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CREEP BEHAVIOR OF Zr-1.5Nb-0.4Sn-0.1Fe-0.1Cu ALLOY

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Acta Mechanica Solida Sinica 2008年第4期21卷 308-311页

作者： Ji Young kim Kwang Su Na Yong Duck kim Ji Hui kim Kwon Yeong Lee Ki Nam kim seon Jin kim Division of Advanced Materials Science and Engineering Hanyang University133-791Korea Technical Research Center Sheet Products Design TeamHyundai Steel CompanyKodae-RiSongak-MyeonDangjin-GunChungnam167-32Korea

Creep behavior of the Zr-1.5Nb-0.4Sn-0.1Fe-0.1Cu alloy sheet is investigated from 300℃ to 400℃ in the stress range from 50 MPa to 180 MPa along the rolling direction. The measured strain rates range from 8.8 × 10^-10 s^-1 to 4.7 × 10^-7 s^-1. The activation energies are estimated to assess the creep deformation mechanisms in this alloy. The strain rate is slightly different at low stress, while it shows a distinct difference at high stresses. Stress exponents of this alloy increase with increasing applied stress at all testing temperatures. It is concluded that the creep deformation of the Zr-1.5Nb-0.4Sn-0.1Fe-0. 1 Cu alloy is controlled by the diffusion creep at low stress region and by the climbing of dislocations at high stress region.

关键词： creep zirconium alloy nuclear cladding

Clinical characteristics of patients in their forties who underwent surgical resection for colorectal cancer in Korea

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World Journal of Gastroenterology 2021年第25期27卷 3901-3912页

作者： Chang Sin Lee Se-Jin Baek Jung-Myun Kwak Jin kim seon-Hahn kim Department of Surgery Korea University College of MedicineSeoul 02841South Korea

BACKGROUND The proportion of young patients with colorectal cancer(CRC),especially in their 40s,is increasing *** To confirm the clinical characteristics of such patients,we planned a study comparing them to patients in their 30s and *** Patients undergoing primary resection for CRC,patients in their 30s,40s and 50s were included in the *** and tumor characteristics,and perioperative and oncologic outcomes were *** Most clinical characteristics of 451(10.5%)patients in their 40s were more similar to those of patients in their 30s than those in their *** pathology data,there were more metastatic lesions(30s vs 40s vs 50s;17.5%vs 21.1%vs 14.9%,P=0.012)in patients in their *** was a trend toward less frequent K-ras mutations among patients in their 40s(48.5%vs 33.3%vs 44.5%,P=0.064).The proportion of patients receiving postoperative chemotherapy was also significantly greater among patients in their 40s(58.3%vs 63.9%vs 56.3%,P=0.032).Five-year overall survival(OS)and disease-free survival(DFS)did not differ between the three groups(5-year OS,92.2%vs 89.8%vs 92.2%,P=0.804;5-year total DFS,98.6%vs 95.7%vs 96.1%,P=0.754;5-year local DFS,98.6%vs 94.3%vs 94.9%,P=0.579;5-year systemic DFS,86.4%vs 87.9%vs 86.4%,P=0.908).CONCLUSION Patients with CRC in their 40s showed significantly more numerous metastatic *** oncologic outcome of stage 1-3 patients in their 40s was not inferior compared to that of those in their 30s and 50s.

关键词： Colorectal neoplasm Young age Hereditary cancer Sporadic cancer Screening

Bowel function and quality of life after minimally invasive colectomy with D3 lymphadenectomy for right-sided colon adenocarcinoma

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World Journal of Gastroenterology 2020年第33期26卷 4972-4982页

作者： Ki-Myung Lee Se-Jin Baek Jung-Myun Kwak Jin kim seon-Hahn kim Department of Surgery Korea University College of MedicineSeoul 02841South Korea

BACKGROUND Changes in bowel function after right-sided colectomy are not well understood compared to those associated with left-sided colectomy or rectal *** particular,there are concerns about bowel function after right-sided colectomy with complete mesocolic excision,which has become popular in the *** To evaluate the functional outcomes of patients who underwent right-sided colectomy with D3 lymphadenectomy for colon *** Functional data from patients who underwent minimally invasive right-sided colectomy for colon cancer from October 2017 to September 2018 were prospectively *** outcomes were evaluated preoperatively and at 3,6,12,and 18 mo *** Prior to surgery,57 patients answered the questionnaire,and 47 responded at three months,52 at 6 mo,52 at 12 mo,and 25 at 18 mo *** scales of quality of life and bowel function improved significantly over *** persisted to a high degree throughout the period without a significant change over *** use of medications for defecation was about 10%over the entire ***(P=0.023)and fecal frequency(P<0.001)increased,and bowel dysfunction group(P=0.028)was more common among patients taking *** six months,resected bowel and colon lengths were significantly different as a risk factor between the dysfunction group and the no dysfunction group[odd ratio(OR):1.095,P=0.026;OR:1.147,P=0.031,respectively]in univariate analysis,but not in multivariate *** Despite D3 lymphadenectomy,most bowel symptoms improved over time after right-sided colectomy using a minimally invasive approach,and continuous medication was needed in only approximately 10%of patients.

