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Changes of the gastric endocrine cells in the C57BL/6 mouse after implantation of murine lung carcinoma: An immunohistochemical quantitative study

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World Journal of Gastroenterology 2005年第9期11卷 1317-1323页

作者： Sae-Kwang Ku Hyeung-Sik Lee Joon-seok Byun Bu-Il seo Jae-hyun Lee Pharmacology and Toxicology Laboratory Department of Herbal Biotechnology College of Oriental Medicine Lab.of Histology

AIM: The regional distributions and relative frequencies of some gastric endocrine cells of C57BL/6 mice were studied by immunohistochemical method using seven types of specific antisera against chromogranin A (CGA), serotonin, somatostatin, gastrin, cholecystokinin (CCK)-8, glucagon and human pancreatic polypeptide (HPP) after subcutaneous implantation of murine lung carcinoma (3LL) cells. METHODS: The experimental animals were divided into two groups, one is non-implanted sham and the other is 3LL-implanted group. Samples were collected from the two regions of stomach (fundus and pylorus) at 28 d after implantation of 3LL cells (1x105 cell/mouse). RESULTS: In this study, all the seven types of immunoreactive (IR) cells were identified except for HPP. Most of these IR cells in the gastric portion were generally spherical or spindle in shape (open-type cell) while cells showing round in shape (closed-type cell) were found occasionally. The regional distributions of gastric endocrine cells in the 3LL-implanted group were similar to those of non-implanted sham. However, significant decreases of some types of IR cells were detected in 3LL-implanted group compared to those of non-implanted sham. In addition, the IR cells showing degranulation were numerously detected in 3LL-implanted group. CGA-, serotonin- and somatostatin-IR cells in the fundus and pylorus regions, and gastrin-IR cells in the pylorus regions of 3LL-implanted groups significantly decreased compared to those of non-implanted sham. However, no changes on frequencies of CCK-8- and glucagon-IR cells were demonstrated between 3LL-implanted and non-implanted groups. CONCLUSION: Endocrine cells are the anatomical units responsible for the production of gut hormones, and the change in their density would reflect a change in the capacity of producing these hormones. Implantation of tumor cell mass (3LL) induced severe quantitative changes of gastric endocrine cell density, and the abnormality in density of gast

关键词： Gastric endocrine cells Gut hormones 3LL

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Polyurethane-based Actuators with Various Polyols

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Journal of Materials Science & Technology 2010年第8期26卷 763-768页

作者： Nam-Ju Jo Do-Hee lim Gyeong-Mi Bark Ho-Hwan Chun In-Won Lee hyun Park Department of Polymer Science and Engineering Pusan National University Advanced Ship Engineering Research Center Pusan National University

This study dealt with the electrostrictive responses of polyurethane （PU） actuators with different microphase separation structure, which was a promising candidate for a material used in polymer actuators. In order to construct PUs with different higher-order structure, PUs with various types of polyol were synthesized： poly（neopentyl glycol adipate）（PNAD）, poly（tetramethylene glycol）（PTMG）, and poly（dimethyl siloxnae）（PDMS）. Synthesized PU was characterized by Fourier transform-infrared （FT-IR） spectroscopy and gel per- meation chromatography （GPC）. Thermal analysis and mechanical properties of PU films were carried out with differential scanning calorimetry （DSC） and UTM （universal testing machine）, respectively. And PU actuator was formed in a type of monomorph, which was made by carbon black electrodes on the both surfaces of PU film by spin coating method. Actuation behavior was mainly influenced on microphase separation struc- ture and mechanical property of PU. In result, PU actuator with PNAD, polyester urethane, had the largest field-induced displacement.

关键词： Electroactive polymer Polyurethane actuator Polyol type Maxwell stress effect Electrostriction effect

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In vivo analysis of post-joint-preserving surgery fracture of 3D-printed Ti-6Al-4V implant to treat bone cancer

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Bio-Design and Manufacturing 2021年第4期4卷 879-888页

作者： Jong Woong Park Ye Chan Shin hyun Guy Kang Sangeun Park Eunhyeok seo Hyokyung Sung Im Doo Jung Division of Convergence Technology National Cancer CenterGoyang 10408Republic of Korea Orthopaedic Oncology Clinic National Cancer CenterGoyang 10408Republic of Korea Department of Materials Engineering and Convergence Technology Gyeongsang National UniversityJin-Ju 52828Republic of Korea Department of Mechanical Engineering Ulsan National Institute of Science and TechnologyUNIST-Gil 50Ulsan 44919Republic of Korea

