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International Journal of Organic Chemistry 2015年第4期5卷 271-281页

作者： Thangavelu Saravanan Anju Chadha Tarur Konikkaledom Dinesh Namasivayam Palani sengottuvelan balasubramanian Laboratory of Bioorganic Chemistry Department of Biotechnology Indian Institute of Technology Madras Chennai India National Center for Catalysis Research Indian Institute of Technology Madras Chennai India Department of Inorganic Chemistry University of Madras Guindy Campus Chennai India ITC Life Sciences and Technology Centre ITC Limited Peenya Industrial Area Phase I Bangalore India

Enantiomerically enriched (R)-1-(2-bromocycloalkenyl)-3-buten-1-ol and its derivatives were obtained via enantioselective hydrolysis [resolution] with good enantioselectivities (E = 31 to >500) using Candida parapsilosis ATCC 7330. The various reaction parameters were optimized for enantioselective hydrolysis to achieve high enantiomeric excess (ee) and conversions. Among the substrates tested, (RS)-1-(2-bromocyclohex-1-en-1-yl) but-3-yn-1-yl acetate was hydrolysed by the biocatalyst in 12 h to the corresponding (R)-alcohol in 49% conversion and >99 ee. The optically pure allylic alcohol thus obtained was used as a chiral starting material for the synthesis of an enantiomerically enriched bicyclic alcohol effectively establishing achemoenzymatic route.

关键词： Chemoenzymatic Synthesis Enantioselective Hydrolysis Candida parapsilosis ATCC 7330 Hydrolases Bicyclic Carbocycle

An Adaptive Scalable Data Pipeline for Multiclass Attack Classification in Large-Scale IoT Networks

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Big Data Mining and Analytics 2024年第2期7卷 500-511页

作者： Selvam Saravanan Uma Maheswari balasubramanian Department of Computer Science and Engineering Amrita School of ComputingAmrita Vishwa VidyapeethamBengaluru 560035India

The current large-scale Internet of Things(IoT)networks typically generate high-velocity network traffic *** use IoT devices to create botnets and launch attacks,such as DDoS,Spamming,Cryptocurrency mining,Phishing,*** service providers of large-scale IoT networks need to set up a data pipeline to collect the vast network traffic data from the IoT devices,store it,analyze it,and report the malicious IoT devices and types of ***,the attacks originating from IoT devices are dynamic,as attackers launch one kind of attack at one time and another kind of attack at another *** number of attacks and benign instances also vary from time to *** phenomenon of change in attack patterns is called concept ***,the attack detection system must learn continuously from the ever-changing real-time attack patterns in large-scale IoT network *** meet this requirement,in this work,we propose a data pipeline with Apache Kafka,Apache Spark structured streaming,and MongoDB that can adapt to the ever-changing attack patterns in real time and classify attacks in large-scale IoT *** concept drift is detected,the proposed system retrains the classifier with the instances that cause the drift and a representative subsample instances from the previous training of the *** proposed approach is evaluated with the latest dataset,IoT23,which consists of benign and several attack instances from various IoT *** classification accuracy is improved from 97.8%to 99.46%by the proposed *** training time of distributed random forest algorithm is also studied by varying the number of cores in Apache Spark environment.

关键词： Internet of Things(IoT) concept drift Apache Spark MongoDB Apache Kafka streaming

Recent advances in understanding neurotoxicity,behavior and neurodegeneration in siluriformes

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Aquaculture and Fisheries 2024年第3期9卷 404-410页

作者： Sonika Kar balasubramanian Senthilkumaran Department of Animal Biology School of Life SciencesUniversity of HyderabadP.O.Central UniversityHyderabadTelangana500046India

Occurrence of neurotoxic chemicals in the aquatic environment is on the rise posing a potential threat to aquatic biota including *** teleosts,zebrafish has become a popular model organism for toxicological studies and testing ***,over the decade,siluriformes(catfish)are also finding ever increasing application being robust as well as their adaptability to adverse ecological conditions,surgical interventions,and tolerant models for toxicity studies and *** information can infer potential effects occurring to other species exposed to neurotoxins in their aquatic environment and predicting potential risks of a chemical for the aquatic *** aim of this review is to compare and interpret recent results published concerning neuro-behavioral and morphological disturbances caused by toxicants/pollutants providing a holistic view of potential neurotoxic outcomes in ***,this review summarizes various effects of toxicants/pollutants in terms of neurotoxicity and neurodegeneration associated with behavioral phenotypes.

