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Long-term outcomes of endoscopic submucosal dissection for undifferentiated type early gastric cancer over 2 cm with R0 resection

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World Journal of Gastrointestinal Endoscopy 2024年第6期16卷 326-334页

作者： Jun Yong Bae Chang Beom Ryu Moon Sung lee Kulwinder S Dua Internal Medicine and Digestive Disease Center Seoul Medical CenterSeoul 02053South Korea Internal Medicine and Digestive Disease Center and Research Institute Soon Chun Hyang University of School of MedicineBucheon 14584South Korea Department of Medicine Medical College of WisconsinMilwaukeeWI 53226United States

BACKGROUND Endoscopic submucosal dissection(ESD)for over 2 cm in size undifferentiated type(UD type)early gastric cancer(EGC)confined to the mucosa is not only challenging,but also long-term outcomes are not well *** To evaluate the long-term outcomes of ESD done for UD type EGCs confined to the mucosa over 2 cm in size and compare the results with those where the lesions were less than 2 *** 143 patients with UD type EGC confirmed on histology after ESD at a tertiary hospital were *** with synchronous and metachronous lesions and a case with emergency surgery after ESD were excluded.A total of 137 cases were enrolled.79 cases who underwent R0 resection were divided into 2 cm or less(group A)and over 2 cm(group B)in *** Among 79 patients who underwent R0 resection,the number in group A and B were 51 and 28,*** mean follow-up period(SD)was 79.71±45.42 *** was a local recurrence in group A(1/51,2%)and group B(1/28,3.6%)*** patient in group A underwent surgery while the patient in group B underwent repeated ESD with no further recurrences in both *** was no regional lymph node metastasis,distant metastasis,and deaths in both *** R0 resection strategy for ESD on lesions over 2 cm,20.4%(28/137)of patients were able to avoid surgery compared with expanded *** If R0 resection is achieved by ESD,UD type EGCs over 2 cm also showed good and similar clinical outcomes as compared to lesions less than 2 cm when followed for over 5 *** R0 resection strategy,several patients can avoid surgery.

关键词： Undifferentiated type early gastric cancer Endoscopic submucosal dissection Long term outcomes Over 2 cm Early gastric cancer

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Highly Elastic,Bioresorbable Polymeric Materials for Stretchable,Transient Electronic Systems

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Nano-Micro Letters 2024年第6期16卷 1-13页

作者： Jeong‑Woong Shin Dong‑Je Kim Tae‑Min Jang Won Bae Han Joong Hoon lee Gwan‑Jin Ko Seung Min Yang Kaveti Rajaram Sungkeun Han Heeseok Kang Jun Hyeon Lim Chan‑Hwi Eom Amay J.Bandodkar Hanul Min Suk‑Won Hwang KU‑KIST Graduate School of Converging Science and Technology Korea University145 Anam‑roSeongbuk‑guSeoul 02841Republic of Korea SK Hynix 2091Gyeongchung‑daeroBubal‑eupIcheon‑siGyeonggi‑do 17336Republic of Korea Hanwha Systems Co. Ltd.188Pangyoyeok‑roBundang‑guSeongnam‑siGyeonggi‑do 13524Republic of Korea Department of Electrical and Computer Engineering North Carolina State UniversityRaleighNC 27606USA Center for Advanced Self‑Powered Systems of Integrated Sensors and Technologies(ASSIST) North Carolina State UniversityRaleighNC 27606USA Department of Integrative Energy Engineering Korea University145 Anam‑roSeongbuk‑guSeoul 02841Republic of Korea Biomaterials Research Center Korea Institute of Science and Technology(KIST)5 Hwarang‑ro 14‑gilSeongbuk‑guSeoul 02792Republic of Korea Semiconductor R&D Center Samsung Electronics Co.Ltd.Hwaseong‑siGyeonggi‑do 18448Republic of Korea Center for Advanced Biomolecular Recognition Biomedical Research DivisionKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea

