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Physiology of gangliosides and the role of antiganglioside antibodies in human diseases

Cellular & Molecular Immunology 2020年第4期17卷 313-322页

作者： Gianni Cutillo Anna-Helena Saariaho seppo meri Translational Immunology Research Program and the Department of Bacteriology and Immunology University of HelsinkiHelsinkiFinland Humanitas University MilanRozzanoItaly Helsinki University Hospital Laboratory(HUSLAB) HelsinkiFinland

Gangliosides are structurally and functionally polymorphic sialic acid containing glycosphingolipids that are widely distributed in the human *** play important roles in protecting us against immune attacks,yet they can become targets for autoimmunity and act as receptors for microbes,like the influenza viruses,and toxins,such as the cholera *** expression patterns of gangliosides vary in different tissues,during different life periods,as well as in different *** against gangliosides(AGA)can target immune attack e.g.,against neuronal cells and neutralize their complement inhibitory *** are important especially in acquired demyelinating immune-mediated neuropathies,like Guillain–Barrésyndrome(GBS)and its variant,the Miller–Fisher syndrome(MFS).They can emerge in response to different microbial agents and immunological ***,they can be involved in a variety of *** addition,antibodies against GM3 were found in the sera of patients vaccinated with Pandemrix®,who developed secondary narcolepsy,strongly supporting the autoimmune etiology of the disease.

关键词： ganglioside Guillain-Barre syndrome complement narcolepsy sialic acid

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Do multiparous women need to work or exercise extra hard to control gestational diabetes?

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Journal of Sport and Health Science 2022年第5期11卷 550-551页

作者： Niina Matikainen seppo meri Endocrinology Abdominal CenterHelsinki University Hospital and University of HelsinkiFIN-00029 HUSHelsinkiFinland Department of Bacteriology and Immunology and Translational Immunology Research program University of HelsinkiFIN-00014HelsinkiFinland HUS Diagnostic Center HUSLABHelsinki University HospitalFIN-00029 HUSHelsinkiFinland

In the current issue of the Journal of Sport and Health Science,Wang et al.^(1)describe their prospective study,where they analyzed whether or not multiple pregnancies would influence glycemia and the glycemic response to physical exercise in gestational diabetes mellitus(GDM).2 Multiparous women are known to be at a higher risk for GDM than *** carries an increased risk for adverse perinatal outcomes,not only for the mothers but also for the newborn *** to a contemporary environment that is conducive to a sedentary lifestyle and obesity,the incidence of GDM among pregnant women is increasing.

关键词： mother diabetes

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