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Factors associated with significant liver fibrosis assessed using transient elastography in general population

World Journal of Gastroenterology 2015年第4期21卷 1158-1166页

作者： seng chan you Kwang Joon Kim Seung Up Kim Beom Kyung Kim Jun Yong Park Do young Kim Sang Hoon Ahn Won Jae Lee Kwang-Hyub Han Department of Internal Medicine Yonsei University College of MedicineSeoul 120-752South Korea Division of Endocrinology and Metabolism Yonsei University College of MedicineSeoul 120-752South Korea Institute of Gastroenterology Yonsei University College of MedicineSeoul 120-752South Korea Liver Cirrhosis Clinical Research Center Seoul 120-752South Korea Seoul Gookgwain School Seoul 110-521South Korea

AIM: To investigate the prevalence of significant liver fibrosis assessed using transient elastography(TE) and its predictors in asymptomatic general ***: A total of 159 subjects without chronic viral hepatitis who underwent comprehensive medical health check-up between January 2012 and July 2012 were prospectively recruited. Significant liver fibrosis was defined as liver stiffness value > 7.0 k ***: The mean age and body mass index(BMI) of the study population(men 54.7%) was 56.0 years and 24.3 kg/m2. Among the study subjects, 11(6.9%) showed significant liver fibrosis. On univariate analysis, BMI, alanine aminotransferase(ALT), homeostasis model assessment of insulin resistance, carotid intimal media thickness(IMT), number of calcified plaques on carotid ultrasound, and visceral fat area on computed tomography were significantly higher in subjects with significant liver fibrosis than in those without(all P < 0.05). However, on multivariate analysis, BMI [odds ratio(OR) =1.487; P = 0.045], ALT(OR = 1.078; P = 0.014), carotid IMT(OR = 3.244; P = 0.027), and the number of calcified carotid plaques(OR = 1.787; P = 0.031) were independent predictors of significant liver fibrosis. CONCLUSION: The prevalence of significant liver fibrosis assessed using TE was 6.9% in apparently healthy subjects. High BMI, high ALT, thicker carotid IMT, and higher numbers of calcified carotid plaqueswere independently associated with the presence of significant liver fibrosis.

关键词： Transient elastography Healthy subjects Fibroscan

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Optimizing distribution of multiple tuned mass dampers for building structures with inverse element exchange method

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Earthquake Engineering and Engineering Vibration 2025年第1期24卷 187-199页

作者： Peng-Tai chan Department of Marine Environment and Engineering Sun Yat-sen University(NSYSU)Kaohsiung 804TaiwanChina

Multiple tuned mass dampers(MTMDs)reduce dynamic response with multiple specified frequencies of building *** optimization algorithms for placement design exist,though they rarely conform to code-based verification nor produce high quality solutions without high computational effort and high *** study proposes an inverse element exchange method(IEEM)with multi-level programming and compares it to a single tuned mass damper(STMD)and uniform distribution of multiple tuned mass dampers in the frequency and time domains.A ten-story shear building is used for the numerical case *** results show that the proposed method can offer improvement over the STMD,uniform distribution of multiple tuned mass dampers,and distribution optimized by genetic algorithms(GA)with regard to minimizing the interstory drift ratio(IDR)in both the frequency and time domains and the time consumption for optimization.

关键词： tuned mass damper multiple tuned mass damper optimal damper placement design transfer function

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Dibutyl phthalate disrupts[Ca^(2+)]_(i),reactive oxygen species,[pH]_(i),protein kinases and mitochondrial activity,impairing sperm function

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Journal of Environmental Sciences 2025年第5期151卷 68-78页

作者： Seung Hyun Park Myung chan Gye Department of Life Science and Institute for Natural Sciences Hanyang UniversitySeoul 04763Republic of Korea

