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CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： Lin yin Yalan Xu Jie Mu Yu Leng Lei Ma Yu Zheng Ruizhi Li yin Wang Peifeng Li Hai Zhu Dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

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Chinese Named Entity Recognition with Character-Level BLSTM and Soft Attention Model

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Journal of Beijing Institute of Technology 2020年第1期29卷 60-71页

作者： Jize yin senlin Luo Zhouting Wu Limin Pan Information System and Security&Countermeasures Experimental Center Beijing Institute of TechnologyBeijing 100081China

Unlike named entity recognition(NER)for English,the absence of word boundaries reduces the final accuracy for Chinese *** avoid accumulated error introduced by word segmentation,a deep model extracting character-level features is carefully built and becomes a basis for a new Chinese NER method,which is proposed in this *** method converts the raw text to a character vector sequence,extracts global text features with a bidirectional long short-term memory and extracts local text features with a soft attention model.A linear chain conditional random field is also used to label all the characters with the help of the global and local text *** based on the Microsoft Research Asia(MSRA)dataset are designed and *** show that the proposed method has good performance compared to other methods,which proves that the global and local text features extracted have a positive influence on Chinese *** more variety in the test domains,a resume dataset from Sina Finance is also used to prove the effectiveness of the proposed method.

关键词： Chinese named entity recognition(NER) character-level bidirectional long short-term memory soft attention model

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Investigation of bubbles escape behavior from low basicity mold flux for high-Mn high-Al steels using 3D X-ray microscope

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 102-110页

作者： Qiang Liu Xiang Li Shen Du Ming Gao Yanbin yin Jiongming Zhang State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

During the continuous casting process of high-Mn high-Al steels,various types of gases such as Ar need to escape through the top of the *** which,the behavior of bubbles traversing the liquid slag serves as a restrictive link,closely associated with viscosity and the thickness of liquid *** contrast to two-dimensional surface observation,three-dimensional(3D)analysis method can offer a more intuitive,accurate,and comprehensive ***,this study employs a 3D X-ray microscope(3D-XRM)to obtained spatial distribution and 3D morphological characteristics of residual bubbles in mold flux under different basicity of liquid slag,different temperatures,and different holding *** results indicate that as basicity of slag increases from 0.52 to 1.03,temperature increases from 1423 to 1573 K,the viscosity of slag decreases,the floating rate of bubbles *** addition,when holding time increases from 10 to 30 s,the bubbles floating distance increases,and the volume fraction and average equivalent sphere diameter of the bubbles solidified in the mold flux gradually *** one word,increasing the basicity,temperature,and holding time leading to an increase in the removal rate of bubbles especially for the *** findings of bubbles escape behavior provide valuable insights into optimizing low basicity mold flux for high-Mn high-Al steels.

关键词： mold flux low basicity bubbles three-dimensional X-ray microscope viscosity

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长轴缓坡辫状河三角洲前缘储层构型研究

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中国科技论文 2016年第9期11卷 1005-1010页

作者：胡张明郑丽君印森林邱永杰陈乃志周明杰光友会中国石油集团西部钻探克拉玛依录井工程公司新疆克拉玛依834000 长江大学计算机科学学院湖北荆州434023

为了探讨长轴缓坡辫状河三角洲前缘储层构型模式,采用层次界面分析及"层次约束,模式拟合,多维互动"的构型表征方法对长轴缓坡背景下的辫状河三角洲前缘不同级次的构型进行精细解剖,得出在不同构造背景下三角洲储层构型样式具有较大的差... 详细信息

为了探讨长轴缓坡辫状河三角洲前缘储层构型模式,采用层次界面分析及"层次约束,模式拟合,多维互动"的构型表征方法对长轴缓坡背景下的辫状河三角洲前缘不同级次的构型进行精细解剖,得出在不同构造背景下三角洲储层构型样式具有较大的差异性。研究表明:辫状河三角洲前缘主要发育分流水道、河口坝、席状砂等构型要素,其中6级、7级、8级及9级界面限定的构型单元分别为单层微相复合体、单一微相复合体、单一微相、微相内部增生体。不同级次的构型单元具有不同的叠置样式和识别依据。在对多级构型要素定性定量识别基础上,建立了以分流水道与河口坝为主体的长轴缓坡辫状河三角洲前缘储层构型模式。

关键词：储层构型河口坝三角洲前缘泥质夹层密井网

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基于不同开发阶段的深层油气田经济评价方法

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长江大学学报（自然科学版） 2021年第5期18卷 38-47页

作者：龙隆陈恭洋印森林裴潇彭少杰郭秋麟长江大学录井技术与工程研究院湖北荆州434023 长江大学经济与管理学院湖北荆州434023 中国石油勘探开发研究院油气资源规划研究所北京100083

近年来我国石油和天然气对外依存度屡创新高,常规勘探深度难以寻找接替领域,深层油气资源的勘探开发能有效缓解能源紧张,保证国家能源安全。深层油气资源由于具有勘探开发技术难度大、投资规模大、风险高等特点,在实施勘探开发前需对其... 详细信息