Cancer growth in the bone due to its random shape disables bone strength and thus changes its capacity to support body weight or muscles,which can crucially affect the quality of human life in terms of normal walking or daily *** successful patient recovery,it is necessary to remove the cancer-affected minimal bone area and quickly replace it with a biocompatible metal implant within less than 2 *** electron beam-melted Ti-6Al-4V implant was designed and applied in a patient to preserve the natural knee joint close to the bone *** developed implant fits the bone defect well,and the independent ambulatory function of the natural knee joint was restored in the patient within six weeks after surgery.A delayed fracture occurred six months after the successful replacement of cancer-affected bone with Ti-6Al-4V implant at the proximal meshed junction of the implant because of a minor downward ***,mechanical,and computational analyses were conducted for the fractured area to find the main reason for the delayed *** findings pertaining to the mechanical and material investigation can help realize the safe implantation of the three-dimensionally printed titanium implant to preserve the natural joints of patients with massive bone defects of the extremities.

关键词： 3D printing Bone cancer Titanium alloy implant Electron beam melting Fracture analysis

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Electrochemically Deposited CZTSSe Thin Films for Monolithic Perovskite Tandem Solar Cells with Efficiencies Over 17%

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Energy & Environmental Materials 2024年第1期7卷 147-152页

作者： Sun Kyung Hwang Ik Jae Park Se Won seo Jae hyun Park So Jeong Park Jin Young Kim Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Korea Department of Applied Physics Sookmyung Women's UniversitySeoul 04310Korea Research Institute of Advanced Materials and Systems Sookmyung Women's UniversitySeoul 04310Korea Research Institute of Advanced Materials(RIAM) Seoul National UniversitySeoul 08826Korea

In spite of the high potential economic feasibility of the tandem solar cells consisting of the halide perovskite and the kesterite Cu2ZnSn(S,Se)4(CZTSSe),they have rarely been demonstrated due to the difficulty in implementing solution-processed perovskite top cell on the rough surface of the bottom ***,we firstly demonstrate an efficient monolithic two-terminal perovskite/CZTSSe tandem solar cell by significantly reducing the surface roughness of the electrochemically deposited CZTSSe bottom *** surface roughness(R_(rms))of the CZTSSe thin film could be reduced from 424 to 86 nm by using the potentiostatic mode rather than using the conventional galvanostatic mode,which can be further reduced to 22 nm after the subsequent ion-milling *** perovskite top cell with a bandgap of 1.65 eV could be prepared using a solution process on the flattened CZTSSe bottom cell,resulting in the efficient perovskite/CZTSSe tandem solar *** the current matching between two subcells involving the thickness control of the perovskite layer,the best performing tandem device exhibited a high conversion efficiency of 17.5%without the hysteresis effect.

关键词： CZTSSe monolithic tandem solar cells perovskite solution process surface roughness control

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Nanocomposite quasi-solid-state electrolyte for high-safety lithium batteries

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Nano Research 2017年第9期10卷 3092-3102页

作者： hyunji Choi hyun Woo Kim Jae-Kwang Kim Young Jun lim Youngsik Kim Jou-Hyeon Ahn School of Energy & Chemical Engineering Ulsan National Institute of Science and Technology (UNIST) Ulsan 689-798 Republic of Korea Department of Solar & Energy Engineering Cheongju University Cheongju Chungbuk 28503 Republic of Korea School of Energy & Chemical Engineering and Research Institute for Green Energy Convergence Technology Gyeongsang National University 900 Gajwa-dong Jinju 660-70 I Republic of Korea

Rechargeable lithium batteries are attractive power sources for electronic devices and are being aggressively developed for vehicular use. Nevertheless, problems with their safety and reliability must be solved for the large-scale use of lithium batteries in transportation and grid-storage applications. In this study, a unique hybrid solid-state electrolyte composed of an ionic liquid electrolyte (LiTFSI/Pyr14TFSI) and BaTiO3 nanosize ceramic particles was prepared without a polymer. The electrolyte exhibited high thermal stability, a wide electrochemical window, good ionic conductivity of 1.3 × 10−3 S·cm−1 at 30 °C, and a remarkably high lithium-ion transference number of 0.35. The solid-state LiFePO4 cell exhibited the best electrochemical properties among the reported solid-state batteries, along with a reasonable rate capability. Li/LiCoO2 cells prepared using this nanocomposite solid electrolyte exhibited high performance at both room temperature and a high temperature, confirming their potential as lithium batteries with enhanced safety and a wide range of operating temperatures.

