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Periodontitis combined with smoking increases risk of the ulcerative colitis: A national cohort study

World Journal of Gastroenterology 2020年第37期26卷 5661-5672页

作者： Eun Ae Kang Jaeyoung Chun Jee Hyun kim Kyungdo Han Hosim Soh Seona Park Seung Wook Hong Jung Min Moon Jooyoung Lee Hyun Jung Lee Jun-beom Park Jong Pil Im Joo Sung kim Department of Internal Medicine and Institute of Gastroenterology Yonsei University College of MedicineSeoul 03722South Korea Department of Internal Medicine Gangnam Severance HospitalYonsei University College of MedicineSeoul 06229South Korea Department of Internal Medicine Bundang CHA Medical CenterCHA University School of MedicineSeoul 13496South Korea Department of Statistics and Actuarial Science Soongsil UniversitySeoul 06978South Korea Department of Internal Medicine and Liver Research Institute Seoul National University College of MedicineSeoul 03080South Korea Department of Periodontics the Catholic University of Korea College of MedicineSeoul 06591South Korea

BACKGROUND Periodontitis is a chronic inflammation of periodontal *** effect of periodontitis on the development of inflammatory bowel disease(IBD)remains *** To assessed the risk of IBD among patients with periodontitis,and the risk factors for IBD related to *** A nationwide population-based cohort study was performed using claims data from the Korean National Healthcare Insurance *** total,9950548 individuals aged≥20 years who underwent national health screening in 2009 were *** diagnosed IBD[Crohn’s disease(CD),ulcerative colitis(UC)]using the International Classification of Disease 10th revision and rare intractable disease codes,was compared between the periodontitis and nonperiodontitis groups until *** A total of 1092825 individuals(11.0%)had *** was significantly associated with older age,male gender,higher body mass index,quitting smoking,not drinking alcohol,and regular *** mean age was 51.4±12.9 years in the periodontitis group and 46.6±14.2 years in the nonperiodontitis group(P<0.01),*** mean body mass index was 23.9±3.1 and 23.7±3.2 in the periodontitis and non-periodontitis groups,respectively(P<0.01).Men were 604307(55.3%)and 4844383(54.7%)in the periodontitis and non-periodontitis groups,*** mean follow-up duration was 7.26 *** with periodontitis had a significantly higher risk of UC than those without periodontitis[adjusted hazard ratio:1.091;95%confidence interval(CI):1.008-1.182],but not CD(adjusted hazard ratio:0.879;95%confidence interval:0.731-1.057).The risks for UC were significant in the subgroups of age≥65 years,male gender,alcohol drinker,current smoker,and reduced physical *** smokers aged≥65 years with periodontitis were at a 1.9-fold increased risk of UC than non-smokers aged≥65 years without *** Periodontitis was significantly associated with the risk of developing UC,b

关键词： Inflammatory bowel disease Periodontitis Smoking Ulcerative colitis Crohn’s disease

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Spontaneous rupture of hepatic metastasis from a thymoma: A case report

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World Journal of Gastroenterology 2016年第44期22卷 9860-9864页

作者： Ho Jae kim Yong Eun Park Min Seo Ki Se Ju Lee Seung Hun beom Dai Hoon Han Young Nyun Park Jun Yong Park Department of Internal Medicine Yonsei University College of Medicine Department of Surgery Yonsei University College of Medicine Department of Pathology Yonsei University College of Medicine

Bleeding resulting from spontaneous rupture of the liver is an infrequent but potentially life threatening complication that may be associated with an underlying liver disease. A hepatocellular carcinoma or hepatic adenoma is frequently reported is such cases. However, hemoperitoneum resulting from a hepatic metastatic thymoma is extremely rare. Here, we present a case of a 62-year-old man with hypovolemic shock induced by ruptured hepatic metastasis from a thymoma. At the first hospital admission, the patient had a 45-mm anterior mediastinal mass that was eventually diagnosed as a type A thymoma. The mass was excised, and the patient was disease-free for 6 years. He experienced sudden-onset right upper quadrant pain and was again admitted to our hospital. We noted large hemoperitoneum with a 10-cm encapsulated mass in S5/8 and a 2.3-cm nodular lesion in the right upper quadrant of the abdomen. He was diagnosed with hepatic metastasis from the thymoma, and he underwent chemotherapy and surgical excision.

