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Enhanced intestinal lymphatic absorption of saquinavir through supersaturated self-microemulsifying drug delivery systems

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Asian Journal of Pharmaceutical Sciences 2020年第3期15卷 336-346页

作者： Kanghee Jo Hyeongmin Kim Prakash Khadka Taejun Jang Soo Jin Kim seong-ha hwang Jaehwi Lee College of Pharmacy Chung-Ang UniversitySeoul 06974Republic of Korea

The therapeutic potential of saquinavir, a specific inhibitor of human immunodeficiency virus(HIV)-1 and HIV-2 protease enzymes, has been largely limited because of a low solubility and consequnt low bioavailability. Thus, we aimed to design a supersaturated selfmicroemulsifying drug delivery system(S-SMEDDS) that can maintain a high concentration of saquinavir in gastro-intestinal fluid thorugh inhibiting the drug precipitation to enhance the lymphatic transport of saquinavir and to increase the bioavailability of saquinavir considerably. Solubilizing capacity of different oils, surfactants, and cosurfactants for saquinavir was evaluated to select optimal ingredients for preparation of *** the construction of pseudo-ternary phase diagram, SMEDDS formulations were established. A polymer as a precipitation inhibitor was selected based on its viscosity and drug precipitation inhibiting capacity. The S-SMEDDS and SMEDDS designed were administered at an equal dose to rats. At predetermined time points, levels of saquinavir in lymph collected from the rats were assessed. SMEDDS prepared presented a proper selfmicroemulsification efficiency and dispersion stability. The S-SMEDDS fabricated using the SMEDDS and hydroxypropyl methyl cellulose 2910 as a precipitation inhibitor exhibited a signficantly enhanced solubilizing capacity for saquinavir. The drug concentration in a simulated intestinal fluid evaluated with the S-SMEDDS was also maintained at higher levels for prolonged time than that examined with the SMEDDS. The S-SMEDDS showed a considerably enhanced lymphatic absoprtion of saquinavir in rats compared to the ***, the S-SMEDDS would be usefully exploited to enhance the lymphatic absorption of hydrophobic drugs that need to be targeted to the lymphatic system.

关键词： Lymphatic drug delivery Self-microemulsifying drug delivery system Saquinavir Precipitation inhibitor Supersaturation Lipid-based formulation

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Acoustofluidic separation of prolate and spherical micro-objects

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Microsystems & Nanoengineering 2024年第1期10卷 217-230页

作者： Muhammad Soban Khan Mushtaq Ali Song ha Lee Keun Young Jang seong Jae Lee Jinsoo Park Department of Mechanical Engineering Chonnam National University77 Yongbong-roBuk-guGwangju 61186Republic of Korea Department of Polymer Engineering The University of Suwon17 Wauan-gilBongdam-eupHwaseongGyeonggi 18323Republic of Korea

Most microfluidic separation techniques rely largely on object size as a separation *** ability to separate micro-objects based on their shape is crucial in various biomedical and chemical ***,we develop an ondemand,label-free acoustofluidic method to separate prolate ellipsoids from spherical microparticles based on traveling surface acoustic wave-induced acoustic radiation force and *** freely rotating non-spherical microobjects were aligned under the progressive acoustic field by the counterrotating radiation torque,and the major axis of the prolate ellipsoids was parallel to the progressive wave *** specific alignment of the ellipsoidal particles resulted in a reduction in the cross-sectional area perpendicular to the wave *** a consequence,the acoustic backscattering decreased,resulting in a decreased magnitude of the radiation *** the variation in radiation force,which depended on the micro-object morphology enabled the acoustofluidic shape-based *** conducted numerical simulations for the wave scattering of spherical and prolate objects to elucidate the working mechanism underlying the proposed method.A series of experiments with polystyrene microspheres,prolate ellipsoids,and peanut-shaped microparticles were performed for *** quantitative analysis of the separation efficiency,we confirmed the high purity and high recovery rate of the proposed acoustofluidic shapebased separation of *** a bioparticle,we utilize Thalassiosira eccentrica to perform shape-based separation,as the species has a variety of potential applications in drug delivery,biosensing,nanofabrication,bioencapsulation and immunoisolation.

