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Acta Pharmacologica Sinica 2003年第2期24卷 133-139页

作者： SON Chang-Gue CHOI Woo-Jin SHIN jang-Woo HAN Seung-Hyun CHO Jung-Hyo SONG Kee-cheol CHO Chong-Kwan Department of Internal Medicine College of Oriental Medicine Daejeon University Daejeon 301-724 Korea Department of Internal Medicine College of Oriental Medicine Daejeon University Daejeon 301-724 Korea nstitute of Traditional Medicine and Bioscience Daejeon University Daejeon 301-724 Korea International Vaccin Institute Seoul University Seoul Korea Department of Internal Medicine College of Oriental Medicine Daejeon University Daejeon 301-724 Korea Department of Internal Medicine College of Oriental Medicine Daejeon University Daejeon 301-724 Korea

AIM: To evaluate the therapeutic effects of Gamichunggantang (GCT) on hyperlipidemia through high cholesterol diet model. GCT is an Oriental herbal medication, which has been used for-the treatment of fatty liver, hyperlipidemia or alcoholic liver disease in Daejeon University Oriental Hospital, Korea since 1999. METHODS: Rats were fed with high cholesterol diet for 4 weeks and GCT was administrated for 2 weeks from 2 weeks later in expermental days. The levels of serum total cholesterol, HDL-cholesterol, and triglyceride were analyzed every week. Absolute and relative liver weight to body, and histophathological changes were determined at last day. And, lipid metabolism-related gene expressions (ACAT and DGAT) in liver tissue were analyzed by using RT-PCR. RESULTS:In GCT group, TG levels were reduced at 3 and 4 weeks after GCT administration (39.4%, P<0.05 and 36.3%,P<0.01 respectively). Total cholesterol levels also were reduced at 3 weeks (20.5%, P<0.05) and 4 weeks (35.86%, P<0.01) after GCT administration, but HDL-cholesterol levels were increased significantly (P<0.05) at 3 weeks(14.7%) and 4 weeks (25.5%) compared with hyperlipidemia-induced group without GCT. In the GCT treated group, liver weight was lower and lipid accumulation was decreased in histological finding. ACAT gene expression was suppressed compared with hyperlipidemia-induced group but not DGAT. CONCLUSION: GCT possesses preventive or therapeutic effects on diet-induced hypedipidemia by inhibiting the intestinal absorption and storage of exogenous and endogenous cholesterol.

关键词：高脂血症甘油三酯胆甾醇 O-酰基转移酶甾醇

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Effects of smoking on cerebral and ventricular volumes in healthy males

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Neural Regeneration Research 2011年第1期6卷 72-75页

作者： Hyun-Jun Kim Mi-Hyun Choi Beob-Yi Lee Su-Jeong Lee Jae-Woong Yang Ji-Hye Kim Jin-Seung Choi Dong-Won Kang jang-Yeon Park Jae-Hoon Jun Gye-Rae Tack Soon-cheol Chung Department of Obstetrics & Gynecology Konkuk University Department of Biomedical Engineering Research Institute of Biomedical EngineeringCollege of Biomedical & Health ScienceKonkuk University Department of Anatomy School of MedicineKonkuk University

Previous studies have reported decreased cerebral volume as a result of smoking. However, little is known about accompanying changes in ventricular volume for healthy subjects who smoke, although ventricular volume is increased in patients with multiple sclerosis who smoke. The present study analyzed whether cerebral volume decreased with smoking through the use of magnetic resonance imaging. In addition, accompanying changes in ventricular volume that resulted from decreased cerebral volume and smoking were analyzed in healthy subjects. When multivariate analysis of covariance was performed by integrating the 2 age groups, aged 20-28 years and 40-49 years, with statistical significance, results showed that cerebral volume of smokers was smaller and ventricular volume was greater compared with the non-smokers. These findings suggest that ventricular volume changes could be utilized to characterize the effects of smoking.

