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Redox sensor QSOX1 regulates plant immunity by targeting GSNOR to modulate ROS generation

Molecular Plant 2021年第8期14卷 1312-1327页

作者： Ho Byoung Chae Min Gab kim Chang Ho Kang Joung Hun Park Eun Seon Lee Sang-Uk Lee Yong Hun Chi seol ki paeng Su Bin Bae Seong Dong Wi Byung-Wook Yun Woe-Yeon kim Dae-Jin Yun David Mackey Sang Yeol Lee Division of Applied Life Sciences(BK21)and PMBBRC Gyeongsang National UniversityJinju 52828Korea College of Pharmacy Research Institute of Pharmaceutical ScienceGyeongsang National UniversityJinju 52828Korea School of Applied Biosciences College of Agriculture and Life SciencesKyungpook National UniversityDaegu 41566Korea Department of Biomedical Science and Engineering Konkuk UniversitySeoul 05029Korea Department of Horticulture and Crop Science Department of Molecular Geneticsand Center for Applied Plant SciencesThe Ohio State UniversityColumbusOH 43210USA College of Life Sciences Qingdao Agricultural UniversityQingdao 266109P.R.China Plant Propagation Team Plant Production DivisionSejong National ArboretumSejong 30106Korea

Reactive oxygen signaling regulates numerous biological processes,including stress responses in *** sensors transduce reactive oxygen signals into cellular ***,we present biochemical evidence that a plant quiescin sulfhydryl oxidase homolog(QSOX1)is a redox sensor that negatively regulates plant immunity against a bacterial *** expression level of QSOX1 is inversely correlated with pathogen-induced reactive oxygen species(ROS)***,QSOX1 both senses and regulates ROS levels by interactingn with and mediating redox regulation of S-nitrosoglutathione reductase,which,consistent with previous findings,influences reactive nitrogen-mediated regulation of ROS ***,our data indicate that QSOX1 is a redox sensorthat negatively regulates plant immunity by linking reactive oxygen and reactive nitrogen signaling to limit ROS production.

关键词： redox sensor plant immu nity QSOX1 GSNOR reactive oxygen species(ROS) reactive nitrogen species(RNS)

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An oxygenating colloidal bioink for the engineering of biomimetic tissue constructs

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Bio-Design and Manufacturing 2024年第3期7卷 240-261页

作者： seol-Ha Jeong Jarno Hiemstra Patrick V.Blokzijl Rebeca Damian-Ferrara Danilo Martins dos Santos Jéssica H.L.da Fonseca Min-Ho Kang Jihyun kim Dilara Yilmaz-Aykut Mei L.L.Cham-Pérez Jeroen Leijten Su Ryon Shin Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02139USA Leijten Lab Department of Developmental BioEngineeringFaculty of Science and TechnologyTechnical Medical CentreUniversity of TwenteDrienerlolaan 57522 NB EnschedeThe Netherlands Nanotechnology National Laboratory for Agriculture(LNNA) Embrapa InstrumentaçãoSao CarlosSao Paulo 13560-970Brazil Department of Biomedical-Chemical Engineering The Catholic University of Korea43 Jibong-roBucheon-siGyeonggi-do 14662Republic of Korea Department of Biotechnology The Catholic University of Korea43 Jibong-roBucheon-siGyeonggi-do 14662Republic of Korea

Ensuring a sufficient oxygen supply is pivotal for the success of bioprinting applications since it fosters tissue integration and natural *** in oxygen concentration among diverse tissues necessitates the precise recreation of tissue-specific oxygen levels in imprinted constructs to support the survival of targeted *** oxygen-releasing biomaterials,such as oxygen-generating microparticles(OMPs),have shown promise for enhancing the oxygen supply of microenvironments in injured tissues,whether this approach is scalable for large tissues and whether tissue-specific bioinks with varying OMP concentrations remain printable remain *** study addresses this critical gap by introducing an innovative class of engineered oxygenated bioinks that combine colloidal-based microgels with *** report that incorporating nanosized calcium peroxide(nCaO_(2))and manganese oxide nanosheets(nMnO_(2))into hydrophobic polymeric microparticles enables precise modulation of oxygen release while controlling hydrogen peroxide ***,the fabrication of oxygenating and cytocompatible colloidal gels is achieved using an aqueous two-phase *** study thoroughly evaluates the fundamental characteristics of the resulting bioink,including its rheological behaviors,printability,shape fidelity,mechanical properties,and oxygen release ***,this study demonstrates the macroscopic scalability and cytocompatibility of printed constructs produced via cell-laden oxygenating colloidal *** showcasing the effectiveness of extrusion-based bioprinting,this study underscores how it can be used to fabricate biomimetic tissues,indicating its potential for new *** findings presented here advance the bioprinting field by achieving scalability with both high cell viability and the possibility of mimicking specifically oxygenated *** work thereby offers a promising avenue for the development of functional tissues with e