Substrates or encapsulants in soft and stretchable formats are key components for transient,bioresorbable electronic systems;however,elastomeric polymers with desired mechanical and biochemical properties are very limited compared to nontransient ***,we introduce a bioresorbable elastomer,poly(glycolide-co-ε-caprolactone)(PGCL),that contains excellent material properties including high elongation-at-break(<1300%),resilience and toughness,and tunable dissolution *** of PGCLs as polymer matrices,in combination with conducing polymers,yields stretchable,conductive composites for degradable interconnects,sensors,and actuators,which can reliably function under external *** of device components with wireless modules demonstrates elastic,transient electronic suture system with on-demand drug delivery for rapid recovery of postsurgical wounds in soft,time-dynamic tissues.

关键词： Biodegradable elastomer Conductive polymer composites Biomedical device Transient electronics

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拟枝孢镰孢Fspgp2基因负调控T-2毒素产量

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菌物学报 2024年第5期43卷 48-59页

作者：王立雯林子涵王冰冰 lee Yinwon 刘馨徐剑宏史建荣江苏大学食品与生物工程学院江苏镇江212013 江苏省农业科学院农产品质量安全与营养研究所江苏南京210014 南京大学金陵学院化学与生命科学学院江苏南京210089 首尔国立大学农业与生物技术学院韩国首尔08826

T-2毒素(T-2 toxin)是单端孢霉烯族毒素中细胞毒性最强的一种,广泛污染粮食作物,在世界多国的大麦、黑麦、燕麦、玉米等样品中均有污染报道,威胁粮食安全与人畜健康。目前T-2毒素标准物质主要是从产毒菌培养物中提取纯化获得,产率较低,... 详细信息

T-2毒素(T-2 toxin)是单端孢霉烯族毒素中细胞毒性最强的一种,广泛污染粮食作物,在世界多国的大麦、黑麦、燕麦、玉米等样品中均有污染报道,威胁粮食安全与人畜健康。目前T-2毒素标准物质主要是从产毒菌培养物中提取纯化获得,产率较低,主要依赖进口,货期长、价格昂贵。本研究筛选了一株产T-2毒素的拟枝孢镰孢Fsp1,通过基因敲除策略构建了T-2毒素负调控元件Fspgp2的敲除突变体,突变体的菌丝生长及产孢量与野生型菌株相比无显著差异,但其T-2毒素产量显著提高,在大米培养基中产量为421.98mg/kg,为构建T-2毒素宏量制备纯化技术提供菌源基础,对于粮食中T-2毒素污染风险的持续监测和控制技术的研发意义重大。

关键词： T-2毒素基因敲除拟枝孢镰孢高产突变体

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Trends in colorectal cancer incidence according to an increase in the number of colonoscopy cases in Korea

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 51-60页

作者： Ga Hee Kim Yeong Chan lee Tae Jun Kim Sung Noh Hong Dong Kyung Chang Young-Ho Kim Dong-Hoon Yang Chang Mo Moon Kyunga Kim Hyun Gun Kim Eun-Ran Kim Division of Gastroenterology Department of Internal MedicineAsan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Department of Digital Health Samsung Advanced Institute for Health Science and TechnologySungkyunkwan University School of MedicineSeoul 06351South Korea Division of Gastroenterology Department of Internal MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351South Korea Division of Gastroenterology Department of Internal MedicineEwha Womans UniversitySeoul 07985South Korea Biomedical Statistics Center Samsung Medical CenterSeoul 06351South Korea Division of Gastroenterology Department of Internal MedicineSoonchunhyang University College of MedicineSeoul 04401South Korea

