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PD-1 blockade-unresponsive human tumor-infiltrating CD8^(+)T cells are marked by loss of CD28 expression and rescued by IL-15

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Cellular & Molecular Immunology 2021年第2期18卷 385-397页

作者： Kyung Hwan Kim Hong Kwan Kim Hyung-Don Kim Chang Gon Kim Hoyoung Lee Ji Won Han seong jin choi seongju Jeong Minwoo Jeon Hyunglae Kim Jiae Koh Bo Mi Ku Su-Hyung Park Myung-Ju Ahn Eui-Cheol Shin Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and TechnologyDaejeonRepublic of Korea Department of Thoracic and Cardiovascular Surgery Samsung Medical CenterSungkyunkwan University School of MedicineSeoulRepublic of Korea Biomedical Science and Engineering Interdisciplinary Program Korea Advanced Institute of Science and TechnologyDaejeonRepublic of Korea Research Institute for Future Medicine Samsung Medical CenterSungkyunkwan University School of MedicineSeoulRepublic of Korea Department of Radiation Oncology Yonsei Cancer CenterYonsei University College of MedicineSeoulRepublic of Korea Division of Hematology-Oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoulRepublic of Korea

Blockade of programmed death-1(PD-1)reinvigorates exhausted CD8^(+)T cells,resulting in tumor regression in cancer ***,reinvigoration of exhausted CD8^(+)T cells following PD-1 blockade was shown to be CD28-dependent in mouse ***,we examined the role of CD28 in anti-PD-1 antibody-induced human T cell reinvigoration using tumor-infiltrating CD8^(+)T cells(CD8^(+)TILs)obtained from non-small-cell lung cancer ***-cell analysis demonstrated a distinct expression pattern of CD28 between mouse and human CD8^(+)***,we found that human CD28^(+)CD8^(+)but not CD28^(–)CD8^(+)TILs responded to PD-1 blockade irrespective of B7/CD28 blockade,indicating that CD28 costimulation in human CD8^(+)TILs is dispensable for PD-1 blockade-induced reinvigoration and that loss of CD28 expression serves as a marker of anti-PD-1 antibody-unresponsive CD8^(+)*** and phenotypically,PD-1 blockade-unresponsive human CD28^(–)PD-1^(+)CD8^(+)TILs exhibited characteristics of terminally exhausted CD8^(+)T cells with low TCF1 ***,CD28^(–)PD-1^(+)CD8^(+)TILs had preserved machinery to respond to IL-15,and IL-15 treatment enhanced the proliferation of CD28^(–)PD-1^(+)CD8^(+)TILs as well as CD28^(+)PD-1^(+)CD8^(+)*** together,these results show that loss of CD28 expression is a marker of PD-1 blockade-unresponsive human CD8^(+)TILs with a TCF1–signature and provide mechanistic insights into combining IL-15 with anti-PD-1 antibodies.

关键词： anti-PD-1 T cells TCF1 CD28 IL-15

High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki Kim Bum Jun Kim Seungyon Koh Hyo jin Cho Xuelian jin Byung Gon Kim Jun Young choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

Assembly of charged aerosols on non-conducting substrates via ion-assisted aerosol lithography （IAAL）

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Particuology 2017年第4期15卷 17-23页

作者： Seunghyon Kang Wooik Jung Dae seong Kim Sei jin Park Mansoo choi School of Mechanical and Aerospace Engineering Seoul National University Seou 108826 Republic of Korea Global Frontier Center for Multiscale Energy Systems Seoul National University Seou108826 Republic of Korea

The development of ion-assisted aerosol lithography （IAAL） has enabled fabrication of complex three- dimensional nanoparticle （NP） structures on conducting substrates. In this work, the applicability of the IAAL technique was investigated on non-conducting substrates. The NP structure growth process on a non-conducting substrate was found to self-terminate and the structures subsequently repel incoming charged NPs and scatter them away. Electric field calculations supported the experimental findings and confirmed that the electric field distortions owing to charge build-up within the structures prevented additional NP deposition thereon. To regulate the charge build-up without compromising the number of NPs available for assembly, a corona discharger and an ion trap were implemented. By varying the number of ions available in the assembly process, an optimum level of ion injection was found that allowed for a prolonged （〉120 rain） assembly of NP structures on non-conducting substrates without the unwanted scattering of NPs.

