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Segmental artery injury during transforaminal percutaneous endoscopic lumbar discectomy:Two case reports

World Journal of Clinical Cases 2022年第33期10卷 12345-12351页

作者： Wan-Jae Cho Ki-Won Kim Hyung-Youl park Bo-Hyoung Kim Jun-seok Lee Department of Orthopedic Surgery Yeouido St.Mary’s HospitalCollege of MedicineCatholic University of KoreaSeoul 07345South Korea Department of Orthopedic Surgery Eunpyeong St.Mary’s HospitalCollege of MedicineCatholic University of KoreaSeoul 03312South Korea

BACKGROUND Since Kambin experimentally induced arthroscopy to treat herniated nucleus pulposus,percutaneous endoscopic lumbar discectomy(PELD)has been *** branch of the segmental artery around the neural foramen may be damaged during PELD using the transforaminal *** report 2 rare cases in which segmental artery injury that occurred during PELD was treated with emergency *** SUMMARY In case 1,a 31-year-old man was transferred to our emergency department with left lower quadrant abdominal pain after PELD at a local *** spine magnetic resonance imaging after the surgery showed a hematoma of the left retroperitoneal area and the psoas muscle *** suspicion of vascular injury,arteriography was *** and blood leakage from the left 4th lumbar segmental artery into the abdominal cavity were *** transarterial embolization was performed using fibered microcoils for bleeding of the segmental *** case 2,a 75-year-old woman was transferred to our emergency department with low blood pressure,right flank pain,and drowsy mental status after PELD at a local *** the patient arrived at the emergency room,the blood pressure decreased from 107/55 mmHg to 72/47 *** blood pressure *** suspicion of vessel injury,arteriography was performed,and the right 4th lumbar segmental artery rupture was *** transarterial embolization was performed for bleeding of segmental *** We were able to find the bleeding focus by angiography and treat the injury of the segmental artery successfully through emergency transarterial embolization.

关键词： Percutaneous endoscopic lumbar discectomy Segmental artery injury Transarterial embolization Angiography Case report

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Silent advanced large cell neuroendocrine carcinoma with synchronous adenocarcinoma of the colon:A case report

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World Journal of Gastrointestinal Oncology 2022年第11期14卷 2266-2272页

作者： Hyeon seok Baek Sang Wook Kim Soo Teik Lee Ho Sung park Seung Young Seo Department of Internal Medicine Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University HospitalJeonju-si 56445Jeollabuk-doSouth Korea Department of Pathology Jeonbuk National University Medical SchoolJeonjusi 56445Jeollabuk-doSouth Korea

BACKGROUND Large cell neuroendocrine carcinoma(LCNEC)accounts for about 0.25%of colorectal cancer ***,synchronous LCNEC and adenocarcinoma coexistence in the colon is very *** are usually aggressive and have a poor ***,colorectal LCNEC patients complain of abdominal symptoms such as pain,diarrhea or hematochezia because it is often diagnosed as an advanced disease that accompanies metastatic *** SUMMARY We describe a case of relatively asymptomatic synchronous LCNEC and colon adenocarcinoma.A 62-year-old male patient visited our hospital due to anemia detected by a local health *** did not complain of melena,hematochezia or abdominal *** examination was unremarkable and his abdomen was soft,nontender and nondistended with no palpable *** tests revealed anemia with hemoglobin 5.1 g/*** revealed an ulcerofungating lesion in the ascending colon and about a 1.5 cm-sized large sessile polyp in the sigmoid *** biopsy of the ascending colon lesion revealed the ulcerofungating mass that was LCNEC and endoscopic mucosal resection at the sigmoid colon lesion showed a large polypoid lesion that was *** liver,lung,bone and lymph nodes metastasis was found on chest/abdominal computed tomography and positron emission *** patient was diagnosed with advanced colorectal LCNEC with liver,lung,bone and lymph node metastasis(stage IV)and synchronous colonic adenocarcinoma *** this case,no specific symptom except anemia was observed despite the multiple *** patient refused systemic chemotherapy and was discharged after *** We report a case of silent LCNEC of the colon despite the advanced state and synchronous adenocarcinoma.

