检索结果-南通市图书馆

A new look at anti-Helicobacter pylori therapy

World Journal of Gastroenterology 2011年第35期17卷 3971-3975页

作者： seng-Kee Chuah Feng-Woei Tsay Ping-I Hsu Deng-Chyang Wu Division of Gastroenterology Kaohsiung Chang Gung Memorial HospitalCollege of MedicineChang Gung University833 KaohsiungTaiwan Division of Gastroenterology Department of Internal MedicineKaohsiung Veterans General HospitalNational Yang-Ming University813 KaohsiungTaiwan Department of General Medicine School of MedicineCollege of MedicineTaipei Medical University110 TaipeiTaiwan Department of Internal Medicine Kaohsiung Medical University Hospital807 KaohsiungTaiwan

With the rising prevalence of antimicrobial resistance,the treatment success of standard triple therapy has recently declined to unacceptable levels (i.e.,80% or less) in most ***,several treatment regimens have emerged to cure Helicobacter pylori (***) *** first-line *** therapies in 2011 include sequential therapy,concomitant quadruple therapy,hybrid (dual-concomitant) therapy and bismuth-containing quadruple *** the failure of standard triple therapy,a bismuth-containing quadruple therapy comprising a proton pump inhibitor (PPI),bismuth,tetracycline and metronidazole can be employed as rescue ***,triple therapy combining a PPI,levofloxacin and amoxicillin has been proposed as an alternative to the standard rescue *** salvage regimen can achieve a higher eradication rate than bismuth-containing quadruple therapy in some regions and has less adverse *** best second-line therapy for patients who fail to eradicate *** with first-line therapies containing clarithromycin,amoxicillin and metronidazole is ***,a levofloxacin-based triple therapy is an accepted rescue *** guidelines suggest that patients requiring third-line therapy should be referred to a medical center and treated according to the antibiotic susceptibility ***,an empirical therapy (such as levofloxacin-based or furazolidone-based therapies) can be employed to terminate *** infection if antimicrobial sensitivity data are unavailable.

关键词： Bismuth-containing quadruple therapy Concomitant quadruple therapy Hybrid (dual-concomitant) therapy Rescue anti-Helicobacter pylori treatment Sequential therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cardiac sympathetic nerve terminal function in congestive heart failure

引用

Acta Pharmacologica Sinica 2007年第7期28卷 921-927页

作者： Chang-seng LIANG School of Medicine and Dentistry,University of Rochester,Rochester,New York 14642,USA School of Medicine and Dentistry University of Rochester Rochester USA

Increased cardiac release of norepinephrine (NE) and depleted cardiac stores ofNE are two salient features of the human failing *** from my labo-ratory have shown that these changes are accompanied by a functional defect ofNE uptake in the cardiac sympathetic nerve *** studies have shownthat the decrease of NE uptake is caused by reduction of NE transporter density inthe sympathetic nerve endings,and this change is responsible,at least in part,forthe increased myocardial interstitial NE,decreased myocardial adrenoceptordensity,and increased myocyte apoptosis in experimental *** also provided evidence in both intact animals and cultured PC12 cells thatthe decrease of NE transporter is induced by the actions of oxidative metabolitesof exogenous NE,involving endoplasmic reticulum stress and impairedN-glycosylation of the NE *** change in the cardiac sympathetic NEuptake function,as demonstrated by [123I] metaiodobenzylguanidine in humanstudies,may not only serve as an important prognostic variable in patients withcongestive heart failure,but also be used as a surrogate for the efficacies ofvarious therapeutic interventions for heart ***,increasing evidencesuggests and further studies are needed to show that the cardiac sympatheticnerve terminal function may be a direct target for pharmacologic treatment ofcongestive heart failure.

