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Muscovite nanoparticles mitigate neuropathic pain by modulating the inflammatory response and neuroglial activation in the spinal cord

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Neural Regeneration Research 2020年第11期15卷 2162-2168页

作者： ju-Young Oh Tae-Yeon Hwang Jae-Hwan Jang Ji-Yeun park Yeonhee Ryu Hyejung Lee Hi-Joon park Acupuncture and Meridian Science Research Center Kyung Hee University26 Kyungheedae-roDongdaemun-guSeoulRepublic of Korea Department of Korean Medical Science Graduate School of Korean MedicineKyung Hee UniversitySeoulRepublic of Korea BK21 PLUS Korean Medicine Science Center College of Korean MedicineKyung Hee UniversitySeoulRepublic of Korea College of Korean Medicine Daejeon UniversityDaejeonRepublic of Korea Korean Institute of Oriental Medicine DaejeonRepublic of Korea

Despite numerous efforts to overcome neuropathic pain,various pharmacological drugs often fail to meet the needs and have many side *** is an aluminosilicate mineral that has been reported to have an anti-inflammatory effect,but the efficacy of muscovite for neuropathic pain has not been ***,we assessed whether muscovite nanoparticles can reduce the symptoms of pain by controlling the inflammatory process observed in neuropathic *** analgesic effects of muscovite nanoparticles were explored using partial sciatic nerve ligation model of neuropathic pain,in which one-third to onehalf of the nerve trifurcation of the sciatic nerve was tightly tied to the dorsal *** nanoparticles(4 mg/100μL)was given intramuscularly to evaluate its effects on neuropathic pain(3 days per week for 4 weeks).The results showed that the muscovite nanoparticle injections significantly alleviated partial sciatic nerve ligation-induced mechanical and cold *** the spinal cord,the muscovite nanoparticle injections exhibited inhibitory effects on astrocyte and microglia activation and reduced the expression of pro-inflammatory cytokines,such as interleukin-1β,tumor necrosis factor-α,interleiukin-6 and monocyte chemoattractant protein-1,which were upregulated in the partial sciatic nerve ligation ***,the muscovite nanoparticle injections resulted in a decrease in activating transcription factor 3,a neuronal injury marker,in the sciatic *** results suggest that the analgesic effects of muscovite nanoparticle on partial sciatic nerve ligation-induced neuropathic pain may result from inhibiting activation of astrocytes and microglia as well as pro-inflammatory *** propose that muscovite nanoparticle is a potential anti-nociceptive candidate for neuropathic *** experimental protocols in this study were approved by the Institutional Animal Ethics Committee(IACUC)at Dongguk University,South Korea(approval No.2017-022-1)

关键词： astrocyte microglia muscovite nanoparticle neuropathic pain partial sciatic nerve ligation pharmacopuncture pro-inflammatory cytokine spinal cord

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Cystic Brunner's gland hamartoma in the duodenum:A case report

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World Journal of Gastroenterology 2009年第39期15卷 4980-4983页

作者： Beom Jin park Min ju Kim Jeong Hyeon Lee Sung-Soo park Deuk Jae Sung Sung Bum Cho Department of Radiology Korea UniversityCollege of MedicineAnam Hospital Department of Pathology Korea UniversityCollege of MedicineAnam Hospital Department of Surgery Korea UniversityCollege of MedicineAnam Hospital

Cystic Brunner's gland hamartoma in the duodenum is exceedingly rare,although microscopic examination may sometimes reveal a Brunner's gland hamartoma containing dilated ducts in the *** present a case of large cystic Brunner's gland hamartoma in the duodenum with a long stalk,which is described in light of multidetector-row computed tomography,magnetic resonance imaging,and a modified small bowel series,together with pathologic correlation and differential diagnosis.

