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Imprinting at the KBTBD6 locus involves species-specific m ternal methylation and monoallelic expression in livestock animals

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Journal of Animal Science and Biotechnology 2024年第1期15卷 127-145页

作者： Jinsoo Ahn In-Sul hwa.g Mi-Ryung Park seongsoo hwa.g Kichoon Lee Department of Animal Sciences The Ohio State UniversityColumbusOH 43210USA Animal Biotechnology Division Rural Development AdministrationNational Institute of Animal ScienceJeonbuk 55365Republic of Korea Columbia Center for Translational Immunology Columbia University Irving Medical CenterColumbia UniversityNew YorkNY 10032USA Animal Welfare Research Team National Institute of Animal ScienceRDA1500Kongjwipatjwi‑roJeollabuk‑do 55365Republic of Korea

Background The primary differentially methylated regions(DMRs) which are maternally hypermethylated serve as imprinting control regions(ICRs) that drive monoallelic gene expression, and these ICRs have been investigated due to their implications in mammalian development. Although a subset of genes has been identified as imprinted, in-depth comparative approach needs to be developed for identification of species-specific imprinted genes. Here, we examined DNA methylation status and allelic expression at the KBTBD6 locus across species and tissues and explored potential mechanisms of *** Using whole-genome bisulfite sequencing and RNA-sequencing on parthenogenetic and normal porcine embryos, we identified a maternally hypermethylated DMR between the embryos at the KBTBD6 promoter Cp g island and paternal monoallelic expression of KBTBD6. Also, in analyzed domesticated mammals but not in humans, non-human primates and mice, the KBTBD6 promoter Cp g islands were methylated in oocytes and/or allelically methyl-ated in tissues, and monoallelic KBTBD6 expression was observed, indicating livestock-specific imprinting. Further analysis revealed that these Cp g islands were embedded within transcripts in porcine and bovine oocytes which coexisted with an active transcription mark and DNA methylation, implying the presence of transcription-dependent *** In this study, our comparative approach revealed an imprinted expression of the KBTBD6 gene in domesticated mammals, but not in humans, non-human primates, and mice which implicates species-specific evolution of genomic imprinting.

关键词： Differentially methylated region Domesticated mammal Imprinting KBTBD6 Parthenogenetic

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Multi-generator Discriminator Network Using Texture-Edge Information

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Computers, Materials & Continua 2023年第5期75卷 3537-3551页

作者： Kyeongseok Jang seongsoo Cho Kwang Chul Son Department of Plasma Bio Display Kwangwoon University20Gwangun-roNowon-guSeoul01897Korea School of Software Soongsil University369Sangdo-roDongjak-guSeoul06978Korea Department of Information Contents Kwangwoon University20Gwangun-roNowon-guSeoul01897Korea

In the proposed paper,a parallel structure type generative Adversarial Network(gAN)using edge and texture information is *** the existing gAN-based model,many learning iterations had to be given to obtaining an output that was somewhat close to the original data,and noise and distortion occurred in the output image even when learning was *** solve this problem,the proposed model consists of two generators and three discriminators to propose a network in the form of a parallel *** the network,each edge information and texture information were received as inputs,learning was performed,and each character was combined and outputted through the Combine *** this,edge information and distortion of the output image were improved even with fewer iterations than DCgAN,which is the existing gAN-based *** a result of learning on the network of the proposed model,a clear image with improved contour and distortion of objects in the image was output from about 50,000 iterations.