关键词： neurotransmitter transporter norepinephrine congestive heart failure nerve growth factors antioxidants

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Addressing challenges in the clinical applications associated with CRISPR/Cas9 technology and ethical questions to prevent its misuse

引用

Protein & Cell 2017年第11期8卷 791-795页

作者： Xiang Jin Kang Chiong Isabella Noelle Caparas Boon seng Soh Yong Fan Key Laboratory for Major Obstetric Diseases of Guangdong Province Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes Center for Reproductive Medicine The Third Affiliated Hospital of Guangzhou Medical University Guangzhou 510150 China Disease Modeling and Therapeutics Laboratory ASTAR Institute of Molecular and Cell Biology 61 Biopolis Drive Proteos Singapore 138673 Singapore

The recently developed RNA-guided clustered regularly interspaced short palindromic repeat （CRISPR）/CRISPR-associated 9 （Cas9） nuclease system has progressed to be an invaluable technology for genome manipulation in somatic cell types and germline model organisms. While the unprecedented advance in human embryo gene editing research has great potential in next-generation therapeutics, it raises various ethical concerns that need to be addressed before being translated for clinical use. Here, we discuss the current and potential applications of CRISPR/Cas9 technology and its limitations in clinical applications, as well as ethical and legal considerations in the treatment, disease prevention or disability in somatic cells or human embryo via gene editing.

关键词： Addressing challenges clinical applications associated CRISPR/Cas9 technology ethical questions prevent its misuse

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Transcriptome analysis of ankylosed primary molars with infraocclusion

引用

International Journal of Oral Science 2020年第1期12卷 68-76页

作者： Annie Tong Yuh-Lit Chow Katie Xu Rita Hardiman Paul Schneider Seong-seng Tan Melbourne Dental School The University of MelbourneMelbourneAustralia Florey Institute of Neuroscience The University of MelbourneMelbourneAustralia

Primary molar ankylosis with infraocclusion can retard dental arch development and cause dental asymmetry. Despite its widespread prevalence, little is known about its molecular etiology and pathogenesis. To address this, RNA sequencing was used to generate transcriptomes of furcal bone from infraoccluded(n = 7) and non-infraoccluded(n = 9) primary second molars, all without succeeding biscuspids. Of the 18 529 expressed genes, 432(2.3%) genes were differentially expressed between the two groups(false discovery rate < 0.05). Hierarchical clustering and principal component analysis showed clear separation in gene expression between infraoccluded and non-infraoccluded samples. Pathway analyses indicated that molar ankylosis is associated with the expression of genes consistent with the cellular inflammatory response and epithelial cell turnover. Independent validation using six expressed genes by immunohistochemical analysis demonstrated that the corresponding proteins are strongly expressed in the developing molar tooth germ, in particular the dental follicle and inner enamel epithelium. The descendants of these structures include the periodontal ligament, cementum, bone and epithelial rests of Malassez;tissues that are central to the ankylotic *** therefore propose that ankylosis involves an increased inflammatory response associated with disruptions to the developmental remnants of the dental follicle and epithelial rests of Malassez.

关键词： occlusion infra molar

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Percutaneous paraumbilical embolization as an unconventional and successful treatment for bleeding jejunal varices

引用

World Journal of Gastroenterology 2009年第30期15卷 3823-3826页

作者： Lee-Guan Lim Yin-Mei Lee Lenny Tan Stephen Chang seng-Gee Lim Department of Gastroenterology and Hepatology National University HospitalSingapore 119074Singapore Department of Diagnostic Radiology National University HospitalSingapore 119074Singapore Department of Surgery National University HospitalSingapore 119074Singapore

A 48-year-old Indian male with alcoholic liver cirrhosis was admitted after being found unresponsive. He was hypotensive and had hematochezia. Esophagogastroduodenoscopy (EGD) showed small esophageal varices and a clean-based duodenal ulcer. He continued to have hematochezia and anemia despite blood transfusions. Colonoscopy was normal. Repeat EGD did not reveal any source of recent bleed. Twelve days after admission, his hematochezia ceased. He refused further investigation and was discharged two days later. He presented one week after discharge with hematochezia. EGD showed non-bleeding Grade 1 esophageal varices and a clean-based duodenal ulcer. Colonoscopy was normal. Abdominal computed tomography (CT) showed liver cirrhosis with mild ascites, paraumbilical varices, and splenomegaly. He had multiple episodes of hematochezia, requiring repeated blood transfusions. Capsule endoscopy identified the bleeding site in the jejunum. Concurrently, CT angiography showed paraumbilical varices inseparable from a loop of small bowel, which had herniated through an umbilical hernia. The lumen of this loop of small bowel opacified in the delayed phase, which suggested variceal bleeding into the small bowel. Portal vein thrombosis was present. As he had severe coagulopathy and extensive paraumbilical varices, surgery was of high risk. He was not suitable for transjugular intrahepatic porto-systemic shunt as he had portal vein thrombosis. Percutaneous paraumbilical embolization via caput medusa was performed on day 9 of hospitalization. Following the embolization, the hematochezia stopped. However, he defaulted subsequent follow-up.

