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The current status of hormone treatment for prostate cancer patients in Korean real-world practice:a multi-institutional observational study

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Asian Journal of Andrology 2019年第2期21卷 115-120页

作者： Jung Kwon Kim Jung Jun Kim Taek Won Gang Tae Kyun Kwon Hong Sup Kim Seung Chui Park Jae-Shin Park Jong-Yeon Park seok joong yoon Youn-Soo Jeon Jin Seon Cho Kwan joong Joo Sung-Hoo Hong seok-Soo Byun the Korean Urological Oncology Society Department of Urology Seoul National University Bundang HospitalSeongnam 13620Korea Department of Urology Hallym University Sacred Heart HospitalAnyang 14068Korea Department of Urology Kangbuk Samsung HospitalSeoul 03181Korea Department of Urology Seoul St.Mary HospitalSeoul 06591Korea 不详 Department of Urology Chonnam National University HospitalGwangju 61469Korea School of Medicine Kyungpook National University Medical CenterDaegu 41404Korea Department of Urology Konkuk University Medical CenterSeoul 05080Korea Department of Urology Wonkwang University HospitalIksan 54538Korea Department of Urology Daegu Catholic University Medical CenterDaegu 41911Korea Department of Urology Ulsan UniversityGangneung Asan HospitalGangneung 25440Korea Department of Urology Chungbuk National University HospitalCheongju 28644Korea Department of Urology Soonchunhyang University HospitalCheonan 31151Korea

We aimed to evaluate the current nationwide trend,efficacy,safety,and quality of life(QoL)profiles of hormone treatment in real-world practice settings for prostate cancer(PCa)patients in Korea.A total of 292 men with any biopsy-proven PCa(TanyNanyMany)from 12 institutions in Korea were included in this multi-institutional,observational study of prospectively collected *** luteinizing hormone-releasing hormone(LHRH)agonists were allowed to be investigational *** was defined as(1)the rate of castration(serum testosterone≤50 ng dl^-1)at 4-week visit and(2)breakthrough(serum testosterone>50 ng dl^-1 after castration).Safety assessments included routine examinations for potential adverse events,laboratory tests,blood pressure,body weight,and bone min era I density(BMD,at baseli ne and at the last follow-up visit).QoL was assessed using the Expa nded Prostate Cancer Index Composite-26(EPIC-26).The most comm on initial therapeutic regimen was LHRH agonist with an ti-androge n(78.0%),and the most commonly used LHRH agonist for combination and mono therapy was leuprolide(64.0%for combi natio n and 58.0%for monotherapy).The castration and breakthrough rates were 78.4%and 6.6%,*** laboratory results related to dyslipidemia worsened after 4 weeks of hormone *** addition,the mean BMD T-score was significantly lower at the last follow-up(mean:-1.950)compared to baseline(mean:-0.195).The mean total EPIC-26 score decreased from 84.8(standard deviation[s.d.]:12.2)to 78.3(s.d.:8.1),with significant deterioration only in the urinary domain(mean:23.5 at baseli ne and 21.9 at the 4-week visit).These findi ngs dem on strate the n ationwide trend of current practice setti ngs in hormone treatment for PCa in Korea.

关键词： efficacy hormonal treatment Korean population prostate cancer safety trend

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Enhanced performance of solution-processed carbon nanotube transparent electrodes in foldable perovskite solar cells through vertical separation of binders by using eco-friendly parylene substrate

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Carbon Energy 2024年第7期6卷 83-93页

作者： Unsoo Kim Jeong-seok Nam Jungjin yoon Jiye Han Mansoo Choi Il Jeon Department of Mechanical Engineering Seoul National UniversitySeoulRepublic of Korea Global Frontier Center for Multiscale Energy Systems Seoul National UniversitySeoulRepublic of Korea Frontier Energy Solution SeoulRepublic of Korea Department of Nano Engineering Department of Nano Science and TechnologySKKU Advanced Institute of Nanotechnology(SAINT)Sungkyunkwan University(SKKU)SuwonRepublic of Korea Department of Materials Science and Engineering Pennsylvania State UniversityUniversity ParkPennsylvaniaUSA