关键词： smoking cerebral and ventricular volumes magnetic resonance imaging

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PD-1 blockade-unresponsive human tumor-infiltrating CD8^(+)T cells are marked by loss of CD28 expression and rescued by IL-15

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Cellular & Molecular Immunology 2021年第2期18卷 385-397页

作者： Kyung Hwan Kim Hong Kwan Kim Hyung-Don Kim Chang Gon Kim Hoyoung Lee Ji Won Han seong Jin Choi seongju Jeong Minwoo Jeon Hyunglae Kim Jiae Koh Bo Mi Ku Su-Hyung Park Myung-Ju Ahn Eui-cheol Shin Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and TechnologyDaejeonRepublic of Korea Department of Thoracic and Cardiovascular Surgery Samsung Medical CenterSungkyunkwan University School of MedicineSeoulRepublic of Korea Biomedical Science and Engineering Interdisciplinary Program Korea Advanced Institute of Science and TechnologyDaejeonRepublic of Korea Research Institute for Future Medicine Samsung Medical CenterSungkyunkwan University School of MedicineSeoulRepublic of Korea Department of Radiation Oncology Yonsei Cancer CenterYonsei University College of MedicineSeoulRepublic of Korea Division of Hematology-Oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoulRepublic of Korea

Blockade of programmed death-1(PD-1)reinvigorates exhausted CD8^(+)T cells,resulting in tumor regression in cancer ***,reinvigoration of exhausted CD8^(+)T cells following PD-1 blockade was shown to be CD28-dependent in mouse ***,we examined the role of CD28 in anti-PD-1 antibody-induced human T cell reinvigoration using tumor-infiltrating CD8^(+)T cells(CD8^(+)TILs)obtained from non-small-cell lung cancer ***-cell analysis demonstrated a distinct expression pattern of CD28 between mouse and human CD8^(+)***,we found that human CD28^(+)CD8^(+)but not CD28^(–)CD8^(+)TILs responded to PD-1 blockade irrespective of B7/CD28 blockade,indicating that CD28 costimulation in human CD8^(+)TILs is dispensable for PD-1 blockade-induced reinvigoration and that loss of CD28 expression serves as a marker of anti-PD-1 antibody-unresponsive CD8^(+)*** and phenotypically,PD-1 blockade-unresponsive human CD28^(–)PD-1^(+)CD8^(+)TILs exhibited characteristics of terminally exhausted CD8^(+)T cells with low TCF1 ***,CD28^(–)PD-1^(+)CD8^(+)TILs had preserved machinery to respond to IL-15,and IL-15 treatment enhanced the proliferation of CD28^(–)PD-1^(+)CD8^(+)TILs as well as CD28^(+)PD-1^(+)CD8^(+)*** together,these results show that loss of CD28 expression is a marker of PD-1 blockade-unresponsive human CD8^(+)TILs with a TCF1–signature and provide mechanistic insights into combining IL-15 with anti-PD-1 antibodies.

关键词： anti-PD-1 T cells TCF1 CD28 IL-15

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利用杀菌剂防治松萎蔫病(英文)

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南京林业大学学报（自然科学版） 2010年第5期34卷 168-169页

作者： Jin-cheol Kim Hyeok Ran Kwon Gyung Ja Choi Yong Ho Choi Kyoung Soo jang Myung Soo Park Nack-Do Sung Mun seong Kang Yilseong Moon Seung Kyu Lee 韩国化学技术研究院韩国忠南大学农业与生命科学学院韩国森林研究院南方森林研究中心柳成化学贸易株式会社

松萎蔫病是一种非常复杂的病害。据报道,松材线虫(Bursaphelenchus xylophilus)及其携带的细菌诱导了该病,但是对于细菌的的作用尚存争议。笔者筛选出杀细菌剂进行了温室和林间防治松萎蔫病的实验。利用每株3年生赤松(Pinus densiflora... 详细信息

松萎蔫病是一种非常复杂的病害。据报道,松材线虫(Bursaphelenchus xylophilus)及其携带的细菌诱导了该病,但是对于细菌的的作用尚存争议。笔者筛选出杀细菌剂进行了温室和林间防治松萎蔫病的实验。利用每株3年生赤松(Pinus densiflora)注射3mg的恶喹酸,松萎蔫病防效达到71%。利用恶喹酸或阿维菌素及两者混合物对大约20年生赤松的试验表明,3种处理均显示了很高的防效。以上结果证明伴生细菌是诱导松萎蔫病的必要因素,对松萎蔫病可利用杀细菌剂或杀细菌剂与杀线剂混合物进行防控。

关键词：松萎蔫病细菌杀细菌剂恶喹酸阿维菌素

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Dosimetry of the Photo Neutron Produced in Medical Linear Accelerators

Dosimetry of the Photo Neutron Produced in Medical Linear Ac...

