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Etiopathogenesis of reproductive tract infections and the emerging role of bitter taste receptors:A scoping review

Asian pacific Journal of Reproduction 2021年第4期10卷 145-154页

作者： Menizibeya O.Welcome Abraham Jeremiah Dennis O.Allagoa senol dane Vladimir A.Pereverzev Department of Physiology Faculty of Basic Medical SciencesNile University of NigeriaAbujaNigeria Department of Surgery Federal Medical CentreYenagoaNigeria Department of Surgery Belarusian State Medical UniversityMinskBelarus Department of Obstetrics and Gynecology Federal Medical CentreYenagoaNigeria Department of Normal Physiology Belarusian State Medical UniversityMinskBelarus

Reproductive tract infections pose an immense public health concern worldwide as over 600 million new cases are recorded annually along with several complications,including infertility,ectopic pregnancy,preterm delivery,and neonatal *** improved understanding of the mechanisms of pathogenic invasion,the etiopathogenesis of reproductive tract infections is yet to be completely *** data has suggested a critical role of bitter taste receptors of the reproductive tract in etiopathogenesis of reproductive tract ***,we review the literature on current etiopathogenesis of reproductive tract infections and the role of bitter taste receptors of the reproductive tract in etiopathogenesis of reproductive tract *** evidence suggests a critical role of microbiota disorder of the reproductive tract in reproductive tract *** bacterial,protozoan parasitic,helminthic parasitic and viral pathogens have been identified as causative agents of reproductive tract *** pathogens subvert host defenses and activate specific architectural units of the uroepithelium such as Toll-like receptors,which recognize conserved motifs on the *** activated Toll-like receptors mediate downstream signaling,stimulating nuclear factor-κB,which in turn activates the production of proinflammatory *** pathway is also associated with recruitment of immunocytes to the site of aggression and release of proteinases,which drive tissue damage in the reproductive *** in detection of pathogenic components by the bitter taste receptors of the reproductive tract may play a critical role in the etiopathogenesis of reproductive tract *** review provides important information for identification of novel frontiers for the treatment of reproductive tract infections.

关键词： Infection Genital inflammation Reproduction Reproductive tract infections Bitter taste receptor Etiopathogenesis Cytokines

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Proton magnetic resonance spectroscopy of the anterior cingulate gyrus and caudate nucleus in schizophrenia patients versus healthy controls

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Neural Regeneration Research 2011年第6期6卷 467-473页

作者： Lutfi Incesu Meral Baydin Kerim Aslan Baris Diren Huseyin Sahin Omer Boke senol dane Department of Radiology Medical FacultyOndokuz Mayis University Department of Radiology Gazi State Hospital Department of Radiology Ataturk State Hospital Department of Radiology Medicana International Hospital Department of Psychiatry Medical FacultyOndokuz Mayis University Department of Physiology Medical FacultyFatih University

Proton magnetic resonance spectroscopy （^1 H-MRS） permits the assessment of cerebral neurometabolites, such as N-acetylaspartate, choline, and creatine, in vivo and has been used to study schizophrenia. The present study used ^1H-MRS to compare the spectroscopy change of N-acetylaspartate, creatine, and choline metabolite levels in the anterior cingulate and caudate nucleus of both schizophrenia patients and healthy controls, as well as between the left and right cerebral hemispheres in the schizophrenia patients. Results showed that N-acetylaspartate and creatine metabolite levels in the left anterior cingulate gyrus were significantly lower in the schizophrenia patients than in the healthy controls, indicating hypometabolism. In addition, choline concentration in the left caudate nucleus of schizophrenia patients was significantly lower than in the right caudate nucleus, indicating that it is necessary to study the cerebral lateralization of ^1H-MRS in schizophrenia patients.

关键词： schizophrenia magnetic resonance spectroscopy anterior cingulate gyrus caudate nucleus neurocognitive test

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