关键词： separation spherical rotating

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Vertical plane depth-resolved surface potential and carrier separation characteristics in flexible CZTSSe solar cells with over 12% efficiency

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Carbon Energy 2024年第3期6卷 36-52页

作者： Dae-Ho Son ha Kyung Park Dae-Hwan Kim Jin-Kyu Kang Shi-Joon Sung Dae-Kue hwang Jaebaek Lee Dong-Hwan Jeon Yunae Cho William Jo Taeseon Lee JunHo Kim Sang-Hoon Nam Kee-Jeong Yang Division of Energy Technology DGISTDaeguRepublic of Korea Research Center for Thin Film Solar Cells DGISTDaeguRepublic of Korea Department of Physics Ewha Womans UniversitySeoulRepublic of Korea Department of Physics Incheon National UniversityIncheonRepublic of Korea Department of Mechanical Engineering Massachusetts Institute of TechnologyCambridgeMassachusettsUSA

Cu2ZnSn(S,Se)4(CZTSSe)solar cells have resource distribution and economic *** main cause of their low efficiency is carrier loss resulting from recombination of photo-generated electron and *** overcome this,it is important to understand their electron-hole behavior *** determine the carrier separation characteristics,we measured the surface potential and the local current in terms of the absorber *** elemental variation in the intragrains(IGs)and at the grain boundaries(GBs)caused a band edge shift and bandgap(Eg)*** the absorber surface and subsurface,an upward Ec and Ev band bending structure was observed at the GBs,and the carrier separation was *** the absorber center,both upward Ec and Ev and downward Ec-upward Ev band bending structures were observed at the GBs,and the carrier separation was *** improve the carrier separation and suppress carrier recombination,an upward Ec and Ev band bending structure at the GBs is desirable.

关键词： carrier separation CZTSSe flexible solar cell local current surface potential

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Generation of double knockout cattle via CRISPR-Cas9 ribonucleoprotein(RNP)electroporation

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Journal of Animal Science and Biotechnology 2024年第1期15卷 456-462页

作者： Gyeong-Min Gim Kyeong-Hyeon Eom Dong-Hyeok Kwon Dae-Jin Jung Dae-Hyun Kim Jun-Koo Yi Jae-Jung ha Ji-Hyun Lee seong-Beom Lee Woo-Jae Son Soo-Young Yum Won-Wu Lee Goo Jang Laboratory of Theriogenology and Biotechnology Department of Veterinary Clinical ScienceCollege of Veterinary Medicine and the Research Institute of Veterinary ScienceSeoul National UniversitySeoulRepublic of Korea LARTBio Co. Ltd.SeoulRepublic of Korea Gyeongsangbukdo Livestock Research Institute YeongjuRepublic of Korea Comparative Medicine Disease Research Center Seoul National UniversitySeoulRepublic of Korea

Background Genome editing has been considered as powerful tool in agricultural ***,genome editing progress in cattle has not been fast as in other mammal species,for some disadvantages including long gestational periods,single pregnancy,and high raising ***,technically demanding methods such as microinjection and somatic cell nuclear transfer(SCNT)are needed for gene editing in *** this point of view,electroporation in embryos has been risen as an *** First,editing efficiency of our electroporation methods were tested for *** of mutation on embryo was confirmed by T7E1 *** first combination,mutation rates for MSTN and PRNP were 57.6%±13.7%and 54.6%±13.5%,*** case of MSTN/BLG,mutation rates were 83.9%±23.6%for MSTN,84.5%±18.0%for ***,the double-KO embryos were transferred to surrogates and mutation rate was identified in resultant calves by targeted deep *** recipients were transferred for MSTN/PRNP,4 calves were delivered,and one calf underwent an induction for double *** surrogates were given double-KO embryos for MSTN/BLG,and four of the six calves that were born had mutations in both *** These data demonstrated that production of genome edited cattle via electroporation of RNP could be effectively ***,MSTN and PRNP from beef cattle and MSTN and BLG from dairy cattle have been born and they will be valuable resources for future precision breeding.

关键词： Beta-lactoglobulin Cattle CRISPR-Cas9 Electroporation Knockout MSTN PRNP

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Neural Wiskott-Aldrich syndrome protein(N-WASP)promotes distant metastasis in pancreatic ductal adenocarcinoma via activation of LOXL2

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Oncology Research 2024年第4期32卷 615-624页

作者： HYUNG SUN KIM YUN SUN LEE SEUNG MYUNG DONG HYO JUNG KIM DA EUN LEE HYEON WOONG KANG MYEONG JIN KIM JOON seong PARK Department of Surgery Gangnam Severance HospitalYonsei University College of MedicineSeoulKorea Department of Surgery Graduate School of Medical ScienceBrain Korea 21 ProjectYonsei University College of MedicineSeoulKorea Gibiome Co. Ltd.Gyeonggi-doKorea

