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耳郭假性囊肿的手术治疗

山东大学耳鼻喉眼学报 2007年第5期21卷 420-422,I0001页

作者：蔡昌枰 Siow Jin-keat Samuel Yeak 上海交通大学医学院附属瑞金医院耳鼻咽喉科上海交通大学医学院耳鼻咽喉科研究所上海200025 Department of Otolaryngology Tan Tock Seng Hospitalsingapore308433

目的评估耳郭假性囊肿手术治疗的临床价值。方法选择合适的患者30例进行治疗。沿对耳轮作皮肤切口,充分暴露囊肿腹侧的软骨膜及其附着的薄层软骨,然后予以切除,并清除囊肿背侧软骨表面可能存在的纤维束或肉芽组织。以常规方式缝合切口后... 详细信息

目的评估耳郭假性囊肿手术治疗的临床价值。方法选择合适的患者30例进行治疗。沿对耳轮作皮肤切口,充分暴露囊肿腹侧的软骨膜及其附着的薄层软骨,然后予以切除,并清除囊肿背侧软骨表面可能存在的纤维束或肉芽组织。以常规方式缝合切口后,再作贯穿耳郭的双侧钮扣缝合固定。结果所有病例均一期愈合,无并发症发生,随访未见复发。结论对耳郭假性囊肿,建议采取手术治疗,但须严格按照无菌操作要求,并防止术后继发感染。

关键词：耳郭假性囊肿压迫钮扣耳郭软骨

Complications and Costs Associated with Initiation of Anti-coagulation Therapy Using Warfarin--An Observation Study

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Journal of Pharmacy and Pharmacology 2015年第6期3卷 262-267页

作者： Jasmine Chiat Ling Ong seng Han lim Chai Ling Ong Liping Chen Elicia Purnata Edmund Joo Sheng See Joel Cho-Lun Chiang Vivian Shi Yin Wong Loke Khee Siow Jin Shing Hon Ming Chai Kong Chi Keong Ching Department of Pharmacy Singapore General Hospital Outram Road Singapore 169608 Singapore Department of Pharmacy National Heart Centre Singapore 5 Hospital Drive Singapore 16960 Singapore Department of Cardiology National Heart Centre Singapore 5 Hospital Drive Singapore 169609 Singapore

To evaluate the safety and cost of anticoagulation therapy in patients newly initiated on warfarin in two institutions in Singapore. All patients newly started on warfarin between December 2011 and May 2012 were recruited and followed up for a period of 6 months. All hospitalization attributed to complications of warfarin therapy, number of INR （international normalized ratio） greater than 4 and total cost of warfarin therapy were collected and analysed. A total of 321 patients were newly initiated on warfarin for standard indications were recruited. At the end of 6 month period, 8.4% of patients were hospitalized for complication related to warfarin therapy. For patients who had stable INR while on warfarin, this rate was almost 2 times lower （3.8% vs 8.4%）. In our study group, patients started on warfarin as inpatients had higher rates of bleeding （15.1% vs 6.7%） and more 1NRs greater than 4 （0.7 per patient vs 0.11 per patient）. The cost of initating warfarin was USD660 over the first 6 months of therapy. Patients newly initiated on warfarin were at a heightened risk of bleeding complications as compared to patients already stable on warfarin therapy. This also translates to considerable costs of warfarin initiation.

关键词： Anticoagulation warfarin initiation complications cost.

