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Epithelial cell proliferation and glandular atrophy in lymphocytic gastritis: Effect of H pylori treatment

World Journal of Gastroenterology 2003年第12期9卷 2706-2710页

作者： Johanna M.Mkinen seppo niemel Tuomo Kerola Juhani Lehtola Tuomo J.Karttunen Department of Pathology University of OuluOuluFinland Department of Internal Medicine Oulu University HospitalOuluFinland Department of Pathology Lnsi-Pohja Central HospitalKemiFinland

AIM:Lymphocytic gastritis is commonly associated with Helicobacter pylori *** presence of glandular atrophy and foveolar hyperplasia in lymphocytic gastritis suggests abnormalities in cell proliferation and differentiation, forming a potential link with the suspected association with gastric *** aim was to compare epibhelial cell proliferation and morphology in H pylori associated lymphocytic gastritis and H pylori gastritis without features of lymphocytic gastritis, and to evaluate the effect of H pylori treatment. METHODS:We studied 14 lymphocytic gastritis patients with H pylori *** controls,we selected 14 matched dyspeptic patients participating in another treatment trial whose H pylori infection had successfully been eradicated. Both groups were treated with a triple therapy and followed up with biopsies for 6-18 months (patients) or 3 months (controls).Blinded evaluation for histopathological features was carried *** determine the cell proliferation index, the sections were labeled with Ki-67 antibody. RESULTS:Before treatment,lymphocytic gastritis was characterized by foveolar hyperplasia (P=0.001) and glandular atrophy in the body (P=0.008),and increased proliferation in both the body (P=0.001) and antrum (P=0.002).Proliferation correlated with foveolar hyperplasia and inflammation *** eradication therapy,the number of intraepithelial lymphocytes decreased in the body (P=0.004) and antrum (P=0.065),remaining higher than in controls (P<0.001).Simultaneously,the proliferation index decreased in the body from 0.38 to 0.15 (P=0.043),and in the antrum from 0.34 to 0.20 (P=0.069),the antral index still being higher in lymphocytic gastritis than in controls (P=0.010). Foveolar hyperplasia and glandular atrophy in the body improved (P=0.021),reaching the non-LG ***: In lymphocytic gastritis, excessive epithelialcell proliferation is predominantly present in the body, where it associates with foveolar hyperpla

关键词： Helicobacter pylori Atrophy Biopsy Cell Division Comparative Study Gastric Fundus Gastric Mucosa Gastritis Gastritis, Atrophic Helicobacter Infections Humans Pyloric Antrum

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Study of methods for endpoint aware inspection in a next generation firewall

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Cybersecurity 2022年第4期5卷 56-70页

作者： Jenny Heino Antti Hakkala seppo Virtanen Department of Computing University of TurkuTurkuFinland Forcepoint LLC HelsinkiFinland

Given the global increase in remote work with the COVID-19 pandemic and deperimeterization due to cloud deployment of next generation frewalls,the concept of a next generation firewall is at a breaking *** is becoming more dificult to define the barrier between the good and the *** provide the best security for an endpoint with minimal false positives or false negatives it is often necessary to identify the communicating endpoint application.n this study,we present an analysis of key research and methods for providing endpoint aware protection in the context of a next generation frewall We examine both academic research as well as state-of-the-art of the existing next generation firewall *** divide endpoint application identification into passive and active *** passive endpoint application identification,we study several traffc fingerprinting methods for different *** active methods we consider active scanning,endpoint metadata analysis and content injection and reference existing *** conclude that there are several open areas for future research,and that none of the considered methods is a silver bullet solution for endpoint aware inspection in the context of a next generation *** our best knowledge,this is the first study to examine current research and existing implementations of endpoint aware inspection.

关键词： Network traffc Endpoint identification NGFW Endpoint aware inspection

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Physiology of gangliosides and the role of antiganglioside antibodies in human diseases

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Cellular & Molecular Immunology 2020年第4期17卷 313-322页

作者： Gianni Cutillo Anna-Helena Saariaho seppo Meri Translational Immunology Research Program and the Department of Bacteriology and Immunology University of HelsinkiHelsinkiFinland Humanitas University MilanRozzanoItaly Helsinki University Hospital Laboratory(HUSLAB) HelsinkiFinland

Gangliosides are structurally and functionally polymorphic sialic acid containing glycosphingolipids that are widely distributed in the human *** play important roles in protecting us against immune attacks,yet they can become targets for autoimmunity and act as receptors for microbes,like the influenza viruses,and toxins,such as the cholera *** expression patterns of gangliosides vary in different tissues,during different life periods,as well as in different *** against gangliosides(AGA)can target immune attack e.g.,against neuronal cells and neutralize their complement inhibitory *** are important especially in acquired demyelinating immune-mediated neuropathies,like Guillain–Barrésyndrome(GBS)and its variant,the Miller–Fisher syndrome(MFS).They can emerge in response to different microbial agents and immunological ***,they can be involved in a variety of *** addition,antibodies against GM3 were found in the sera of patients vaccinated with Pandemrix®,who developed secondary narcolepsy,strongly supporting the autoimmune etiology of the disease.