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The Second Asian and Oceanic Congress for Radiation Protection

作者： Bon cheol KOO Hong Suk KIM Jae-seong LEE Chan Woo JEONG Korea Institute of Nuclear Safety Daejeon Republic of Korea Korea Institute of Nuclear Safety Daejeon Republic of Korea Korea Institute of Nuclear Safety Daejeon Republic of Korea Korea Institute of Nuclear Safety Daejeon Republic of Korea

Currently, medical linear accelerators （LINACs） are the most common method of radiotherapy for tumor treatments and more than 90 LINACs are installed and operated in Korea in 2005. To increase the treatment efficiency, LINACs are trending toward higher energy（more than 15MV） nowadays. Meanwhile, the increased photon energy above about 8MV can produce undesired photo neutrons through photonuclear reaction between photon and surrounding materials in LINAC. In this study, the neutron generation and flux around the head geometry of a Varian Clinac 2100C LINAC has been simulated by a Monte Carlo calculation to evaluate photo neutron dose. Monte Carlo calculation using the MCNPX code has been performed for two different photons （generated from Varian 10MV, Varian 15MV） for three different field sizes （0ì 0 cm2, 10ì 10 cm2,20ì 20 cm2）. To compare with the calculation results, additional experimental measurements have been conducted by bubbledetectors on neutron dose and neutron energy spectrum.

关键词： Photo Neutrons Linear Accelerators Bubble Detectors

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Analysis of microsatellite instability in stool DNA of patients with colorectal cancer using denaturing high performance liquid chromatography

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World Journal of Gastroenterology 2006年第41期12卷 6689-6692页

作者： Seok-Byung Lim Seung-Yong Jeong Il-Jin Kim Dae Yong Kim Kyung Hae Jung Hee Jin Chang Hyo seong Choi Dae Kyung Sohn Hio Chung Kang Yong Shin Sang-Geun jang Jae-Hyun Park Jae-Gahb Park Research Institute and Hospital National Cancer CenterGoyangKorea Cancer Research Institute and Cancer Research Center Seoul National UniversitySeoulKorea

AIM： To evaluate the usefulness of denaturing high performance liquid chromatography （DHPLC） for analyzing microsatellite instability （MSI） status in stool DNA of patients with colorectal cancer. METHODS： A total of 80 cancer tissues from patients with primary sporadic colorectal tumor （proximal cancer： 27, distal cancer： 53） and matched stool （which were employed for comparison with the tissues） were analyzed for MSI status in BAT 26. DNA samples extracted from stool were evaluated by nested polymerase chain reaction （PCR） and DHPLC for MSI analysis. RESULTS： Six cases （7.5%） of MSI were identified in BAT 26 from 80 cancer tissues. All the stool DNA samples from patients whose cancer tissue showed IVlSI also displayed MSI in BAT 26. CONCLUSION： As MSI is one of the established fecal DNA markers to screen colorectal cancer, we propose to use DHPLC for the IVlSI analysis in fecal DNA.

关键词： Colorectal cancer Denaturing high performance liquid chromatography Fecal DNA MicrosateUite instability Stool

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Successful Treatment of a Case of First Bite Syndrome without Any Cause

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World Journal of Neuroscience 2015年第5期5卷 331-333页

作者： seong Ho Chang Byung Sun Jun Jong Ouck Choi Jung Jun Kim Young jang Department of Anesthesiology and Pain Medicine College of Medicine Korea University Seoul Korea Gwanak Otolaryngology Anesthesia and Pain Clinic Seoul Korea Gwanak Otolaryngology Head and Neck Surgery Clinic Seoul Korea

Background: For the first bite syndrome (FBS), various causes were suggested such as parapharyngeal space surgery, resection of styloid process, carotid endarterectomy, parotid gland tumor, submandibular gland tumor, and upper cervical surgery. Actually, the real cause of FBS is still not clear. Also, suggested methods of treatment for the FBS are botulinum toxin injection, laser tympanic plexus ablation, pharmacologic approach, and no treatment. The results of those treatments were not satisfactory. Aim: The authors tried to find out the adequate method of treatment for the FBS and also tried to figure out pathologic cause of the FBS through observation of the patient response to the treatment. Case Presentation: A 38-year-old male was presented at head and neck surgery clinic with a sharp pain on the left parotid area especially at the first bite of eating food for two days. There was no cause. The patient was given trigger point injections on his left sternocleidomastoid, masseter, and temporal muscles with left mandibular nerve block five times 3 - 4 days apart. Also small amount of oral anticonvulsants were added for four weeks. Before finishing taking oral medication, the pain was gone completely. Conclusion: The authors experienced a case of FBS with no detectable cause, and treated successfully with the methods of trigger point injection, mandibular nerve block, and oral antiepileptic medication.