关键词： Neurotoxicity Behavior Neurodegeneration Siluriformes Bioaccumulation

Neuroendocrine facets of behavior and toxicology

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Aquaculture and Fisheries 2024年第3期9卷 337-338页

作者： Keith B.Tierney balasubramanian Senthilkumaran Department of Biological Sciences and the School of Public HealthUniversity of AlbertaEdmontonABT6G 2E9Canada Department of Animal Biology School of Life SciencesUniversity of HyderabadP O Central UniversityGachibowliHyderabad500046TelanganaIndia

Professor ***,who I came to know as Senthil,came over to visit the University of Alberta in the summer of 2022 in connection with his Global Ambassador Fellowship program at University of Saskatechewan,***,there was that reason to visit,but there was another one as well,one that tied us *** years before Senthil had been considered for a postdoctoral fellowship with the legend that was Dick ***,it didn’t materialize and then he moved to Japan to do his Post Doc Under *** *** had been Dean and a preeminent endocrinologist at the U of A.I came to know Dick near the end of my PhD;he had brought me out to Bamfield Marine Sciences Centre to carryout research using their then-new,and very expensive,simulated *** left an incredible mark on all of us that knew him;he represented all that was wonderful and achievable in *** spent time with him was akin to shaking Sinatra’s hand,at least in the world of biology in that *** this common history,Senthil and I were fast friends.

关键词： Canada shaking carry

Effects of Enteromorpha prolifera polysaccharides on growth performance,intestinal barrier function and cecal microbiota in yellow-feathered broilers under heat stress

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Journal of Animal Science and Biotechnology 2024年第1期15卷 344-361页

作者： Wenchao Liu Huimei Liu Yaoyao Wang Zhongxiang Zhao Balamuralikrishnan balasubramanian Rajesh Jha Department of Animal Science College of Coastal Agricultural SciencesGuangdong Ocean UniversityZhanjiangGuangdong 524088People’s Republic of China Department of Food Science and Biotechnology College of Life ScienceSejong UniversitySeoul 05006South Korea Department of Human Nutrition Food and Animal SciencesCollege of Tropical Agriculture and Human ResourcesUniversity of Hawaii at ManoaHonoluluHI 96822USA

Background Global warming leading to heat stress(HS)is becoming a major challenge for broiler *** study aimed to explore the protective effects of seaweed(Enteromorpha prolifera)polysaccharides(EPS)on the intestinal barrier function,microbial ecology,and performance of broilers under HS.A total of 144 yellow-feathered broilers(male,56 days old)with 682.59±7.38 g were randomly assigned to 3 groups:1)TN(thermal neutral zone,23.6±1.8℃),2)HS(heat stress,33.2±1.5℃ for 10 h/d),and 3)HSE(HS+0.1%EPS).Each group contained 6 replicates with 8 broilers per *** study was conducted for 4 weeks;feed intake and body weights were measured at the end of weeks 2 and *** the end of the feeding trial,small intestine samples were collected for histomorphology,antioxidant,secretory immunoglobulin A(s Ig A)content,apoptosis,gene and protein expression analysis;cecal contents were also collected for microbiota analysis based on 16S r DNA *** Dietary EPS promoted the average daily gain(ADG)of broilers during 3–4 weeks of HS(P<0.05).At the end of HS on broilers,the activity of total superoxide dismutase(T-SOD),glutathione S-transferase(GST),and the content of s Ig A in jejunum were improved by EPS supplementation(P<0.05).Besides,dietary EPS reduced the epithelial cell apoptosis of jejunum and ileum in heat-stressed broilers(P<0.05).Addition of EPS in HS group broilers'diet upregulated the relative m RNA expression of Occludin,ZO-1,γ-GCLc and IL-10 of the jejunum(P<0.05),whereas downregulated the relative m RNA expression of NF-κB p65,TNF-αand IL-1βof the jejunum(P<0.05).Dietary EPS increased the protein expression of Occludin and ZO-1,whereas it reduced the protein expression of NF-κB p65 and MLCK(P<0.01)and tended to decrease the protein expression of TNF-α(P=0.094)in heat-stressed ***,the proportions of Bacteroides and Oscillospira among the three groups were positively associated with jejunal apoptosis and pro-inflammatory cytokine ex

关键词： Broilers Cecal microbiota Heat stress Intestinal barrier function Seaweed polysaccharides

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Comprehensive review on ethnomedicinal, phytochemistry and pharmacological profile of Ficus Religiosa L.