BACKGROUND The incidence of colorectal cancer(CRC)and preinvasive CRC(e.g.,early colon cancer and advanced adenoma)is gradually increasing in several *** To evaluate the trend in incidence of CRC and preinvasive CRC according to the increase in the number of colonoscopies performed in *** This retrospective cohort study enrolled Korean patients from 2002 to 2020 to evaluate the incidence of CRC and preinvasive CRC,and assess the numbers of diagnostic colonoscopies and colonoscopic ***-related complications by age group were also *** The incidence of CRC showed a rapid increase,then decreased after 2012 in the 50-75 year-age *** the study period,the rate of incidence of preinvasive CRC increased at a similar level in patients under 50 and 50-75 years of *** 2009,the increase has been rapid,showing a pattern similar to the increase in *** rate of colonoscopic polypectomy in patients aged under 50 was similar to the rate in patients over 75 years of age after *** rate of complications after colonoscopy and related deaths within 3 mo was high for those over 75 years of *** The diagnosis of preinvasive CRC increased with the increase in the number of colonoscopies *** the risk of colonoscopy-related hospitalization and death is high in the elderly,if early lesions at risk of developing CRC are diagnosed and treated under or at the age of 75,colonoscopy-related complications can be reduced for those aged 76 years or over.

关键词： Colorectal cancer Preinvasive colorectal cancer Colorectal polypectomy Colonoscopy

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The SARS-CoV-2 spike protein induces lung cancer migration and invasion in a TLR2-dependent manner

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Cancer Communications 2024年第2期44卷 273-277页

作者： Mi-Jeong Kim Ji Young Kim Ji Hye Shin Juhee Son Yeeun Kang Soo-Kyung Jeong Duk-Hwan Kim Kyun-Hwan Kim Eunyoung Chun Ki-Young lee Department of Immunology Samsung Biomedical Research InstituteSungkyunkwan University School of MedicineSuwonRepublic of Korea Research and Development Center CHA Vaccine InstituteSeongnam-siRepublic of Korea Department of Molecular Cell Biology Sungkyunkwan University School of MedicineSuwonRepublic of Korea Department of Precision Medicine Sungkyunkwan University School of MedicineSuwonRepublic of Korea Department of Health Sciences and Technology Samsung Advanced Institute for Health Sciences&TechnologySamsung Medical CenterSungkyunkwan UniversitySeoulRepublic of Korea

Dear editor,Severe acute respiratory syndrome coronavirus2(SARS-CoV-2)infection can lead to severe outcomes in patients with cancer[1].It has been reported that patients with lung cancers disproportionately manifest severe COVID-19 with a high rate of hospitalization and death[2].Notably,the SARS-CoV-2 Spike(S)protein can induce hyper-inflammation in both epithelial cells and macrophages through toll-like receptor(TLR)1/TLR2 or TLR2/6-dependent nuclear factor-kappaB(NF-κB)path-way[3].However,molecular and cellular evidence on whether the SARS-CoV-2 virus affects the severity of lung cancer patients through TLR1/2 or TLR2/6 signaling remains unclear.

关键词： lung TLR2 invasion

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Investigation into charge carrier dynamics in organic light-emitting diodes

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Nano Research Energy 2024年第2期3卷 39-46页

作者： Dong-Guang Zheng Hyeon-Dong lee Gyeong Won lee Dong-Soo Shin Jeongwon Kim Jong-In Shim Zhiqun Lin Tae-Woo lee Dong Ha Kim Information Engineering College Hangzhou Dianzi UniversityHangzhou 311305China Department of Materials Science and Engineering Seoul National University1 Gwanak-roGwanak-guSeoul 08826Republic of Korea Department of Photonics and Nanoelectronics Hanyang University ERICA55 Hanyangdeahak-roSangnok-guAnsanGyeonggi 15588Republic of Korea Department of Chemistry and Nanoscience Ewha Womans University52Ewhayeodae-gilSeodaemun-guSeoul 03760Republic of Korea Department of Chemical and Biomolecular Engineering National University of Singapore4 Engineering Drive 4Singapore 117585Singapore School of Chemical and Biological Engineering Institute of Engineering ResearchResearch Institute of Advanced MaterialsSoft FoundrySeoul National University1 Gwanak-roGwanak-guSeoul 08826Republic of Korea Basic Sciences Research Institute(Priority Research Institute) Ewha Womans UniversitySeoul 03760Republic of Korea Nanobio∙Energy Materials Center(National Research Facilities and Equipment Center) Ewha Womans UniversitySeoul 03760Republic of Korea