The successful utilization of an eco-friendly and biocompatible parylene-C substrate for high-performance solution-processed double-walled carbon nanotube(CNT)electrode-based perovskite solar cells(PSCs)was *** the use of a novel inversion transfer technique,vertical separation of the binders from the CNTs was induced,rendering a stronger p-doping effect and thereby a higher conductivity of the *** resulting foldable devices exhibited a power conversion efficiency of 18.11%,which is the highest reported among CNT transparent electrode-based PSCs to date,and withstood more than 10,000 folding cycles at a radius of 0.5 mm,demonstrating unprecedented mechanical ***,solar modules were fabricated using entirely laser scribing processes to assess the potential of the solution-processable nanocarbon ***,this is the only one to be processed entirely by the laser scribing process and to be biocompatible as well as eco-friendly among the previously reported nonindium tin oxide-based perovskite solar modules.

关键词： double-walled carbon nanotubes parylene substrates perovskite modules perovskite solar cells solution-processable electrodes surfactant removal

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Trifunctional robust electrocatalysts based on 3D Fe/N-doped carbon nanocubes encapsulating Co4N nanoparticles for efficient battery-powered water electrolyzers

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Carbon Energy 2024年第6期6卷 124-139页

作者： Hyung Wook Choi Hongdae Lee Jun Lu seok Bin Kwon Dong In Jeong Beum Jin Park Jiwon Kim Bong Kyun Kang Gun Jang Dae Ho yoon Ho seok Park SKKU Advanced Institute of Nano Technology(SAINT) Sungkyunkwan UniversitySuwon-siGyeonggi-doRepublic of Korea School of Chemical Engineering Sungkyunkwan UniversitySuwon-siGyeonggi-doRepublic of Korea School of Advanced Materials Science and Engineering Sungkyunkwan UniversitySuwon-siGyeonggi-doRepublic of Korea Department of Electronic Materials Devicesand Equipment EngineeringSoonchunhyang UniversityAsan CityChungnamRepublic of Korea SKKU Institute of Energy Science and Technology(SIEST) Sungkyunkwan UniversitySuwon-siGyeonggi-doRepublic of Korea Department of Health Sciences and Technology Samsung Advanced Institute for Health Sciences and Technology(SAIHST)Sungkyunkwan UniversitySuwonRepublic of Korea

Herein,we have designed a highly active and robust trifunctional electrocatalyst derived from Prussian blue analogs,where Co_(4)N nanoparticles are encapsulated by Fe embedded in N-doped carbon nanocubes to synthesize hierarchically structured Co_(4)N@Fe/N-C for rechargeable zinc-air batteries and overall water-splitting *** confirmed by theoretical and experimental results,the high intrinsic oxygen reduction reaction,oxygen evolution reaction,and hydrogen evolution reaction activities of Co_(4)N@Fe/N-C were attributed to the formation of the heterointerface and the modulated local electronic ***,Co_(4)N@Fe/N-C induced improvement in these trifunctional electrocatalytic activities owing to the hierarchical hollow nanocube structure,uniform distribution of Co_(4)N,and conductive encapsulation by Fe/***,the rechargeable zinc-air battery with Co_(4)N@Fe/N-C delivers a high specific capacity of 789.9 mAh g^(-1) and stable voltage profiles over 500 ***,the overall water electrolyzer with Co_(4)N@Fe/N-C achieved better durability and rate performance than that with the Pt/C and IrO2 catalysts,delivering a high Faradaic efficiency of 96.4%.Along with the great potential of the integrated water electrolyzer powered by a zinc-air battery for practical applications,therefore,the mechanistic understanding and active site identification provide valuable insights into the rational design of advanced multifunctional electrocatalysts for energy storage and conversion.