关键词： Embolization Jejunal varices Obscurebleed Capsule endoscopy Angiography

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

郭明冬教授从“虚-瘀-毒-郁”病理网络辨证论治老年冠心病的理论与实践

引用

世界中西医结合杂志 2024年第1期19卷 80-83,110页

作者：周倩赵小森郭明冬李琦山西中医药大学山西太原030024 中国中医科学院西苑医院北京100091

老年冠心病是老年人的常见病、多发病。虚、瘀、毒、郁之间常常相互作用,相互影响,恶性循环,形成“虚-瘀-毒-郁”病理网络,成为老年冠心病发病的基础,其中“虚”是老年冠心病的病理基础,“瘀”是老年冠心病发病的关键因素,“毒”是老年... 详细信息

老年冠心病是老年人的常见病、多发病。虚、瘀、毒、郁之间常常相互作用,相互影响,恶性循环,形成“虚-瘀-毒-郁”病理网络,成为老年冠心病发病的基础,其中“虚”是老年冠心病的病理基础,“瘀”是老年冠心病发病的关键因素,“毒”是老年冠心病发展变化的重要促进因素,“郁”是老年冠心病发病的重要影响因素。因此,郭明冬教授认为,“虚-瘀-毒-郁”病理网络是老年冠心病的基本病机,并提出益气活血,解毒开郁是老年冠心病的主要治法,经在临床实践中反复应用,取得了良好的疗效。

关键词：老年冠心病 “虚-瘀-毒-郁”病理网络论治临床经验

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of formulation of alginate beads on their mechanical behavior and stiffness

引用

Particuology 2011年第3期9卷 228-234页

作者： Eng-seng Chan Tek-Kaun Lim Wan-Ping Voo Ravindra Pogaku Beng Ti Tey Zhibing Zhang School of Engineering Monash University Jalan Lagoon Selatan 4~150 Bandar Sunway 5elangor Malaysia Centre of Materials and Minera/s School of Engineering and Information Technology Universiti Malaysia Sabah 88999 Kota Kinabalu Sabah Malaysia Department of Chemical and Environmental Engineering Faculty of Engineering Universiti Putra Malaysia 43400 Serdang Selangor Malaysia School of Chemical Engineering University of Birmingham Edgbaston Birmingham BI5 27Z United Kingdom

The aim of this work was to determine the effect of formulation of alginate beads on their mechanical behavior and stiffness when compressed at high speed. The alginate beads were formulated using different types and concentrations of alginate and gelling cations and were produced using an extrusiondripping method, Single wet beads were compressed at a speed of 40 mm/min, and their elastic limits were investigated, and the corresponding force versus displacement data were obtained. The Young＇s moduli of the beads were determined from the force versus displacement data using the Hertz＇s contact mechanics theory. The alginate beads were found to exhibit plastic behavior when they were compressed beyond 50% with the exception of copper-alginate beads for which yield occured at lower deformation, Alginate beads made of higher guluronic acid contents and gelling cations of higher chemical affinity were found to have greater stiffness. Increasing the concentration of alginate and gelling ions also generated a similar effect. At such a compression speed, the values of Young＇s modulus of the beads were found to be in the range between 250 and 900 kPa depending on the bead formulation.

关键词： Algioate Young's modulus Elastic limit Deformation Compression Hertz theory

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

SnSb@carbon nanocable anchored on graphene sheets for sodium ion batteries

引用

Nano Research 2014年第10期7卷 1466-1476页

作者： Li Li Kuok Hau seng Dan Li Yongyao Xia Hua Kun Liu Zaiping Guo Institute for Superconducting and Electronic Materials University of Wollongong North Wollongong NSW 2500 Australia Department of Chemistry Institute of New Energy Fudan University Shanghai 200438 China School of Mechanical Materials and Mechatronics Engineering University of Wollongong Wollongong NSW 2522 Australia