关键词： Deep learning convolution neural network generative adversarial network edge information texture information

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Soft Computing Based Metaheuristic Algorithms for Resource Management in Edge Computing Environment

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Computers, Materials & Continua 2022年第9期72卷 5233-5250页

作者： Nawaf Alhebaishi Abdulrhman M.Alshareef Tawfiq Hasanin Raed Alsini gyanendra Prasad Joshi seongsoo Cho Doo Ill Chul Department of Information Systems Faculty of Computing and Information TechnologyKing Abdulaziz UniversityJeddahSaudi Arabia Department of Computer Science and Engineering Sejong UniversitySeoulKorea School of Software Soongsil UniversitySeoul06978Korea Artificial Intelligence Education Hankuk University of Foreign StudiesDongdaemun-guSeoul02450Korea

In recent times,internet of things(IoT)applications on the cloud might not be the effective solution for every IoT scenario,particularly for time sensitive applications.A significant alternative to use is edge computing that resolves the problem of requiring high bandwidth by end *** computing is considered a method of forwarding the processing and communication resources in the cloud towards the *** of the considerations of the edge computing environment is resource management that involves resource scheduling,load balancing,task scheduling,and quality of service(QoS)to accomplish improved *** this motivation,this paper presents new soft computing based metaheuristic algorithms for resource scheduling(RS)in the edge computing *** SCBMARS model involves the hybridization of the group Teaching Optimization Algorithm(gTOA)with rat swarm optimizer(RSO)algorithm for optimal resource *** goal of the SCBMA-RS model is to identify and allocate resources to every incoming user request in such a way,that the client’s necessities are satisfied with the minimum number of possible resources and optimal energy *** problem is formulated based on the availability of VMs,task characteristics,and queue *** integration of gTOA and RSO algorithms assist to improve the allocation of resources among VMs in the data *** experimental validation,a comprehensive set of simulations were performed using the CloudSim *** experimental results showcased the superior performance of the SCBMA-RS model interms of different measures.

关键词： Resource scheduling edge computing soft computing fitness function virtual machines

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Regular truss structure model equivalent to continuum structure

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International Journal of Agricultural and Biological Engineering 2015年第5期8卷 151-161页

作者： Won Choi JeongJae Lee seongsoo Yoon Department of Rural Systems Engineering College of Agriculture and Life SciencesSeoul National UniversitySeoul 151-921South Korea Department of Rural Systems Engineering Research Institute of Agriculture and Life SciencesCollege of Agriculture and Life SciencesSeoul National UniversitySeoul 151-921South Korea Department.of Agricultural and Rural Engineering College of AgricultureLife and Environments SciencesChungbuk National UniversityChungbuk 362-763South Korea

It is difficult to solve the structural problems related to agricultural engineering,due to the wide ranges of the means of related variables and complex structural *** these reasons,discrete models are required that are able to replace or simplify solid structure components used in traditional analysis ***,the objective of this study was to develop a regular truss structure model that behaves the same way as a solid *** was assumed that if a unit element consists of truss elements with each hinge at the end of the element and the size of the element is infinitesimal,the stress distribution and displacement field will be constant throughout the domain of the unit ***,the behavior of the truss element was assumed to be in a linear state in a two-dimensional *** law of energy conservation,based on the theory of elasticity,was applied to determine the equilibrium conditions between discretized and solid *** restrictive condition that we obtained revealed that applications are limited to only ideal elastic materials with a Poisson’s ratio of 1 to *** volumetric ratio of the equivalent truss to the continuum structures was 3:1,regardless of the size or number of the *** calculate the internal stress and strain of the unit element,the geometric relationships of each truss member,which has its own role against different stress directions,were *** calculated von Misses stresses were used to verify this *** concentrations,as explained based on Saint Venant’s principle,were also observed in the equivalent truss structure *** main stress paths,indicating the areas where reinforcement bars should be placed,were successfully shown without the requirement that each element be transformed in the direction of principal stress;this was done by eliminating elements with only compressive and near-zero stresses.

