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Traumatic axonal injury of the cingulum in patients with mild traumatic brain injury: a diffusion tensor tractography study

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Neural Regeneration Research 2019年第9期14卷 1556-1561页

作者： Sung ho Jang seong ho Kim Han Do Lee Department of Physical Medicine and Rehabilitation College of MedicineYeungnam UniversityNamkuDaeguRepublic of Korea Department of Neurosurgery College of MedicineYeungnam UniversityNamkuDaeguRepublic of Korea

The cingulum,connecting the orbitofrontal cortex to the medial temporal lobe,involves in diverse cognition functions including attention,memory,and *** investigate the relationship between the cingulum injury and cognitive impairment in patients with chronic mild traumatic brain injury,we evaluated the integrity between the anterior cingulum and the basal forebrain using diffusion tensor tractography in 73 patients with chronic mild traumatic brain injury(39 males,34 females,age 43.29±11.42 years)and 40 healthy controls(22 males,18 females,age 40.11±16.81 years).The patients were divided into three subgroups based on the integrity between the anterior cingulum and the basal forebrain on diffusion tensor tractography:subgroup A(n=19 patients)– both sides of the anterior cingulum were intact;subgroup B(n=36 patients)– either side of the anterior cingulum was intact;and subgroup C(18 patients)– both sides of the anterior cingulum were *** were significant differences in total Memory Assessment Scale score between subgroups A and B and between subgroups A and *** were no significant differences in diffusion tensor tractography parameters(fractional anisotropy,apparent diffusion coefficient,and fiber volume)between patients and *** findings suggest that the integrity between the anterior cingulum and the basal forebrain,but not diffusion tensor tractography parameter,can be used to predict the cognitive function of patients with chronic mild traumatic brain *** study was approved by Yeungnam University hospital Institutional Review Board(approval ***-2014-01-425-010)on August 16,2017.

关键词： mild traumatic brain injury brain trauma diffusion tensor tractography diffusion tensor imaging cognitive impairment cingulum memory Glasgow Coma Scale neural regeneration

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CT colonography in the diagnosis and management of colorectal cancer:Emphasis on pre-and post-surgical evaluation

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World Journal of Gastroenterology 2014年第8期20卷 2014-2022页

作者： Nurhee hong seong ho Park Department of Radiology and Research Institute of Radiology University of Ulsan College of MedicineAsan Medical CenterSeoul 138-736South Korea

This article addresses the use of computed tomographic colonography (CTC) for the diagnosis and management of colorectal cancer, focusing on presurgical evaluation of the colon proximal to an occlusive cancer and surveillance after cancer resection surgery. The key evidences accumulated in the literature and future work needed are summarized. CTC is a technically robust and the most practical method to evaluate the colon proximal to an occlusive cancer, which prevents colonoscopic examination past the occlusion, either before or after metallic stent placement. The high sensitivity of CTC for detecting cancers and advanced adenomas in the proximal colon can help prevent additional surgical procedures in patients showing negative results. however, the accuracy of CTC for distinguishing intramural cancers from adenomas is low, and the technique is limited in guiding management when a medium-sized lesion that do not show invasive features such as pericolic extension or nodal metastasis is found in the proximal colon. A maximal diameter ≥ 15 mm has been proposed as a criterion for surgical removal of proximal lesions. however, this needs to be verified in a larger cohort. In addition, the influence of presurgical CTC results on the current post-cancer resection colonic surveillance timeline remains to be determined. CTC can be readily added to the routine abdominopelvic CT in the form of contrast-enhanced CTC, which can serve as an effective stand-alone tool for post-cancer resection surveillance of both the colorectum and extracolonic organs. Although the accuracy of CTC has been demonstrated, its role in the current colonoscopy-based postoperative colonic surveillance protocols remains to be determined. Readers of CTC also need to be knowledgeable on the colonic lesions that are unique to the postoperative colon.