Pancreatic ductal adenocarcinoma(PDAC)is one of the most aggressive solid malignancies.A specific mechanism of its metastasis has not been *** this study,we investigated whether Neural Wiskott-Aldrich syndrome protein(N-WASP)plays a role in distant metastasis of *** found that N-WASP is markedly expressed in clinical patients with *** analysis showed a notably more distant metastatic pattern in the N-WASP-high group compared to the N-WASP-low group.N-WASP was noted to be a novel mediator of epithelialmesenchymal transition(EMT)via gene expression profile *** of N-WASP in pancreatic cancer cells significantly inhibited cell invasion,migration,and *** also observed positive association of lysyl oxidase-like 2(LOXL2)and focal adhesion kinase(FAK)with the N-WASP-mediated response,wherein EMT and invadopodia function were *** N-WASP and LOXL2 depletion significantly reduced the incidence of liver and lung metastatic lesions in orthotopic mouse models of pancreatic *** results elucidate a novel role for N-WASP signaling associated with LOXL2 in EMT and invadopodia function,with respect to regulation of intercellular communication in tumor cells for promoting pancreatic cancer *** findings may aid in the development of therapeutic strategies against pancreatic cancer.

关键词： Pancreatic cancer Neural Wiskott-Aldrich syndrome protein(N-WASP)signaling Metastasis Epithelial-mesenchymal transition(EMT) Lysyl oxidase-like 2(LOXL2)

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Automated Service Search Model for the Social Internet of Things

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Computers, Materials & Continua 2022年第9期72卷 5871-5888页

作者： Farhan Amin seong Oun hwang Department of Computer Engineering Gachon UniversitySeongnam13120Korea

The social internet of things(SIoT)is one of the emerging paradigms that was proposed to solve the problems of network service discovery,navigability,and service *** SIoT aims to socialize the IoT devices and shape the interconnection between them into social interaction just like human *** IoT,an object can offer multiple services and different objects can offer the same services with different parameters and interest *** proliferation of offered services led to difficulties during service customization and service *** problem is known as service *** selection of suitable service that fits the requirements of applications and objects is a challenging *** address these issues,we propose an efficient automated query-based service search model based on the local network navigability concept for the *** the proposed model,objects can use information from their friends or friends of their friends while searching for the desired services,rather than exploring a global *** employ a centrality metric that computes the degree of importance for each object in the social IoT that helps in selecting neighboring objects with high centrality *** distributed nature of our navigation model results in high scalability and short navigation *** verified the efficacy of our model on a real-world SIoT-related *** experimental results confirm the validity of our model in terms of scalability,navigability,and the desired objects that provide services are determined quickly via the shortest path,which in return improves the service search process in the SIoT.

关键词： Social internet of things service discovery local navigability object discovery query generation model

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A probabilistic model of quantum states for classical data security

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Frontiers of physics 2023年第5期18卷 281-292页

作者： Muhammad Waseem hafiz seong Oun hwang Department of IT Convergence Engineering Gachon UniversitySeongnam 13120South Korea Department of Computer Engineering Gachon UniversitySeongnam 13120South Korea

The phenomenal progress of quantum information theory over the last decade has substantially broadened the potential to simulate the superposition of states for exponential speedup of quantum algorithms over their classical ***,the conventional and modern cryptographic standards(encryption and authentication)are susceptible to Shor’s and Grover’s algorithms on quantum *** significant improvement in technology permits consummate levels of data protection by encoding classical data into small quantum states that can only be utilized once by leveraging the capabilities of quantum-assisted classical *** the frequent data breaches and increasingly stringent privacy legislation,we introduce a hybrid quantum-classical model to transform classical data into unclonable states,and we experimentally demonstrate perfect state transfer to exemplify the classical *** alleviate implementation complexity,we propose an arbitrary quantum signature scheme that does not require the establishment of entangled states to authenticate users in order to transmit and receive arbitrated states to retrieve classical *** consequences of the probabilistic model indicate that the quantum-assisted classical framework substantially enhances the performance and security of digital data,and paves the way toward real-world applications.

关键词： information security quantum-classical cryptography quantum information processing quantum spin states spin-1/2 algebra user authentication

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An Enhanced Privacy Preserving, Secure and Efficient Authentication Protocol for VANET

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Computers, Materials & Continua 2022年第5期71卷 3703-3719页

作者： Safiullah Khan Ali Raza seong Oun hwang Department of IT Convergence Engineering Gachon UniversitySeongnam13320Korea ENSAIT GEMTEX-Laboratoire de Genie et Materiaux TextilesUniversity of LilleLilleF59000France School of Computing&Institute of Cyber Security(ICSS) University of KentUnited Kingdom Department of Computer Engineering Gachon UniversitySeongnam13320Korea

