检索结果-南通市图书馆

Subacute electroacupuncture at Baihui (GV 20) and Dazhui (GV 14) promotes post-stroke functional recovery via neurogenesis and astrogliosis in a photothrombotic stroke mouse model

引用

Journal of Traditional Chinese Medicine 2019年第6期39卷 833-841页

作者： Young-Wook Park Gi Yoon Heo Min Jae Kim seo-yeon lee Byung Tae Choi Hwa Kyoung Shin Division of Meridian and Structural Medicine School of Korean MedicinePusan National UniversityYangsanGyeongnam 50612Republic of Korea Department of Korean Medical Science School of Korean MedicinePusan National UniversityYangsanGyeongnam 50612Republic of Korea Graduate Training Program of Korean Medicine for Healthy-Aging Pusan National UniversityYangsanGyeongnam 50612Republic of Korea Korean Medical Science Research Center for Healthy-Aging Pusan National UniversityYangsanGyeongnam 50612Republic of Korea

OBJECTIVE:To investigate the optimal timing and underlying mechanism of electroacupuncture(EA)at Baihui(GV 20)and Dazhui(GV 14)for improved long-term functional recovery after focal cerebral ischemia in a photothrombotic stroke mouse ***:Totally 50 adult male C57 BL/6 J mice were assigned into 5 groups:(a)the control group,sham-operated mice(n=10);(b)the vehicle group,focal cerebral ischemia induction without EA(n=10);(c)the acute EA group,mice received EA immediately post-ischemia,followed by once-daily treatments for 7 consecutive days(n=10);(d)the subacute EA group,mice received EA 4 days post-ischemia,followed by once-daily treatments for 7 consecutive days(n=10);(e)the delayed EA *** stimulation(2 Hz,2 V for 20 min)was applied to acupuncture points(acupoints),Baihui(GV 20)and Dazhui(GV 14),once a day for 7 consecutive days beginning immediately(acute treatment),4 d(subacute treatment)and 10 d(delayed treatment)after focal cerebral ischemia in C57 BL/6 J *** assessments were conducted 21 and 28 d post-ischemia and histopathological analyses were performed 28 days ***:The subacute EA treatment at Baihui(GV20)and Dazhui(GV 14)significantly improved functional recovery compared to the vehicle group 28 d after ischemic brain injury,although brain atrophy was not *** number of Neu N+and Neu N+/Brd U+cells as well as GFAP intensity in the ipsilateral cortex were significantly increased in the subacute group compared to the vehicle group 28 d *** concluded that EA stimulation 4 d post-ischemia(subacute treatment)enhanced neurogenesis and astrogliosis,likely contributing to long-term functional recovery following focal cerebral ***:Our findings suggest that the timing of the EA therapy at Baihui(GV 20)and Dazhui(GV 14)determines the therapeutic effects in mice with focal cerebral ischemia induced by photothrombotic occlusion.

关键词： Electroacupuncture Stroke Astrocytes Neurogenesis Post-stroke remodeling

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Aligned Ion Conduction Pathway of Polyrotaxane‑Based Electrolyte with Dispersed Hydrophobic Chains for Solid‑State Lithium–Oxygen Batteries

引用

Nano-Micro Letters 2025年第2期17卷 169-186页

作者： Bitgaram Kim Myeong‑Chang Sung Gwang‑Hee lee Byoungjoon Hwang Sojung seo Ji‑Hun seo Dong‑Wan Kim Department of Materials Science and Engineering Korea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea School of Civil Environmental and Architectural EngineeringKorea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea Materials Science and Chemical Engineering Center Institute for Advanced Engineering(IAE)Yongin 17180Republic of Korea

A critical challenge hindering the practical application of lithium–oxygen batteries(LOBs)is the inevitable problems associated with liquid electrolytes,such as evaporation and safety *** study addresses these problems by proposing a modified polyrotaxane(mPR)-based solid polymer electrolyte(SPE)design that simultaneously mitigates solvent-related problems and improves ***-SPE exhibits high ion conductivity(2.8×10^(−3)S cm^(−1)at 25℃)through aligned ion conduction pathways and provides electrode protection ability through hydrophobic chain *** this mPR-SPE into solid-state LOBs resulted in stable potentials over 300 *** situ Raman spectroscopy reveals the presence of an LiO_(2)intermediate alongside Li_(2)O_(2)during oxygen *** situ X-ray diffraction confirm the ability of the SPE to hinder the permeation of oxygen and moisture,as demonstrated by the air permeability *** present study suggests that maintaining a low residual solvent while achieving high ionic conductivity is crucial for restricting the sub-reactions of solid-state LOBs.