关键词： Spontaneous rupture Hemoperitoneum Transarterial chemoembolization Hepatic metastasis Thymoma

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Alterations of cardiac functions after chordae tendineae rupture using echocardiogram in dogs.

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畜牧与兽医 2012年第S2期44卷 52-53页

作者： Sehoon kim Jooho kim Jury kim Dongbin Lee Choong-Sup kim Hanjin kim Kwan kim Jaehyun Bae Yong-Hwan Kwon Hye-Yeon Cheong Jimo Jeong Yechan Jung Hae-beom Lee Kichang Lee Nam-Soo kim Min-Su kim The Institutional Animal Care and Use Committee (IACUC)(korea)

Chordae tendineae rupture(CTR),mostly occurred posterior,was identified in 16.1%of dogs with mitral valve disease(MVD).We form a hypothesis that selective transect of posterior chordae tendineae(CT)would alter the cardiac functions in *** objective of this study was to observe alterations of cardiac function to make a canine MR model from CTR.1 Materials and methods Nine healthy beagles weighed were *** had normal heart function from echocardiography.A left thoracotomy was performed through the 6thor 7thintercostal space.A specific hook was inserted into the left ventricle(LV)

关键词： rupture alterations mitral inserted hook canine valve ventricle mostly hypothesis

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High Prevalence of Genetic Alterations in Infantile-Onset Cardiomyopathy

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Congenital Heart Disease 2021年第4期16卷 397-410页

作者： Junsung Park Go Hun Seo Yena Lee Yunha Choi Minji Kang Hyo-Sang Do Young-Hwue kim Jeong Jin Yu Ellen Ai-Rhan kim Euiseok Jung Byong Sop Lee Jae Suk Baek beom Hee Lee Department of Pediatrics Asan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea billion Inc.SeoulKorea Genome Research Center for Birth Defects and Genetic Diseases Asan Institute for Life SciencesAsan Medical CenterSeoulKorea Division of Cardiology Department of PediatricsAsan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea Division of Neonatology Department of PediatricsAsan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea Medical Genetics Center Asan Medical Center Children’s HospitalUniversity of Ulsan College of MedicineSeoulKorea

Background and Method:The genetic cause of infantile-onset cardiomyopathy is rarely ***,we conducted whole exome sequencing(WES)and mitochondrial DNA(mtDNA)sequencing in eight patients with infantile-onset cardiomyopathy to identify genetic ***:Among these patients,two(25%)had dilated cardiomyopathy(DCMP),two(25%)had left ventricular non-compaction(LVNC),and four(50%)had hypertrophic cardiomyopathy(HCMP).Except four patients identified prenatally,the remaining patients presented at a median age of 85.5 *** identified genetic variants in a total of seven(87.5%)patients and mtDNA sequencing in the other ***1 and MYH7 variants were identified in the two patients with DCMP;MYH11 and MYLK2 variants in the two patients with LVNC;HRAS,BRAF,and MYH7 variants in three patients with HCMP;and MT-ND1 variant in one patient with HCMP having high blood lactic acid *** the eight variants,four were classified as pathogenic or likely-pathogenic according to the American College of Medical Genetics(ACMG)guidelines,and the remaining were identified as variants of unknown significance(VUSs).Three pathogenic mutations were de novo,whereas four(likely-pathogenic or VUSs)were inherited from a respective parent,excluding one variant where parental testing was unavailable,questioning whether these inherited variants are *** patients died before 3 months of ***:Genomic studies,such as WES with additional mtDNA sequencing,can identify a genetic variant in high proportions of patients with infantile-onset *** clinical implication of the parentally inherited variant needs to be assessed in a larger patient and family cohort with a longitudinal follow-up.