关键词： Colonic neoplasm Right colectomy Bowel function D3 lymphadenectomy Complete mesocolic excision Quality of life

Recent research progress on magnesium alloys in Korea:A review

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Journal of Magnesium and Alloys 2023年第10期11卷 3545-3584页

作者： Sung Hyuk Park Ye Jin kim Hyun Ji kim Sang-Cheol Jin Jong Un Lee Alexander Komissarov Kwang seon Shin School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea Laboratory of Hybrid Nanostructured Materials National University of Science and TechnologyMoscow 119049Russia Laboratory of Medical Bioresorption and Bioresistance Moscow State University of Medicine and DentistryMoscow 127473Russia Magnesium Technology Innovation Center School of Materials Science and EngineeringSeoul National UniversitySeoul 08826Republic of Korea

This review highlights the recent advancements in Mg research in South Korea with a prime focus on high-speed-extrudable Mg–Bi-based alloys for high productivity and strength,innovative techniques utilizing{10–12}twinning for improved mechanical properties,and alloying and processing methods for enhanced corrosion ***-alloyed Mg–Bi-based alloys possess thermally stableα-Mg matrix and secondary phase,which ensures high-speed extrusion of these alloys at elevated temperatures without hot ***,they exhibit outstanding extrudability with a maximum extrusion speed of up to 70 m/***,their high alloying contents offer excellent strength even after high-speed extrusion through strong solid solution hardening and particle hardening effects,making them suitable for high-performance extruded Mg *** pre-twinning process utilizing{10–12}twinning and the combined process of pre-twinning and subsequent annealing have shown promise in controlling microstructure and texture of wrought Mg alloys and thus enhancing their mechanical *** pre-twinning process enhances tensile strength,fatigue properties,and age-hardening rate of Mg ***,the combined processes of pre-twinning and subsequent annealing considerably improve their ductility,stretch formability,bending formability,and damping *** have been made to improve the corrosion resistance of Mg alloys through alloying additions,process treatments,and surface *** elements like Ca,Sc,and Sm alter the microstructural features(such as secondary phases and grain size)that affect the corrosion *** treatments such as multidirectional forging,screw rolling,and pulse electron beam can also improve the corrosion resistance by refining the ***,advanced surface coating technologies can create durable and corrosion-resistant layers for effectively protecting the Mg *** these research activities conducted

关键词： South Korea Mg–Bi alloys {10–12}twinning Corrosion Mechanical properties

Association of low muscle strength with metabolic dysfunctionassociated fatty liver disease:A nationwide study

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World Journal of Gastroenterology 2023年第45期29卷 5962-5973页

作者： Gyu Bae Lee Youn Huh Sang Hyun Lee Byoungduck Han Yang-Hyun kim Do-Hoon kim seon Mee kim Youn seon Choi Kyung Hwan Cho Ga Eun Nam Department of Family Medicine Korea University College of MedicineSeoul 02841South Korea Department of Family Medicine Uijeongbu Eulji Medical CenterEULJI UniversityDaejeon 11759South Korea School of Electrical Engineering Korea UniversitySeoul 02841South Korea

BACKGROUND There is limited evidence regarding the association between muscle strength and metabolic dysfunction-associated fatty liver disease(MAFLD).AIM To investigate the association between muscle strength and MAFLD in the general population in *** This nationwide representative cross-sectional study included 31649 individuals aged≥19 years who participated in the Korea National Health and Nutrition Examination Survey between 2015 and *** ratios(ORs)and 95%confidence intervals(95%CIs)for MAFLD according to sex-specific quartiles of muscle strength,defined by relative handgrip strength,were calculated using multivariable logistic regression ***,multivariable logistic regression analysis was used to assess the association between muscle strength and probable liver fibrosis in patients with *** Of all the participants,29.3%had *** prevalence of MAFLD was significantly higher in the lower muscle strength quartile groups for all participants,sexes,and age groups(P<0.001).A 1.92-fold(OR=1.92,95%CI:1.70–2.16)and 3.12-fold(OR=3.12,95%CI:2.64–3.69)higher risk of MAFLD was observed in the lowest quartile(Q1)group than in the other groups(Q2–Q4)and the highest quartile(Q4)group,*** ORs of MAFLD were significantly increased in the lower muscle strength quartile groups in a dose-dependent manner(P for trend<0.001).These associations persisted in both *** inverse association between muscle strength and the risk of MAFLD was observed in all subgroups according to age,obesity,and diabetes *** patients with MAFLD,the odds of severe liver fibrosis were higher in Q1(OR=1.83,95%CI:1.25–2.69)than in other groups(Q2–Q4).CONCLUSION Among Korean adults,low muscle strength was associated with an increased risk of MAFLD and liver fibrosis in patients with MAFLD.