Organic light-emitting diodes(OLEDs)have demonstrated remarkable advancements in both device lifetime and luminous ***,insufficient operation lifetime due to device degradation remains a major hurdle,especially for brighter *** the degradation mechanisms of OLEDs due to the degradation of functional materials and the formation of defects in device architectures continues to be a significant ***,we evaluate the degradation characteristics by scrutinizing the electrical and optical properties,as well as analyzing the charge carrier dynamics in pristine and aged states of phosphorescent OLEDs(PhOLEDs).We show that degradation mechanisms in PhOLEDs can be elucidated in terms of the ideality factors of current and luminance in pristine and aged device *** consistent shifts in distinct ideality factors across various states points out that the device degradation is attributed to the deterioration of the guest material,***-light-emitting phosphorescent ***,the incongruity in ideality factor changes between the two states indicates that the degradation results from the deterioration of non-light-emitting *** characterization experiments provide further evidence that this degradation is primarily attributed to the deterioration of CBP-host *** thorough understanding of degradation mechanisms established in this study can contribute to realizing the highly reliable PhOLEDs with a long lifetime.

关键词： organic light-emitting diodes ideality factor carrier transport processes degradation mechanism

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Complicated calcified alloplastic implants in the nasal dorsum:A clinical analysis

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World Journal of Clinical Cases 2024年第18期12卷 3351-3359页

作者： Yong-Seon Hwang Taek-Kyun Kim Dong-Jun Yang Si-Hyong Jang Da-Woon lee Department of Plastic and Reconstructive Surgery College of MedicineSoonchunhyang UniversityCheonan-Si 31151South Korea Department of Plastic Surgery The PLUS Plastic Surgery ClinicSeoul 06035South Korea Department of Plastic Surgery CDU Plastic Surgery ClinicSeoul 06067South Korea Department of Pathology College of MedicineSoonchunhyang UniversityCheonan 31151Chungcheongnam-doSouth Korea

BACKGROUND In rhinoplasty,calcification around silicone implants is frequently observed in the tip dorsum(TD)***,based on a review of various literature,it is presumed that calcification in silicone implants occurs due to both inflammatory chemical reactions and physical friction against the *** calcification of nasal silicone implants not only results in the functional loss of the implants,but also leads to material ***,there is a lack of research on calcification of nasal silicone implants in the current *** To elucidate various clinical characteristics of calcification around nasal silicone implants,using histological and radiological *** This study analyzed data from 16 patients of calcified nasal implants,who underwent revision rhinoplasty for various reasons after undergoing augmentation rhinoplasty with silicone *** collected data included information on implant duration,implant types,location of calcification,presence of inflammatory reactions,and computed tomography(CT)*** The most common location of calcification,as visually analyzed,was in the TD area,accounting for 56%.Additionally,the analysis of CT scans revealed a trend of increasing Hounsfield Unit values for calcification with the duration of implantation,although this trend was not statistically significant(P=0.139).CONCLUSION Our study shows that reducing the frequency of calcification may be achievable by using softer silicone implants and by minimizing the damage to perioperative tissues.