关键词： Brunner's gland Hamartoma Duodenum Multidetector-row computed tomography Magnetic resonance imaging

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Polyurethane-based Actuators with Various Polyols

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Journal of Materials Science & Technology 2010年第8期26卷 763-768页

作者： Nam-ju Jo Do-Hee Lim Gyeong-Mi Bark Ho-Hwan Chun In-Won Lee Hyun park Department of Polymer Science and Engineering Pusan National University Advanced Ship Engineering Research Center Pusan National University

This study dealt with the electrostrictive responses of polyurethane （PU） actuators with different microphase separation structure, which was a promising candidate for a material used in polymer actuators. In order to construct PUs with different higher-order structure, PUs with various types of polyol were synthesized： poly（neopentyl glycol adipate）（PNAD）, poly（tetramethylene glycol）（PTMG）, and poly（dimethyl siloxnae）（PDMS）. Synthesized PU was characterized by Fourier transform-infrared （FT-IR） spectroscopy and gel per- meation chromatography （GPC）. Thermal analysis and mechanical properties of PU films were carried out with differential scanning calorimetry （DSC） and UTM （universal testing machine）, respectively. And PU actuator was formed in a type of monomorph, which was made by carbon black electrodes on the both surfaces of PU film by spin coating method. Actuation behavior was mainly influenced on microphase separation struc- ture and mechanical property of PU. In result, PU actuator with PNAD, polyester urethane, had the largest field-induced displacement.

关键词： Electroactive polymer Polyurethane actuator Polyol type Maxwell stress effect Electrostriction effect

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Polyaniline and multi-walled carbon nanotube composite electrode for rechargeable battery

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中国有色金属学会会刊：英文版 2012年第S3期22卷 717-721页

作者： Yu-Jeong LIM Min-Young park Sang-Keol LEE Won-Ki LEE Nam-ju JO Department of Polymer Science & Engineering Pusan National University Hankook Tire Co.Ltd. Department of Polymer Engineering Pukyong National University

The multi-walled carbon nanotube was introduced into the polymer matrix (PANI) to improve the electric conductivity as well as mechanical properties of the original polymer ***/multi-walled carbon nanotube (MWCNT) composites were synthesized via ex-situ and in-situ polymerization to improve their electrical *** the DC conductivities of PANI/MWCNT according to content and diameter of MWCNT were measured by four-point *** highest electric conductivity of PANI/MWCNT composite is 20 S/cm when 0.3% (mass fraction) MWCNTs with 10 nm in diameter and 15 μm in length are added in composite.

关键词： polymer electrode electric conductivity multi-walled carbon nanotube conducting polymer

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Biomass growth characteristics of 13-year-old Pinus densiflora *** *** a post-fire plantation on different contour conditions in Samcheuk,Korea

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Journal of Mountain Science 2016年第7期13卷 1238-1244页

作者： Lee ju-Hyoung Lee Do-Hyung Kim Do-Hyun park Jin-Hwa KimJae-Hee Department of Forest Resources Yeungnam UniversityGyeongsan 712-749Republic of Korea Useful Plant Resources Center Korea National ArboretumYangpgeong-gun 12519Republic of Korea Korea Forest Welfare Institute Therapy-ro 209Bonghyeon-myeonYeongju-siGyeongsangbuk-doRepublic of Korea Department of forest genetic resources National Institute of Forest Science57HoegiroDongdaemun-guSeoul 02455Republic of Korea

We used preliminary data to estimate the growth volume of artificially reforested Pinus densiflora in a post-fire area on three different contour conditions. We compared the growth of P. densiflora on a south-facing slope(Ssth), north-facing slope(Snth) and ridge area(Ridge), using 7 trees selected from each stand aspect. The tree height, diameter and growth volume were measured and the dry weight of each plant part were compared and analyzed. The results revealed that the total dry weight was highest on Ssth(5992.3 g), followed by Snth(4833.2 g) and lowest on Ridge(3160.1 g). The height growth was highest on Snth(285.8 cm), followed by Ssth(274.5 cm) and lowest on Ridge(211.5 cm). The diameter growth was greatest on Ssth(7.37 cm), followed by Snth(7.10 cm) and lowest on Ridge(5.72 cm). The volume growth was highest on Ssth(4257.7 cm3), followed by Snth(3750.7 cm3) and lowest on Ridge(2093.7 cm3). Therefore, we should consider and include the concept of slope orientation together with differences in habitat environments in afforestation projects when creating artificial forests with P. densiflora. These study results can serve as important preliminary data for future establishment of artificial forest of P. densiflora in a post-fire plantation.