关键词： structural analysis regular mesh equivalent truss structure model discretized element energy method

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Single-atom Pd catalyst anchored on Zr-based metal-organic polyhedra for Suzuki-Miyaura cross coupling reactions in aqueous media

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Nano Research 2021年第2期14卷 486-492页

作者： seongsoo Kim Seohyeon Jee Kyung Min Choi Dong-Sik Shin Division of Chemical and Bioengineering Kangwon National UniversityGangwon-do 24341Republic of Korea Department of Chemical and Biological Engineering Sookmyung Womens University100 Cheongpa-ro 47-gilYongsan-guSeoul 04310Republic of Korea

The challenge for single-atom catalysts in various C-C cross coupling reaction exists in the development of solid supporting *** has been desired tofind a supporting material designed in molecular level to anchor a single-atom catalyst and provide high degree of dispersion and substrate access in aqueous ***,we prepared discrete cages of metal-organic polyhedra anchoring single Pd atom(MOP-BPY(Pd))and successfully performed a Suzuki-Miyaura cross coupling reaction with various substrates in aqueous *** was revealed that each tetrahedral cage of MOP-BPY(Pd)has 4.5 Pd atoms on average and retained its high degree of dispersion up to 3 months in *** coupling efficiencies of the Suzuki-Miyaura cross coupling reaction exhibited more than 90.0%for various substrates we have tested in the aqueous media,which is superior to those of the molecular Pd complex and metal-organic framework(MOF)anchoring Pd ***,MOP-BPY(Pd)was successfully recovered and recycled without performance degradation.

关键词： metal-organic polyhedra Suzuki-Miyaura cross coupling reaction structure characterization aqueous phase reaction high-degree of dispersion

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Crack simulation and probability analysis using irregular truss structure modeling equivalent to a continuum structure

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International Journal of Agricultural and Biological Engineering 2017年第1期10卷 234-247页

作者： Won Choi seongsoo Yoon JeongJae Lee Dept.of Rural Systems Engineering College of Agriculture and Life SciencesSeoul National UniversitySeoul 151-921South Korea Dept.of Agricultural and Rural Engineering College of AgricultureLife and Environments SciencesChungbuk National UniversityChungbuk 362-763South Korea Dept.of Rural Systems Engineering Research Institute of Agriculture and Life SciencesCollege of Agriculture and Life SciencesSeoul National UniversitySeoul 151-921South Korea

The problems related to agricultural structure engineering for crack simulation and reliability analysis are complicated because its variables contain wide ranges of mean and standard *** paper describes an integrated model to perform crack simulation and reliability analysis of a continuum *** structure is assumed to be under a two-dimensional plane stress and the deformation is infinitesimal.A truss structure model that has the same behaviour as a continuum structure was developed using irregular triangle truss components where each element consists of two hinges with an axial degree of freedom at both of their ends.A Monte-Carlo simulation(MCS)was adopted for the reliability *** the length of one side of the irregular triangle mesh is shorter than the thickness of the structure,the slenderness associated with compressive failure needs to be examined only for the short *** that reason,the failure criterion suitable for the equivalent truss structure model was established by checking only axial stresses acting on truss *** nodes of the equivalent truss structure model for the structural analysis in this study consist of hinges,development of plastic hinges that occurred during crack propagation were not considered in this *** simulate the development of crack,truss members over allowable stresses of tension or compression among truss members with the largest amount of stress at each completed structural analysis time step were sequentially *** irregular triangle meshes have an uncertainty in themselves to compare with regular meshes,the equivalent truss structure model could describe crack propagation more *** failure probabilities of structures under various loads and boundary conditions had good agreement with the analytical solutions directly solved from the limit state equations expressed in the form of moments.

关键词： crack simulation probability analysis irregular truss structure model failure criteria Monte Carlo simulation

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System reliability analysis of downstream spillways based on collapse of upstream spillways

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International Journal of Agricultural and Biological Engineering 2015年第4期8卷 140-150,I0003页

作者： Won Choi Jeongbae Jeon Jinseon Park JeongJae Lee seongsoo Yoon Department of Rural Systems Engineering College of Agriculture and Life SciencesSeoul National UniversitySeoul 151-921South Korea Department of Agricultural and Rural Engineering College of AgricultureLife and Environments SciencesChungbuk National UniversityChungbuk 362-763South Korea Department of Rural Systems Engineering Research Institute of Agriculture and Life SciencesCollege of Agriculture and Life SciencesSeoul National UniversitySeoul 151-921South Korea