To explore the mechanism of sperm dysfunction caused by dibutyl phthalate(DBP),the effects of DBP on intracellular[Ca^(2+)]and[pH],reactive oxygen species(ROS),lipid peroxidation(LPO),mitochondrial permeability transition pore(mPTP)opening,mitochondrial membrane potential(MMP),adenosine triphosphate(ATP)levels,phosphorylation of protein kinase A(PKA)substrate proteins and phosphotyrosine(p-Tyr)proteins,sperm motility,spontaneous acrosome reaction,and tail bending were examined in mouse *** 100μg/mL,DBP significantly increased tail bending and[Ca^(2+)]***,DBP showed biphasic effects on[pH]*** at 10–100μg/mL significantly decreased sperm ***,Ca^(2+)ionophore A23187 decreased[pH]_(i)sperm motility,suggesting that DBP-induced excessive[Ca^(2+)]_(i)decreased sperm *** significantly increased ROS and *** at 100μg/mL significantly decreased mPTP closing,MMP,and ATP levels in spermatozoa,as did H2O2,indicative of ROS-mediatedmitochondrial dysfunction caused by *** as well as H2O2 increased p-Tyr sperm proteins and phosphorylated PKA substrate sperm *** at 1–10μg/mL significantly increased the spontaneous acrosome reaction,suggesting that DBP can activate sperm ***,DBP showed a biphasic effect on intracellular signaling in *** concentrations relevant to seminal ortho-phthalate levels,DBP activates[pH]i,protein tyrosine kinases and PKA via physiological levels of ROS generation,potentiating sperm *** at high doses excessively raises[Ca^(2+)]_(i)and ROS and disrupts[pH]i,impairing the mitochondrial function,tail structural integrity,and sperm motility.

关键词： Dibutyl phthalate Reactive oxygen species(ROS) [Ca^(2+)]_(i) [pH]_(i) Mitochondria Protein kinases Sperm

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Liver transplantation for hepatocellular carcinoma: Current status in Hong Kong, China

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Hepatobiliary & Pancreatic Diseases International 2025年第1期24卷 45-49页

作者： Karin Ho Albert chan Liver Transplant Center Queen Mary HospitalDepartment of SurgeryThe University of Hong KongHong KongChina

With the advances in transplant oncology in recent years, the role of liver transplantation has expanded to make curative treatment a possibility for a wider patient population. We highlight strategies in Hong Kong, China that have enabled preoperative prognostication for judicious patient selection, downstaging therapy to definitive treatment, and postoperative therapies that have provided a growing role for liver transplantation in patients with more advanced hepatocellular carcinoma.

关键词： Living donor liver transplantation Downstaging Conversion therapy Transplant oncology

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Consumer products are important reservoirs and sources of organophosphate tri-esters and di-esters:Characteristics,mass inventory,and implication for waste management

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Journal of Environmental Sciences 2025年第5期151卷 550-559页

作者： Jie Zhou chan Liang Jinyun Li Jiayi Gu Amina Salamova Liangying Liu Guangdong Key Laboratory of Environmental Pollution and Health School of EnvironmentJinan UniversityGuangzhou 511443China Gangarosa Department of Environmental Health Rollins School of Public HealthEmory UniversityGeorgia 30322USA

Numerous studies documented the occurrence of organophosphate tri-esters(tri-OPEs)and di-esters(di-OPEs)in the *** information is available on their occurrence in waste consumer products,reservoirs and sources of these *** study collected and analyzed 92 waste consumer products manufactured from diverse polymers,including polyurethane foam(PUF),polystyrene(PS),acrylonitrile butadiene styrene(ABS),polypropylene(PP),and polyethylene(PE)to obtain information on the occurrence and profiles of 16 tri-OPEs and 10 *** concentrations of di-OPEs(18−370,000 ng/g,median 1,700 ng/g)were one order of magnitude lower than those of tri-OPEs(94−4,500,000 ng/g,median 5,400 ng/g).The concentrations of both tri-and di-OPEs in products made of PUF,PS,and ABS were orders of magnitude higher than those made of PP and *** compositional patterns of OPEs varied among different polymer types but were generally dominated by bisphenol A bis(diphenyl phosphate),triphenyl phosphate,tris(1-chloro-2-propyl)phosphate,di-phenyl phosphate(DPHP),and bis(2-ethylhexyl)*** industrially applied di-OPEs(di-n-butyl phosphate and DPHP)exhibited higher levels than their respective tri-OPEs,contrary to their production *** non-industrially applied chlorinated di-OPEs were also detected,with concentrations up to 97,000 ng/*** findings suggest that degradation of tri-OPEs during the manufacturing and use of products is an important source of *** mass inventories of tri-OPEs and di-OPEs in consumer products were estimated at 3,100 and 750 tons/year,*** study highlights the importance of consumer products as emission sources of a broad suite of OPEs.