关键词： Large cell neuroendocrine carcinoma Colon Synchronous Adenocarcinoma Case report

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Pyruvate dehydrogenase kinase is a negative regulator of interleukin-10 production in macrophages

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Journal of Molecular Cell Biology 2020年第7期12卷 543-555页

作者： Yi Rang Na Daun Jung Juha Song Jong-Wan park Jung joo Hong Seung Hyeok seok Macrophage Lab Department of Microbiology and Immunology and Institute of Endemic DiseaseSeoul National University College of MedicineChongno-guSeoul 03080Republic of Korea Department of Biomedical Science BK21-Plus Education ProgramSeoul National University College ofMedicineJongno-guSeoul 03080Republic of Korea Department of Pharmacology Seoul National University College of MedicineJongno-guSeoul 03080Republic of Korea Cancer Research Institute and Ischemic/Hypoxic Disease Institute Seoul National University College ofMedicineJongno-guSeoul 03080Republic of Korea National Primate Research Center Korea Research Institute of Bioscience and BiotechnologyCheongju 28116Republic of Korea

Interleukin-10(IL-10)is the most potent anti-inflammatory cytokine in the body and plays an essential role in determining outcomes of many inflammatory *** metabolism is a critical determinant of immune cell function;however,it is currently unclear whether metabolic processes are specifically involved in IL-10 *** this study,we aimed to find the central metabolic molecule regulating IL-10 production of macrophages,which are the main producers of *** analysis identified that metabolic changes were predominantly enriched in Kupffer cells at the early inflammatory phase of a mouse endotoxemia *** them,pyruvate dehydrogenase kinase(PDK)-dependent acute glycolysis was negatively involved in IL-10 *** or knockdown of PDK selectively increased macrophage IL-10 ***,PDK inhibition increased IL-10 production via profound phosphorylation of adenosine monophosphate(AMP)-activated protein kinase alpha 1(AMPKα1)by restricting glucose uptake in lipopolysaccharide-stimulated ***α1 consequently activated p38 mitogen-activated protein kinase,c-Jun N-terminal kinase,and cyclic AMP-responsive element-binding protein to regulate IL-10 *** study uncovers a previously unknown regulatory mechanism of IL-10 in activated macrophages involving an immunometabolic function of PDK.

关键词： macrophage pyruvate dehydrogenase kinase AMP-activated protein kinase interleukin-10

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Construction of random sheared fosmid library from Chinese cabbage and its use for Brassica rapa genome sequencing project

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Journal of Genetics and Genomics 2011年第1期38卷 47-53页

作者： Tae-Ho park Beom-seok park Jin-A Kim joon Ki Hong Mina Jin Young-joo Seol Jeong-Hwan Mun Genomics and Functional Bio-Material Division National Academy of Agricultural ScienceRural Development Administration The Department of Horticultural Science Daegu University

As a part of the Multinational Genome Sequencing Project of Brassica rapa, linkage group R9 and R3 were sequenced using a bacterial artificial chromosome （BAC） by BAC strategy. The current physical contigs are expected to cover approximately 90% euchromatins of both chromosomes. As the project progresses, BAC selection for sequence extension becomes more limited because BAC libraries are restriction enzyme-specific. To support the project, a random sheared fosmid library was constructed. The library consists of 97536 clones with average insert size of approximately 40 kb corresponding to seven genome equivalents, assuming a Chinese cabbage genome size of 550 Mb. The library was screened with primers designed at the end of sequences of nine points of scaffold gaps where BAC clones cannot be selected to extend the physical contigs. The selected positive clones were end-sequenced to check the overlap between the fosmid clones and the adjacent BAC clones. Nine fosmid clones were selected and fully sequenced. The sequences revealed two completed gap filling and seven sequence extensions, which can be used for further selection of BAC clones confirming that the fosmid library will facilitate the sequence completion of B. rapa.