关键词： Cardiomyopathy whole exome sequencing infantile-onset

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Factors Affecting the Genetic Diagnostic Rate in Congenital Heart Disease

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Congenital Heart Disease 2022年第6期17卷 653-673页

作者： Jun Sung Park Go Hun Seo Yunha Choi Soojin Hwang Minji Kang Hyo-Sang Do Young-Hwue kim Jeong Jin Yu Ellen Ai-Rhan kim Euiseok Jung Byong Sop Lee Jae Suk Baek beom Hee Lee Department of Pediatrics Asan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea 3 Billion Inc.SeoulKorea Genome Research Center for Birth Defects and Genetic Diseases Asan Institute for Life SciencesAsan Medical CenterSeoulKorea Division of Cardiology Department of PediatricsAsan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea Division of Neonatology Department of PediatricsAsan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea Medical Genetics Center Asan Medical Center Children’s HospitalUniversity of Ulsan College of MedicineSeoulKorea

Background: Over 400 genes contribute to the development of congenital heart disease (CHD). Additionally,multisystemic manifestations accompanying syndromic CHD pose a higher risk of genetic diseases. This studyinvestigated the diagnostic yield of whole-exome sequencing (WES) in patients with sporadic syndromic CHDand the phenotypic factors affecting the genetic diagnostic rate. Methods: Sixty-four patients with sporadic syndromicCHD aged 0.05), betweenthe groups with and without a diagnostic variant. However, patients with ≥3 extracardiac phenotypes had a significantlyhigher likelihood of having a diagnostic variant than those with ≤2 (38.3% vs. 5.9%, odds ratio = 9.93,95% confidence interval = 1.21–81.44, P = 0.013). Conclusions: The number of extracardiac phenotypes is importantin predicting the possibility of genetic diagnosis. Physicians will be able to select patients with a high probabilityof genetic diagnosis and provide appropriate genetic counseling based on the results of this study.

关键词： Heart defects congenital whole-exome sequencing genetic testing phenotype

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Surgical outcomes of Korean ulcerative colitis patients with and without colitis-associated cancer

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World Journal of Gastroenterology 2015年第12期21卷 3547-3553页

作者： Yong Sik Yoon Yong beom Cho Kyu Joo Park Seung Hyuk Baik Sang Nam Yoon Seung-Bum Ryoo Kil Yeon Lee Hungdai kim Ryung-Ah Lee Chang Sik Yu Department of Colon and Rectal Surgery University of Ulsan College of Medicine and Asan Medical Center epartment of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine Department of Surgery Seoul National University College of Medicine Department of Surgery Yonsei University College of Medicine Severance Hospital Department of Surgery Kangnam Sacred Heart Hospital Hallym University College of Medicine Department of Surgery Kyung Hee University School of Medicine Department of Surgery Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine Department of Surgery Ewha Womans University School of Medicine

AIM: To determine the clinicopathologic characteristics of surgically treated ulcerative colitis(UC) patients, and to compare the characteristics of UC patients with colitis-associated cancer(CAC) to those without CAC. METHODS: Clinical data on UC patients who underwent abdominal surgery from 1980 to 2013 were collected from 11 medical institutions. Data were analyzed to compare the clinical features of patients with CAC and those of patients without ***: Among 415 UC patients, 383(92.2%) underwent total proctocolectomy, and of these, 342(89%) were subjected to ileal pouch-anal anastomosis. CAC was found in 47 patients(11.3%). Adenocarcinoma was found in 45 patients, and the others had either neuroendocrine carcinoma or lymphoma. Comparing the UC patients with and without CAC, the UC patients with CAC were characteristically older at the time of diagnosis, had longer disease duration, underwent frequent laparoscopic surgery, and were infrequently given preoperative steroid therapy(P < 0.001-0.035). During the 37 mo mean follow-up period, the 3-yearoverall survival rate was 82.2%.CONCLUSION: Most Korean UC patients experience early disease exacerbation or complications. Approximately 10% of UC patients had CAC, and UC patients with CAC had a later diagnosis, a longer disease duration, and less steroid treatment than UC patients without CAC.

关键词： Ulcerative colitis Colorectal neoplasms Colorectal

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Chloride Penetration Capacity in NPP Structures caused by Crack

Chloride Penetration Capacity in NPP Structures caused by Cr...

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2011 First International Conference on High Performance Structures and Materials Engineering (ICHPSM 2011)

作者： Ki-beom kim Do-Gyeum kim Jang-Hwa Lee Structural Engineering ＆ Bridges Research Division Korea Institute of Construction Technology

The speed of chloride penetration caused by cracking at the concrete surface is determined by the crack *** this study,the impact of the cracks that can occur on the concrete surface（occurring from the contraction during concrete curing） on the chloride penetration speed was revealed through *** accuracy of the established model was also verified through laboratory *** definition of the minimum crack width that affects the chloride penetration speed was established,based on testing and consideration of *** comparison of crack widths（20,85,125um） based on the chloride profile and model prediction showed that there is virtually no chloride penetration at 20 μm,while the chloride penetration speed increased sharply at crack widths of 85 μm and 125 μm.

