检索结果-南通市图书馆

Characteristics of Atmospheric Circulation Associated with Cold Surge Occurrences in East Asia:A Case Study During 2005/06 Winter

在线全文

学校读者我要写书评

暂无评论

Advances in Atmospheric Sciences 2008年第5期25卷 791-804页

作者： Tae-won PARK Jee-Hoon JEONG Chang-Hoi HO seong-Joong KIM School of Earth and Environmental Sciences Seoul National University Seoul Korea Department of Earth Sciences University of Gothenburg Gothenburg Sweden Korea Polar Research Institute Incheon Korea

The characteristics of the upper-level circulation and thermodynamical properties for the period when two distinct cold surges broke out over East Asia during the 2005/06 winter are investigated. From early December 2005 to early January 2006, exceptionally cold weather lasted for approximately one month due to two successive cold surges that took place on 2 December 2005 and 2 January 2006, respectively. This study reveals that both involve the upper-tropospheric circulation, which induces the amplification and expansion of the surface Siberian high toward East Asia, but arose from different causes： the former is caused by the upper-level blocking originated from the North Pacific and the latter is caused by the upper-level wave train across the Eurasian Continent. In particular, it is suggested that the lower-tropospheric anomalous wind caused by upper-level circulation anomalies and a steep meridional temperature gradient amplified by phase-locked annual cycle combined to induce very strong cold advection in East Asia, which resulted in exceptionally cold weather that lasted for several weeks. The present results emphasize that the characteristics of the upper-tropospheric circulation can be considered as important precursors to cold surge occurrences in East Asia.

关键词： cold surge Siberian high East Asia East Asian winter monsoon upper-tropospheric circulation

Optimal sequential therapy using tyrosine kinase inhibitors as the first-line treatment in patients with metastatic renal cell carcinoma: A nationwide multicenter study

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Urology 2024年第3期11卷 450-459页

作者： Jung Ki Jo seong Il Seo MinYong Kang Jinsoo Chung Cheol Kwak Sung-Hoo Hong Cheryn Song Jae Young Park Chang Wook Jeong Seok Hwan Choi Sung Han Kim Eu Chang Hwang Chan Ho Lee Hakmin Lee Department of Urology Medical and Digital EngineeringCollege of MedicineHanyang UniversitySeoulRepublic of Korea Department of Urology Samsung Medical CenterSungkyunkwan University School of MedicineSeoulRepublic of Korea Department of Urology National Cancer CenterGoyangRepublic of Korea Department of Urology Seoul National University HospitalSeoulRepublic of Korea Department of Urology Kangnam St Mary’s HospitalSeoulRepublic of Korea Department of Urology Asan Medical CenterSeoulRepublic of Korea Department of Urology Korea University Ansan HospitalAnsanRepublic of Korea Department of Urology Kyungpook National University HospitalDaeguRepublic of Korea Department of Urology Chonnam National University Hwasun HospitalHwasunRepublic of Korea Department of Urology Inje University Busan Paik HospitalBusanRepublic of Korea Department of Urology Seoul National University Bundang HospitalSeongnamRepublic of Korea

Objective:The purpose of the study was to identify the best sequence of therapy beginning with a tyrosine kinase inhibitor(TKI)as the first-line therapy for patients with metastatic renal cell carcinoma(mRCC)in terms of overall survival(OS),progression-free survival(PFS),and rates of discontinuation and adverse effects during the treatment ***:This is a retrospective,nationwide multicenter study of patients with mRCC after diagnosis at 10 different tertiary medical centers in Korea from January 1992 to December *** focused on patients at either“favorable”or“intermediate”risk according to the International mRCC Database Consortium criteria,and they were followed up(median 335 days).Finally,a total of 1409 patients were selected as the study *** generated a Cox proportional hazard model adjusted for covariates,and the different therapy schemes were statistically tested in terms of OS as well as *** addition,frequencies of discontinuation and adverse events were compared among the therapy ***:Of the primary patterns of treatment sequences(24 sequences),“sunitinib epazopanib”and“sunitinibeeverolimuseimmunotherapy”showed the most beneficial results in both OS and PFS with significantly lower hazards than“sunitinib”,which is the most commonly treated agent in *** that the“TKIeTKI”structure showed relatively higher discontinuation rates with higher adverse effects,the overall beneficial sequence would be“sunitinibeeverolimuseimmunotherapy”.Conclusion:Among several sequential therapy starting with TKIs,“sunitinibeeverolimuse immunotherapy”was found to be the best scheme for mRCC patients with“favorable”or“intermediate”risks.

关键词： Tyrosinekinase inhibitor Metastaticrenalcell carcinoma Overall survival Progression-free survival

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

从焦虑到行动

科学新闻 2024年第4期 62-63页

作者： Tae Seok moon 倪伟波美国圣路易斯华盛顿大学

“Tae Seok，你知道该怎么做——让大家安静下来，并把他赶出去。”“他”是我最好的研究生之一，在5年内发表了4篇论文，从美国寄钱给在非洲的家人。但当他在走廊接一个公司的面试电话时，与一位教授发生了冲突。鉴于他的肤色，教授以...