关键词： Computed tomographic colonography Colonic cancer Rectal cancer Surgery Colonoscopy

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Application of an aerosol electrical mobility spectrum analyzer: Charged-particle polarity ratio measurement in the Antarctic and Arctic regions

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Journal of Environmental Sciences 2021年第7期33卷 81-89页

作者： Handol Lee Hyeok Chung kang-ho Ahn Department of Environmental Engineering Inha University100 Inha-roMichuhol-guIncheon 22212South Korea Aerosol Research and Technology Plus(ART+) 195-62Daepyeong-roDaewol-myeonIcheonGyunggi-do 17343South Korea Department of Mechanical Engineering Hanyang UniversityERICA55 Hanyangdaehak-roSangnok-guAnsan 15588South Korea

An aerosol electrical mobility spectrum analyzer(AEMSA),developed at Hanyang University,was employed to investigate the particle charge characteristics in the Antarctic and Arctic *** particle charge characteristics in these areas were compared with the charging state in Ansan,South Korea,located in the midlatitude,where artificial factors,such as human activity,urbanization,and traffic,might result in a higher total ***,in Ansan,South Korea,the charged-particle polarity ratio was very stable and was close to ***,notably different particle charge characteristics were obtained in the Antarctic and Arctic *** imbalance between the numbers of positively and negatively charged particles was evident,resulting in more positive charges on the atmospheric *** average,the positively charged particle concentrations in the Antarctic and Arctic areas were 1.4 and 2.8 times higher,respectively,compared with the negatively charged *** developed AEMSA system and the findings of this study provide useful information on the characteristics of atmospheric aerosols in the Antarctic and Arctic regions and can be further utilized to study particle formation mechanisms.

关键词： Aerosol electrical mobility spectrum analyzer Antarctic Arctic Charged-particle polarity ratio

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Neuroinflammation in neurodegenerative disorders:the roles of microglia and astrocytes

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Translational Neurodegeneration 2020年第4期9卷 535-546页

作者： Hyuk Sung Kwon seong-ho Koh Department of Neurology Hanyang University College of MedicineSeoulRepublic of Korea Department of Translational Medicine Hanyang University Graduate School of Biomedical Science&EngineeringSeoulRepublic of Korea

Neuroinflammation is associated with neurodegenerative diseases,such as Alzheimer's disease,Parkinson's disease,ancamyotrophic lateral *** and astrocytes are key regulators of inflammatory responses in the central nervous *** activation of microglia and astrocytes is heterogeneous and traditionally categorized as neurotoxi(M1-phenotype microglia and A1-phenotype astrocytes)or neuroprotective(M2-phenotype microglia and A2-phenotype astrocytes).however,this dichotomized classification may not reflect the various phenotypes of microgliaand *** relationship between these activated glial cells is also very complicated,and the phenotypic distribution can change,based on the progression of neurodegenerative diseases.A better understanding of the rolesof microglia and astrocytes in neurodegenerative diseases is essential for developing effective *** this review,we discuss the roles of inflammatory response in neurodegenerative diseases,focusing on the contributions of microglia and astrocytes and their *** addition,we discuss biomarkers to measure neuroinflammation andstudies on therapeutic drugs that can modulate neuroinflammation.

关键词： Neuroinflammation Neurodegenerative diseases Microglia Astrocytes

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Injury of thalamocortical connection between the mediodorsal nucleus of the thalamus and the orbitofrontal cortex in a patient with traumatic brain injury

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Neural Regeneration Research 2018年第6期13卷 1118-1120页

作者： Sung ho Jang seong ho Kim Sang Seok Yeo Department of Physical Medicine and Rehabilitation College of Medicine Yeungnam University Department of Neurosurgery College of Medicine Yeungnam University Department of Physical Therapy College of Health Sciences Dankook University

The prefrontal cortex（PFC）is responsible for personality expression and various cognitive functions,including working memory,recognition memory,decision making,attention,and motivation（Frey and Petrides,2000,2002;M... 详细信息

关键词： TBI OFC DTI MD

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Measured Performance and Analysis of the Residual Settlement of a PVD-Improved Marine Soft Ground

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Journal of Ocean University of China 2021年第5期20卷 1055-1066页