关键词： 3D bioprinting Bioink Colloidal gels Extrusion printing Oxygen-generating microparticle

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Limit Theorems for Inverse Process Tn of Hawkes Process

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Acta Mathematica Sinica,English Series 2017年第1期33卷 51-60页

作者： Youngsoo seol Department of Mathematics and Statistics University of South Florida Tampa FL 33620 USA

We consider linear Hawkes process Nt and its inverse process Tn. The limit theorems for Nt are well known and studied by many authors. In this paper, we study the limit theorems for Tn. In particular, we investigate the law of large numbers, the central limit theorem and the large deviation principle for Tn. The main tool of the proof is based on immigration-birth representation and the observations on the relation between N＋ and Tn

关键词： Hawkes processes self-exciting processes central limit theorems law of large numbers,large deviations

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Moderate Deviations for Marked Hawkes Processes

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Acta Mathematica Sinica,English Series 2017年第10期33卷 1297-1304页

作者： Youngsoo seol Department of Mathematics and Statistics University of South Florida Tampa FL 33620 USA

We consider a linear Hawkes process with random marks. Some limit theorems have been studied by Karabash and Zhu [Stoch. Models, 31,433-451 （2015）]. In this paper, we obtain a moderate deviation principle for marked... 详细信息

关键词： Marked Hawkes processes self-exciting processes moderate deviation principles largedeviations Hawkes processes

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Delayed asymptomatic progressive aortic dissecting aneurysm in patient with STEMI

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Journal of Geriatric Cardiology 2017年第6期14卷 425-426页

作者： Yun-Seok Song Sang-Hoon seol Dong-kie kim ki-Hun kim Doo-Il kim Division ofCardiology Department of Internal Medicine Inje University College of Medicine Haeundae Paik hospital Busan South Korea

An 80-year-old woman visited emergency room because of resting chest pain for one hour. She had history of hypertension for 10 years. The blood pressure was 80/50 mmHg and the pulse rate was 51 beats/min. The electrocardiogram demonstrated Junctional bradycardia and ST elevation in lead Ⅱ, Ⅲ and aVF. Chest X-ray indicated cardiomegaly （Figure 1A）. Coronary angiography revealed near total occlusion of proximal right coronary artery （RCA）. She underwent percutaneous coronary intervention （PCI） for the RCA lesion successfully. Echocardiography showed hypokinesia of RCA territory （Figure 2A）.

关键词： Delayed Dissecting aneurysm STEMI

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Transient severe mitral regurgitation after paroxysmal supraventricular tachycardia in patient with WPW syndrome

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Journal of Geriatric Cardiology 2017年第10期14卷 652-653页

作者： Yun-Seok Song Sang-Hoon seol Dong-kie kim ki-Hun kim Doo-Il kim Division of Cardiology Department of lnternal Medicine Inje University College of Medicine Haeundae Paik hospital Busan South Korea

A 65-year-old woman was presented with acute ab- dominal pain. The initial heart rate was 170 beats/min and the ECG showed supraventricular tachycardia （Figure IA）. After intra-venous adenosine administered, it recovered to sinus rhythm and the follow-up ECG showed WPW pattern （Figure 1B）. The echocardiography revealed mitral valve prolapse of mid portion of anteromedial valve leaflet （A2） with severe mitral regurgitation （MR）（Figure 2）.

关键词： Tachycardia Transient mitral regurgitation WPW syndrome

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Induced atrial fibrillation during defibrillation test on implantation of subcutaneous implantable cardioverter defibrillator

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Journal of Geriatric Cardiology 2020年第8期17卷 525-527页

作者： ki-Hun kim Sang-Hoon seol Jino Park Yeo-Jeong Song Seunghwan kim Dong-kie kim Division of Cardiology Department of Internal MedicineHaeundae Paik HospitalInje University College of MedicineBusanKorea

The subcutaneous implantable cardioverter defibrillator(S-ICD)has become an alternative to the transvenous ICD in indicated ***,inappropriate shock or failed ventricular tachycardia/fibrillation conversion is the most... 详细信息

关键词： Atrial fibrillation Defibrillation test Subcutaneous implantable cardioverter defibrillator

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Biomimetic Quadruped Robot with a Spinal Joint and Optimal Spinal Motion via Reinforcement Learning

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Journal of Bionic Engineering 2021年第6期18卷 1280-1290页