关键词： Muscle strength Handgrip strength Metabolic dysfunction-associated fatty liver disease Liver fibrosis Korea National Health and Nutrition Examination Survey

Enhancement parameters of contrast-enhanced computed tomography for pancreatic ductal adenocarcinoma: Correlation with pathologic grading

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World Journal of Gastroenterology 2020年第28期26卷 4151-4158页

作者： Woorim Seo Young Chul kim seon Jeong Min Sang Min Lee Department of Radiology Hallym University Dongtan Sacred Heart HospitalGyeonggi-do 18450South Korea Department of Radiology Hallym University Sacred Heart HospitalGyeonggido 14068South Korea

BACKGROUND Pancreatic ductal adenocarcinoma(PDA)is a malignancy with a high mortality rate and short survival *** conventional computed tomography(CT)has been worldwide used as a modality for diagnosis of PDA,as CT enhancement pattern has been thought to be related to tumor angiogenesis and pathologic grade of *** To evaluate the relationship between the pathologic grade of pancreatic ductal adenocarcinoma and the enhancement parameters of contrast-enhanced *** In this retrospective study,42 patients(Age,mean±SD:62.43±11.42 years)with PDA who underwent surgery after preoperative CT were *** radiologists evaluated the CT images and calculated the value of attenuation at the aorta in the arterial phase and the pancreatic phase(VAarterial and VApancreatic)and of the tumor(VTarterial and VTpancreatic)by finding out four regions of *** between the tumor and the aorta enhancement on the arterial phase and the pancreatic phase(TARarterial and TARpancreatic)was figured out through dividing VT arterial by VAarterial and VTpancreatic by ***-to-aortic enhancement fraction(TAF)was expressed as the ratio of the difference between attenuation of the tumor on arterial and parenchymal images to that between attenuation of the aorta on arterial and pancreatic *** Kruskal-Wallis analysis of variance and Mann-Whitney U test for statistical analysis were *** Forty-two PDAs(23 men and 19 women)were divided into three groups:Welldifferentiated(n=13),moderately differentiated(n=21),and poorly differentiated(n=8).TAF differed significantly between the three groups(P=0.034)but TARarterial(P=0.164)and TARpancreatic(P=0.339)did *** median value of TAF for poorly differentiated PDAs(0.1011;95%CI:0.01100-0.1796)was significantly higher than that for well-differentiated PDAs(0.1941;95%CI:0.1463-0.3194).CONCLUSION Calculation of TAF might be useful in predicting the pathologic grade of PDA.

关键词： Computed tomography Pancreatic ductal carcinoma Diagnostic imaging Clinical pathology Neoplasm grading Prognosis

Bile-derived circulating extracellular mi R-30d-5p and mi R-92a-3p as potential biomarkers for cholangiocarcinoma

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Hepatobiliary & Pancreatic Diseases International 2020年第1期19卷 41-50页

作者： Hye Sook Han Mi Jin kim Joung-Ho Han Jieun Yun Hee Kyung kim Yaewon Yang Ki Bae kim seon Mee Park Department of Internal Medicine Chungbuk National University HospitalCheongju 28644Korea Departments of Internal Medicine Chungbuk National University College of MedicineCheongju 28644Korea Department of Pharmaceutical Engineering College of Science EngineeringCheongju UniversityCheongju 28644Korea

