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Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein improves diagnostic accuracy for hepatocellular carcinoma

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World Journal of Gastroenterology 2021年第28期27卷 4687-4696页

作者： Han Ah Lee Yoo Ra Lee Young-Sun Lee Young Kul Jung Ji Hoon Kim Hyunggin An Hyung joon Yim Yoon Tae Jeen Jong Eun Yeon Kwan Soo Byun Yeon seok Seo Department of Internal Medicine Korea University College of MedicineSeoul 02841South Korea Department of Biostatistics Korea University Anam HospitalSeoul 02841South Korea

BACKGROUND Diagnostic accuracy of various tumor markers and their combinations for hepatocellular carcinoma(HCC)was not fully *** To evaluate the diagnostic accuracy of alpha-fetoprotein(AFP),the Lens culinaris agglutinin-reactive fraction of AFP(AFP-L3),and protein induced by vitamin K absence or antagonist-II(PIVKA-II)and their combination for HCC *** Patients with newly detected liver mass or elevated serum AFP levels were considered *** AFP level,AFP-L3 fraction,and PIVKA-II level were measured at the first *** In total,622 patients were included;355 patients(57.1%)had chronic liver disease,and 208(33.4%)had liver *** was diagnosed in 160 patients(25.7%).The area under the receiver operating characteristics curves(AUROCs)of the serum AFP,AFP-L3 fraction,AFP-L3,and PIVKA-II levels for the diagnosis of HCC were 0.775,0.792,0.814,and 0.834,respectively.A novel diagnostic model was developed by classifying patients in a 1:1 ratio into training and validation *** the binary regression analysis of the training cohort,the AFP,AFP-L3 fraction,and PIVKA-II(ALPs)score was calculated as follows:ALPs score=3.8×[serum AFP level(ng/mL)×AFP-L3 fraction(%)×0.01]+0.2×PIVKA-II level(mAU/mL).The AUROC of the ALPs score for diagnosis of HCC was 0.878,significantly higher than that of serum AFP level(P<0.001),AFP-L3 fraction(P<0.001),PIVKA-II level(P=0.036),and AFP-L3 level(P=0.006).The optimal ALPs score cut-off was 5.3(sensitivity,85.0%,specificity 80.1%).The validation cohort showed similar *** The ALPs score calculated using serum AFP level,AFP-L3 fraction,and PIVKA-II level showed improved accuracy in HCC diagnosis.

关键词： Alpha-fetoprotein Lens culinaris agglutinin-reactive fraction of alphafetoprotein Protein induced by vitamin K absence or antagonist-II Hepatocellular carcinoma

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Surgical Management of Symptomatic Adventitial Cystic Disease of the Popliteal Artery as a Cause of Deep Vein Thrombosis

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Chinese Medical Journal 2018年第17期131卷 2141-2142页

作者： Jong seok Lee Jeong Kye hwang Sun Cheol Park Sang Dong Kim Department of Surgery Division Medical Detachment Ministry of National Defense Gangwon-do 24151 Korea Department of Surgery Division of-Vascular and Transplant Surgery College of Medicine The Catholic University of Korea Seoul 06591 Korea

To the Editor： A 67-year-old female was referred for persisted swelling in right leg despite of anticoagulation during 2 months for deep vein thrombosis （DVT） of the right popliteal vein （PV）. Initial duplex ultrasonography of local clinic at 2 months ago showed the acute DVT of right PV with thrombus and dilated vein [Figure 1a].

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Adenosine monophosphate enhances callus regeneration competence for de novo plant organogenesis

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Molecular Plant 2023年第12期16卷 1867-1870页

作者： Hong Gil Lee Seo Young Jang Eun Yee Jie Seung Hee Choi Ok-Sun Park Soon Hyung Bae Hyun-Soon Kim Suk Weon Kim Geum-Sook hwang Pil joon Seo Department of Chemistry Seoul National UniversitySeoul 08826Korea Plant Genomics and Breeding Institute Seoul National UniversitySeoul 08826Korea Integrated Metabolomics Research Group Western Seoul CenterKorea Basic Science InstituteSeoul 03759Korea Biological Resource Center Korea Research Institute of Bioscience and BiotechnologyJeongeup56212Korea Plant Systems Engineering Research Center Korea Research Institute of Bioscience and BiotechnologyDaejeon 34141Korea College of Pharmacy Chung-Ang UniversitySeoul 06974Korea