Some agricultural reservoirs in South Korea are vulnerable to situations in which they are unable to function as reservoirs because of essential safety *** is because 70%of existing agricultural reservoirs were originally constructed more than 50 years ago;most of these reservoirs have not been maintained or managed since their initial *** the worst cases,reservoirs are connected to one another by short distances and/or the sizes of upstream reservoirs are larger than the sizes of downstream *** components of the reservoirs,such as their embankments,spillways,and water intake facilities,have been considered in order to understand the main factors associated with potential reservoir ***,this study aims to estimate the probability of failure in downstream spillways upon the collapse of upstream spillways(for reservoirs connected in series).A simple equation to calculate the rise in the water level in downstream spillways,which is caused by the collapse of upstream spillways,was *** equation was based on the discharge equation of an overflowing rectangular weir and the scaling law for continuous *** verify the proposed simple equation,the water level increments were compared with the simulated results of the commercial software FLOW-3D,which is an accurate computational fluid dynamics(CFD)program that is used for tracking free-surface *** values predicted through the simple formula were close to the simulated data(within a maximum prediction error of 5%).The values were updated to reflect the effects of hydraulic pressures on the walls of downstream spillways,thereby allowing the failure probabilities(due to overturning,sliding,and settlement)of the downstream spillways to be *** study found that the failure probabilities of independent components in reservoirs are significantly different from the systematic failure values observed in sequential modes.

关键词： failure probability collapse spillway discharge scaling law FLOW-3D

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Design and Performance Evaluation of Roaming Service base on MIP in Heterogeneous Network

Design and Performance Evaluation of Roaming Service base on...

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The 2004 Joint Conference of the 10～(th) Asia-Pacific Conference on Communications and the 5～(th) International Symposium on Multi-Dimensional Mobile Communications

作者： seongsoo Park New Technology Development Team Network R＆D Center SK Telecom

＜正＞In this paper, we describe the roaming service with mobile IP between public WLAN and cdma2000 1x design, and show the implementation in SK Telecom cellular network. In terms of network configuration, the coverage of public WLAN network is overlapped with that of cellular network. In this configuration, mobile terminal will decide the access system among the available systems. We propose the roaming method based on measuring the power of WLAN signal in heterogeneous network environments, and implement it. In order to confirm the effectiveness of our roaming method, we apply our proposed solution to both seamless roaming service and VOD streaming service.

关键词： Mobile IP(MIP) Seamless Roaming Public WLAN Cellular Network

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BLET:Battery Lifetime Enhancement Technology

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Journal of Measurement Science and Instrumentation 2010年第S1期1卷 15-18页

作者： Yong-Ju Jang seongsoo Lee School of Electronics Engineering Soongsil UniversitySeoulRepublic or Korea

In recent years,mobile devices and high-hearth because of the multifunctional,battery capacity has been *** this paper,without the overhead by using the battery discharge characteristics,and application of technology to extend the battery life is explained. Experiment H.264 video transmission to take some losses and extended battery life was achieved.

关键词： low-power battery lifetime H.264

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Digital FIR filter design for bio-signal processing system

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Journal of Measurement Science and Instrumentation 2013年第1期4卷 94-96页

作者： Woojin Nam guang Yang seongsoo Lee School of Electronic Engineering Soongsil UniversitySeoul 156-743Korea

Recently,real-time processing systems for bio-signal of the muscles generated by the movement of the user have been *** impulse response(FIR)filter for bio-signal processing in bio-signal process systems is composed of multiple multiplier and adder of *** makes the chip area increase *** solve this problem,a low-area digital FIR filter is proposed in this paper,which can reduce the chip area.

关键词：数字FIR滤波器信号处理系统生物信号设计实时处理系统有限脉冲响应芯片面积加法器

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