关键词： Nanoparticle assembly Non-conducting substrate Ion-assisted aerosol lithography Ion trap

Monolayer Graphitic Carbon Nitride as Metal-Free Catalyst with Enhanced Performance in Photo- and Electro-Catalysis

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Nano-Micro Letters 2022年第3期14卷 308-321页

作者： Huiyan Piao Goeun choi Xiaoyan jin seong‑Ju Hwang Young Jae Song Sung‑Pyo Cho jin‑Ho Choy Intelligent Nanohybrid Materials Laboratory(INML) Institute of Tissue Regeneration Engineering(ITREN)Dankook UniversityCheonan 31116Republic of Korea College of Science and Technology Dankook UniversityCheonan 31116Republic of Korea Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center for Regenerative Medicine Dankook UniversityCheonan 31116Republic of Korea Department of Materials Science and Engineering College of EngineeringYonsei UniversitySeoul 03722Republic of Korea SKKU Advanced Institute of Nanotechnology(SAINT) Sungkyunkwan University(SKKU)Suwon 440‑746Republic of Korea Department of Nano Engineering Sungkyunkwan University(SKKU)Suwon 440‑746Republic of Korea National Center for Inter‑University Research Facilities(NCIRF) Seoul National UniversitySeoul 08826Republic of Korea Graphene Research Center Advanced Institute of Convergence TechnologySuwon 16229Republic of Korea Department of Pre‑Medical Course College of MedicineDankook UniversityCheonan 31116Republic of Korea Tokyo Tech World Research Hub Initiative(WRHI) Institute of Innovative ResearchTokyo Institute of TechnologyYokohama 226‑8503Japan

The exfoliation of bulk graphitic carbon nitride(g-C_(3)N_(4))into monolayer has been intensively studied to induce maximum sur-face area for fundamental studies,but ended in failure to realize chemi-cally and physically well-defined monolayer of g-C_(3)N_(4)mostly due to the difficulty in reducing the layer thickness down to an atomic *** has,therefore,remained as a challenging issue in two-dimensional(2D)chemistry and physics *** this study,an“atomic monolayer of g-C_(3)N_(4)with perfect two-dimensional limit”was successfully prepared by the chemically well-defined two-step *** atomically resolved monolayer of g-C_(3)N_(4)was also confirmed by spectroscopic and micro-scopic *** addition,the experimental Cs-HRTEM image was collected,for the first time,which was in excellent agreement with the theoretically simulated;the evidence of monolayer of g-C_(3)N_(4)in the perfect 2D limit becomes now clear from the HRTEM image of orderly hexagonal symmetry with a cavity formed by encirclement of three adjacent heptazine *** to bulk g-C_(3)N_(4),the present g-C_(3)N_(4)monolayer showed significantly higher photocatalytic gen-eration of H2O2 and H2,and electrocatalytic oxygen reduction *** addition,its photocatalytic efficiency for H2O2 production was found to be the best for any known g-C_(3)N_(4)nanomaterials,underscoring the remarkable advantage of monolayer formation in optimizing the catalyst performance of g-C_(3)N_(4).