Agreement of angle closure assessments between gonioscopy, anterior segment optical coherence tomography and spectral domain optical coherence tomography

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International Journal of Ophthalmology(English edition) 2015年第2期8卷 342-346页

作者： Elton Lik Tong Tay Vernon Khet Yau Yong Boon Ang lim Stelson Sia Elizabeth Poh Ying Wong Leonard Wei Leon Yip Department of Ophthalmology Tan Tock Seng Hospital Republic of Singapore Air Force Aeromedical Centre Cardinal Santos Medical Center

AIM: To determine angle closure agreements between gonioscopy and anterior segment optical coherence tomography(AS-OCT), as well as gonioscopy and spectral domain OCT(SD-OCT). A secondary objective was to quantify inter-observer agreements of AS-OCT and SD-OCT ***: Seventeen consecutive subjects(33 eyes)were recruited from the study hospital’s Glaucoma *** was performed by a glaucomatologist masked to OCT results. OCT images were read independently by 2 other glaucomatologists masked to gonioscopy findings as well as each other’s analyses of OCT ***: Totally 84.8% and 45.5% of scleral spurs were visualized in AS-OCT and SD-OCT images respectively(P <0.01). The agreement for angle closure between AS-OCT and gonioscopy was fair at k =0.31(95% confidence interval, CI: 0.03-0.59) and k =0.35(95%CI: 0.07-0.63) for reader 1 and 2 respectively. The agreement for angle closure between SD-OCT and gonioscopy was fair at k =0.21(95% CI: 0.07-0.49) and slight at k =0.17(95% CI: 0.08-0.42) for reader 1 and 2 respectively. The inter-reader agreement for angle closure in AS-OCT images was moderate at 0.51(95% CI: 0.13-0.88). The inter-reader agreement for angle closure in SD-OCT images was slight at 0.18(95% CI: 0.08-0.45).CONCLUSION: Significant proportion of scleral spurs were not visualised with SD-OCT imaging resulting in weaker inter-reader agreements. Identifying other angle landmarks in SD-OCT images will allow more consistent angle closure assessments. Gonioscopy and OCT imaging do not always agree in angle closure assessments but have their own advantages, and should be used together and not exclusively.

关键词： anterior segment imaging spectral domain imaging angle closure assessment

Peak stent discomfort occurs early and ureteral stent with distal loop design has less paineA pilot prospective randomised singleblinded trial over 2 weeks

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Asian Journal of Urology 2020年第4期7卷 357-362页

作者： Kheng Sit lim Zhi Wei Law Marcus Way Lunn Chow Allen Soon Phang Sim Henry Sun Sien Ho Department of Urology Singapore General HospitalSingapore Department of Urology Tan Tock Seng HospitalSingapore

Objectives:The Polarisloop ureteric stent reduces the severity of stent discomfort by minimising stent material in the *** impact of ureteral stenting on quality of life(QoL)within 1 week remains *** usefulness of the patient-administered ureteral stent symptoms questionnaire(USSQ)during this period of stent insertion was *** this pilot single-blinded prospective randomised study,we investigate 1)the presence of early(within the 1st week)stent discomfort via the visual analog scale(VAS);2)determine the QoL of the loop stent against conventional ***:Forty adults requiring retrograde unilateral ureteral stent placements were *** with single ureteric stone or benign stricture were *** were randomised in 1:1 ratio to the loop and pigtail *** USSQ was administered before placement(baseline),USSQ and VAS were administered on Day 3,7,and ***:There were no significant differences between the USSQ *** pain scores on Day 3 were lower in the loop stent group(2.9 vs.4.0,pZ0.047).There was a significant reduction in pain from Day 3e7(0 vs.1,pZ0.016)in the pigtail ***:Our results suggest that peak stent discomfort occurs but resolves quickly within 1 week of post-stent *** loop stent offers a better pain profile compared with conventional stents at Day 3 but no difference in *** loop stent reduces early pain experience post-stent insertion and may have a role in the care of patients who experience significant stent discomfort previously.