关键词： battery-powered electrolyzers hierarchical structure Prussian blue analog trifunctional electrocatalyst zinc-air battery

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New anti-mesenteric delta-shaped stapled anastomosis: Technical report with short-term postoperative outcomes in patients with Crohn’s disease

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2592-2601页

作者： Jong Lyul Lee Yong Sik yoon Hyun Gu Lee Young Il Kim Min Hyun Kim Chan Wook Kim In Ja Park seok-Byung Lim Chang Sik Yu Division of Colon and Rectal Surgery Department of SurgeryUniversity of Ulsan College of MedicineAsan Medical CenterSeoul 05505South Korea Department of Surgery Gangdong Kyung Hee University HospitalSeoul 05278South Korea

BACKGROUND Medical treatment for Crohn’s disease(CD)has continuously improved,which has led to a decrease in surgical recurrence *** these advancements,25%of patients will undergo repeat intestinal *** of CD com-monly occurs on the mesentery side of the anastomosis *** To compare the new anti-mesenteric side-to-side delta-shaped stapled anasto-mosis(DSA)with the conventional stapled functional end-to-end anastomosis(CSA).METHODS This retrospective study included CD patients who underwent ileo-ileal or ileo-colic anastomosis between January 2020 and December *** DSA technique employed a stapler to maintain the concept of anti-mesentery side-to-side ana-stomosis by performing a 90°vertical closure of the open window compared with the CSA *** the corner where the open window is closed,the DSA avoids forming a pouch and creates an anastomosis resembling a delta shape within the intestinal *** compared demographics,preoperative condition,operative findings,and operative outcomes for the two *** The study included 175 patients,including 92 in the DSA group and 83 in the CSA *** two groups were similar in baseline characteristics,preoperative medical treatment,and operative findings except for the Montreal classification *** 30-days postoperative complication rate was signi-ficantly lower in the DSA group compared with the CSA group(16.3%vs 32.5%,P=0.009).Ileus incidence was significantly lower in the DSA group than in the CSA group(4.3%vs 14.5%,P=0.033),and the hospital stay was shorter in the DSA group than in the CSA group(5.67±1.53 days vs 7.39±3.68 days,P=0.001).CONCLUSION The DSA technique was feasible and showed comparable postoperative outcomes with lower short-term complic-ations compared with the CSA *** studies on CD recurrence and long-term complications are warranted.

关键词： Crohn’s disease Surgery Anastomosis Complication Recurrence

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Platycodon grandiflorum extract represses up-regulated adipocyte fatty acid binding protein triggered by a high fat feeding in obese rats

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World Journal of Gastroenterology 2007年第25期13卷 3493-3499页

作者： yoon Shin Park Yoosik yoon Hong seok Ahn Division of Intractable Diseases Center for Biomedical Sciences National Institute of Health 194 Tongillo Eunpyeong-gu Seoul 122-701 South Korea College of Medicine Chung Ang University 221 Heukseok-dong Dongjak-gu Seoul 156-756 South Korea Sungshin Women's University Department Food and Nutrition 5 Dongsun-Dong Sungbuk-Gu Seoul 136-742 South Korea