近年来我国石油和天然气对外依存度屡创新高,常规勘探深度难以寻找接替领域,深层油气资源的勘探开发能有效缓解能源紧张,保证国家能源安全。深层油气资源由于具有勘探开发技术难度大、投资规模大、风险高等特点,在实施勘探开发前需对其经济可行性进行评估,借以达到降低投资风险,提高经济效益的目的。探索了深层油气资源勘探开发过程中的技术及经济因素,并将风险理念贯穿于资源评价的全过程,根据不同勘探开发程度,分别建立了适用于低勘探区的“基于多指标综合评分的资源经济性评价法”和适用于高勘探区的“基于蒙特卡洛模拟的贴现现金流模型”。通过对我国12个低勘探区和5个高勘探区的深层油气田的相关数据进行测试,验证了模型的可行性,实现了深层油气资源的风险量化经济评价,并针对不同勘探开发阶段的深层油气资源采用不同的方法,探索了勘探开发一体化评价新模式。

关键词：深层油气资源经济评价多指标蒙特卡洛模拟

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基于录井资料的浅层低阻油层随钻识别及评价——以珠江口盆地恩平凹陷韩江组为例

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长江大学学报（自然科学版） 2020年第4期17卷 16-22,I0002,I0003页

作者：蒋钱涛张伟白林坤韦少校熊亭程乐利印森林中海石油(中国)有限公司深圳分公司广东深圳518067 中海油田服务股份有限公司测井事业部北京101149 中法渤海地质服务有限公司天津300452 长江大学录井技术与工程研究院湖北荆州434023

油气勘探作业中往往要求做到即发现即解释,对随钻储层解释评价的要求越来越高。为了提高珠江口盆地恩平凹陷韩江组浅层低阻油层的随钻解释评价精度,探索了利用录井资料进行浅层低阻油层随钻识别及评价的方法:从岩性及沉积环境因素、构... 详细信息

油气勘探作业中往往要求做到即发现即解释,对随钻储层解释评价的要求越来越高。为了提高珠江口盆地恩平凹陷韩江组浅层低阻油层的随钻解释评价精度,探索了利用录井资料进行浅层低阻油层随钻识别及评价的方法:从岩性及沉积环境因素、构造因素和工程因素3个方面系统分析了韩江组浅层低阻油层的成因;针对韩江组浅层疏松、砂泥岩薄互层、荧光显示低和气体比低的特点,利用三维定量荧光、FLAIR(fluid logging&analysis in real time,实时地层流体录井)及岩石热解色谱等录井新技术,对研究区典型浅层低阻油层进行了识别和评价。评价结果与取样结论一致,对提高研究区勘探效益有一定帮助。

关键词：浅层低阻油层三维定量荧光实时地层流体录井(FLAIR) 岩石热解色谱录井技术

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Advancements and Challenges in Organic–Inorganic Composite Solid Electrolytes for All‑Solid‑State Lithium Batteries

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Nano-Micro Letters 2025年第1期17卷 46-97页

作者： Xueyan Zhang Shichao Cheng Chuankai Fu Geping yin Liguang Wang Yongmin Wu Hua Huo State Key Laboratory of Space Power‑Sources School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001People’s Republic of China College of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310058People’s Republic of China State Key Laboratory of Space Power-Sources 2965 Dongchuan RoadMinhang DistrictShanghai 200240People’s Republic of China

To address the limitations of contemporary lithium-ion batteries,particularly their low energy density and safety concerns,all-solid-state lithium batteries equipped with solid-state electrolytes have been identified as an up-and-coming *** the various SEs,organic–inorganic composite solid electrolytes(OICSEs)that combine the advantages of both polymer and inorganic materials demonstrate promising potential for large-scale ***,OICSEs still face many challenges in practical applications,such as low ionic conductivity and poor interfacial stability,which severely limit their *** review provides a comprehensive overview of recent research advancements in ***,the influence of inorganic fillers on the main functional parameters of OICSEs,including ionic conductivity,Li+transfer number,mechanical strength,electrochemical stability,electronic conductivity,and thermal stability are systematically *** lithium-ion conduction mechanism of OICSE is thoroughly analyzed and concluded from the microscopic ***,the classic inorganic filler types,including both inert and active fillers,are categorized with special emphasis on the relationship between inorganic filler structure design and the electrochemical performance of ***,the advanced characterization techniques relevant to OICSEs are summarized,and the challenges and perspectives on the future development of OICSEs are also highlighted for constructing superior ASSLBs.