作者： kang Gichun KIM Tae-Hyung YUN seong-Kyu Department of Civil Engineering College of EngineeringGyeongsang National UniversityJinju 52828Republic of Korea Department of Civil Engineering Korea Maritime and Ocean UniversityBusan 606-791Republic of Korea Engineering Research Institute Gyeongsang National UniversityJinju 52828Republic of Korea

Prefabricated vertical drains(PVDs)are commonly used to shorten the drainage path for consolidation as part of the improvement of marine soft *** studies that focus on the primary consolidation settlement of PVD-improved soft ground have been conducted;however,residual settlement has been scarcely *** settlement is the net effect of secondary compression and the remaining primary consolidation and generally occurs while the facilities are *** this study,residual settlement was investigated using the measured field settlement data obtained from the surface settlement plate and multilayer settlement *** study determined that PVD still has some effect on residual settlement and can reduce the settlement *** settlement is only related to the PVD-improved soil layer and only occurs significantly in the middle zone of that layer over a few *** middle zone may be related to the time delay of excess pore water pressure *** study concluded that the remaining primary consolidation in the PVD-improved soil layer is the primary cause of residual settlement,whereas secondary compression in the PVD-improved soil layer is only a minor cause.

关键词： residual settlement prefabricated vertical drain(PVD) operating facilities primary consolidation secondary compres-sion marine soft ground

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Checkpoint Management with Double Modular Redundancy Based on the Probability of Task Completion

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Journal of Computer Science & Technology 2012年第2期27卷 273-280页

作者： seong Woo Kwak Kwan-ho You Jung-Min Yang Department of Electronic Engineering Keimyung University School of Information & Communication Engineering Sungkyunkwan University Department of Electrical Engineering Catholic University of Daegu

This paper proposes a checkpoint rollback strategy for real-time systems with double modular *** built-in fault-detection and spare processors,our scheme is able to recover from both transient and permanent *** comparisons are conducted at each ***,the states stored in two consecutive checkpoints of one processor are compared for checking integrity of the *** states of two processors are also compared for detecting faults and the system rolls back to the previous checkpoint whenever required by logic of the proposed scheme.A Markov model is induced by the fault recovery scheme and analyzed to provide the probability of task completion within its *** optimal number of checkpoints is selected so as to maximize the probability of task completion.

关键词： checkpoint scheme double modular redundancy (DMR) real-time task fault tolerance Markov model

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High-efficiency technique based on dielectrophoresis for assembling metal,semiconductor,and polymer nanorods

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2011年第5期12卷 368-373页

作者： Heng YUAN Kyu-jin KIM Won-seok kang Byoung-ho kang Se-hyuk YEOM Jae-ho KIM Shin-won kang School of Electrical Engineering and Computer Science Kyungpook National University 1370 Sankyuk-dong Bukgu Daegu 702-701 Korea) Department of Molecular Science and Technology Ajou University San s.Woncheon-dongYeongtong-guSuwon 443-749Korea School of Electronic Engineering College oflT Engineering Kyungpook National University 13 70 Sankyuk-dong Bukgu Daegu 702-701 Korea

This paper presents a high-efficiency technique based on dielectrophoresis (DEP) for assembling metal, semiconductor, and polymer nanorods, which are synthesized by electrochemical deposition (ECD). The assembly patterns of these nanorods (width: 20 nm; length: 7 μm) were designed using a finite element method (FEM) simulation tool. Further, these nanorods were used in our experiment after their assembly patterns were fabricated. The assembly yield was found to be approximately 70% at an AC voltage of 30 Vp-p and at frequencies of 20 and 30 kHz, and the DC voltage prevented the random alignment of the nanorods at the edge of the assembly pattern. Moreover, the above-mentioned nanorods, which had different permittivities, were found to have similar assembly yields. The proposed method can be improved and applied to nanostructure device fabrication.