Background: Cholangiocarcinoma (CCA) is from cholangiocytes, and therefore bile is a potentially rich source of biomarkers for CCA. The aim of the study was to identify and validate microRNAs (miRNAs) in bile samples that are differentially expressed between benign biliary disease (BBD) and CCA. Methods: Bile samples from 106 patients with obstructive biliary disease were allocated consecutively to a discovery set (10 patients with BBD and 11 with CCA) and then a validation set (48 patients with BBD and 37 with CCA). An miRNA microarray platform was used to screen 1209 miRNAs in the discovery set. Quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) was used to validate the pro ling results in the discovery and validation sets. In addition, the levels of carbohydrate antigen 19-9 (CA19-9) and carcinoembryonic antigen (CEA) were determined from patient serum samples. Results: Microarray pro ling showed that miR-30d-5p and miR-92a-3p were signi cantly upregulated in bile from the CCA group compared with those from the BBD group. qRT-PCR results indicated that the expression levels of miR-30d-5p and of miR-92a-3p were signi cantly upregulated in the CCA group compared to the BBD group, validating the miRNA microarray results. Pathway analysis suggested that putative target genes of miR-30d-5p and of miR-92a-3p were involved in CCA-associated signalling path- ways, such as Hippo, Wnt, p53, MAPK, and EGFR. Receiver operating curve analysis revealed that the areas under the curve for bile miR-30d-5p, miR-92a-3p, serum CA19-9, and CEA were 0.730, 0.652, 0.675, and 0.603, respectively, and bile miR-30d-5p showed the best diagnostic performance with a sensitivity of 81.1% and a speci city of 60.5%. Conclusions: The levels of extracellular miR-30d-5p and miR-92a-3p in bile were signi cantly higher in patients with CCA than those in patients with BBD. Bile-derived circulating extracellular miR-30d-5p and miR-92a-3p are potential biomarkers for discr

关键词： Bile Biomarkers Cholangiocarcinoma MicroRNA

Predicting Bitcoin Trends Through Machine Learning Using Sentiment Analysis with Technical Indicators

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Computer Systems Science & Engineering 2023年第8期46卷 2231-2246页

作者： Hae Sun Jung seon Hong Lee Haein Lee Jang Hyun kim Department of Applied Artificial Intelligence/Department of Human-Artificial Intelligence Interaction Sungkyunkwan UniversitySeoul03063Korea Department of Interaction Science/Department of Human-Artificial Intelligence Interaction Sungkyunkwan UniversitySeoul03063Korea

Predicting Bitcoin price trends is necessary because they represent the overall trend of the cryptocurrency *** the history of the Bitcoin market is short and price volatility is high,studies have been conducted on the factors affecting changes in Bitcoin *** have been conducted to predict Bitcoin prices using Twitter ***,the amount of data was limited,and prices were predicted for only a short period(less than two years).In this study,data from Reddit and LexisNexis,covering a period of more than four years,were *** data were utilized to estimate and compare the performance of the six machine learning techniques by adding technical and sentiment indicators to the price data along with the volume of *** accuracy of 90.57%and an area under the receiver operating characteristic curve value(AUC)of 97.48%were obtained using the extreme gradient boosting(XGBoost).It was shown that the use of both sentiment index using valence aware dictionary and sentiment reasoner(VADER)and 11 technical indicators utilizing moving average,relative strength index(RSI),stochastic oscillators in predicting Bitcoin price trends can produce significant ***,the input features used in the paper can be applied on Bitcoin price ***,this approach allows investors to make better decisions regarding Bitcoin-related investments.

关键词： Bitcoin cryptocurrency sentiment analysis price trends prediction natural language processing machine learning

Underwater endoscopic mucosal resection for neoplasms in the pyloric ring of the stomach: Four case reports

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World Journal of Clinical Cases 2020年第14期8卷 3050-3056页

作者： Dong Hyun kim seon-Young Park Chang Hwan Park Hyun Soo kim Sung Kyu Choi Division of Gastroenterology Department of Internal MedicineChonnam National University Hospital and Medical SchoolGwangju 61469South Korea

BACKGROUND Tumors located in the pylorus are technically more complex to resect by endoscopic resection,as the anatomical characteristics of this region can affect the adequate assessment of margins and performance of the *** reported the results of underwater endoscopic mucosal resection(UEMR)of benign mucosal neoplasms located in the pyloric *** SUMMARY This case series describes 4 patients with 4 mucosal neoplasms located in the pyloric *** diameter of each neoplasm was less than 15 *** performed UEMR for the *** immersion enabled slight floating of the lesions,resulting in easy *** achieved en bloc resection with a snare and electrosurgical *** procedure were performed within 3 min without adverse *** examination showed low-grade dysplasia with clear resection margins in one case and hyperplastic polyps in three *** UEMR can be an effective and safe treatment method for neoplasms in the gastric pyloric ring.

关键词： Duodenoscopy Endoscopic mucosal resection Neoplasm Pylorus Stomach Case report