“Tae Seok，你知道该怎么做——让大家安静下来，并把他赶出去。”“他”是我最好的研究生之一，在5年内发表了4篇论文，从美国寄钱给在非洲的家人。但当他在走廊接一个公司的面试电话时，与一位教授发生了冲突。鉴于他的肤色，教授以为他不是学生，于是报了警，警察把他带走了。除了受到侮辱之外，我的学生还因此失去了他梦寐以求的工作。他向学校反歧视办公室投诉——现在学校领导让我解决这件事。我很愤怒，但无能为力。我的终身职位马上就要接受评估了，我觉得没有能力反击。

关键词：

Catalpa bignonioides extract improves exercise performance through regulation of growth and metabolism in skeletal muscles

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Biomedicine 2024年第2期14卷 47-54页

作者： Hoibin Jeong Dong-joo Lee Sung-Pil Kwon SeonJu Park Song-Rae Kim Seung Hyun Kim Jae-Il Park Deug-chan Lee Kyung-Min Choi wonWoo Lee Ji-won Park Bohyun Yun Su-Hyeon Cho Kil-Nam Kim Seoul Center Korea Basic Science InstituteSeoul 02841Republic of Korea Chuncheon Center Korea Basic Science InstituteChuncheon 24341Republic of Korea Research&Development Center Chungdam CDC JNPharm LLC.Chuncheon 24341Republic of Korea Department of Biomedical Technology Kangwon National UniversityChuncheon 24341Republic of Korea Yonsei Institute of Pharmaceutical Sciences College of PharmacyYonsei UniversityIncheon 21983Republic of Korea Gwangju Center Korea Basic Science InstituteGwangju 61751Republic of Korea Honam National Institute of Biological Resources 99Gohadoan-gilMokpo-siJeollanam-do58762Republic of Korea Department of Bio-analysis Science University of Science&TechnologyDaejeon34113Republic of Korea

Objective:To evaluate the effects of Catalpa bignonioides fruit extract on the promotion of muscle growth and muscular capacity in vitro and in ***:Cell viability was measured using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide *** proliferation was assessed using a 5-bromo-2’-deoxyuridine(BrdU)assay *** blot analysis was performed to determine the protein expressions of related *** effects of Catalpa bignonioides extract were investigated in mice using the treadmill exhaustion test and whole-limb grip strength *** composition analysis was performed using high-performance liquid chromatography(HPLC).Results:Catalpa bignonioides extract increased the proliferation of C2C12 mouse myoblasts by activating the Akt/mTOR signaling *** also induced metabolic changes,increasing the number of mitochondria and glucose metabolism by phosphorylating adenosine monophosphate-activated protein *** an in vivo study,the extract-treated mice showed improved motor abilities,such as muscular endurance and grip ***,HPLC analysis showed that vanillic acid may be the main component of the Catalpa bignonioides extract that enhanced muscle ***:Catalpa bignonioides improves exercise performance through regulation of growth and metabolism in skeletal muscles,suggesting its potential as an effective natural agent for improving muscular strength.

关键词： Catalpa bignonioides Skeletal muscle Cell proliferation Mitochondria Energy metabolism C2C12

Gas Sensing Characteristics of SnO_2 Whiskers Prepared from SNC_2O_4

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

稀有金属材料与工程 2006年第A3期35卷 100-103页

作者： Ki-won Kim Pyeong-Seok Cho Jong-Heun Lee seong-Hyeon Hong Department of Materials Science & Engineering Korea UniversitySeoui 136-713Korea School of Materials Science and Engineering and Nano Systems Institute-National Core Research Center Seoul National UniversitySeoul 151-744Korea

SnO_2 whiskers were prepared from the decomposition of whisker-like SnC_2O_4,which was precipitated by a reaction between an aqueous SnCl_2 and oxalic acid solution at high solution temperatures (80℃).After the decomposition of SnC_2O_4 at 450℃,SnO_2 whiskers containing both of rutile and metastable orthorhombic phases were obtained with the content of the orthorhombic phase decreasing with increasing heat-treatment temperature and *** effect of orthorhombic phase upon CO gas sensitivity was investigated by measuring the evolution of the primary particle size and the CO sensitivity with repeating heat treatment at 450℃.The 50μg/g CO sensitivity increased with decreasing concentration of the orthorhombic phase despite particle coarsening,which suggests that the orthorhombic phase is detrimental to the CO gas sensitivity.

关键词： SnO2 whisker orthorhombic phase gas sensor SnC2O4

Performance of a New Ion Source for KSTAR Tokamak Plasma Heating

在线全文

学校读者我要写书评

暂无评论

Plasma Science and Technology 2014年第6期16卷 620-624页

作者： Tae-seong KIM Seung Ho JEONG Doo Hee CHANG Kwang won LEE Sang-Ryul IN Korea Atomic Energy Research Institute

In the experimental campaign of 2010 and 2011 on KSTAR, the NBI-1 system was equipped with one prototype ion source and operated successfully, providing a neutral beam power of 0.7-1.6 MW to the tokamak plasma. The new ion source planned for the 2012 KSTAR campaign had a much more advanced performance compared with the previous one. The target performance of the new ion source was to provide a neutral deuterium beam of 2 MW to the tokamak plasma. The ion source was newly designed, fabricated, and assembled in 2011. The new ion source was then conditioned up to 64 A/100 keV over a 2-hour beam extraction and performance tested at the NB test stand （NBTS） at the Korea Atomic Energy Research Institute （KAERI） in 2012. The measured optimum perveance at which the beam divergence is a minimum was about 2.5μP, and the minimum beam divergent angle was under 1.0° at 60 keV. These results indicate that the 2.0 MW neutral beam power at 100 keV required for the heating of plasma in KSTAR can be delivered by the installation of the new ion source in the KSTAR NBI-1 system.