关键词： Nanorod Assembly Dielectrophoresis (DEP) Finite element method (FEM) Electrochemical deposition (ECD) method

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Prostate-specific antigen density predicts favorable pathology and biochemical recurrence in patients with intermediate-risk prostate cancer

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Asian Journal of Andrology 2016年第3期18卷 480-484,I0012页

作者： ho Won kang Hae Do Jung Joo Yong Lee Jong Kyou Kwon seong Uk Jeh kang Su Cho Won Sik Ham Young Deuk Choi Department of Urology Chungbuk National University College of Medicine Cheongju Korea Department of Urology Severance Hospital Urological Science InstituteYonsei University College of Medicine Seoul Korea Department of Urology. Inje university Haeundae Paik hospital Busan Korea Department of Urology Gyeongsang National University School of Medicine Jinju Korea Department of Urology Gangnam Severance Hospital Urological Science Institute Yonsei University Uollege of Medicine Seoul Korea Robot and Minimal Invasive Surgery Center Severance Hospital Yonsei University College of Medicine Seoul Korea.

This study was designed to identify clinical predictors of favorable pathology and biochemical recurrence （BCR） in patients with intermediate-risk prostate cancer （IRPCa）. Between 2006 and 2012, clinicopathological and oncological data from 203 consecutive men undergoing robot-assisted radical prostatectomy （RARP） for IRPCa were reviewed in a single-institutional retrospective study. Favorable pathology was defined as Gleason score 〈6 and organ-confined cancer as detected by surgical pathology. Logistic regression analysis was used to determine predictive variables of favorable pathology, and the Kaplan-Meier and multivariate Cox regression model were used to estimate BCR-free survival after RARP. Overall, 38 patients （18.7%） had favorable pathology after RARP. Lower quartile prostate-specific antigen density （PSAD） was associated with favorable pathology compared to the highest quartile PSAD after adjusting for preoperative PSA, clinical stage and biopsy Gleason score （odds ratio, 5.42; 95% confidence interval, 1.01-28.97; P = 0.048）. During a median 37.8 （interquartile range, 24.6-60.2） months of follow-up, 66 patients experienced BCR. There were significant differences with regard to BCR free survival by PSAD quartiles （log rank, P = 0.003）. Using a multivariable Cox proportion hazard model, PSAD was found to be an independent predictor of BCR in patients with IRPCa after RARP （hazard ratio, 4.641; 95% confidence interval, 1.109-19.417; P = 0.036）. The incorporation of the PSAD into risk assessments might provide additional prognostic information and identify some patients in whom active surveillance would be appropriate in patients with IRPCa.

关键词： biochemical recurrence prostatectomy prostate-specific antigen prostate-specific antigen density prostatic neoplasms

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Radiologic evaluation of nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2014年第23期20卷 7392-7402页

作者： Seung Soo Lee seong ho Park Department of Radiology and Research Institute of Radiology University of Ulsan College of MedicineAsan Medical CenterSeoul 138-736South Korea

Nonalcoholic fatty liver disease(NAFLD)is a frequent cause of chronic liver diseases,ranging from simple steatosis to nonalcoholic steatohepatitis(NASH)-related liver *** liver biopsy is still the gold standard for the diagnosis of NAFLD,especially for the diagnosis of NASH,imaging methods have been increasingly accepted as noninvasive alternatives to liver *** is a well-established and costeffective imaging technique for the diagnosis of hepatic steatosis,especially for screening a large population at risk of *** has a reasonable accuracy in detecting moderate-to-severe hepatic steatosis although it is less accurate for detecting mild hepatic steatosis,operator-dependent,and rather *** tomography is not appropriate for general population assessment of hepatic steatosis given its inaccuracy in detecting mild hepatic steatosis and potential radiation ***,computed tomography may be effective in specific clinical situations,such as evaluation of donor candidates for hepatic *** resonance spectroscopy and magnetic resonance imaging are now regarded as the most accurate practical methods of measuring liver fat in clinical practice,especially for longitudinal followup of patients with *** elastography and magnetic resonance elastography are increasingly used to evaluate the degree of liver fibrosis in patients with NAFLD and to differentiate NASH from simple *** article will review current imaging methods used to evaluate hepatic steatosis,including the diagnostic accuracy,limitations,and practical applicability of each *** will also briefly describe the potential role of elastography techniques in the evaluation of patients with NAFLD.

关键词： Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis Liver steatosis Magnetic resonance spectroscopy Magnetic resonance imaging Ultrasonography Computed tomography Elastography

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