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Journal of Traditional Chinese Medicine 2024年第5期44卷 1052-1057页

作者： Rahul Rawat Harish Kumar Neetu Singh Aakash Deep balasubramanian Narasimhan Surender Singh Yadav Sanjiv Kumar Department of Pharmaceutical Sciences Chaudhary Bansi Lal University Department of Botany Maharshi Dayanand University Faculty of Pharmaceutical Sciences Maharshi Dayanand University

Ficus religiosa L.(F. religiosa) or sacred fig is a large perennial tree belonging to the family Moraceae or mulberry family. Though the tree has pan-tropical distribution but originally it is indigenous to the Indian subcontinent and Indochina region. Popularly the tree is named "Pepal or bodhi tree". Traditionally, it is practiced for the treatment of asthma, nose bleeding, heart disorders, diabetes, wound healing, ear problems, constipation, hyperlipidemia, gonorrhea, ulcers and infectious disorders. Chemical analysis demonstrated the presence of numerous bioactives including tannins, phenols, saponins, sugars, alkaloids, methionine, terpenoids, flavonoids, glycosides, proteins, separated amino acids, essential and volatile oils and steroids etc., which are probably responsible for its diverse pharmacological actions. The present work is an attempt to compile up-to-date comprehensive information on F. religiosa that covers its taxonomy, ethnomedicinal importance, phytochemistry, pharmacological attributes and clinical trials. Keeping in mind the various health attributes of F. religiosa, future research can be aimed at in-depth elucidation of the structure-function relationship and multifactorial signalings pathways.

关键词： Ficus religiosa clinical trials ethnomedicine health benefits pharmacology phytoconstituents

A Novel Eccentric Intrusion Detection Model Based on Recurrent Neural Networks with Leveraging LSTM

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Computers, Materials & Continua 2024年第3期78卷 3089-3127页

作者： Navaneetha Krishnan Muthunambu Senthil Prabakaran balasubramanian Prabhu Kavin Kishore Senthil Siruvangur Kavitha Chinnadurai Jehad Ali Department of Computer Applications Karpagam College of EngineeringCoimbatore641032India Department of Computer Science and Engineering Karpagam College of EngineeringCoimbatore641032India Department of Data Science and Business Systems College of Engineering and TechnologySRM Institute of Science and TechnologyKattankulathur603203India Department of Computer Science and Engineering Sathyabama Institute of Science and TechnologyJeppiaar NagarRajiv Gandhi SalaiChennai600119India Department of AI Convergence Network Ajou UniversitySuwon16499Korea

The extensive utilization of the Internet in everyday life can be attributed to the substantial accessibility of online services and the growing significance of the data transmitted via the ***,this development has expanded the potential targets that hackers might *** adequate safeguards,data transmitted on the internet is significantly more susceptible to unauthorized access,theft,or *** identification of unauthorised access attempts is a critical component of cybersecurity as it aids in the detection and prevention of malicious *** research paper introduces a novel intrusion detection framework that utilizes Recurrent Neural Networks(RNN)integrated with Long Short-Term Memory(LSTM)*** proposed model can identify various types of cyberattacks,including conventional and distinctive *** networks,a specific kind of feedforward neural networks,possess an intrinsic memory *** Neural Networks(RNNs)incorporating Long Short-Term Memory(LSTM)mechanisms have demonstrated greater capabilities in retaining and utilizing data dependencies over extended *** such as data types,training duration,accuracy,number of false positives,and number of false negatives are among the parameters employed to assess the effectiveness of these models in identifying both common and unusual *** are utilised in conjunction with LSTM to support human analysts in identifying possible intrusion events,hence enhancing their decision-making capabilities.A potential solution to address the limitations of Shallow learning is the introduction of the Eccentric Intrusion Detection *** model utilises Recurrent Neural Networks,specifically exploiting LSTM *** proposed model achieves detection accuracy(99.5%),generalisation(99%),and false-positive rate(0.72%),the parameters findings reveal that it is superior to state-of-the-art techniques.

