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The Effect of Grain Size on the Viscosity and Yield Stress of Fine-Grained Sediments

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Journal of Mountain Science 2014年第1期11卷 31-40页

作者： Sueng won jeong Korea Institute of Geoscience and Mineral Resources

In debris flow modelling,the viscosity and yield stress of fine-grained sediments should be determined in order to better characterize sediment *** particular,it is important to understand the effect of grain size on the rheology of fine-grained sediments associated with *** looking at the relationship between shear stress and shear rate before yielding,a high-viscosity zone(called pseudoNewtonian viscosity) towards the apparent yield stress *** yielding,plastic viscosity(called Bingham viscosity) governs the *** examine the effect of grain size on the rheological characteristics of fine-grained sediments,clay-rich materials(from the Adriatic Sea,Italy; Cambridge Fjord,Canada; and the Mediterranean Sea,Spain),silt-rich debris flow materials(from La Valette,France) and silt-rich materials(iron tailings from Canada) were *** characteristics were examined using a modified Bingham *** materials examined,including the Canadian inorganic and sensitive clays,exhibit typical shear thinning behavior and strong *** the relationships between the liquidity index and rheological values(viscosity and apparent yield stress),the effect of grain size on viscosity and yield stress is significant at a given liquidity *** viscosity and yield stress of debris flow materials are higher than those of low-activity clays at the same liquid *** the viscosity and yield stress of the tailings,which are mainly composed of silt-sized particles,are slightly lower than those of low-activity clays.

关键词： Debris Flow Viscosity Yield Stress Grain Size Fine-Grained Sediments

Pediatric schwannoma of the tongue:A case report and review of literature

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World Journal of Clinical Cases 2021年第24期9卷 7212-7217页

作者： Chang Bin Yun Young-Mo Kim jeong-seok Choi Ji won Kim Department of Otorhinolaryngology-Head and Neck Surgery Inha University College of MedicineIncheon 22212South Korea

BACKGROUND Neurogenic tumors account for about ten percent of all tumors of childhood,and benign tumor originating from Schwann cells is rare in peripheral *** of the tongue is quite rare in *** SUMMARY We present the case of an 8-year-old male with schwannoma in the anterolateral *** mass was slow-growing for one year with no pain and *** underwent transoral mass excision under general *** examination revealed a smooth surfaced,17 mm×14 mm×7 mm sized,encapsulated nodule with a clear resection *** of the tongue was confirmed by the pathological *** reported no motor or sensory change,such as dysgeusia or paresthesia,or phonation difficulty during postoperative 12 mo *** Schwannoma of the tongue is a rare benign neoplasm in *** a painless firm mass is encountered in the tongue of a child,solid tumors like schwannoma should be considered in the differential diagnosis.

关键词： Schwannoma Tongue Child Pediatric Neurogenic Tumor Case report

Harnessing SARS-CoV-2-specific CD8^(+)T cells to kill target tumor cells for cancer immunotherapy

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Cancer Communications 2024年第1期44卷 173-177页

作者： Keunok Jung Deok-Han Ko jeong-Yun Jang Young Rong Kim Jung Yeon Heo Yong-Sung Kim Department of Allergy and Clinical Immunology Ajou University School of MedicineSuwonRepublic of Korea Department of Molecular Science and Technology Ajou UniversitySuwonRepublic of Korea Department of Infectious Diseases Ajou University School of MedicineSuwonRepublic of Korea

Dear Editor,During the coronavirus disease 2019(COVID-19)pan-demic era,many individuals were naturally infected with or vaccinated against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),resulting in the p... 详细信息

关键词： acute respiratory immunotherapy

Protein Arginine Methyltransferase 1 Ablation in Motor Neurons Causes Mitochondrial Dysfunction Leading to Age-related Motor Neuron Degeneration with Muscle Loss

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Research 2024年第1期2023卷 637-649页

作者： Hyun-Kyung So Hyebeen Kim Jinwoo Lee Chang-Lim You Chae-Eun Yun Hyeon-Ju jeong Eun-Ju Jin Yunju Jo Dongryeol Ryu Gyu-Un Bae Jong-Sun Kang Department of Molecular Cell Biology Sungkyunkwan University School of MedicineSuwonKorea Single Cell Network Research Center Sungkyunkwan University School of MedicineSuwonKorea Research Institute of Aging-Related Diseases AniMusCureInc.SuwonKorea Drug Information Research Institute Muscle Physiome Research CenterCollege of PharmacySookmyung Women’s UniversitySeoulKorea