关键词： Composite solid electrolytes Inorganic filler Interfacial stability Li-ion conduction mechanism Characterization techniques

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Ultra‑High Sensitivity Anisotropic Piezoelectric Sensors for Structural Health Monitoring and Robotic Perception

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Nano-Micro Letters 2025年第2期17卷 432-446页

作者： Hao yin Yanting Li Zhiying Tian Qichao Li Chenhui Jiang Enfu Liang Yiping Guo State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Beijing Vacuum Electronics Research Institute Beijing 100015People’s Republic of China Fundamental Science On Vibration Shock and Noise LaboratoryState Key Laboratory of Mechanical System and VibrationSchool of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Monitoring minuscule mechanical signals,both in magnitude and direction,is imperative in many application scenarios,e.g.,structural health monitoring and robotic sensing ***,the piezoelectric sensor struggles to satisfy the requirements for directional recognition due to the limited piezoelectric coefficient matrix,and achieving sensitivity for detecting micrometer-scale deformations is also ***,we develop a vector sensor composed of lead zirconate titanate-electronic grade glass fiber composite filaments with oriented arrangement,capable of detecting minute anisotropic *** as-prepared vector sensor can identify the deformation directions even when subjected to an unprecedented nominal strain of 0.06%,thereby enabling its utility in accurately discerning the 5μm-height wrinkles in thin films and in monitoring human pulse *** ultra-high sensitivity is attributed to the formation of porous ferroelectret and the efficient load transfer efficiency of continuous lead zirconate titanate ***,when integrated with machine learning techniques,the sensor’s capability to recognize multi-signals enables it to differentiate between 10 types of fine textures with 100%*** structural design in piezoelectric devices enables a more comprehensive perception of mechanical stimuli,offering a novel perspective for enhancing recognition accuracy.

关键词： Flexible piezoelectric filaments Anisotropic Ultra-high sensitivity Structural health detection Texture recognition

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Exosomes:the next-generation therapeutic platform for ischemic stroke

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Neural Regeneration Research 2025年第5期20卷 1221-1235页

作者： Wenjing yin Hongyin Ma Yang Qu Jiaxin Ren yingying Sun Zhen-Ni Guo Yi Yang Stroke Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience Research Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina

Current therapeutic strategies for ischemic stroke fall short of the desired objective of neurological functional ***,there is an urgent need to develop new methods for the treatment of this *** are natural cell-derived vesicles that mediate signal transduction between cells under physiological and pathological *** have low immunogenicity,good stability,high delivery efficiency,and the ability to cross the blood–brain *** physiological properties of exosomes have the potential to lead to new breakthroughs in the treatment of ischemic *** rapid development of nanotechnology has advanced the application of engineered exosomes,which can effectively improve targeting ability,enhance therapeutic efficacy,and minimize the dosages *** in technology have also driven clinical translational research on *** this review,we describe the therapeutic effects of exosomes and their positive roles in current treatment strategies for ischemic stroke,including their antiinflammation,anti-apoptosis,autophagy-regulation,angiogenesis,neurogenesis,and glial scar formation reduction ***,it is worth noting that,despite their significant therapeutic potential,there remains a dearth of standardized characterization methods and efficient isolation techniques capable of producing highly purified *** optimization strategies should prioritize the exploration of suitable isolation techniques and the establishment of unified workflows to effectively harness exosomes for diagnostic or therapeutic applications in ischemic ***,our review aims to summarize our understanding of exosome-based treatment prospects in ischemic stroke and foster innovative ideas for the development of exosome-based therapies.

关键词： blood–brain barrier electroacupuncture engineering exercise exosomes ischemic stroke mesenchymal stem cells microglia neuroprotection stents

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Dynamic Regulation of Hydrogen Bonding Networks and Solvation Structures for Synergistic Solar‑Thermal Desalination of Seawater and Catalytic Degradation of Organic Pollutants

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Nano-Micro Letters 2025年第2期17卷 548-565页

作者： Ming‑Yuan Yu Jing Wu Guang yin Fan‑Zhen Jiao Zhong‑Zhen Yu Jin Qu Beijing Key Laboratory of Advanced Functional Polymer Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029People’s Republic of China

Although solar steam generation strategy is efficient in desalinating seawater,it is still challenging to achieve continuous solar-thermal desalination of seawater and catalytic degradation of organic ***,dynamic regulations of hydrogen bonding networks and solvation structures are realized by designing an asymmetric bilayer membrane consisting of a bacterial cellulose/carbon nanotube/Co_(2)(OH)_(2)CO_(3)nanorod top layer and a bacterial cellulose/Co_(2)(OH)_(2)CO_(3)nanorod(BCH)bottom ***,the hydrogen bonding networks inside the membrane can be tuned by the rich surface–OH groups of the bacterial cellulose and Co_(2)(OH)_(2)CO_(3)as well as the ions and radicals in situ generated during the catalysis ***,both SO_(4)^(2−)and HSO_(5)−can regulate the solvation structure of Na^(+)and be adsorbed more preferentially on the evaporation surface than Cl^(−),thus hindering the de-solvation of the solvated Na^(+)and subsequent nucleation/growth of ***,the heat generated by the solar-thermal energy conversion can accelerate the reaction kinetics and enhance the catalytic degradation *** work provides a flow-bed water purification system with an asymmetric solar-thermal and catalytic membrane for synergistic solar thermal desalination of seawater/brine and catalytic degradation of organic pollutants.

关键词： Solar steam generation Seawater desalination Catalytic degradation Bacterial cellulose Cobalt hydroxycarbonate nanorods

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