关键词： Brassica rapa Chinese cabbage Fosmid library Genome sequencing Physical contig

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Unveiling the redox electrochemistry of 1D,urchin-like vanadium sulfide electrodes for high-performance hybrid supercapacitors

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Journal of Energy Chemistry 2023年第4期79卷 569-580页

作者： K.Karuppasamy Dhanasekaran Vikraman Sajjad Hussain Balamurugan Thirumalraj P.Santhoshkumar Hemalatha Parangusan Hyun-Chang park Jongwan Jung Hyun-seok Kim Division of Electronics and Electrical Engineering Dongguk University-SeoulSeoul 04620Republic of Korea Department of Nanotechnology and Advanced Materials Engineering Sejong UniversitySeoul 05006Republic of Korea School of Materials Science&Engineering Kookmin UniversitySeoul 02707Republic of Korea Millimeter-Wave Innovation Technology Research Center(MINT) Dongguk University-SeoulSeoul 04620Republic of Korea Qatar University Young Scientist Center(QUYSC) Qatar UniversityP.O.Box 2713DohaQatar

Exploring novel versatile electrode materials with outstanding electrochemical performance is the key to the development of advanced energy conversion and storage *** this work,we aim to construct new-fangled one-dimensional(1D)quasi-layered patronite vanadium tetrasulfide(VS_(4))nanostructures by using different sulfur sources,namely thiourea,thioacetamide,and L-cysteine through an ethyleneaminetetraacetic-acid(EDTA)-mediated solvothermal *** as-prepared VS4exhibits several unique morphologies such as urchin,fluffy nanoflower,and polyhedron with appropriate surface *** the prepared nanostructures,the VS_(4)-1@NF nanostructure exhibited excellent electrochemical properties in 6 M KOH solution,and we explored its redox electrochemistry in *** asprepared VS_(4)-1@NF electrode exhibited battery-type redox characteristics with the highest capacity of280 C g^(-1)in a three-electrode ***,it offered a capacity of 123 F g^(-1)in a hybrid twoelectrode set-up at 1 A g^(-1)with the highest specific energy and specific power of 38.5 W h kg^(-1)and750 W kg^(-1),***,to ensure the practical applicability and real-world performance of the prepared hybrid AC@NF//VS_(4)-1@NF cell,we performed a cycling stability test with more than 5,000galvanostatic charge–discharge cycles at 2 A g^(-1),and the cell retained around 84.7%of its capacitance even after 5,000 cycles with a CE of 96.1%.

关键词： Patronite Redox electrochemistry Urchin VS_(4) 1D material Mesoporous

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Geometric Properties of Ribs and Fans of a Bézier Curve

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Journal of Computer Science & Technology 2006年第2期21卷 279-283页

作者： joo-Haeng Lee Hyungjun park Electronics and Telecommunications Research Institute Daejeon 305-350 Korea Chosun University Gwangju 501-759 Korea

Ribs and fans are interesting geometric entities that are derived from a given Bézier curve or surface based on the recent theory of rib and fan decomposition. In this paper, we present some of new geometric properties of ribs and fans for a Bézier curve including composite fans, rib-invariant deformation, and fan-continuity in subdivision. We also give some examples for the presented properties.

关键词： geometric algorithm Bézier curve composite fan rib-invariance fan-continuity

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Comparative effectiveness of combined antiplatelet treatments in acute minor ischaemic stroke

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Stroke & Vascular Neurology 2022年第1期7卷 13-21页

作者： Shina Kim joon-Tae Kim Ji Sung Lee Beom joon Kim Jong-Moo park Kyusik Kang Soo joo Lee Jae Guk Kim Jae-Kwan Cha Dae-Hyun Kim Tai Hwan park Sang-Soon park Kyung Bok Lee Jun Lee Keun-Sik Hong Yong-Jin Cho Hong-Kyun park Byung-Chul Lee Kyung-Ho Yu Mi Sun Oh Dong-Eog Kim Wi-Sun Ryu Jay Chol Choi Jee-Hyun Kwon Wook-joo Kim Dong-Ick Shin Sung-Il Sohn Jeong-Ho Hong Man-seok park Kang-Ho Choi Ki-Hyun Cho Juneyoung Lee Hee-joon Bae Department of Neurology Chonnam National University HospitalChonnam National University Medical SchoolGwangjuKorea Clinical Research Center Asan Institute for Life SciencesAsan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea Department of Neurology Cerebrovascular CenterSeoul National University Bundang HospitalSeongnamKorea Department of Neurology Uijeongbu Eulji Medical CenterEulji University School of MedicineUijeongbu-siKorea Department of Neurology Nowon Eulji Medical CenterEulji UniversitySeoulKorea Department of Neurology Eulji University HospitalEulji UniversityDaejeonKorea Department of Neurology Dong-a UniversityBusanKorea Department of Neurology Seoul Medical CenterSeoulKorea Department of Neurology Soonchunhyang University HospitalSeoulKorea Department of Neurology Yeungnam University HospitalDaeguKorea Department of Neurology Inje University Ilsan Paik HospitalInje University College of MedicineGoyangKorea Department of Neurology Hallym University Sacred Heart HospitalAnyangKorea Department of Neurology Dongguk University Ilsan HospitalGoyangKorea Department of Neurology Jeju National University HospitalJeju National University School of MedicineJejuKorea Department of Neurology University of Ulsan College of MedicineUlsanKorea Department of Neurology Chungbuk National University HospitalCheongjuKorea Department of Neurology Keimyung University Dongsan Medical CenterDaeguKorea Department of Biostatistics Korea University College of MedicineSeoulKorea