Neuromuscular dysfunction is tightly associated with muscle wasting that occurs with age or due to degenerative ***,the molecular mechanisms underlying neuromuscular dysfunction are currently *** studies have proposed important roles of Protein arginine methyltransferase 1(Prmt1)in muscle stem cell function and muscle *** the current study,we set out to determine the role of Prmt1 in neuromuscular function by generating mice with motor neuron-specific ablation of Prmt1(mnKO)using *** exhibited age-related motor neuron degeneration and neuromuscular dysfunction leading to premature muscle loss and ***1 deficiency also impaired motor function recovery and muscle reinnervation after sciatic nerve *** transcriptome analysis of aged mnKO lumbar spinal cords revealed alterations in genes related to inflammation,cell death,oxidative stress,and ***,mnKO lumbar spinal cords of sciatic nerve injury model or aged mice exhibited elevated cellular stress response in motor ***,Prmt1 inhibition in motor neurons elicited mitochondrial *** findings demonstrate that Prmt1 ablation in motor neurons causes agerelated motor neuron degeneration attributing to muscle ***,Prmt1 is a potential target for the prevention or intervention of sarcopenia and neuromuscular dysfunction related to aging.

关键词： degeneration impaired prevention

Pressure-responsive pH-triggered layer-by-layer coating of paclitaxel-eluting balloon catheters for instant high-dose drug delivery for percutaneous coronary artery intervention

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Nano Research 2024年第10期17卷 9141-9151页

作者： jeong Yu Lee Shonit Nair Sharma Sung-Yu Hong Young-Guk Ko Yangsoo Jang Minjae Do Michael Christopher Stark Qiwen Peng Benjamin Allen Mossburg Bo Chan Seo Yuhan Lee Department of Materials Science and Engineering Korea Advanced Institute of Science and TechnologyDaejeon 305-701Republic of Korea Department of Anesthesiology Perioperativeand Pain MedicineCenter for Accelerated Medical Innovation&Center for NanomedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115USA Department of Biological Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA Cardiovascular Product Evaluation Center Yonsei University College of MedicineSeoul 120-752Republic of Korea Division of Cardiology Department of Internal MedicineSeverance Cardiovascular HospitalYonsei University College of MedicineSeoul 120-752Republic of Korea

Cardiovascular diseases remain the leading cause of mortality worldwide,with percutaneous coronary interventions(PCI)using drug-eluting stents(DES)as the standard treatment for coronary artery *** advancements in DES technology,challenges such as restenosis and stent thrombosis still necessitate further interventions and carry considerable risks,highlighting an urgent need for a novel therapeutic approach with lower restenosis rates and reduced reintervention *** balloons(DEBs)coated with anti-proliferative agents offer a novel method of local drug delivery for reducing restenosis by directly administering drugs to the lesion ***,efficient delivery of drugs within the brief procedural window while minimizing drug loss during maneuvering to the target site remains a ***,we developed a pressure-responsive and pH-triggered,paclitaxel(PTX)coated DEB catheter for rapid and high-dose delivery of paclitaxel to the lesion sites,overcoming the limitations of drug dispersion and inefficiencies associated with conventional *** the charge reversion of albumin around its isoelectric point,paclitaxel-loaded human serum albumin nanoparticles(PTX-HSA-NPs)and heparin were coated using a layer-by-layer deposition method at pH *** exposure to physiological pH(i.e.,7.4),the coating is rapidly released from the balloon *** with a protective shellac coating,the DEB achieved controlled release of high-dose paclitaxel to the arterial tissue in vivo(up to 400μg per gram tissue),exceeding current DEBs in the *** results suggest the pH-responsive,multi-layer coated DEB’s potential for superior procedural outcomes,addressing a critical unmet need in PCI.

关键词： drug-eluting balloon layer-by-layer coating coronary artery disease paclitaxel

Oxygen vacancy engineering for tuning the catalytic activity of LaCoO_(3) perovskite

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Journal of Rare Earths 2024年第3期42卷 506-514,I0003页

作者： jeong Hyun Cho Minjae Kim Inchan Yang Kyung Tae Park Chang Houn Rhee Hai Woong Park Ji Chul Jung Department of Chemical Engineering Myongji UniversityYongin 17058Republic of Korea Institute of Advanced Composite Materials Korea Institute of Science and TechnologyWanju-gunJeollabuk-do 55324Republic of Korea Iron&Steel Process Engineering Research Group POSCOPohang 37859Republic of Korea Hydrogen Research Center Research Institute of Industrial Science&Technology(RIST)Pohang 37673Republic of Korea

Herein, we attempted to engineer oxygen vacancies on the surface of LaCoO_(3) perovskite through simple post-treatments(acid or reductive thermal treatments). Acid treatment induces oxygen vacancies through the selective etching of the La cations, whereas thermal treatment in a reducing atmosphere generates oxygen vacancies by directly removing lattice oxygen. The characterization results confirm that the number of surface oxygen vacancies, which are crucial in various catalytic oxidation reactions,considerably increases in the LaCoO_(3) catalysts treated with acid or reducing gas. Acid treatment enriches the oxygen vacancies while maintaining the structure of the LaCoO_(3) catalysts, which can not be achieved through reductive thermal treatment. Therefore, the acid treatment is considered a promising technique for oxygen vacancy engineering of perovskite catalysts for tuning their catalytic activities. Furthermore,the catalytic activities of the posttreated LaCoO_(3) catalysts for CO oxidation were evaluated and are noted to be considerably better than those of the pristine LaCoO_(3) catalyst due to their abundant oxygen vacancies. Consequently, we conclude that the oxygen vacancies of perovskite catalysts can be effectively engineered via two simple methods and play a significant role in CO oxidation.