作者： Young Kook kim Woojin seol Jihyuk Park LV R&D Team Electro-technology R&D CenterLS Electric Co.LtdCheongju28437Republic of Korea Digital Innovation Unit Korea Hydro&Nuclear Power Co.Ltd1312-gil YuseongdaeroYusung-guDaejeon34101Republic of Korea Department of Automotive Engineering College of Mechanical and IT EngineeringYeungnam University280 Daehak-roGyeongsanGyeongbuk38541Republic of Korea

Feline animals can run quickly using spinal joints as well as the joints that make up their four *** paper describes the development of a quadruped robot including a spinal joint that biomimics feline *** developed robot platform consists of four legs with a double 4-bar linkage type and one simplified rotary *** addition,Q-learning,a type of machine learning,was used to find the optimal motion profile of the spinal *** bounding gait was implemented on the robot system using the motion profile of the spinal joint,and it was confirmed that using the spinal joint can achieve a faster Center of Mass(CoM)forward speed than not using the spinal *** the motion profile obtained through Q-learning did not exactly match the spinal angle of a feline animal,which is more multiarticular than that of the developed robot,the tendency of the actual feline animal spinal motion profile,which is sinusoidal,was similar.

关键词： Quadruped robot system Bioinspired methods Legged robots Machine learning Q-learning

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Incidence and Related Risk Factors of Junctional Ectopic Tachycardia in Infants after Cardiac Surgery for Congenital Heart Disease

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Congenital Heart Disease 2022年第5期17卷 569-578页

作者： Jae Hee seol Se Yong Jung Jae Young Choi Han ki Park Young Hwan Park Nam Kyun kim Department of Pediatrics Congenital Heart Disease CenterDivision of Pediatric CardiologySeverance Cardiovascular HospitalYonsei University College of MedicineSeoulKorea Department of Pediatrics Yonsei University Wonju College of MedicineWonjuKorea Department of Thoracic and Cardiovascular Surgery Division of Cardiovascular SurgeryCongenital Heart Disease CenterSeverance Cardiovascular HospitalYonsei University College of MedicineSeoulKorea Department of Pediatrics and Biomedical Engineering School of MedicineEmory UniversityAtlantaUSA

Objective:Junctional ectopic tachycardia is common after cardiac surgery for congenital heart ***,its incidence and related risk factors in infants after cardiac surgery are not well *** objective of this study was to determine the overall incidence and related risk factors for junctional ectopic tachycardia in neonates and ***:We enrolled a total of 271 patients aged<1 year who underwent open cardiac surgery at Severance Cardiovascular Hospital from January 2018 to December *** criteria were immediate postoperative mortality,other arrhythmias detected in the perioperative period,and ***:The overall incidence of junctional ectopic tachycardia was 12.9%.The logistic regression analysis revealed that longer cardiopulmonary bypass time,surgery involving atrioventricular node stretching,and the presence of early repolarization on preoperative electrocardiography increased the risk of junctional ectopic *** with junctional ectopic tachycardia had longer intubation time and intensive care unit ***:Junctional ectopic tachycardia is a common arrhythmia after cardiac surgery for congenital heart disease in ***,infants developing junctional ectopic tachycardia after cardiac surgery have specific preoperative electrocardiography *** risk factors for junctional ectopic tachycardia were associated not only with surgical procedural factors but also with preoperative electrocardiographic parameters.

关键词： Junctional ectopic tachycardia congenital heart disease early re-polarization

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Modified embedded-atom method interatomic potentials for Mg-Al-Ca and Mg-Al-Zn ternary systems

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Journal of Magnesium and Alloys 2021年第1期9卷 317-335页

作者： Hyo-Sun Jang Donghyuk seol Byeong-Joo Lee Department of Materials Science and Engineering Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea

Al,Ca,and Zn are representative commercial alloying elements for Mg *** investigate the effects of these elements on the deformation and recrystallization behaviors of Mg alloys,we develop interatomic potentials for the Al-Ca,Al-Zn,Mg-Al-Ca and Mg-Al-Zn systems based on the second nearest-neighbor modified embedded-atom method *** developed potentials describe structural,elastic,and thermodynamic properties of compounds and solutions of associated alloy systems in reasonable agreement with experimental data and higher-level *** applicability of these potentials to the present investigation is confirmed by calculating the generalized stacking fault energy for various slip systems and the segregation energy on twin boundaries of the Mg-Al-Ca and Mg-Al-Zn alloys,accompanied with the thermal expansion coefficient and crystal structure maintenance of stable compounds in those alloys.

关键词： 2NN MEAM Interatomic potential Mg-Al-Ca Mg-Al-Zn Atomistic simulation

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