关键词： Solid polymer electrolyte Lithium-oxygen batteries Polyrotaxane ion conductivity Hydrophobic chain

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Significant control of metal-insulator transition temperature through catalytic excessive oxygen doping in high-performance vanadium dioxide nanobeam channel

引用

Journal of Materials Science & Technology 2020年第9期44卷 96-101页

作者： Minhwan Ko Sang yeon lee Jucheol Park Hyungtak seo Department of Energy Systems Research Ajou UniversitySuwon16499Republic of Korea Gyeongbuk Science Technology Promotion Center Gumi Electronics&Information Technology Research InstituteGumi39717Republic of Korea Department of Materials Science and Engineering Ajou UniversitySuwon16499Republic of Korea

The strategy of a reliable transition temperature control of vanadium dioxide(VO2)is *** VO2 nanobeams were synthesized by a thermal chemical vapor deposition(TCVD)*** metal-insulator transition(MIT)temperature increases to above 380K when the TiO2 ratio of the source is 5 at.%,although the Ti source is not physically doped into VO2 *** XPS spectra of the V 2p orbital reveal the excessive oxidation of V after the TCVD processes with a higher TiO2 ratio,indicating that the TiO2 precursor is important in the O-doping of the surface V O bonds when forming volatile Ti-O gas ***,TiO2 reactants can be used as a VO2 surface chemical modifier to manipulate the MIT transition temperature and maintain a homogenous VO2 phase,which is useful for a Mott device application with a record on/off switching ratio>104 and Mott transition temperature>380 K.

关键词： VO2 Mott transition Metal-insulator transition temperature Oxygen doping Titanium catalyst

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Aluminum doping for optimization of ultrathin and high-k dielectric layer based on SrTiO3

引用

Journal of Materials Science & Technology 2020年第7期42卷 28-37页

作者： Ji-Ye Baek Le Thai Duy Sang yeon lee Hyungtak seo Department of Energy Systems Research Ajou UniversitySuwon 443-749South Kore Department of Materials Science and Engineering Ajou UniversitySuwon 443-749South Korea

An ultrathin SrTiO3 dielectric layer is optimized through Al doping to solve the problems existing in development of ultra-high-k oxide MOS *** post-deposition annealing,Al doping induces changes in the electronic structure of SrTiO3,thereby effectively reducing leakage current to 80) of ultrathin SrTMO3 MOS *** titanate(SrTiO3) is a high-k material but its bandgap is smaller than that of other oxide dielectrics(e.g.,SiO2,Al2 O3).Consequently,an ultrathin SrTiO3 film may have a high tunneling leakage current,which is not suitable for capacitor-based *** improve the performance of metal-oxide-semiconductor(MOS) capacitors using SrTiO3,an approach based on homogenous and uniform aluminum doping to SrTiO3 through co-sputtering is *** bandgap of a pristine SrTiO3 film showed an increase of 0.5 eV after Al ***,Al doping decreased the leakage current of SrTiO3/Si-based MOS capacitors by more than five orders of magnitude(at the level of nanoampere per square centimeter).Importantly,a dielectric constant of 81.3 and equivalent oxide thickness less than 5 A were achieved in an 8-nm-thick Al-doped SrTiO3 film owing to changes in its crystal structure and conduction band edge electronic ***,the obtained data show the effectiveness of the proposed approach for solving the problems existing in the development of ultra-high-k oxide MOS capacitors.