Background No study has thoroughly compared the effectiveness of combined antiplatelet treatments(other than clopidogrel–aspirin)versus clopidogrel–aspirin or aspirin alone for early secondary prevention in acute ischaemic *** We identified patients with acute,minor,non-cardiogenic ischaemic stroke treated with aspirin alone,clopidogrel–aspirin or other combination *** scores considering the inverse probability of treatment weighting were used to adjust for baseline *** primary outcome was the composite of all strokes(ischaemic or haemorrhagic),myocardial infarction and all-cause mortality at 3 *** Among 12234 patients(male:61.9%;age:65.5±13 years)who met the eligibility criteria,aspirin,clopidogrel–aspirin and other combination treatments were administered in 52.2%,42.9%and 4.9%of patients,*** the crude analysis,the primary outcome event at 3 months occurred in 14.5%of the other combination group,14.4%of the aspirin group and 13.0%of the clopidogrel–aspirin *** the weighted Cox proportional hazards analysis,the 3-month primary outcome event occurred less frequently in the clopidogrel–aspirin group than in the other combination group(weighted HR:0.82(0.59–1.13)),while no association was found between the aspirin group(weighted HR:1.04(0.76–1.44))or other combination group and the 3-month primary *** Other combined antiplatelet treatment,compared with aspirin alone or clopidogrel–aspirin,was not associated with reduced risks of primary composite vascular events or recurrent stroke during the first 3 months after ***,the results suggest that other combination treatments,particularly the cilostazol-based combination,may not be effective alternatives for clopidogrel–aspirin to prevent early vascular events in patients with acute minor *** exploration in clinical trials will be needed.

关键词： prevention treatment alone

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“One stone,two birds”solvent system to fabricate microcrystalline cellulose–Ti_(3)C_(2)T_(x)nanocomposite film as a flexible dielectric and thermally conductive material

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Nano Research 2023年第2期16卷 3240-3253页

作者： Yong-Zhu Yan Shuwei Li Sung Soo park Wei-Jin Zhang Jun seok Lee Jung Rae Kim Dong Gi Seong Chang-Sik Ha Department of Polymer Science and Engineering School of Chemical EngineeringPusan National UniversityBusan 46241Republic of Korea School of Chemical and Biomolecular Engineering Pusan National UniversityBusan 46241Republic of Korea Division of Advanced Materials Engineering Dong-Eui UniversityBusan 47340Republic of Korea

A strategy for fabricating microcrystalline cellulose–Ti_(3)C_(2)T_(x)(MCC–MXene)nanocomposite films with high relative permittivity,high thermal conductivity,and excellent mechanical properties was *** MCC–MXene nanocomposite film was fabricated by casting a solution containing N,N-dimethylacetamide/lithium chloride(DMAc/LiCl)-soluble MCC and DMAcdispersible MXene nanosheets,followed by humidity control *** MXene nanosheets greatly enhanced the permittivity of the nanocomposite films owing to interfacial ***,the nanocomposite film with 20 wt.%MXene content achieved a desirable permittivity of 71.4 at 102 Hz(a 770%improvement against that of neat cellulose),while the dielectric loss only increased by 1.8 times(from 0.39 to 0.70).The obtained nanocomposite films with 20 wt.%and 30 wt.%MXene exhibited remarkable in-plane thermal conductivities of 8.523 and 9.668 W∙m^(−1)∙K^(−1),respectively,owing to the uniform dispersion and selfalignment of the MXene layered ***,the uniformly dispersed MXene nanosheets in the MCC network with interfacial interaction(hydrogen bonding)and mechanical entanglement endowed the nanocomposite films with excellent mechanical properties and ***,the thermal stability,water resistance,and antibacterial properties of the nanocomposite films were effectively improved with the introduction of ***,using DMAc/LiCl as the solvent system not only improves the compatibility between MCC and MXene but also avoids the problem of easy oxidation of MXene in aqueous *** the high stability of the MCC–MXene solution and enhanced properties of the MCC–MXene films,the proposed strategy manifests great potential for fabricating natural biomass-based dielectric materials.