关键词： Silicone implants Rhinoplasty Calcification Complication Hounsfield unit

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MODELING ON THE CYCLIC OPERATION OF STANDING COLUMN WELLS UNDER REGIONAL GROUNDWATER FLOW

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Journal of Hydrodynamics 2011年第3期23卷 295-301页

作者： lee Kun Sang Department of Natural Resources and Environmental Engineering Hanyang University

Coupled hydrogeological-thermal simulation of the Standing Column Well （SCW） system is essential to provide an optimized configuration and operation schedule for boreholes on the site. This paper presents numerical investigations and thermo-hydraulic evaluation of standing column well system operating under cyclic flow regime. A three-dimensional numerical model for groundwater flow and heat transport is used to analyze the heat exchange in the ground. The model includes the effects of convective and conductive heat transfer, heat loss to the adjacent confining strata, and hydraulic anisotropy. The operation scenario consists of cyclic injection and recovery and four periods per year to simulate the seasonal temperature conditions. For different parameters of the system, performances have been evaluated in terms of variations in recovery temperature. The calculated temperatures at the producing pipe are relatively constant within a certain range through the year and fluctuating quarterly a year. Pipe-to-pipe distance, injection/production rate, ground thickness, and permeability considered in the model are shown to impact the predicted temperature profiles at each stage and the recovery water temperature. The influence of pressure gradient, which determines the velocity of regional groundwater flow, is most substantial.

关键词： standing column well thermo-hydraulic evaluation cyclic regime numerical simulation

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Color liquid crystal grating based color holographic 3D display system with large viewing angle

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Light(Science & Applications) 2024年第1期13卷 103-112页

作者： Di Wang Yi-Long Li Fan Chu Nan-Nan Li Zhao-Song Li Sin-Doo lee Zhong-Quan Nie Chao Liu Qiong-Hua Wang School of Instrumentation and Optoelectronic Engineering Beihang UniversityBeijing 100191China State Key Laboratory of Virtual Reality Technology and Systems Beihang UniversityBeijing 100191China Display Technology Research Center Seoul National UniversityGwanak-ro 1Gwanak-guSeoul 08826Republic of Korea Key Lab of Advanced Transducers and Intelligent Control System Ministry of EducationTaiyuan University of TechnologyTaiyuan 030024China

Holographic 3D display is highly desirable for numerous applications ranging from medical treatments to military ***,it is challenging to simultaneously achieve large viewing angle and high-fidelity color reconstruction due to the intractable constraints of existing ***,we conceptually propose and experimentally demonstrate a simple and feasible pathway of using a well-designed color liquid crystal grating to overcome the inevitable chromatic aberration and enlarge the holographic viewing angle,thus enabling large-viewing-angle and color holographic 3D *** use of color liquid crystal grating allows performing secondary diffraction modulation on red,green and blue reproduced images simultaneously and extending the viewing angle in the holographic 3D display *** principle,a chromatic aberration-free hologram generation mechanism in combination with the color liquid crystal grating is proposed to pave the way for on such a superior holographic 3D *** proposed system shows a color viewing angle of~50.12°,which is about 7 times that of the traditional system with a single spatial light *** work presents a paradigm for achieving desirable holographic 3D display,and is expected to provide a new way for the wide application of holographic display.

关键词： holographic angle crystal

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ISOMORPHISMS AND DERIVATIONS IN C*-ALGEBRAS

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Acta Mathematica Scientia 2011年第1期31卷 309-320页

作者： lee Jung-Rye Shin Dong-Yun Department of Mathematics Daejin University Department of Mathematics University of Seoul

In this article, we prove the Hyers-Ulam-Rassias stability of the following Cauchy-Jensen functional inequality：‖f （x）＋ f （y）＋ 2f （z）＋ 2f （w）‖ ≤‖ 2f x ＋ y2 ＋ z ＋ w ‖（0.1）This is applied to investigate isomorphisms between C＊-algebras, Lie C＊-algebras and JC＊-algebras, and derivations on C＊-algebras, Lie C＊-algebras and JC＊-algebras, associated with the Cauchy-Jensen functional equation 2f （x ＋ y/2 ＋ z ＋ w） = f（x）＋ f（y）＋ 2f（z）＋ 2f（w）.

关键词： Jordan-von Neumann type Cauchy-Jensen functional equation C*-algebra isomorphism Lie C*-algebra isomorphism JC*-algebra isomorphism Hyers-Ulam-Rassias stability Cauchy-Jensen functional inequality derivation

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