关键词： Pinus densiflora Growth characteristics Contour conditions Planted stand Post-fire plantation

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HOS1 Facilitates the Phytochrome B-Mediated Inhibition of PIF4 Function during Hypocotyl Growth in Arabidopsis

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Molecular Plant 2017年第2期10卷 274-284页

作者： ju-Heon Kim Hyo-jun Lee Jae-Hoon jung Sangmin Lee Chung-Mo park Department of Chemistry Seoul National University Seoul 08826 Korea Sainsbury Laboratory University of Cambridge Cambridge CB2 1LR UK Plant Genomics and Breeding Institute Seoul National University Seoul 08826 Korea These authors contributed equally to this article Present address: SK Innovation Daejeon 34124 Korea

Upon exposure to light, developing seedlings undergo photomorphogenesis, as illustrated by inhibition of hypocotyl elongation, cotyledon opening, and leaf greening. During hypocotyl photomorphogenesis, light signals are sensed by multiple photoreceptors, among which the red/far-red light-sensing phytochromes have been extensively studied. However, it is not fully understood how the phytochromes modulate hypo- cotyl growth. Here, we demonstrated that HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENES 1 （HOS1）, which is known to either act as E3 ubiquitin ligase or affect chromatin organization, inhibits the transcriptional activation activity of PHYTOCHROME INTERACTING FACTOR 4 （PIF4）, a key transcrip- tion factor that promotes hypocotyl growth. Consistent with the negative regulatory role of HOSl in hypo- cotyl growth, HOSl-defective mutants exhibited elongated hypocotyls in the light. Notably, phyB induces HOS1 activity in inhibiting PIF4 function. Taken together, these observations provide a molecular basis for the phyB-mediated suppression of hypocotyl growth in Arabidopsis.

关键词： photomorphogenesis hypocotyl growth phytochrome signaling HOS1 PIF4

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Neuromorphic devices based on fluorite-structured ferroelectrics

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InfoMat 2022年第12期4卷 1-32页

作者： Dong Hyun Lee Geun Hyeong park Se Hyun Kim ju Yong park Kun Yang Stefan Slesazeck Thomas Mikolajick Min Hyuk park Department of Materials Science and Engineering&Inter-University Semiconductor Research Center College of EngineeringSeoul National UniversitySeoulRepublic of Korea Research Institute of Advanced Materials Seoul National UniversitySeoulRepublic of Korea NaMLab gGmbH DresdenGermany Institute of Engineering Research Seoul National UniversitySeoulRepublic of Korea

A continuous exponential rise has been observed in the storage and processing of the data that may not curtail in the foreseeable *** required data processing speed and power consumption are restricted by the buses between the logic and memory devices that are characteristic of the von Neumann computing ***-mimicking neuromorphic computing has garnered considerable academic and industrial interest to resolve these ***,devices based on emerging nonvolatile memories capable of mimicking the behaviors of synapses and neurons,which are the main elements in biological computing systems(brains),are attracting significant interest from the device *** the discovery of ferroelectricity in fluorite-structured oxides,such as HfO2 and ZrO2,which are compatible with the state-of-the-art complementary-metal-oxide-semiconductor processes,ferroelectric devices have rapidly evolved as the main direction of these research and development *** science related to fluorite-structured ferroelectrics has been intensively studied over the last *** present,the focus is gradually moving to practical applications,including neuromorphic computing and advanced classical processing or memory units in the conventional von Neumann ***,despite its rapid development,the wealth of recent progress in neuromorphic computing devices based on fluorite-structured ferroelectrics has not been reviewed and *** progress report comprehensively reviews and systemizes the recent progress in artificial synaptic and spiking neuron devices for neuromorphic computing based on fluorite-structured ferroelectrics.