关键词： First Bite Syndrome Mandibular Nerve Block Oral Medication Trigger Point Injection

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Hepatectomy vs radiofrequency ablation for colorectal liver metastasis:A propensity score analysis

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World Journal of Gastroenterology 2015年第11期21卷 3300-3307页

作者： Huisong Lee Jin Seok Heo Yong Beom Cho seong Hyeon Yun Hee cheol Kim Woo Yong Lee seong Ho Choi Dong Wook Choi Department of Surgery Samsung Medical CenterSungkyunkwan University School of Medicine

AIM:To compare outcomes from radiofrequency ablation(RFA) and hepatectomy for treatment of colorectal liver metastasis(CRLM).METHODS:From January 2000 to December 2009,408 patients underwent curative intent treatment for *** excluded patients using the criteria:size of CRLM > 3 cm,number of CRLM ≥ 5,percutaneous RFA,follow-up period 2 cm) CRLM(P = 0.034).However,survival curves were similar for single or small(≤ 2 cm) CRLM(P = 0.714,P = 0.740).CONCLUSION:Hepatectomy is better than RFA for the treatment of ***,RFA might be suitable for selected patients with single,small(≤ 2 cm) CRLM.

关键词： Colorectal neoplasm Metastasis Catheter ablation H

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Effects of obesity on lower urinary tract symptoms in Korean BPH patients

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Asian Journal of Andrology 2009年第6期11卷 663-668页

作者： Seung Hwan Lee Joon Chul Kim Ji-Youl Lee jang Hwan Kim cheol Young Oh Seung Wook Lee Se Jeong Yoo Byung Ha Chung Department of Urology Yonsei University Health System Seoul 135-720 Korea Department of Urology The Catholic University of Korea Seoul 137-701 Korea Department of Urology Hallym University Chuncheon 200-704 Korea Department of Urology Eulji Medical Center Eulji University Seoul 139-230 Korea

We analyzed the effects of obesity on lower urinary tract symptoms （LUTSs） in Korean benign prostatic hyperplasia （BPH） patients. This is a multicenter, cross-sectional, prospective study conducted in four centers in Korea. A total of 602 men with LUTSs secondary to BPH were included. BPH/LUTSs cases were men aged ≥ 40 years with intemational prostate symptom scores （IPSS） ≥ 8 points. Height, weight and waist circumference were measured. Among the 602 patients, 156 patients had a waist circumference above 90 cm, representing central obesity, and 215 patients had a body mass index above 25 kg m2. Waist circumference was positively correlated with prostate volume （P = 0.034）. Men with waist circumference 〉 90 cm experienced a 1.36-fold increased risk of severe LUTSs （95% CI 0.82-2.41） compared with men with waist circumference ≤ 90 cm. Prostate volume was positively correlated with urgency and nocturia in men with central obesity. In this population of Korean men diagnosed with BPH, central obesity rather than overall obesity seems to be the more important predictor of LUTSs correlated with BPH.

关键词： benign prostatic hyperplasia central obesity lower urinary tract symptom prostate

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A Study on Water Repellent Effectiveness of Natural Oil-Applied Soil as a Building Material

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Open Journal of Civil Engineering 2015年第1期5卷 139-148页

作者： Jong-Kook Lee Jee-Eun Lee seong-cheol Park Hee-Dong Cho Hye-Woong Yoo Young-Sang Kim seong-Ryong Ryu Woo-Suk Kim Dong-Joon Ahn School of Architecture Kumoh National Institute of Technology Gumi Republic of Korea

This study was performed to investigate the water repellent effectiveness of natural oil-applied soil when it is used as a building material. Natural oil types such as olive oil, bean oil, perilla oil and linseed oil, which are being used for producing water repellent timber, are selected for the experiments. It is expected that perilla oil and in seed oil, which are drying oil types will have better water repellent effectiveness than the other types. For the evaluation of water repellence of natural oil-applied soil, a contact angle test was performed. A contact angle of water drop on various surface conditions were tested, and large differences were seen between the natural oil-applied soil and untreated soil. As a result, it is showed that all natural oil types have water repellent effectiveness. However, linseed oil, which is a drying oil type, shows an outstanding water repellent effectiveness value, while perila oil, which is also a drying oil type, shows the lowest value. Additionally, results show that there is no link between water repellent effectiveness and the number of applications of natural oil. Nevertheless, existing commercial water repellents show better performance than natural oil, and it is anticipated that the results of this study will provide essential information for further research to enhance the water repellent effectiveness of soil as a building material.

关键词： Natural Oil Water Repellent Soil as a Building Material Contact Angle Iodine Value

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