Dear Editor,Plant tissue culture involves callus formation and de novo shoot ***,explants from differentiated tissues are used to generate a pluripotent cell mass,called callus,on auxin-rich callus-inducing medium(CIM),followed by shoot regeneration on cytokinin-rich shoot-inducing medium(SiM).Callus results from division of pericycle-like cells(Atta et al.,2009;Sugimoto et al.,2010);its cellular identity resembles that of lateral root primordia(Atta et al.,2009;Sugimoto et al.,2010).Callus acquires cellular pluripotency by forming root stem cell niches on CIM(Sugimoto et al.,2010)。

关键词： Adenosine callus

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Flexural Behavior of FRP-Reinforced Concrete Composite Member

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Journal of Mechanics Engineering and Automation 2012年第1期2卷 52-58页

作者： joon-seok Park Jin-Woo Choi Hyung-joong Joo Soon-Jong Yoon Department of Civil Engineering Hongik University Seoul 121-791 Korea

Concrete Filled FRP （Reinforced Polymeric Plastic） Tubes （CFFT） and Reinforced Concrete Filled FRP Tubes （RCFFT） are known to have the capability to enhance structural performance in terms of structural stability, ductility, as well as chemical resistance when compared with conventional concrete members. In this study, the authors evaluate the structural performance of the CFFT and the RCFFT through flexural tests for the purpose of applying the members as flexural ones. Moreover, the compressive behavior of the CFFT and the RCFFT members was investigated to examine their confinement effects. Based on the experimental and analytical results of the compressive behavior of the members, equations for estimating the ultimate compressive strengths of the CFFT and the RCFFT were proposed. In addition, the degree of improvement on the flexural performance of the RCFFT member strengthened by the FRP was analyzed from the flexural tests.

关键词： FRP (reinforced polymeric plastic) CFFT (concrete filled FRP tubes) confinement effect compression flexure.

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Radar Cross Section Analysis Using Physical Optics and Its Applications to Marine Targets

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Journal of Applied Mathematics and Physics 2015年第2期3卷 166-171页

作者： joon-Tae hwang Suk-Yoon Hong Jee-Hun Song Hyun-Wung Kwon Department of Naval Architecture and Ocean Engineering Seoul National University Seoul Republic of Korea Department of Naval Architecture and Ocean Engineering Seoul National University Seoul Republic of Korea Department of Naval Architecture and Ocean Engineering Chonnam National University Yeosu Republic of Korea Department of Naval Architecture and Ocean Engineering Kojecollege Koje Republic of Korea

Radar Cross Section (RCS) is one of the most considerable parameters for ship stealth design. As modern ships are larger than their predecessors, RCS must be managed at each design stage for its reduction. For predicting RCS of ship, Radar Cross Section Analysis Program (RACSAN) based on Kirchhoff approximation in high frequency range has been developed. This program can present RCS including multi-bounce effect in exterior and interior structure by combination of geometric optics (GO) and physical optics (PO) methods, coating effect by using Fresnel reflection coefficient, and response time pattern for detected target. In this paper, RCS calculations of ship model with above effects are simulated by using this developed program and RCS results are discussed.

关键词： Radar Cross Section (RCS) Kirchhoff Approximation Multi-Bounce Effect Response Time Pattern

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Long-term administration of scopolamine interferes with nerve cell proliferation, differentiation and migration in adult mouse hippocampal dentate gyrus, but it does not induce cell death

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Neural Regeneration Research 2014年第19期9卷 1731-1739页

作者： Bing Chun Yan joon Ha Park Bai Hui Chen Jeong-Hwi Cho In Hye Kim Ji Hyeon Ahn Jae-Chul Lee In Koo hwang Jun Hwi Cho Yun Lyul Lee Il-Jun Kang Moo-Ho Won Department of Integrative Traditional & Western Medicine Medical CollegeYangzhou University Department of Neurobiology School of MedicineKangwon National University Department of Physiology College of MedicineInstitute of Neurodegeneration and NeuroregenerationHallym University Department of Anatomy and Cell Biology College of Veterinary MedicineSeoul National University Department of Emergency Medicine School of MedicineKangwon National University Department of Food Science and Nutrition Hallym University