关键词： Chloride penetration Concrete crack Chloride ion diffusion Chloride profile

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Prediction of Coastal Fecal Indicator Bacteria Concentrations Using Multivariate Data Analysis

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Journal of Environmental Science and Engineering(A) 2012年第4期1卷 440-447页

作者： Ki beom kim Jae Hoon kim Youngsul Jeong Young Seon Jeong Sung-Jae Chung Walt Whitman High School Bethesda MD 20817 USA Washington Baptist University Annandale VA 22003 USA College of Engineering Khalifa University of Science Technology and Research Abu Dhabi UAE Marymount University Arlington VA 22207 USA

The application of multivariate data analysis, a method for coping with multi-colinearity among independent variables in analyzing coastal water quality data, is presented. This study investigates the statistical regression modeling of FIB （fecal indicator bacteria） concentrations at the outlet of Talbert Marsh in Orange County, California. The multivariate data modeling utilized FIB and physical variables measurements （n = 5,580） collected during a series of longitudinal study of the Talbert Marsh. For the statistical prediction modeling in predicting the FIB concentrations at the outlet of the Talbert Marsh, multivariate analysis techniques such as PCR （principal components regression）, PLS （partial least-squares） regression and SVM （support vector machine） regression were adopted. Statistical modeling results suggest that the statistical modeling predictions are all fell within the reasonable range of actual measurement data. In addition, it is indicated that the accuracy of SVM regression for predicting FIB concentrations at the Talbert Marsh outlet is better than that of other models.

关键词： Multivariate statistical analysis fecal pollution coastal saltwater marsh.

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Photonic control of ligand nanospacing in self-assembly regulates stem cell fate

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Bioactive Materials 2024年第4期34卷 164-180页

作者： Sungkyu Lee Jounghyun Yoo Gunhyu Bae Ramar Thangam Jeongyun Heo Jung Yeon Park Honghwan Choi Chowon kim Jusung An Jungryun kim Kwang Rok Mun Seungyong Shin Kunyu Zhang Pengchao Zhao Yuri kim Nayeon Kang Seong-beom Han Dahee kim Jiwon Yoon Misun Kang Jihwan kim Letao Yang Solmaz Karamikamkar Jinjoo kim Yangzhi Zhu Alireza Hassani Najafabadi Guosheng Song Dong-Hwee kim Ki-Bum Lee Soong Ju Oh Hyun-Do Jung Hyun-Cheol Song Woo Young Jang Liming Bian Zhiqin Chu Juyoung Yoon Jong Seung kim Yu Shrike Zhang Yongju kim Ho Seong Jang Sehoon kim Heemin Kang Department of Materials Science and Engineering Korea UniversitySeoul02841Republic of Korea Chemical and Biological Integrative Research Center Korea Institute of Science and TechnologySeoul02792Republic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul02841Republic of Korea Department of Chemistry Korea UniversitySeoul02841Republic of Korea Materials Architecturing Research Center Korea Institute of Science and TechnologySeoul02792Republic of Korea School of Biomedical Sciences and Engineering Guangzhou International CampusSouth China University of TechnologyGuangzhou511442China Department of Chemistry and Chemical Biology Rutgers UniversityPiscatawayNJ08854USA Terasaki Institute for Biomedical Innovation Los AngelesCA90064USA State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha410082China Department of Biomedical-Chemical Engineering The Catholic University of KoreaGyeonggi-do14662Republic of Korea Electronic Materials Research Center Korea Institute of Science and TechnologySeoul02792Republic of Korea KIST-SKKU Carbon-Neutral Research Center Sungkyunkwan University(SKKU)Suwon16419Republic of Korea Department of Orthopedic Surgery Korea University Anam HospitalSeoul02841Republic of Korea Department of Electrical and Electronic Engineering and Joint Appointment with School of Biomedical Sciences The University of Hong KongHong Kong518057China Department of Chemistry and Nanoscience Ewha Womans UniversitySeoul03760Republic of Korea Division of Engineering in Medicine Department of MedicineBrigham and Women’s Hospital Harvard Medical SchoolCambridgeMA02139USA Division of Nano&Information Technology KIST SchoolKorea University of Science and Technology(UST)Seoul02792Republic of Korea College of Medicine Korea UniversitySeoul02841Republic of Korea Division of Materials Science and Engineering Hanyang UniversitySeoul04763Republic of Korea