关键词： Aluminum doping SrTiO3 ultrathin High dielectric constant MOS capacitors

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Targeted down-regulation of Hipp1 ameliorates tau-induced deficits in Drosophila melanogaster

引用

Genes & Diseases 2023年第6期10卷 2248-2251页

作者： Sung yeon Park Jieun seo Seulbee lee Joohyung Kim Sang Jeong Kim Seungbok lee Yang-Sook Chun Ischemic/Hypoxic Disease Institute Seoul National University College of MedicineSeoul 03080Republic of Korea Department of Biomedical Sciences Seoul National University College of MedicineSeoul 03080Republic of Korea Department of Physiology Seoul National University College of MedicineSeoul 03080Republic of Korea Department of Brain and Cognitive Sciences Seoul National UniversitySeoul 08826Republic of Korea Department of Cell and Developmental Biology and Dental Research Institute Seoul National UniversitySeoul 08826Republic of Korea

Tauopathies,such as Alzheimer's disease(AD),are neurodegenerative diseases characterized by the deposition of neurofibrillary tangles comprising hyperphosphorylated tau protein in the human brain.1 Given that abnormal epigenetic alterations in heterochromatin configuration have been documented in AD patients and transgenic animal models of AD,2 we investigated the roles of novel heterochromatin-associated interactors3 in *** transgenic flies via UAS-Gal4 binary system,we found that knockdown of Hipp1(HP1a and insulator partner protein-1)3 ***4ow(referred to as"tau"hereafter for simplicity)2-induced locomotion defects,reduced lifespan,and degeneration of brain ***,Hipp1 knockdown restored tau-driven aberrant expression of putative insulator targets and aberrant insulator-mediated epigenetic ***1 may have a role as an insulator-binding partner regarding being implicated in tauinduced neurodegeneration.

关键词： tau alterations degeneration

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of High-Performance Steel on the Tension Stiffening and Cracking Behavior of Reinforced Concrete (RC) Tension Ties

引用

Journal of Iron and Steel Research International 2011年第S1期18卷 812-816页

作者： Yun Hyun-do lee Young-oh Ryu Seung-hyun seo Soo-yeon Department of Architectural Engineering Chungnam National University Daejeon 305764 South Korea Department of Architectural Engineering Chungju National University Chungju South Korea

In construction industry, the application of high-performance reinforcement bar is required strongly. Unfortunately, not nearly enough research has been conducted on high-performance steel in comparison with high strength concrete. This paper describes the effect of high-performance steel as reinforcement steel bar on the tension response and cracking behavior of concrete and fiber-reinforced strain-hardening cement-based composite (SHCC) tension members. High-performance steel is characterized by higher strength in comparison to ASTM A615-06 Grade 60 steel. The tension stiffening effect on high-performance reinforcing bars embedded in cement-based composite prism is investigated experimentally. The variables in the study are types of cement-based composite (conventional concrete, synthetic fiber-reinforced cement composite), yielding strength of steel bars (400MPa and 600MPa), and types of loading (monotonic and repeated tension loading).

关键词： crack width tension stiffening fiber-reinforced strain-hardening cement-based composite tension

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The Development of Metabolic Derangement in Male Offspring after Perinatal Exposure to Di-(2-Ethylhexyl) Phthalate

引用

Biomedical and Environmental Sciences 2018年第7期31卷 531-534页

作者： Yun-jung Yang Moon-seo Park Eui-Jin lee yeon-pyo Hong Department of Preventive Medicine College of Medicine Chung-Ang University Institute of Biomedical Science Catholic Kwandong University International St. Mary’s Hospital Institute for Catholic Integrative Medicine Incheon St. Mary’s Hospital College of Medicine The Catholic University of Korea

The prevalence of obesity and type 2 diabetes mellitus（T2DM）has been increasing throughout the world over the past 20 *** chemicals known to regulate the endocrine system have been considered as a risk factor for th... 详细信息

关键词： PND Phthalate The Development of Metabolic Derangement in Male Offspring after Perinatal Exposure to Di Ethylhexyl

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Antiviral efficacy of adefovir dipivoxil versus lamivudine in patients with chronic hepatitis B sequentially treated with lamivudine and adefovir due to lamivudine resistance