关键词： Cybersecurity intrusion detection machine learning leveraging long short-term memory(LLSTM) CICIDS2019 dataset innovative cyberattacks

Accelerated intermetallic phase amorphization in a Mg-based high-entropy alloy powder

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Journal of Magnesium and Alloys 2024年第5期12卷 1792-1798页

作者： Prince Sharma Purvam Mehulkumar Gandhi Kerri-Lee Chintersingh Mirko Schoenitz Edward L.Dreizin Sz-Chian Liou Ganesh balasubramanian Institute for Functional Materials&Devices Lehigh UniversityBethlehemPA 18015USA Center of Materials for Advanced Energetics New Jersey Institute of TechnologyNewarkNJ 07102USA

We describe a novel mechanism for the synthesis of a stable high-entropy alloy powder from an otherwise immiscible Mg-Ti rich metallic mixture by employing high-energy mechanical *** presented methodology expedites the synthesis of amorphous alloy powder by strategically injecting entropic disorder through the inclusion of multi-principal elements in the alloy *** from first principles and materials theory corroborate the results from microscopic characterizations that reveal a transition of the amorphous phase from a precursor intermetallic *** transformation,characterized by the emergence of antisite disorder,lattice expansion,and the presence of nanograin boundaries,signifies a departure from the precursor intermetallic ***,this phase transformation is accelerated by the presence of multiple principal elements that induce severe lattice distortion and a higher configurational *** atomic size mismatch of the dissimilar elements present in the alloy produces a stable amorphous phase that resists reverting to an ordered lattice even on annealing.

关键词： High-entropy alloy High-energy milling Antisite disorder Amorphous Intermetallic

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Bioactivation of titanium dioxide scaffolds by ALP-functionalization

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Bioactive Materials 2017年第2期2卷 108-115页

作者： A.sengottuvelan P.balasubramanian J.Will A.R.Boccaccini Department of Materials Science and Engineering Institute of BiomaterialsUniversity of Erlangen-NurembergCauerstraße 691058 ErlangenGermany

Three dimensional TiO2 scaffolds are receiving renewed attention for bone tissue engineering (TE) due totheir biocompatibility and attractive mechanical properties. However the bioactivity of these scaffolds iscomparatively lower than that of bioactive glass or hydroxyapatite (HA) scaffolds. One strategy toimprove bioactivity is to functionalize the surface of the scaffolds using biomolecules. Alkaline phosphatase(ALP) was chosen in this study due to its important role in the bone mineralization process. Thecurrent study investigated the ALP functionalization of 3D titanium dioxide scaffolds using selfpolymerizationof dopamine. Robust titanium scaffolds (compressive strength^2.7 ± 0.3 MPa) wereproduced via foam replica method. Enzyme grafting was performed by dip-coating in polydopamine/ALPsolution. The presence of ALP was indirectly confirmed by contact angle measurements and enzymaticactivity study. The influence of the enzyme on the bioactivity, e.g. hydroxyapatite formation on thescaffold surface, was measured in simulated body fluid (SBF). After 28 days in SBF, 5 mg ALP coatedtitania scaffolds exhibited increased hydroxyapatite formation. It was thus confirmed that ALP enhancesthe bioactivity of titania scaffolds, converting an inert bioceramic in an attractive bioactive system forbone TE.

关键词： Alkaline phosphatase Titanium dioxide Scaffolds Polydopamine Surface modification Bioactivity

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满盒巧克力

中学生英语 2024年第25期 13-15页

作者： balasubramanian 周硕

从前，有两个朋友理查德和乔治，两人的关系很好。一天，理查德在商店里看到一块美味的巧克力棒。他非常想要它。一想到它，他就流口水。当他梦见巧克力棒时，他的好朋友乔治来了。理查德那天得到了一支新铅笔。乔治看到了那支铅笔，非...

从前，有两个朋友理查德和乔治，两人的关系很好。一天，理查德在商店里看到一块美味的巧克力棒。他非常想要它。一想到它，他就流口水。当他梦见巧克力棒时，他的好朋友乔治来了。理查德那天得到了一支新铅笔。乔治看到了那支铅笔，非常喜欢它。他问理查德铅笔的价格。这只铅笔两美元，但他谎称它质量很好，花了他五美元。乔治非常喜欢这支铅笔，于是他花光了自己存的钱，付给了理查德。乔治得到了铅笔，理查德把钱花在了巧克力棒上。

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