关键词： NBI ion source KSTAR neutral beam plasma heating positive based ion

Application of response surface method for optimal transfer conditions of multi-layer ceramic capacitor alignment system

在线全文

学校读者我要写书评

暂无评论

Journal of Central South University 2011年第3期18卷 726-730页

作者： PARK Su-seong KIM Jae-min CHUNG won-jee SHIN O-chul School of Mechatronics Changwon National University

The multi-layer ceramic capacitor (MLCC) alignment system aims at the inter-process automation between the first and the second plastic *** a result of testing performance verification of MLCC alignment system,the average alignment rates are 95% for 3216 chip,88.5% for 2012 chip and 90.8% for 3818 *** MLCC alignment system can be accepted for practical use because the average manual alignment is just 80%.In other words,the developed MLCC alignment system has been upgraded to a great extent,compared with manual *** on the successfully developed MLCC alignment system,the optimal transfer conditions have been explored by using *** simulations using ADAMS has been performed according to the cube model of *** using MiniTAB,the model of response surface has been established based on the simulation *** optimal conditions resulted from the response optimization tool of MiniTAB has been verified by being assigned to the prototype of MLCC alignment system.

关键词： multi-layer ceramic capacitor (MLCC) alignment system response surface method (RSM) MiniTAB ADAMS

The change of anterior segment parameters after cataract surgery in normal-tension glaucoma

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2017年第8期10卷 1239-1245页

作者： wonseok Lee Hyoung won Bae Chart Yun Kim Gong Je seong Institute of Vision Research Department of OphthalmologYonsei University College of Medicine Seou103722 Korea

AIM： To investigate the change of anterior chamber angle morphology and intraocular pressure （lOP） reduction after cataract surgery in patients with normal-tension glaucoma （NTG） using swept-source optical coherence tomography （SS-OCT）. METHODS： This prospective, comparative, observational study recruited patients into two groups. Group 1 was the control group including normal subjects except those with cataracts （cataract group, n=67 eyes of 67 patients）, and group 2 was NTG group including patients who were diagnosed with NTG and cataracts （n=43 eyes of 43 patients）, which were treated with phacoemulsification and intraocular lens implantation. Before surgery, and at postoperative 1 and 6too, anterior chamber angles were evaluated by SS-OCT under dark conditions using three- dimensional angle analysis scan protocol. Angle opening distance （AOD）, angle recess area （ARA）, and trabecular- iris surface area （TISA） at four quadrants （temporal, nasal, superior, and inferior） were calculated automatically by SS-OGT, after the observer marked scleral spurs. RESULTS： A total of 106 patients （54 males and 52 females） were enrolled in the study. Angle parameters, AOD, ARA, and TISA were increased after surgery in both groups. However, changes of angle parameters were only significant in group 2. In group 2, preoperative lOP was 13.2＋2.9 mm Hg, and postoperative lOP at 1 and 6mo were 10.5＋3.0 and 10.7＋2.8 mm Hg, respectively. In group 1, preoperative lOP was 12.42.8 mm Hg, and postoperative lOP at 1 and 6mo were 11.6＋2.5 and 12.0＋2.8 mm Hg, respectively. After cataract surgery, angle parameters changed significantly while IOP significantly reduced and was maintained in group 2 （P〈0.001）. The changes in angle parameters （＆AOD500, ATISAS00 at temporal; ＆AOD500, S, RA500 at nasal） were linearly correlated with postoperative IOP changes. CONCLUSION： Cataract surgery may have improved antedor chamber angle parameters and decreased lOP in NTG patients.

关键词： normal-tension glaucoma cataract surgery intraocular pressure reduction swept-source optical coherence tomography angle parameters

Generation and Control of Game Virtual Environment

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Automation and computing 2007年第1期4卷 25-29页

作者： Myeong won Lee Jae moon Lee Department of Internet Information Engineering The University of SuwonGyeonggi-do 445-743Korea Department of Computers The University of SuwonGyeonggi-do 445-743Korea

In this paper, we present a framework for the generation and control of an Internet-based 3-dimensional game virtual environment that allows a character to navigate through the environment. Our framework includes 3-dimensional terrain mesh data processing, a map editor, scene processing, collision processing, and walkthrough control. We also define an environment-specific semantic information editor, which can be applied using specific location obtained from the real world. Users can insert text information related to the characters real position in the real world during navigation in the game virtual environment.

关键词： Virtual environment virtual reality 3D game 3D navigation 3D scene management.