关键词： ganglioside Guillain-Barre syndrome complement narcolepsy sialic acid

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Impacts of common factors of life style on serum liver enzymes

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World Journal of Gastroenterology 2014年第33期20卷 11743-11752页

作者： Joanna Danielsson Pivikki Kangastupa Tiina Laatikainen Mauri Aalto Onni niemel Department of Laboratory Medicine Sein?joki Central Hospital and University of Tampere 60220 Sein?joki Finland Medical Research Unit Sein?joki Central Hospital and University of Tampere 60220 Sein?joki Finland National Institute for Health and Welfare (THL) 00271 Helsinki Finland The Institute of Public Health and Clinical Nutrition University of Eastern Finland 70211 Kuopio Finland Hospital District of North Karelia 80210 Joensuu Finland

AIM: To investigate the impacts of gender, age and factors of life style (alcohol, overweight, coffee and smoking) on serum liver enzymes.

关键词： Alcohol Obesity Aging Smoking Liver en-zymes Oxidative stress

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Do multiparous women need to work or exercise extra hard to control gestational diabetes?

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Journal of Sport and Health Science 2022年第5期11卷 550-551页

作者： Niina Matikainen seppo Meri Endocrinology Abdominal CenterHelsinki University Hospital and University of HelsinkiFIN-00029 HUSHelsinkiFinland Department of Bacteriology and Immunology and Translational Immunology Research program University of HelsinkiFIN-00014HelsinkiFinland HUS Diagnostic Center HUSLABHelsinki University HospitalFIN-00029 HUSHelsinkiFinland

In the current issue of the Journal of Sport and Health Science,Wang et al.^(1)describe their prospective study,where they analyzed whether or not multiple pregnancies would influence glycemia and the glycemic response to physical exercise in gestational diabetes mellitus(GDM).2 Multiparous women are known to be at a higher risk for GDM than *** carries an increased risk for adverse perinatal outcomes,not only for the mothers but also for the newborn *** to a contemporary environment that is conducive to a sedentary lifestyle and obesity,the incidence of GDM among pregnant women is increasing.

关键词： mother diabetes

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校园城市村落芬兰埃斯波

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世界建筑导报 2024年第2期39卷 104-105页

作者： Juho Grönholm Antti Nousjoki Janne Teräsvirta Samuli Woolston Willem Barendregt Vladimir Ilic Julius Kekoni Auvo Lindroos Aleksi niemeläinen Pekka Sivula Pekka Tainio Jussi Vuori Haley Zhou ErikaÖsterlund ALA建筑师事务所

ALA建筑师事务所在阿尔托大学的2015校园国际设计竞赛中提出了“大型联合建筑群——活动孵化器”的理念。他们的目标是连接现有的结构和项目,创建一个新的区域热点,一个充满街道生活气息的城市集中区,促进创造力的展示。

关键词：建筑师事务所国际设计竞赛孵化器创造力生活气息阿尔托大学校园集中区

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Vibrations of a laboratory-scale gas-stirred ladle with two eccentric nozzles and multiple sensors

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Journal of Iron and Steel Research International 2019年第10期26卷 1031-1040页

作者： Najib Alia Mika Pylvanainen Ville-Valtteri Visuri Volker John seppo Ollila Weierstrass Institute for Applied Analysis and Stochastics(WIAS) Berlin 10117Germany Intelligent Machines and Systems University of OuluOulu 90014Finland Process Metallurgy Research Unit University of OuluOulu 90014Finland Department of Mathematics and Computer Science Freie Universit(a)it BerlinBerlin 14195Germany SSAB Europe Oy Raahe 92101Finlan

During ladle stirring,a gas is injected into the steel bath to generate a mixing of the liquid *** optimal process control requires a reliable measurement of the stirring intensity,for which the induced ladle wall vibrations have proved to be a potential *** experimental cold water ladle with two eccentric nozzles and eight mono-axial accelerometers was thus investigated to measure the *** effect of the sensors'positions with respect to the gas plugs on the vibration intensity was analyzed,and experimental data on several points of the ladle were collected for future numerical *** is shown that the vibration root-mean-square values depend not only on process parameters,such as gas flow rate,water,and oil heights,but also on the radial and axial positions of the *** vibration intensity is clearly higher,close to the gas plumes,than in the opposite *** one of the nozzles is clogged,the vibration intensity close to the clogged nozzle drops drastically(-36 to-59%),while the vibrations close to the normal operating nozzle are hardly *** on these results,guidelines are provided for an optimized vibration-based stirring.