The development of materials with unique nanostructures is an effective strategy for the improvement of sodium storage in sodium ion batteries to achieve stable cycling performance and good rate capability. In this work, SnSb- core/carbon-shell nanocables directly anchored on graphene sheets （GS） were synthesized by the hydrothermal technique and chemical vapor deposition. The simultaneous carbon coating and the encapsulation of SnSb alloy is effective for alleviating the volume-change problem in sodium ion batteries. After optimizing the electrolyte for SnSb in the sodium ion batteries, the optimized coaxial SnSb/carbon nanocable/GS （SnSb/CNT@GS） nanostructure demonstrated stable cycling capability and rate performance in 1 M NaClO4 with propylene carbonate （PC）＋ 5% fluoroethylene carbonate （FEC）. The SnSb/CNT@GS electrode can retain a capacity of 360 mAh/g for up to 100 cycles, which is 71% of the theoretical capacity. This is higher than in the other three electrolytes tested （1 M NaClO4 in PC, 1 M NaC104 in PC/FEC （1：1 v/v） and 1 M NaPF6 ＋ PC）, and higher than that of the sample without the addition of graphene. The good electrochemical performance can be attributed to the efficient buffering provided by the outer carbon nanocable layer and the graphene inhibiting the agglomeration of SnSb particles, as well as its high conductivity.

关键词： SnSb grapheme coaxial structure sodium ion batteries

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

ENHANCEMENT OF SPEECH SIGNAL CORRUPTED BY HIGH ACOUSTIC NOISE

ENHANCEMENT OF SPEECH SIGNAL CORRUPTED BY HIGH ACOUSTIC NOIS...

引用

计算机，通信，控制与电力工程国际会议

作者： Wee-Soon Ching Peng-seng Toh School of Electrical and Electronic Engineering Nanyang Technological University

ISBN: (纸本)0780312333

Additive broad band noise is a common source of corruption in speech signals and often limits the effective operation of speech communication systems. This paper presents a new spectral-subtraction-based speech enhancement algorithm which exploits the correlation property of speech signal,the masking characteristic of the human ear,the speech redundancy property,and the frame-to-frame randomness of the noise that is present in the signal for the enhancement. Informal listening tests show that the proposed algorithm greatly improved the quality of the noisy speech even when the speech signal is corrupted by high acoustic *** the algorithm has low complexity and uses only a single input,it is well suited to a wide range of speech processing applications.

关键词： ENHANCEMENT OF SPEECH SIGNAL CORRUPTED BY HIGH ACOUSTIC NOISE

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Construction and Co-expression of Grass Carp Reovirus VP6 Protein and Enhanced Green Fluorescence Protein in the Insect Cells

引用

中国病毒学 2007年第5期22卷 397-404页

作者： Qin FANG Eng Khuan seng Wen DAI Lan-lan ZHANG State Key Laboratory of Virology Wuhan Institute of Virology Chinese Academy of Sciences Wuhan 430071 China School of Chemical ＆ Life Sciences Nanyang Polytechnic 180 Ang Mo Kio Ave 8 569830 Singapore Graduate school of the Chinese Academy of Sciences Beijing 100039 China

Grass carp reovirus(GCRV),a disaster agent to aquatic animals,belongs to Genus Aquareovirus of family *** analysis revealed GCRV genome segment 8(s8) was 1 296 bp nucleotides in length encoding an inner capsid protein VP6 of about *** obtain in vitro non-fusion expression of a GCRV VP6 protein containing a molecular of fluorescence reporter,the recombinant baculovirus,which contained the GCRVs8 and eGFP(enhanced green fluorescence protein) genes,was constructed by using the Bac-to-Bac insect expression *** this study,the whole GCRVs8 and eGFP genes,amplified by PCR,were constructed into a pFastBacDual vector under polyhedron(PH) and p10 promoters,*** constructed dual recombinant plasmid(pFbDGCRVs8/eGFP) was transformed into DH10Bac cells to obtain recombinant Bacmid(AcGCRVs8/eGFP) by ***,the recombinant bacluovirus(vAcGCRVs8/eGFP) was obtained from transfected Sf9 insect *** green fluorescence that was expressed by transfected Sf9 cells was initially observed 3 days post transfection,and gradually enhanced and extended around 5 days culture in P1(Passage1) *** stable high level expression of recombinant protein was observed in P2 and subsequent passage budding virus(BV) ***,PCR amplification from P1 and amplified P2 BV stock further confirmed the validity of the dual-recombinant *** results provide a foundation for expression and assembly of the GCRV structural protein in vitro.

关键词：草鱼呼肠孤病毒 VP6蛋白增强绿色荧光蛋白杆状病毒表达系统共表达

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：