关键词： Organophosphate tri-esters Organophosphate di-esters Waste consumer products Source assessment Mass inventory

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Deep ResNet Strategy for the Classification of Wind Shear Intensity Near Airport Runway

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Computer Modeling in Engineering & Sciences 2025年第2期142卷 1565-1584页

作者： Afaq Khattak Pak-wai chan Feng Chen Abdulrazak H.Almaliki Department of Civil Structural and Environmental EngineeringTrinity College DublinDublinD02 PN40Ireland Hong Kong Observatory 134A Nathan RoadKowloonHong Kong999077China College of Transportation Engineering Tongji UniversityShanghai201804China Department of Civil Engineering College of EngineeringTaif UniversityTaif21944Saudi Arabia

Intense wind shear(I-WS)near airport runways presents a critical challenge to aviation safety,necessi-tating accurate and timely classification to mitigate risks during takeoff and *** study proposes the application of advanced Residual Network(ResNet)architectures including ResNet34 and ResNet50 for classifying I-WS and Non-Intense Wind Shear(NI-WS)events using Doppler Light Detection and Ranging(LiDAR)data from Hong Kong International Airport(HKIA).Unlike conventional models such as feedforward neural networks(FNNs),convolutional neural networks(CNNs),and recurrent neural networks(RNNs),ResNet provides a distinct advantage in addressing key challenges such as capturing intricate WS dynamics,mitigating vanishing gradient issues in deep architectures,and effectively handling class imbalance when combined with Synthetic Minority Oversampling Technique(SMOTE).The analysis results revealed that ResNet34 outperforms other models with a Balanced Accuracy of 0.7106,Probability of Detection of 0.8271,False Alarm Rate of 0.328,F1-score of 0.7413,Matthews Correlation Coefficient of 0.433,and Geometric Mean of 0.701,demonstrating its effectiveness in classifying I-WS *** findings of this study not only establish ResNet as a valuable tool in the domain of WS classification but also provide a reliable framework for enhancing operational safety at airports.

关键词： Aviation safety wind shear deep residual network Doppler LiDAR

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MINIMAL WIDTHSS AND ORTHOGONALITY TYPES

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Acta Mathematica Scientia 2025年第1期45卷 27-39页

作者： chan HE Horst MARTINI Senlin WU School of Mathematics North University of ChinaTaiyuan030051China Fakultät für Mathematik Technische Universität Chemnitz09107ChemnitzGermany

The minimal widths of three bounded subsets of the unit sphere associated to a unit vector in a normed linear space are studied,and three related geometric constants are *** characterizations of inner product spaces are also *** the perspective of minimal width,strongε-symmetry of Birkhoff orthogonality is introduced,and its relation toε-symmetry of Birkhoff orthogonality is *** most of the existing parameters of the underlying space,these new constants are full dimensional in nature.

关键词： Birkhoff orthogonality isosceles orthogonality minimal width Singer orthogonality strong e-symmetry of Birkhoff orthogonality width function

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Human endogenous retrovirus type-W and multiple sclerosis–related smoldering neuroinflammation

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Neural Regeneration Research 2025年第3期20卷 813-814页

作者： Joel Gruchot Laura Reiche Andrew chan Robert Hoepner Patrick Küry Department of Neurology Medical Faculty and University Hospital DüsseldorfHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neurology InselspitalBern University Hospital and University of BernBernSwitzerland

Introduction to human endogenous retrovirus type-W(HERV-W): Genomic inheritance from the past includes retroviral sequences that have been stably incorporated into our genomes and account for up to 8% of human DNA.