关键词： Quality of life Stent discomfort Ureteral stent symptoms questionnaire Ureteric stents

Advances of macroalgae biomass for the third generation of bioethanol production

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Comparison of the Efficacy of Oral Oxycodone and Oral Codeine in the Treatment of Post-Craniotomy Pain—A Randomized, Double-Blind Trial

中国化学工程学报（英文版） 2020年第2期

作者： Inn Shi Tan Man Kee Lam Henry Chee Yew Foo Steven lim keat Teong Lee

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Open Journal of Anesthesiology 2020年第3期10卷 80-88页

作者： Rui Min Lee Beatrice C. L. lim Chin Ted Chong Mandy P. P. lim Department of Anaesthesiology Intensive Care and Pain Medicine Tan Tock Seng Hospital Singapore

Background: Post-craniotomy pain has been reported to be moderate to severe. Management of post-craniotomy pain is often inadequate, yet limited by the side effects of opioids. We aim to find out the efficacy of oral oxycodone as compared to oral codeine for the treatment of post-craniotomy pain in our institution. Methods: A randomized, double-blinded controlled trial was used to evaluate the efficacy of oral oxycodone versus oral codeine. 40 patients were randomized to the control group of codeine (n = 20) or the experimental group receiving oxycodone (n = 20) in addition to regular oral paracetamol for both groups of patients. Results: There was no difference in the visual analogue scale scores at 24 hours (2.78 versus 1.85, p = 0.11) or side effects in the oxycodone group compared with the codeine group. Conclusions: Oral oxycodone had similar efficacy as oral codeine in the management of post-craniotomy pain.

关键词： Post-Craniotomy Pain Oxycodone Codeine

Risk Management of Clinical Reference Dosimetry of a Large Hospital Network Using Statistical Process Control

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Search for a cure for chronic hepatitis B infection: How close are we?

International Journal of Medical Physics, Clinical Engineering and Radiation Oncology（医学物理学、临床工程、放射肿瘤学） 2021年第3期

作者： seng-Boh lim Thomas LoSasso Maria Chan Laura Cervino Dale Michael Lovelock

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World Journal of Hepatology 2015年第9期7卷 1272-1281页

作者： Wah Wah Phyo Alex Yu Sen Soh seng Gee lim Guan Huei Lee Department of Gastroenterology and Hepatology University Medicine Cluster National University Hospital of Singapore

Chronic hepatitis B(CHB) remains a significant unmet medical need, with 240 million chronically infected persons worldwide. It can be controlled effectively with either nucleoside/nucleotide-based or interferonbased therapies. However, most patients receiving these therapies will relapse after treatment withdrawal. During recent years, the advances in molecular biology and immunology have enabled a better understanding of the viral-host interaction and inspired new treatment approaches to achieve either elimination of the virus from the liver or durable immune control of the infection. This review aims to provide a brief overview on the potential new therapies that may overcome the challenge of persistent CHB infection in the near future.

关键词： Hepatitis B Antiviral therapy Covalentlyclosed circular DNA Drug target Immunomodulator

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慢性乙型肝炎治疗开始和停药时机的影响因素

中华实验和临床感染病杂志（电子版） 2019年第6期13卷 528-528页

作者： seng-Gee lim AASLD亚太地区咨询委员会

【内容简介】本视频重点介绍慢性乙型肝炎(chronic hepatitis B,CHB)患者治疗开始和停药时机的影响因素。依据血清乙型肝炎病毒(hepatitis B virus,HBV)DNA、丙氨酸氨基转移酶(alanine aminotransferase,ALT)水平和肝脏疾病严重程度,同... 详细信息

【内容简介】本视频重点介绍慢性乙型肝炎(chronic hepatitis B,CHB)患者治疗开始和停药时机的影响因素。依据血清乙型肝炎病毒(hepatitis B virus,HBV)DNA、丙氨酸氨基转移酶(alanine aminotransferase,ALT)水平和肝脏疾病严重程度,同时需结合年龄、家族史和伴随疾病等因素,综合评估患者疾病进展风险,决定是否需要启动抗病毒治疗。慢性乙型肝炎治疗的总体目标为预防肝硬化、肝功能衰竭和肝细胞肝癌的发生,提高生存率。

关键词：疾病严重程度伴随疾病丙氨酸氨基转移酶停药时机肝功能衰竭慢性乙型肝炎肝细胞肝癌抗病毒治疗