关键词： nanocomposition solidified ionic liquid shell charge space safety lithium battery

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Electrically driven, phosphor-free, white light-emitting diodes using gallium nitride-based double concentric truncated pyramid structures

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Light(Science & Applications) 2016年第1期5卷 665-670页

作者： Seung-Hyuk lim Young-Ho Ko Christophe Rodriguez Su-hyun Gong Yong-Hoon Cho Department of Physics and KI for the NanoCentury Korea Advanced Institute of Science and Technology291 Daehak-roYuseong-guDaejeon 34141Korea Electronics and Telecommunications Research Institute(ETRI) 218 Gajeong-roYuseong-guDaejeon 34129Korea The Laboratoire Nanotechnologies Nanosystémes(LN2)-CNRS UMI-3463 Institut Interdisciplinaire d’Innovation Technologique(3IT)Universitéde Sherbrooke3000 boulevard UniversitéJ1K 0A5QCCanada

White light-emitting diodes(LEDs)are becoming an alternative general light source,with huge energy savings compared to conventional ***,white LEDs using phosphor(s)suffer from unavoidable Stokes energy converting losses,higher manufacturing cost,and reduced thermal ***,we demonstrate electrically driven,phosphor-free,white LEDs based on three-dimensional gallium nitride structures with double concentric truncated hexagonal *** electroluminescence spectra are stable with varying *** origin of the emission wavelength is studied by cathodoluminescence and high-angle annular dark field scanning transmission electron microscopy *** variation of the carrier injection efficiency is also investigated by a comparative analysis between spatially resolved photoluminescence and electroluminescence.

关键词： indium gallium nitride light-emitting diodes phosphor-free three-dimensional structures white color

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Incidental accumulation of Technetium-99m pertechnetate in subacute cerebral infarction: A case report

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World Journal of Clinical Cases 2022年第23期10卷 8400-8405页

作者： Yeon-Hee Han Hwan-Jeong Jeong hyun Goo Kang seok Tae lim Department of Nuclear Medicine Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University HospitalJounbuk National University Medical School and HospitalJeonju 54907JeonbukSouth Korea Department of Neurology Jeonbuk National University Medical School and HospitalJeonju 54907JeonbukSouth Korea

BACKGROUND When interpreting nuclear medicine images,unexpected findings are sometimes *** these findings and determining the mechanism of their occurrence could have a significant impact on early diagnosis of critical diseases and the appropriate management of *** SUMMARY A 59-year-old man was admitted to the emergency room due to left hemiparesis,left hemifacial palsy,and mild *** 2 wk of hospitalization,the patient complained of dry eyes and ***,salivary scintigraphy was performed to evaluate the functional status of his salivary *** accumulation in the right frontoparietal area was found on salivary ***-attenuated inversion recovery phase magnetic resonance(FLAIR phase MR)image showed diffuse high signal intensity in the same *** and posterior horns of the right lateral ventricle were obliterated and the midline was slightly shifted to the left side due to right frontoparietal *** salivary scintigraphy,Tc-99m pertechnetate was incidentally accumulated in a subacute cerebral infarction *** years after the diagnosis of acute infarction,the second series of salivary scintigraphy showed no abnormal activity in the *** phase MR image also demonstrated markedly decreased high signal intensity in the previous infarction lesion without evidence of swelling indicating chronic cerebral *** This case highlights that Tc-99m pertechnetate could accumulate in a subacute cerebral infarction *** mechanism of an unexpected uptake of Tc-99m pertechnetate in unusual sites should be evaluated and kept in mind for better interpretation.

关键词： Cerebral infarction Tc-99m pertechnetate Salivary scintigraphy Case report

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Fatal rhabdomyolysis and disseminated intravascular coagulation after total knee arthroplasty under spinal anesthesia:A case report

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World Journal of Clinical Cases 2022年第4期10卷 1349-1356页

作者： Dae Hun Yun Eun Ha Suk Wan Ju Eun Hyoung seo hyun Kang Department of Anesthesiology and Pain Medicine Kwangju Christian HospitalGwangju 61661South Korea

BACKGROUND Rhabdomyolysis develops as a result of skeletal muscle cell collapse from leakage of the intracellular contents into *** severe cases,it can be associated with acute kidney injury and disseminated intravascular coagulation,leading to life threatening *** can occur in the perioperative period from various etiologies but is rarely induced by tourniquet use during orthopedic *** SUMMARY A 77-year-old male underwent right total knee arthroplasty using a tourniquet under spinal *** 24 h after surgery,he was found in a drowsy mental state and manifested features of severe rhabdomyolysis,including fever,hypotension,oliguria,high creatine kinase,myoglobinuria,and disseminated intravascular *** supportive care,cardiac arrest developed abruptly,and the patient was not able to be *** Severe rhabdomyolysis and disseminated intravascular coagulation can develop from surgical tourniquet,requiring prompt,aggressive treatments to save the patient.