Vehicular ad hoc networks (VANETs) have attracted growing interest in both academia and industry because they can provide a viable solutionthat improves road safety and comfort for travelers on roads. However, wireless communications over open-access environments face many security andprivacy issues that may affect deployment of large-scale VANETs. Researchershave proposed different protocols to address security and privacy issues in aVANET, and in this study we cryptanalyze some of the privacy preservingprotocols to show that all existing protocols are vulnerable to the Sybilattack. The Sybil attack can be used by malicious actors to create fakeidentities that impair existing protocols, which allows them to imitate trafficcongestion or at worse cause an accident that may result in the loss of humanlife. This vulnerability exists because those protocols store vehicle identitiesin an encrypted form, and it is not possible to search over the encryptedidentities to find fake vehicles. This attack is serious in nature and veryprevalent for privacy-preserving protocols. To cope with this kind of attack,we propose a novel and practical protocol that uses Public key encryptionwith an equality test (PKEET) to search over the encrypted identities withoutleaking any information, and eventually eliminate the Sybil attack. Theproposed approach improves security and at the same time maintains privacyin VANET. Our performance analysis indicates that the proposed protocoloutperforms state-of-the-art protocols: The proposed beacon generation timeis constant compared to a linear increase in existing protocols, with beaconverification shown to be faster by 7.908%. Our communicational analysisshows that the proposed protocol with a beacon size of 322 bytes has the leastcommunicational overhead compared to other state-of-the-art protocols.

关键词： VANET authentication protocol cryptanalysis privacy preserving intelligent systems

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Amine functionalization on thermal and mechanical behaviors of graphite nanofibers-loaded epoxy composites

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Journal of Materials Science & Technology 2023年第20期151卷 80-88页

作者： seong-hwang Kim Sang-Jin Park Seul-Yi Lee Soo-Jin Park Department of Chemistry Inha University100 InharoIncheon 22212the Republic of Korea

With the growing demand for faster and more powerful computing,effective heat dissipation is essential to ensure the longevity,reliability,and high performance of electronic *** the field of modern electronic packaging materials,there is a great need for graphitic material-loaded polymeric composites(GPCs)with excellent thermal ***,the enhancement efficiency of GPCs is hindered by the agglomeration of fillers and the interfacial thermal resistance caused by the lack of continuous thermally conductive pathways between the filler and *** the interfaces between filler and matrix is of great importance in optimizing the performances of ***,we fabricated graphite nanofibers(GNF)-loaded nanocomposites using acid-functionalized GNF(AGNF)and acidtetraethylenepentamine-functionalized(TGNF)as a filler and epoxy resin as a matrix with different GNF loading contents to explore the interfacial properties of the *** optimal GNF loading for AGNF was 0.5 wt.%,while the TGNF showed 0.75 wt.%.The highest thermal conductivity(0.51 W m^(−1) K^(−1))and fracture toughness(25.8 MPa m^(1/2))values were found in the TGNF-loaded nanocomposites with a fraction of 0.75 wt.%,representing enhancements of∼145%and∼400%,respectively,compared to those of neat *** experimental data presented herein demonstrate that the interfacial properties play a significant role in enhancing the thermal and mechanical performances of the *** present approach is expected to serve as a valuable tool in the design of conductive polymeric nanocomposites for further practical applications,such as thermal interface materials and packaging of high-power electric devices.

关键词： Graphite nanofiber Nanocomposites Interfacial interaction Thermal conductivity Fracture resistance

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Management of symptomatic cervical facet cyst with cervical interlaminar epidural block: A case report

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World Journal of Clinical Cases 2022年第32期10卷 11936-11941页

作者： seong Min hwang Min Kyu Lee Saeyoung Kim Department of Anesthesiology and Pain Medicine School of MedicineKyungpook National UniversityDaegu 41944South Korea

BACKGROUND Symptomatic cervical facet cysts are relatively rare compared to those in the lumbar *** cysts are usually located in the 7th cervical and 1st thoracic vertebral(C7/T1)area,and surgical excision is performed in most ***,facet cysts are associated with degenerative conditions,and elderly patients are often ineligible for surgical *** interlaminar epidural block has been used in patients with cervical radiating symptoms and achieved good ***,cervical interlaminar epidural block may be the first-choice treatment for symptomatic cervical facet *** SUMMARY A 70-year-old man complained of a tingling sensation in the left hand,focused on the 4th and 5th fingers,for 1 year,and posterior neck pain for over 5 *** patient’s numeric rating scale(NRS)score was 5/*** patient was diagnosed with symptomatic cervical facet cyst at the left C7/T1 facet *** cervical interlaminar epidural block at the C7/T1 level with 20 mg triamcinolone and 5 mL of 0.5%lidocaine was *** patient's symptoms improved immediately after the block,with an NRS score of 3 *** 3 mo,his left posterior neck pain and tingling along the left 8th cervical dermatome were relieved,with an NRS score of *** A cervical interlaminar epidural block is a good alternative for managing symptomatic cervical facet cysts.

关键词： Cervical vertebrae Cysts Epidural Injections Neck pain Therapeutics Zygapophyseal joint Case report

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