引用

World Journal of Gastroenterology 2007年第30期13卷 4072-4079页

作者： yeon seok seo Ji Hoon Kim Jong Eun yeon Jong-Jae Park Jae seon Kim Kwan Soo Byun Young-Tae Bak Chang Hong lee Division of Gastroenterology and Hepatology Department of Internal Medicine Korea University College of Medicine Seoul Korea Division of Gastroenterology and Hepatology Department of Internal Medicine Konkuk University College of Medicine Seoul Korea

AIM： To compare the antiviral efficacy of adefovir （ADV） in lamivudine （LMV）-resistant patients with LMV treatment in nucleoside-naive patients, using serum samples collected sequentially during the course of treatment progressing from LMV to ADV.METHODS： Forty-four patients with chronic hepatitis B （CHB） were included. The patients were initially treated with LMV and then switched to ADV when LMV resistance developed. Antiviral efficacy was assessed by measuring the following： reduction in serum HBV DNA from baseline, HBV DNA negative conversion （defined as HBV DNA being undectable by the hybridization assay）, and HBV DNA response （either HBV DNA level ≤ 10^s copies/mL or a ≥ 2 log10 reduction from baseline HBV DNA level）.RESULTS： After two and six months of treatment, HBV DNA reduction was greater with LMV compared to ADV treatment （P = 0.021）. HBV DNA negative conversion rates were 64% and 27% after one month of LMV and ADV treatment respectively （P = 0.001）. Similarly, HBV DNA response rates were 74% and 51% after two months of LMV and ADV treatment respectively （P = 0.026）. The time taken to HBV DNA negative conversion and to HBV DNA response were both delayed in ADV treatment compared with LMV.CONCLUSION： The antiviral efficacy of ADV in LMV-resistant patients is slower and less potent than that with LMV in nucleoside-naive patients during the early course of treatment.

关键词： Chronic hepatitis B Lamivudine Adefovir Treatment efficacy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

PGLYRP1 protein as a novel mediator of cellular dialogue in neuroinflammation

引用

Neural Regeneration Research 2025年第7期20卷 1993-1994页

作者： Anup Bhusal Won-Ha lee Kyoungho Suk Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea BK21 Plus KNU Biomedical Convergence Program Department of Biomedical ScienceSchool of MedicineKyungpook National UniversityDaeguRepublic of Korea School of Life Sciences BK21 plus KNU Creative BioResearch GroupKyungpook National UniversityDaeguRepublic of Korea Brain Science and Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Neuroinflammation has been identified as a crucial element in several neurological disorders. Glial cells play a critical role in directing neuroinflammation, both in deleterious and beneficial ways.

关键词： inflammation considerably

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Single-cell and spatial omics:exploring hypothalamic heterogeneity

引用

Neural Regeneration Research 2025年第6期20卷 1525-1540页

作者： Muhammad Junaid Eun Jeong lee Su Bin Lim Department of Biochemistry&Molecular Biology Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Graduate School of Ajou UniversitySuwonSouth Korea Department of Brain Science Ajou University School of MedicineSuwonSouth Korea

Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technologies have significantly evolved, overcoming initial technical challenges in capturing and analyzing individual cells. These high-throughput omics technologies now offer a remarkable opportunity to comprehend the complex spatiotemporal patterns of transcriptional diversity and cell-type characteristics across the entire hypothalamus. Current single-cell and single-nucleus RNA sequencing methods comprehensively quantify gene expression by exploring distinct phenotypes across various subregions of the hypothalamus. However, single-cell/single-nucleus RNA sequencing requires isolating the cell/nuclei from the tissue, potentially resulting in the loss of spatial information concerning neuronal networks. Spatial transcriptomics methods, by bypassing the cell dissociation, can elucidate the intricate spatial organization of neural networks through their imaging and sequencing technologies. In this review, we highlight the applicative value of single-cell and spatial transcriptomics in exploring the complex molecular-genetic diversity of hypothalamic cell types, driven by recent high-throughput achievements.

关键词： cellular diversity hypothalamus multi-omics single-cell transcriptomics spatial transcriptomics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：