关键词： Ti_(3)C_(2)T_(x) microcrystalline cellulose flexible dielectric thermally conductive N,N-dimethylacetamide/lithium chloride(DMAc/LiCl) compatibility

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Effect of CaF2 content in refining slag on formation behavior of spinel inclusion in Ni-Cr-V-alloyed special steel

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Journal of Iron and Steel Research(International) 2018年第2期25卷 157-163页

作者： Jae-hong Shin joo-hyun park Department of Materials Engineering Hanyang UniversityAnsan 426-791 Korea

The influence of CaF2 content on the formation behavior of spinel inclusions in the Ni-Cr-V-alloyed special steel was presented. The spinel was not formed at CaF2 content lower than 10 wt%. However, it was formed at early stage when the CaF2 content was greater than 30 wt%, followed by a modification to the aluminosilicate-type inclusions. Because the slag was saturated by MgO, the activity of MgO was unity irrespective of CaF2 content in the slag. Thus, Mg was transferred from slag to metal phase. Mg transferred to molten steel reacted with Al2O3-rich inclusions to form ***2O3 spinel. However, the spinel inclusion was modified to aluminosilicate-type inclusions by the reaction with Si and Ca transferred from slag to molten steel about 2-3 h later.

关键词： Spinel inclusion Refining slag CaF2 content Ni-Cr-V-alloyed special steel

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Sodium-Coordinated Polymeric Phthalocyanines as Stable High-Capacity Organic Anodes for Sodium-Ion Batteries

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Energy & Environmental Materials 2023年第4期6卷 22-30页

作者： Jeongyeon Lee Yoonbin Kim Soyong park Kang Ho Shin Gun Jang Min Jun Hwang Daekyu Kim Kyung-Ah Min Ho seok park Byungchan Han Dennis K.P.Ng Lawrence Yoon Suk Lee Department of Applied Biology and Chemical Technology and Research Institute for Smart Energy The Hong Kong Polytechnic UniversityHung HomKowloon Hong Kong SAR China Department of Chemistry The Chinese University of Hong KongShatinNew Territories Hong Kong SAR China Convergence Research Center for Energy and Environmental Sciences Sungkyunkwan UniversitySuwon Korea Department of Chemical and Biomolecular Engineering Yonsei UniversitySeoul Korea School of Chemical Engineering Sungkyunkwan UniversitySuwon Korea

Sodium-ion batteries(SIBs)have attracted considerable interest as an alternative to lithium-ion batteries owing to their similar electrochemical performance and superior long-term cycle *** materials are regarded as promising anode materials for constructing SIBs with high capacity and good ***,utilization of organic materials is rather limited by their low energy density and poor stability at high current *** overcome these limitations,we utilized a novel polymeric disodium phthalocyanines(pNaPc)as SIB anodes to provide stable coordination sites for Na ions as well as to enhance the stability at high current *** varying the linker type during a one-pot cyclization and polymerization process,two pNaPc anodes with O-(O-pNaPc)and S-linkers(S-pNaPc)were prepared,and their structural and electrochemical properties were *** O-pNaPc binds Na ions with a lower binding energy compared with S-pNaPc,which leads to more facile Na-ion coordination/dissociation when engaged as SIB *** use of O-pNaPc significantly improves the redox kinetics and cycle stability and allows the fabrication of a full cell against Na_(3)V_(2)(PO_(4))_(2)F_(3)/C cathode,which demonstrates its practical application with high energy density(288 Wh kg^(-1))and high power density(149 W kg^(-1)).

关键词： coordination chemistry organic anode phthalocyanine polymerization sodium ion battery

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