Extracellular matrix(ECM)undergoes dynamic inflation that dynamically changes ligand nanospacing but has not been *** we utilize ECM-mimicking photocontrolled supramolecular ligand-tunable Azo^(+)self-assembly composed of azobenzene derivatives(Azo^(+))stacked via cation-πinteractions and stabilized with RGD ligand-bearing poly(acrylic acid).Near-infrared-upconverted-ultraviolet light induces cis-Azo^(+)-mediated inflation that suppresses cation-πinteractions,thereby inflating liganded *** inflation increases nanospacing of“closely nanospaced”ligands from 1.8 nm to 2.6 nm and the surface area of liganded selfassembly that facilitate stem cell adhesion,mechanosensing,and differentiation both in vitro and in vivo,including the release of loaded molecules by destabilizing water bridges and hydrogen bonds between the Azo^(+)molecules and loaded ***,visible light induces trans-Azo^(+)formation that facilitates cation-πinteractions,thereby deflating self-assembly with“closely nanospaced”ligands that inhibits stem cell adhesion,mechanosensing,and *** stark contrast,when ligand nanospacing increases from 8.7 nm to 12.2 nm via the inflation of self-assembly,the surface area of“distantly nanospaced”ligands increases,thereby suppressing stem cell adhesion,mechanosensing,and ***-term in vivo stability of self-assembly via real-time tracking and upconversion are *** tuning of ligand nanospacing can unravel dynamic ligand-cell interactions for stem cell-regulated tissue regeneration.

关键词： Dynamic self-assembly Ligand nanospacing In vivo tracking Stem cell adhesion Stem cell fate

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Reevaluation of the expanded indications in undifferentiated early gastric cancer for endoscopic submucosal dissection

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World Journal of Gastroenterology 2022年第15期28卷 1548-1562页

作者： Jiyoung Yoon Seung-Yeon Yoo Young Soo Park Kee Don Choi beom Su kim Moon-Won Yoo In Seob Lee Jeong Hwan Yook Ga Hee kim Hee Kyong Na Ji Yong Ahn Jeong Hoon Lee Kee Wook Jung Do Hoon kim Ho June Song Gin Hyug Lee Hwoon-Yong Jung Department of Gastroenterology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Department of Pathology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Department of Surgery Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea

BACKGROUND Although the criteria for the indication of endoscopic submucosal dissection(ESD)for undifferentiated early gastric cancer(UD-EGC)have been recently proposed,accumulating reports on the non-negligible rate of lymph node metastasis(LNM)after indicated ESD raise questions on the reliability of the current *** To investigate the prevalence and risk factors of LNM in UD-EGC cases meeting the expanded indication for *** We retrospectively reviewed 4780 UD-EGC cases that underwent surgical resection between January 2008 and February 2019 at Asan Medical Center,a tertiary university hospital in *** identify the risk factors of LNM of UDEGC meeting the expanded criteria for ESD,we performed a case-control study by matching the cases with LNM to those without at a ratio of 1:*** reviewed the clinical,endoscopic,and histologic features of the cases to identify features with a significant difference according to the presence of *** and multivariate logistic regression analyses were performed to estimate the odds ratios(ORs).RESULTS Of the 4780 UD-EGC cases,1240(25.9%)were identified to meet the expanded indication for *** the 1240 cases,14(1.1%)cases had *** the various clinical,endoscopic,and histopathological features that were evaluated,mixed histology(tumors consisting of 10%-90%of signet ring cells)had a marginally significant association(P=0.059)with the risk of ***,diffuse blurring of the muscularis mucosae(MM)underneath the tumorous epithelium,a previously unrecognized histologic feature,had a significant association with the absence of LNM(P=0.028).Multivariate logistic regression analysis showed that the blurring of MM was the only explanatory variable significantly associated with a reduced risk of LNM(OR:0.12,95%CI:0.02-0.95;P=0.045).CONCLUSION The risk of LNM is higher than expected when using the current expanded indication for *** evaluation could provide useful clues for reducing the

关键词： Gastric cancer Undifferentiated carcinoma Endoscopic submucosal dissection Lymph node metastasis

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