关键词： endogenous inflammation Human

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Clinical and endoscopic characteristics of colorectal traditional serrated adenomas with dysplasia/adenocarcinoma in a Korean population

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World Journal of Gastrointestinal Oncology 2025年第2期17卷 119-131页

作者： Ki-Hyun Kim Eun Myung Hyung Hoon Oh chan-Muk Im young-Eun Seo Je-Seong Kim Chae-June Lim Ga-Ram you Sung-Bum Cho Wan-Sik Lee Myung-Giun Noh Kyung-Hwa Lee young-Eun Joo Department of Internal Medicine Chonnam National University Medical SchoolHwasun-eup 58128South Korea Department of Pathology Chonnam National University Medical SchoolHwasun-eup 58128South Korea

BACKGROUND Traditional serrated adenoma(TSA)is a rare and precancerous lesion of colorectal *** clinical and endoscopic differentiations between TSAs without dysplasia or adenocarcinoma(TSAOs)and TSAs with dysplasia or adenocarcinoma(TSADs)remain *** To evaluate the characteristics of colorectal TSAs and compare the characteristics of TSAOs with those of *** This retrospective study included 193 patients who underwent endoscopic resection and received a pathologic diagnosis of *** reviewed the medical,endoscopic,and histopathologic records of patients who underwent endoscopic resection of TSAs between January 2010 and December *** TSAs were more frequently located in the rectosigmoid *** TSAs had 0-Ip,0-Isp,or 0-Is *** TSAD lesions were larger than TSAO *** lesions more commonly had a red color and an irregular border than TSAO *** were usually treated using conventional endoscopic mucosal resection,whereas TSADs were treated using conventional endoscopic mucosal resection,endoscopic submucosal dissection,and ***-polypectomy bleeding was more common with TSADs than with *** analysis showed that gastrointestinal bleeding,red color,0-IIa,irregular border,and lobular mucosal surface were significantly associated with *** analysis showed that gastrointestinal bleeding,an irregular border,and a lobular mucosal surface were significantly associated with *** TSAs with gastrointestinal bleeding,an irregular border,and a lobular mucosal surface are associated with an increased risk of dysplasia or adenocarcinoma.

关键词： Traditional serrated adenoma Dysplasia Carcinoma Endoscopic features Gastrointestinal bleeding

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Pinelliae Rhizoma:a systematic review on botany,ethnopharmacology,phytochemistry,preclinical and clinical evidence

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Chinese Journal of Natural Medicines 2025年第1期23卷 1-20页

作者： Zuanji Liang Jinchao Wei Sioi chan Siyuan Zhang Li Xu Chenxiao Shen Zhangfeng Zhong Yitao Wang Macao Centre for Research and Development in Chinese Medicine State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences University of Macau

Pinelliae Rhizoma(PR), known as Banxia in Chinese, Hange in Japanese, and Banha in Korean,is a renowned herbal medicine in East Asia derived from the dry tuber of Pinellia ternata(Thunb.) Breit.(PT). It is extensively utilized in dispensing granules, classical prescriptions,and herbal formulas to treat various conditions, including cough, infection, phlegm, nausea,asthma, and inflammation. Despite numerous studies on PR and its classical prescriptions over recent decades, a comprehensive synthesis of available evidence regarding its multifunctional roles and therapeutic potential is lacking. This review aims to address this gap by examining emerging evidence from metabonomics, preclinical studies, and clinical trials, while exploring potential trends and prospects for future research. A systematic literature search was conducted across six electronic databases, including Pub Med, Web of Science, Scopus,Science Direct, Wanfang, and China National Knowledge Infrastructure, to identify relevant articles on PR published until March 2023. PR contains 107 compounds with diverse pharmacological activities, including anti-inflammatory, immune regulatory, anti-viral, anti-cancer,anti-asthma, antitussive and expectorant, antioxidant, anti-obesity, anti-atherosclerosis, antimicrobial, emetic and anti-emetic, anti-convulsant and anti-epileptic, sedative and hypnotic,learning and memory enhancement, and anti-depressant effects. Metabonomic studies suggest that raw PR may exhibit cardiotoxicity and pregnancy toxicity while showing no apparent hepatorenal toxicity. However, limited pharmacokinetic investigations on PR constrain its clinical translation. Furthermore, clinical safety data on PR is scarce, with only four clinical trials assessing its positive effects in pediatric epilepsy, nausea and vomiting, soft tissue injury, and chronic sinus tract. This review aims to enhance understanding of PR and provide valuable information and recommendations for further research and devel

关键词： Classical prescription Dispensing granule Herbal medicine Pinellia ternata Pinelliae Rhizoma

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