduce the postoperative morbidity and mortality *** is a synthetic analog of prostaglandin I2,and its experimental administration has shown encouraging *** has already been approved by the Food and Drug Administration in the United States for pulmonary arterial hypertension and has been used in liver transplantation,where preliminary encouraging results showed its safety and feasibility by using continuous intravenous administration at a dose of 5 ng/kg/*** improves renal and hepatic function,diminishes hepatic oxidative stress and lipid peroxidation,reduces hepatictoll-like receptor 9 and inflammation,inhibits hepatic apoptosis and restores hepatic adenosine triphosphate(ATP)levels and ATP synthases,which is necessary for functional maintenance of *** exhibits vasodilatory properties and antiplatelet activity and regulates proinflam-matory cytokines;therefore,it can potentially minimize ischemia-reperfusion ***,it may have beneficial effects on cardiovascular parameters,and much current research interest is concentrated on this compound.

关键词： Hepatic ischemia-reperfusion syndrome Myocardial damage Prostaglandins Treprostinil Liver transplantation Hepatectomy

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放线菌素D对新生鼠肝细胞溶酶体的效应

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广东解剖学通报 1989年第2期 153-153页

作者： O.B.kotoulas

用生物化学测定、电子显微镜和定量形态测量等方法研究了新生鼠肝对放线菌素D 的效应。放线菌素D 防止正常新生儿升高α1,4糖苷酶(麦芽糖酶)活动力和分解溶酶

关键词：鼠肝细胞溶酶体放线菌素化学测定形态测量活动力出生后分解代谢

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放射建筑

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时代建筑 2016年第5期59卷 135-135页

作者：索蒂里奥斯.科托拉斯周渐佳索蒂里奥斯公司加拿大马尼托巴大学建筑系冶是工作室

恐怖之处在于,我只是一条线,但是在正常生活中.应当是一个球体,一个能洞察全景的球体——亨利·米肖《悲惨奇迹》在北极圈之上,质点否认黄昏那般明暗交接的存在,生产出全白的极昼与全黑的极夜。迁移的北极磁极从太阳和地球的磁场中吸收... 详细信息

恐怖之处在于,我只是一条线,但是在正常生活中.应当是一个球体,一个能洞察全景的球体——亨利·米肖《悲惨奇迹》在北极圈之上,质点否认黄昏那般明暗交接的存在,生产出全白的极昼与全黑的极夜。迁移的北极磁极从太阳和地球的磁场中吸收粒子,来自不同源头的力量被汇聚成一种异常现象。当两种磁场交错时,来自空间的粒子与场能进入地球的磁场,在那里收集、释放出亚暴①。

关键词：米肖极夜一条线场能空间的能量场沉浸式二元对立身体接触人工地平

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