关键词： Graphitic carbon nitride Monolayer Atomic image Electro-and photo-catalysis

Sulfur-doped hard carbon hybrid anodes with dual lithium-ion/metal storage bifunctionality for high-energy-density lithium-ion batteries

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Carbon Energy 2023年第1期5卷 71-81页

作者： Sungmin Cho Jong Chan Hyun Son Ha Yeonhua choi Honggyu seong Jaewon choi Hyoung-Joon jin Young Soo Yun Program in Environmental and Polymer Engineering Inha UniversityIncheonSouth Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoulSouth Korea Departmant of Chemistry and Research Institute of Natural Science Gyeongsang National UniversityJinjuSouth Korea Department of Polymer Science and Engineering Inha UniversityIncheonSouth Korea Division of Energy Engineering Kangwon National UniversityGangwon-doSouth Korea

Bifunctional hybrid anodes(BHAs),which are both a high-performance active host material for lithium-ion storage as well as a guiding agent for homogeneous lithium metal nucleation and growth,exhibit significant potential as anodes for next-generation high-energy-density lithium-ion batteries(LIBs).In this study,sulfur-doped hard carbon nanosphere assemblies(S-HCNAs)were prepared through a hydrothermal treatment of a liquid organic precursor,followed by high-temperature thermal annealing with elemental sulfur for application as BHAs for *** a carbonate-based electrolyte containing fluoroethylene carbonate additive,the S-HCNAs showed high lithium-ion storage capacities in sloping as well as plateau voltage sections,good rate capabilities,and stable *** addition,high average Coulombic efficiencies(CEs)of~96.9%were achieved for dual lithium-ion and lithium metal storage *** the LIB full-cell tests with typical NCM811 cathodes,the S-HCNA-based BHAs containing~400 mA h g^(−1) of excess lithium led to high energy and power densities of~500Wh kg^(−1) and~1695Wkg^(−1),respectively,and a stable cycling performance with~100%CEs was achieved.

关键词： hard carbon hybrid anode lithium-ion batteries lithium metal anode lithium metal batteries sulfur-doped carbon

Analysis of liver metastasis after resection for pancreatic ductal adenocarcinoma

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World Journal of Gastrointestinal Oncology 2012年第5期4卷 109-114页

作者： Kwang Yeol Paik seong Ho choi jin Seok Heo Dong Wook choi Department of Surgery Yeouido St.Mary's HospitalCatholic UniversityCollege of Medicine# 62 Yeouido-dongYeongdeungpo-gu150-713 SeoulSouth Korea Department of Surgery Samsung Medical CenterSungkyunkwan University School of Medicine135-710 SeoulSouth Korea

AIM:To investigate the risk factors affecting the liver metastasis(LM) of pancreatic ductal adenocarcinoma(PDAC) after ***:We retrospectively analyzed 101 PDAC patients who underwent surgical resection at the Samsung Medical Center between January 2000 and December *** one patients with LM were analyzed for the time of metastasis,prognostic factors affecting LM,and ***:LM was found in 40.6%.The median time of the LM(n = 41) was 6.0 ± 4.6 mo and most LM occurred within 1 *** univariate analysis,tumor size,preoperative carbohydrate antigen 19-9,and perineural invasion were factors affecting LM after *** multivariate analysis,tumor size was the most important factor for *** univariate analysis,tumor cell differentiation was significant to LM in low-risk ***:LM after resection of PDAC occurs early and shows poor *** size is the key indicator for LM after resection.

关键词： Pancreatic ductal adenocarcinoma Liver metastasis Recurrence

Multiplexed DNA-functionalized graphene sensor with artificial intelligence-based discrimination performance for analyzing chemical vapor compositions

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Microsystems & Nanoengineering 2023年第2期9卷 113-125页

作者： Yun Ji Hwang Heejin Yu Gilho Lee Iman Shackery jin seong Youngmo Jung Seung-Hyun Sung Jongeun choi seong Chan Jun School of Mechanical Engineering Yonsei University500Yonsei-roSeodaemun-guSeoul 03722Republic of Korea