Long-term administration of scopolamine, a muscarinic receptor antagonist, can inhibit the survival of newly generated cells, but its effect on the proliferation, differentiation and migration of nerve cells in the adult mouse hippocampal dentate gyrus remain poorly understood. In this study, we used immunohistochemistry and western blot methods to weekly detect the biological behaviors of nerve cells in the hippocampal dentate gyrus of adult mice that received intraperito- neal administration of scopolamine for 4 weeks. Expression of neuronal nuclear antigen （NeuN; a neuronal marker） and Fluoro-]ade B （a marker for the localization of neuronal degeneration） was also detected. After scopolamine treatment, mouse hippocampal neurons did not die, and Ki-67 （a marker for proliferating cells）-immunoreactive cells were reduced in number and reac hed the lowest level at 4 weeks. Doublecortin （DCX; a marker for newly generated neurons）-im- munoreactive cells were gradually shortened in length and reduced in number with time. After scopolamine treatment for 4 weeks, nearly all of the 5-bromo-2＇-deoxyuridine （BrdU）-labeled newly generated cells were located in the subgranular zone of the dentate gyrus, but they did not migrate into the granule cell layer. Few mature BrdU/NeuN double-labeled cells were seen in the subgranular zone of the dentate gyrus. These findings suggest that long-term administration of scopolamine interferes with the proliferation, differentiation and migration of nerve cells in the adult mouse hippocampal dentate gyrus, but it does not induce cell death.

关键词： nerve regeneration neurogenesis scopolamine dentate gyrus cell proliferation neuroblastdifferentiation neuroblast migration granule cell layer neural regeneration

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Deep-learning-based inverse design model for intelligent discovery of organic molecules

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npj Computational Materials 2018年第1期4卷 103-109页

作者： Kyungdoc Kim seokho Kang Jiho Yoo Youngchun Kwon Youngmin Nam Dongseon Lee Inkoo Kim Youn-Suk Choi Yongsik Jung Sangmo Kim Won-joon Son Jhunmo Son Hyo Sug Lee Sunghan Kim Jaikwang Shin Sungwoo hwang Samsung Advanced Institute of Technology Samsung Electronics Co.Ltd.130 Samsung-roYeongtong-guSuwon-siGyeonggi-do 16678Republic of Korea Department of Systems Management Engineering Sungkyunkwan University2066 Seobu-roJangan-guSuwon-siGyeonggi-do 16419Republic of Korea

The discovery of high-performance functional materials is crucial for overcoming technical issues in modern *** efforts have been devoted toward accelerating and facilitating this process,not only experimentally but also from the viewpoint of materials ***,machine learning has attracted considerable attention,as it can provide rational guidelines for efficient material exploration without time-consuming iterations or prior human *** this regard,here we develop an inverse design model based on a deep encoder-decoder architecture for targeted molecular *** by neural machine language translation,the deep neural network encoder extracts hidden features between molecular structures and their material properties,while the recurrent neural network decoder reconstructs the extracted features into new molecular structures having the target *** material design tasks,the proposed fully data-driven methodology successfully learned design rules from the given databases and generated promising light-absorbing molecules and host materials for a phosphorescent organic light-emitting diode by creating new ligands and combinatorial rules.

关键词： inverse learning devoted

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The Outcome of the Chemotherapy and Oncothermia for Far Advanced Adenocarcinoma of the Lung: Case Reports of Four Patients

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Advances in Lung Cancer 2015年第1期4卷 1-7页

作者： Doo Yun Lee joon seok Park Hae Chul Jung Eun Seol Byun seok Jin Haam Sung Soo Lee Department of Thoracic Cardiovascular Surgery Bundang CHA Medical Center CHA University Kyunggido Korea Department of Thoracic Cardiovascular Surgery Gangnam Severance Hospital College of Medicine Yonsei University Seoul Korea

Lung cancer is one of the most aggressive and lethal form of cancers. Patients with far advanced lung cancer are treated by chemotherapy with or without radiotherapy. However, median survival of these patients is less than 6 months. To increase survival and quality of life for these patients, various forms of complementary treatments have been tried in clinical practices, and oncothermia is supposed to be one of the promising candidates. From May 2008 to November 2013, 4 patients with far advanced lung adenocarcinoma (stages IIIB and IV) were treated with oncothermia in addition to conventional chemotherapy at Gangnam Severance Hospital and Bundang CHA Hospital. All these patients have survived for more than 2 years.