AIM: To investigate the effect of Platycodon grandi- florum extract (PGE) on lipid metabolism and FABP mRNA expression in subcutaneous adipose tissue of high fat diet-induced obese rats. METHODS: PGE was treated to investigate the inhibitory effect on the pre-adipocyte 3T3-L1 differentiation and pancreatic lipase activity. Male Sprague-Dawley rats with an average weight of 439.03 ± 7.61 g were divided into four groups: the control groups that fed an experimental diet alone (C and H group) and PGE treatment groups that administered PGE along with a control diet or HFD at a concentration of 150 mg/kg body weight (C + PGE and H + PGE group, respectively) for 7 wk. Plasma total cholesterol (TC) and triglycerol (TG) concentrations were measured from the tail vein of rats. Adipocyte cell area was measured from subcutaneous adipose tissue and the fatty acid binding protein (FABP) mRNA expression was analyzed by northern blot analysis. RESULTS: PGE treatment inhibited 3T3-L1 pre-adipocyte differentiation and fat accumulation, and also decreased pancreatic lipase activity. In this experiment, PGE signifi cantly reduced plasma TC and TG concentrations as well as body weight and subcutaneous adipose tissue weight. PGE also significantly decreased the size of subcutaneous adipocytes. Furthermore, it significantly repressed the up-regulation of FABP mRNA expression induced by a high-fat feeding in subcutaneous adipose tissue. CONCLUSION: PGE has a plasma lipid lowering-effect and anti-obesity effect in obese rats fed a high fat *** these results, we can suggest the possibility that PGE can be used as a food ingredient or drug component to therapeutically control obesity.

关键词： Obesity High fat diet Platycodon grandiflorum extract Fatty acid binding protein Subcutaneousadipose tissue

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Modeling the effects of constructed wetland on nonpoint source pollution control and reservoir water quality improvement

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Journal of Environmental Sciences 2010年第6期22卷 834-839页

作者： Jonghwa Ham Chun G.yoon Hyung-joong Kim Hyung-Chul Kim Rural Research Institute of KRC Environmental Science Department Konkuk University

This article describes the integrated modeling approach for planning the size and the operation of constructed wetlands for maximizing retention of nonpoint source pollutant loads and reservoir water-quality improvement at a catchment scale. The experimental field-scale wetland systems （four sets, 0.88 ha each） have been in operation since 2002, where water depth was maintained at 30-50 cm and hydraulic loading rate was at 6.3-18.8 cm/day. The wetland system was found to be adequate for treating polluted stream water with stable removal efficiency even during the winter. The integrated modeling system （modified-BASINS） was applied to the seokmoon estuarine reservoir watershed and calibrated with monitoring data from constructed wetland, stream, and reservoir. The calibrated integrated modeling system estimated that constructing wetlands on 0.5% （about 114 ha） of the watershed area at the mouth of reservoir could reduce 11.61% and 13.49% of total external nitrogen and phosphorus loads, respectively. It also might improve the nitrogen and phosphorus concentration of the reservoir by 9.69% and 16.48%, respectively. The study suggested that about 0.1%-1.0% of the watershed area should be allocated for constructed wetland to meet specified water-quality standards for the estuarine reservoir at the polder area where land use planning is relatively less complicated.

关键词： constructed wetland estuarine reservoir integrated modeling system nonpoint source pollution control polder area water quality improvement

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High-speed and high-performance polarization-based quantum key distribution system without side channel effects caused by multiple lasers

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Photonics Research 2018年第3期6卷 214-219页

作者： HEASlN Ko BYUNG-seok CHOI joong-SEON CHOE KAP-joong KIM JONG-Hol KIM CHUN JU YOUN Photonic/Wireless Convergence Components Research Division Electronics and Telecommunications Research InstituteDaejeon 34129South Korea School of Advanced Device Technology University of Science&TechnologyDaejeon 34113South Korea

Side channel effects such as temporal disparity and intensity fluctuation of the photon pulses caused by random bit generation with multiple laser diodes in high-speed polarization-based BB84 quantum key distribution(QKD) systems can be eliminated by increasing the DC bias current condition. However, background photons caused by the spontaneous emission process under high DC bias current degrade the performance of QKD systems. In this study, we investigated the effects of spontaneously emitted photons on the system performance in a high-speed QKD system at a clock rate of 400 MHz. Also, we show further improvements in the system performance without side channel effects by utilizing the temporal filtering technique with real-time fieldprogrammable gate array signal processing.