This study presents a new technology that can detect and discriminate individual chemical vapors to determine the chemical vapor composition of mixed chemical composition in situ based on a multiplexed DNA-functionalized graphene(MDFG)nanoelectrode without the need to condense the original vapor or target *** the best of our knowledge,our artificial intelligence(Al)-operated arrayed electrodes were capable of identifying the compositions of mixed chemical gases with a mixed ratio in the early *** innovative technology comprised an optimized combination of nanodeposited arrayed electrodes and artificial intelligence techniques with advanced sensing capabilities that could operate within biological limits,resulting in the verification of mixed vapor chemical *** selective sensors that are tolerant to high humidity levels provide a target for"breath chemovapor fingerprinting"for the early diagnosis of *** feature selection analysis achieved recognition rates of 99%and above under low-humidity conditions and 98%and above under humid conditions for mixed chemical *** 1D convolutional neural network analysis performed better,discriminating the compositional state of chemical vapor under low-and high-humidity conditions almost *** study provides a basis for the use of a multiplexed DNA-functionalized graphene gas sensor array and artificial intelligence-based discrimination of chemical vapor compositions in breath analysis applications.

关键词： humidity functional intelligence

Patterning of Metal Halide Perovskite Thin Films and Functional Layers for Optoelectronic Applications

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Nano-Micro Letters 2023年第10期15卷 494-513页

作者： jin‑Wook Lee seong Min Kang Department of Nano Engineering and Department of Nano Science and Technology SKKU Advanced Institute of Nanotechnology(SAINT)Sungkyunkwan UniversitySuwonRepublic of Korea SKKU Institute of Energy Science and Technology(SIEST) Sungkyunkwan UniversitySuwonRepublic of Korea Department of Mechanical Engineering Chungnam National UniversityDaejeon 34134Republic of Korea

In recent years,metal halide perovskites have received significant attention as materials for next-generation optoelectronic devices owing to their excellent optoelectronic *** unprecedented rapid evolution in the device performance has been achieved by gaining an advanced understanding of the composition,crystal growth,and defect engineering of *** device performances approach their theoretical limits,effective optical management becomes essential for achieving higher *** this review,we discuss the status and perspectives of nano to micron-scale patterning methods for the optical management of perovskite optoelectronic *** initially discuss the importance of effective light harvesting and light outcoupling via optical ***,the recent progress in various patterning/texturing techniques applied to perovskite optoelectronic devices is summarized by categorizing them into top-down and bottom-up ***,we discuss the perspectives of advanced patterning/texturing technologies for the development and commercialization of perovskite optoelectronic devices.

关键词： Perovskites Optoelectronics Light outcoupling Light harvesting Patterning

Moth-eye Structured Polydimethylsiloxane Films for High-Efficiency Perovskite Solar Cells

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Nano-Micro Letters 2019年第3期11卷 271-280页

作者： Mincheol Kim Segeun Jang Jiwoo choi seong Min Kang Mansoo choi Global Frontier Center for Multiscale Energy Systems Seoul National UniversitySeoul151.744Republic of Korea Department of Mechanical and Aerospace Engineering Seoul National UniversitySeoul151.744Republic of Korea Department of Mechanical Engineering Hanbat National UniversityDaejeon34158Republic of Korea Department of Mechanical Engineering Chungnam National UniversityDaejeon34134Republic of Korea

Large-area polydimethylsiloxane(PDMS)films with variably sized moth-eye structures were fabricated to improve the efficiency of perovskite solar *** approach that incorporated photolithography,bilayer PDMS deposition and replication was used in the fabrication *** simply attaching the moth-eye PDMS films to the transparent substrates of perovskite solar cells,the optical properties of the devices could be tuned by changing the size of the moth-eye *** device with 300-nm moth-eye PDMS films greatly enhanced power conversion efficiency of ~21 % due to the antireflective effect of the moth-eye ***,beautiful coloration was observed on the 1000-nm moth-eye PDMS films through optical interference caused by the diffraction grating *** results imply that moth-eye PDMS films can greatly enhance the efficiency of perovskite solar cells and building-integrated photovoltaics.

关键词： Polydimethylsiloxane films Moth-eye Photolithography Perovskite solar cells Photovoltaic