关键词： ferroelectrics hafnia neuromorphic computing semiconductor devices

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H∞ synchronization of chaotic neural networks with time-varying delays

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Chinese Physics B 2013年第11期22卷 244-252页

作者： O. M. Kwon M. J. park ju H. park S. M. Lee E. J. Cha School of Electrical Engineering Chungbuk National University Department of Electrical Engineering Yeungnam University School of Electronic Engineering Daegu University Department of Biomedical Engineering School of Medicine Chungbuk National University

In this paper, we investigate the problem of H∞ synchronization for chaotic neural networks with time-varying delays. A new model of the networks with disturbances in both master and slave systems is presented. By constructing a suitable Lyapunov–Krasovskii functional and using a reciprocally convex approach, a novel H∞ synchronization criterion for the networks concerned is established in terms of linear matrix inequalities （LMIs） which can be easily solved by various effective optimization algorithms. Two numerical examples are given to illustrate the effectiveness of the proposed method.

关键词： chaotic neural networks time-varying delays H∞ synchronization Lyapunov method

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Research on flexible display at Ulsan National Institute of Science and Technology

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npj Flexible Electronics 2017年第1期1卷 47-59页

作者： Jihun park Sanghyun Heo Kibog park Myoung Hoon Song ju-Young Kim Gyouhyung Kyung Rodney Scott Ruoff Jang-Ung park Franklin Bien School of Materials Science and Engineering Ulsan National Institute of Science and Technology(UNIST)Ulsan Metropolitan City 44919Republic of Korea School of Electrical and Computer Engineering Ulsan National Institute of Science and Technology(UNIST)Ulsan Metropolitan City 44919Republic of Korea Department of Physics Ulsan National Institute of Science and Technology(UNIST)Ulsan Metropolitan City 44919Republic of Korea School of Design and Human Engineering Ulsan National Institute of Science and Technology(UNIST)Ulsan Metropolitan City 44919Republic of Korea Center for Multidimensional Carbon Materials Institute for Basic Science(IBS)Ulsan 44919Republic of Korea Department of Chemistry Ulsan National Institute of Science and Technology(UNIST)Ulsan 44919Republic of Korea

Displays represent information visually,so they have become the fundamental building block to visualize the data of current electronics including ***,electronics have been advanced toward flexible and wearable electronics that can be bent,folded,or stretched while maintaining their performance under various ***,recent advances in research to demonstrate flexible and wearable displays are *** introduce these results by dividing them into several categories according to the components of the display:active-matrix backplane,touch screen panel,light sources,integrated circuit for fingerprint touch screen panel,and characterization tests;and we also present mechanical tests in nano-meter scale and visual ergonomics research.

关键词： dividing electronics panel

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The photodynamic therapy on Streptococcus mutans biofilms using erythrosine and dental halogen curing unit

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International Journal of Oral Science 2012年第4期4卷 196-201页

作者： Young-Ho Lee Ho-Won park ju-Hyun Lee Hyun-Woo Seo Si-Young Lee Department of Pediatric Dentistry Graduate SchoolCollege of DentistryGangneung-Wonju National University Department of Pediatric Dentistry College of DentistryGangneung-Wonju National University Department of Microbiology and Immunology College of DentistryGangneung-Wonju National University

The purpose of our study was to evaluate the effect of photodynamic therapy （PDT）, using erythrosine as a photosensitizing agent and a dental halogen curing unit as a light source, on Streptococcus mutans in a biofilm phase. The S. mutans biofilms were formed in a 24-well cell culture cluster. Test groups consisted of biofilms divided into four groups： group 1： no photosensitizer or light irradiation treatment （control group）; group 2： photosensitizer treatment alone; group 3： light irradiation alone; group 4： photosensitizer treatment and light irradiation. After treatments, the numbers of colony-forming unit （CFU） were counted and samples were examined by confocal laser scanning fluorescence microscopy （CLSM）. Only group 4 （combined treatment） resulted in significant increases in cell death, with rates of 75% and 55% after 8 h of incubation, and 74% and 42% at 12 h, for biofilms formed in brain-heart infusion （BHI） broth supplemented with 0% or O. 1% sucrose, respectively. Therefore, PDT of S. mutans biofilms using a combination of erythrosine and a dental halogen curing unit, both widely used in dental clinics, resulted in a significant increase in cell death. The PDT effects are decreased in biofilms that form in the presence of sucrose.

关键词： biofilms dental halogen curing unit erythrosine photodynamic therapy Streptococcus mutans

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