关键词： LaCoO_(3)perovskite Acid treatment Reductive thermal treatment Oxygen vacancy CO oxidation Rare earths

Improved estimation of rotor position for sensorless control of a PMSM based on a sliding mode observer

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Journal of Central South University 2016年第7期23卷 1643-1656页

作者： Wahyu Kunto Wibowo seok-Kwon jeong Department of Electrical Engineering Universitas Pertamina Refrigeration and Air-Conditioning Engineering Pukyong National University

This work proposes a new strategy to improve the rotor position estimation of a permanent magnet synchronous motor(PMSM) over wide speed range. Rotor position estimation of a PMSM is performed by using sliding mode observer(SMO). An adaptive observer gain was designed based on Lyapunov function and applied to solve the chattering problem caused by the discontinuous function of the SMO in the wide speed range. The cascade low-pass filter(LPF) with variable cut-off frequency was proposed to reduce the chattering problem and to attenuate the filtering capability of the SMO. In addition, the phase shift caused by the filter was counterbalanced by applying the variable phase delay compensation for the whole speed area. High accuracy estimation result of the rotor position was obtained in the experiment by applying the proposed estimation strategy.

关键词： rotor position estimation permanent magnet synchronous motor sliding mode observer adaptive observer gain cascadelow-pass filter variable cut-off frequency variable phase delay compensation

Poly (ADP-ribose): A double-edged sword governing cancer cell survival and death

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World Journal of Clinical Oncology 2024年第7期15卷 806-810页

作者： Keun-Yeong jeong Ji-Hyuk Kang Head Office Research CenterSeoul 07292South Korea Department of Biomedical Laboratory Science College of Health and Medical ScienceDaejeon UniversityDaejeon 34520South Korea

Poly(ADP-ribose)(PAR),a polymer of ADP-ribose,is synthesized by PAR po-lymerase and is crucial for the survival of cancer cells due to its vital functions in DNA repair and post-translational *** its supportive role,PAR also triggers cancer cell death by excessive accumulation of PAR leading to an energy crisis and *** phenomenon underscores the potential of targeting PAR regulation as a novel anticancer strategy,and the rationale would present an engaging topic in the field of anticancer ***,this editorial provides an overview of the mechanisms determining cancer cell fate,emphasizing the central role of *** further introduces promising methods for modulating PAR concentrations that may pave the way for innovative anticancer therapies.

关键词： ADP-ribose Poly(ADP-ribose) ADP ribosylation PARylation Parthanatos Anticancer

Hepatitis B virus reactivation in patients with hepatocellular carcinoma undergoing anti-cancer therapy

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World Journal of Gastroenterology 2014年第24期20卷 7675-7685页

作者： jeong won Jang Division of Hepatology Department of Internal MedicineCollege of MedicineThe Catholic University of KoreaSeoul 137-701South Korea

Patients with hepatocellular carcinoma (HCC) often experience hepatic morbidity. Hepatitis B virus (HBV) reactivation is well documented as a serious hepatic morbidity during anti-cancer therapy. Reported rates of HBV reactivation in chronic carriers with HCC undergoing chemotherapy range from 4%-67%. Apart from chemotherapy, HBV reactivation has been increasingly identified in settings of hepatectomy and local ablation therapies. The rates of HBV reactivation vary with different levels of immunosuppression and depend on treatment, viral factors, and patient characteristics. The principal concern relating to reactivation is that a substantial proportion of patients with reactivation suffer from liver dysfunction during therapy, which often leads to disruption of planned, potentially life-prolonging treatments, adversely affecting the patients’ final outcome. The first step in the management of HBV reactivation is identification of patients at risk of reactivation by testing for HBV serology prior to commencing anti-cancer therapy. Although it is a serious complication, HBV reactivation is preventable with prophylactic anti-HBV drugs. Multiple publications have shown the benefit of prophylactic or preemptive antiviral therapy in this setting and justified such an approach before the start of therapy. Given the tumors and underlying cirrhosis, long-term use of antivirals with high potency and low risk of resistance is recommended in patients with HCC. This topic review will summarize the epidemiology, pathogenesis, and clinical issues related to HBV reactivation in HCC patients, and will discuss proper management against HBV reactivation during anti-cancer therapy for HCC.

关键词： Hepatitis B virus Virus activation Hepatic morbidity Hepatocellular carcinoma Immunosuppression