关键词： Rhabdomyolysis Total knee arthroplasty Tourniquet Disseminated intravascular coagulation Case report

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Tai Chi for Management of Type 2 Diabetes Mellitus:A Systematic Review

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Chinese Journal of Integrative Medicine 2011年第10期17卷 789-793页

作者： Myeong Soo Lee Tae-Young Choi hyun-Ja lim Edzard Ernst Division of Standard Research Korea Institute of Oriental MedicineDaeieonSouth Korea Complementary Medicine Peninsula Medical SchoolUniversity of ExeterExeterUK Division of Standard Research Korea Institute of Oriental MedicineDaejeonSouth Korea Department of Nursing Chodang UniversityMuanSouth Korea

Objective： Tai chi has been recommended for treating type 2 diabetes mellitus. The purpose of this systematic review was to evaluate evidence from controlled clinical trials testing the effectiveness of tai chi in treating type 2 diabetes mellitus. Methods： Systematic searches were conducted on 14 electronic databases without restrictions on either population characteristics or language of publication. The outcome measures considered for inclusion were changes in fasting blood glucose （FBG）, glycosylated haemoglobin A1c （HbA1c） and quality of life （QOL）. Results： Eight randomised clinical trials （RCTs） and two controlled clinical trials （CCTs） met all inclusion criteria. Three RCTs from 1 trial compared the effects of tai chi with sham exercise and failed to show effectiveness of tai chi on FBG, HbA1c, or QOL. The other 3 RCTs tested the effects of tai chi compared with other types of exercise on FBG. The meta-analysis failed to show an FBG-lowering effect of tai chi [n=118, weighted mean difference （WMD）： -0.14 mmol/L, 95% CI：-0.86 to 0.58,P=0.70]. Four studies （2 RCTs and 2 CCT） compared tai chi with no treatment or self-management programme and failed to report significant differences between the experimental and control groups except for QOL from 1 RCT and 1 CCT. Conclusion： The existing evidence does not suggest that tai chi is an effective therapy for type 2 diabetes. Currently, there are few high-quality trials on which to make definitive judgements.

关键词： type 2 diabetes mellitus tai chi fast blood glucose complementary medicine

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Anticancer effects of oligomeric proanthocyanidins on human colorectal cancer cell line, SNU-C4

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World Journal of Gastroenterology 2005年第30期11卷 4674-4678页

作者： Youn-Jung Kim Hae-Jeong Park seo-hyun Yoon Mi-Ja Kim Kang-hyun Leem Joo-Ho Chung Hye-Kyung Kim Department of Dental Hygiene Department of Pharmacology Department of Obesity Management College of Oriental Medicine Department of Food and Biotechnology

AIM: Oligomeric proanthocyanidins (OPC), natural polyphenolic compounds found in plants, are known to have antioxidant and anti-cancer effects. We investigated whether the anti-cancer effects of the OPC are induced by apoptosis on human colorectal cancer cell line, ***: Colorectal cancer cell line, SNU-C4 was cultured in RPMI 1640 medium supplemented with 10% fetal bovine serum. The cytotoxic effect of OPC was assessed by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenylt-etrazolium bromide (MTT) assay. To find out the apoptotic cell death, 4, 6-diamidino-2-phenylindole (DAPI) staining,terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) assay, reverse transcriptionpolymerase chain reaction (RT-PCR), and caspase-3 enzyme assay were ***: In this study, cytotoxic effect of OPC on SNUC4 cells appeared in a dose-dependent manner. OPC treatment (100 μg/mL) revealed typical morphological apoptotic features. Additionally OPC treatment (100 μg/mL)increased level of BAX and CASPASE-3, and decreased level of BCL-2 mRNA expression. Caspase-3 enzyme activity was also significantly increased by treatment of OPC (100 μg/mL) compared with ***: These data indicate that OPC caused cell death by apoptosis through caspase pathways on human colorectal cancer cell line, SNU-C4.

关键词： Oligomeric pranthocyanidins Apoptosis Anticancer effects Colorectal cancer

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