关键词： Ladle metallurgy Gas stirring Ladle vibration Optimal position Sensor

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Specific probiotics alleviate allergic rhinitis during the birch pollen season

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World Journal of Gastroenterology 2009年第26期15卷 3261-3268页

作者： Arthur C Ouwehand Merja Nermes Maria Carmen Collado Nina Rautonen seppo Salminen Erika Isolauri Health & Nutrition Danisco Finland Department of Pediatrics Turku University Hospital Functional Foods Forum Turku University

AIM： To investigate whether birch pollen allergy symptoms are linked with gut microbiota changes and whether probiotics have an effect on these. METHODS： Forty seven children with confirmed birch pollen allergy were randomized to receive either a probiotic combination of Lactobacillus acidophilus （L. acidophilus） NCFM^TM （ATCC 700396） and Bifidobacterium lactis （B. lactis） BI-04 （ATCC SD5219） or placebo in a double-blind manner for 4 mo, starting prior to onset of the birch pollen season. Symptoms were recorded in a diary. Blood samples were taken for analysis of cytokines and eosinophils. Fecal samples were analysed for microbiota components, calprotectin and IgA. Nasal swabs were taken for analysis of eosinophils.RESULTS： The pollen season induced a reduction in Bifldobacterium , Clostridium and Bacteroides which could not be prevented by the probiotic intervention. During the intervention, significantly higher numbers ofB. lactis 11.2 × 10^7 ± 4.2 ×10^7 vs 0.1 × 10^7 ± 0.1 × 10^7 bacteria/g feces （P 〈 0.0001） and L. acidophilus NCFMTM 3.5 × 10^6 ± 1.3 × 10^6 vs 0.2 × 10^6 ±0.1 × 10^6 bacteria/g feces （P 〈 0.0001） were observed in the probiotic group compared to the placebo *** May, there was a tendency for fewer subjects, （76.2% vs 95.2%, P = 0.078） to report runny nose, while during June, fewer subjects, 11.1% vs 33.3%, reported nasal blocking in the probiotics group （P = 0.101）. Concomitantly, fewer subjects in the probiotic group had infiltration of eosinophils in the nasal mucosa compared to the placebo group, 57.1% vs 95% （P = 0.013）. Eye symptoms tended to be slightly more frequent in the probiotic group, 12.5 d [interquartile range （IQR） 6-18] vs 7.5 d （IQR 0-11.5）（P = 0.066） during May. Fecal IgA was increased in the placebo group during the pollen season; this increase was prevented by the probiotics （P = 0.028）. CONCLUSION： Birch pollen allergy was shown to be associated with changes in fecal microbiota composition. The specific combinat

关键词： Probiotics Pollen allergy Intestines Microbiology Immunity Eosinophilia Lactobacillus acidoph/lus Bil^dobacterium lactis

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Probiotics in dietary guidelines and clinical recommendations outside the European Union

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World Journal of Gastroenterology 2014年第43期20卷 16095-16100页

作者： Stephan Ebner Linda N Smug Wolfgang Kneifel seppo J Salminen Mary Ellen Sanders University of Natural Resources and Life Sciences Vienna 1190 ViennaAustria Department of Bioprocess Engineering Wroc?aw University of EconomicsKomandorska 118/12053-345 Wroc?awPoland University of Turku 20014 TurkuFinland Dairy and Food Culture Technologies CentennialCO 80122United States

Fermented foods have been consumed for centuries across many geographical locales and have traditionally been considered healthy foods, partly because of the live microbes contained in them. The concept of “probiotics” further requires that the microbes be defined and their health effects be demonstrated through human intervention studies or other suitable investigations before marketing with corresponding health messages. Here, we review recommendations for fermented foods and probiotics in several countries outside the EU, focusing on food-based dietary guidelines. We emphasize recommendations on yoghurt and probiotics made by expert bodies. We found that dietary guidelines commonly advocate the consumption of yoghurt or similar products, but specific comments on probiotics are rare. Further, we reviewed guidelines from clinical associations. In general, they acknowledge the beneficial effects of probiotics, but often suggest the need for further research. This is true despite good quality evidence supporting the role of probiotics for certain health effects, such as prevention of eczema in infants, management of side effects from antibiotics and alleviation of functional bowel symptoms. Additional research to support future dietary recommendations should focus on determining effect size, identifying responders and non-responders, clarifying strain-specificity of effects and confirming mechanisms.

关键词： Fermented foods Probiotics Dietary guidelines Health claims

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A SURVEY OF THE HOLARCTIC LINYPHIIDAE (ARANEAE),A REVIEW OF THE ERIGONINE GENUS ZORNELLA JACKSON, 1932

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动物分类学报 2007年第1期32卷 21-34页

作者： Yuri M. Marusik Donald J. Buckle seppo Koponen Institute for Biological Problems of the North Portovaya Str. 18 Magadan 685000 Russia 620 Albert Avenue Saskatoon Saskatchewan S7N 1G7 Canada Zoological Museum University of Turku FI-20014 Turku Finland

The Holarctic erigonid genus Zornella has been surveyed. Four species are recognized in this genus, two Palaearctic: ***(***,11879) & *** ***., and two Nearctic: ***(Banks, 1906) & *** Chamberlin,*** is demonstrated that neither nearctic species is conspecific with *** as was thought by Holm and other authors. *** ***. is described from northeastern Siberia. All of the species are illustrated and their distributions mapped.

关键词： Spiders Araneae Erigoninae Holarctic Zornella new species redescription

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