关键词： Lung Cancer Chemotherapy

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Time- and cell-type specific changes in iron, ferritin, and transferrin in the gerbil hippocampal CA1 region after transient forebrain ischemia

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Neural Regeneration Research 2016年第6期11卷 924-930页

作者： Dae Young Yoo Ki-Yeon Yoo joon Ha Park Hyun Jung Kwon Hyo Young Jung Jong Whi Kim Goang-Min Choi Seung Myung Moon Dae Won Kim Yeo Sung Yoon Moo-Ho Won In Koo hwang Department of Anatomy and Cell Biology College of Veterinary Medicine and Research Institute for Veterinary Science Seoul National University Department of Oral Anatomy Research Institute of Oral Sciences College of Dentistry Gangneung-Wonju National University Department of Neurobiology School of Medicine Kangwon National University Department of Biochemistry and Molecular Biology Research Institute of Oral Sciences College of Dentistry Gangneung-Wonju National University Department of Thoracic and Cardiovascular Surgery Chuncheon Sacred Heart Hospital College of Medicine Hallym University Department of Neurosurgery Dongtan Sacred Heart Hospital College of Medicine Hallym University

In the present study, we used immunohistochemistry and western blot analysis to examine changes in the levels and cellular localization of iron, heavy chain ferritin（ferritin-H）, and transferrin in the gerbil hippocampal CA1 region from 30 minutes to 7 days following transient forebrain ischemia. Relative to sham controls, iron reactivity increased significantly in the stratum pyramidale and stratum oriens at 12 hours following ischemic insult, transiently decreased at 1–2 days and then increased once again within the CA1 region at 4–7 days after ischemia. One day after ischemia, ferritin-H immunoreactivity increased significantly in the stratum pyramidale and decreased at 2 days. At 4–7 days after ischemia, ferritin-H immunoreactivity in the glial components in the CA1 region was significantly increased. Transferrin immunoreactivity was increased significantly in the stratum pyramidale at 12 hours, peaked at 1 day, and then decreased significantly at 2 days after ischemia. Seven days after ischemia, Transferrin immunoreactivity in the glial cells of the stratum oriens and radiatum was significantly increased. Western blot analyses supported these results, demonstrating that compared to sham controls, ferritin H and transferrin protein levels in hippocampal homogenates significantly increased at 1 day after ischemia, peaked at 4 days and then decreased. These results suggest that iron overload-induced oxidative stress is most prominent at 12 hours after ischemia in the stratum pyramidale, suggesting that this time window may be the optimal period for therapeutic intervention to protect neurons from ischemia-induced death.

关键词： ferritin transferrin hippocampal stratum minutes glial Ferritin hippocampus rabbit reactivity

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Two-step generation of induced pluripotent stem cells from mouse fibroblasts using Id3 and Oct4

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Journal of Molecular Cell Biology 2012年第1期4卷 59-62页

作者： Jai-Hee Moon June seok Heo Suhyun Kwon Jihyun Kim Jihye hwang Phil Jun Kang Aeree Kim Hyun Ok Kim Kwang Youn Whang Byung Sun Yoon Seungkwon You Laboratory of Cell Function Regulation College of Life Sciences and BiotechnologyKorea UniversitySeoulRepublic of Korea Cell Therapy Center College of MedicineYonsei UniversitySeoulRepublic of Korea Department of Pathology College of MedicineKorea University Guro HospitalSeoulRepublic of Korea Division of Biotechnology College of Life Sciences and BiotechnologyKorea UniversitySeoulRepublic of Korea

Dear Editor,Somatic cells can be reprogrammed into pluripotent stem cells,called induced pluripotent stem cells(iPSCs),by defined transcription factors(Takahashi et al.,2006).The reprogramming of somatic cells may be a continuous stochastic process in which nearly all somatic donor cells have the ability to give rise to iPSCs with continuous passaging and the expression of defined factors(Hanna et al.,2009).However,the reprogramming process can be divided into discrete stages,including the generation of dedifferentiated pre-pluripotent cells followed by authentic pluripotent cells(Silva et al.,2009).

关键词： pluripotent programming

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