关键词： QKD High-speed and high-performance polarization-based quantum key distribution system without side channel effects caused by multiple lasers

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Mechanical characteristics of fused cast basalt tube encased in steel pipe for protecting steel surface

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中国有色金属学会会刊：英文版 2009年第4期19卷 935-940页

作者： Jee-seok WANG Jong-Do KIM Hee-Jong yoon Division of Mechanical and Information Engineering Korea Maritime University Division of Marine System Engineering Korea Maritime University Department of Research and Development Dongdo Basalt Industry Co.Ltd

Because of the various excellent characteristics of cast basalt materials,such as,anti-corrosion,anti-wearing,good hardness,high chemical stability,of which steel may not possess,the steel-basalt composite pipes are used in severe environments for compensating the defects of *** limit of bending moment with which steel-basalt composite pipe may safely endure was calculated and the limit curvature of the composite pipe in the safe range was *** application temperature of steel-basalt pipe was examined due to a different coefficient among basalt,mortar and mild steel.

关键词：玄武岩钢管表面保护机械特性包裹熔铸化学稳定性复合管

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Question-Answering Pair Matching Based on Question Classification and Ensemble Sentence Embedding

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Computer Systems Science & Engineering 2023年第9期46卷 3471-3489页

作者： Jae-seok Jang Hyuk-yoon Kwon Department of Computer Science and Engineering Seoul National University of Science and TechnologySeoul01811Korea Department of Industrial Engineering/Graduate School of Data Science Seoul National University of Science and TechnologySeoul01811Korea

Question-answering(QA)models find answers to a given *** necessity of automatically finding answers is increasing because it is very important and challenging from the large-scale QA data *** this paper,we deal with the QA pair matching approach in QA models,which finds the most relevant question and its recommended answer for a given *** studies for the approach performed on the entire dataset or datasets within a category that the question writer manually *** contrast,we aim to automatically find the category to which the question belongs by employing the text classification model and to find the answer corresponding to the question within the *** to the text classification model,we can effectively reduce the search space for finding the answers to a given ***,the proposed model improves the accuracy of the QA matching model and significantly reduces the model inference ***,to improve the performance of finding similar sentences in each category,we present an ensemble embedding model for sentences,improving the performance compared to the individual embedding *** real-world QA data sets,we evaluate the performance of the proposed QA matching *** a result,the accuracy of our final ensemble embedding model based on the text classification model is 81.18%,which outperforms the existing models by 9.81%∼14.16%***,in terms of the model inference speed,our model is faster than the existing models by 2.61∼5.07 times due to the effective reduction of search spaces by the text classification model.

关键词： Question-answering text classification model data augmentation text embedding

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Ultrasound-guided intra-articular corticosteroid injection in a patient with manubriosternal joint involvement of ankylosing spondylitis:A case report

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World Journal of Clinical Cases 2023年第9期11卷 2043-2050页

作者： Min-Hee Choi In-Young yoon Won-joong Kim Department of Anesthesiology and Pain Medicine Ewha Womans University Mokdong HospitalSeoul 07985South Korea

BACKGROUND Manubriosternal joint(MSJ)disease is a rare cause of anterior chest pain but can be a major sign of systemic arthritic *** patients with ankylosing spondylitis(AS),a type of systemic arthritis,chest pain can be due to MSJ involvement and can be improved by ultrasound-guided corticosteroid injection into the *** SUMMARY A 64-year-old man visited our pain clinic complaining of anterior chest *** were no abnormal findings on lateral sternum X-ray,but arthritic changes in the MSJ were observed on single-photon emission computed tomography-computed *** performed additional laboratory tests,and he was finally diagnosed with *** pain relief,we performed ultrasound-guided intra-articular(IA)corticosteroid injections into the *** the injections,his pain nearly *** For patients complaining of anterior chest pain,AS should be considered,and single-photon emission computed tomography-computed tomography can be helpful in *** addition,ultrasound-guided IA corticosteroid injections may be effective for pain relief.

关键词： Ankylosing spondylitis Anterior chest pain Manubriosternal joint Single-photon emission computed tomography-computed tomography Case report

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