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Prevalence of anxiety among gestational diabetes mellitus patients: A systematic review and meta-analysis

World Journal of Meta-Analysis 2020年第3期8卷 275-284页

作者： Kai Wei Lee Hong Chuan Loh seng choi chong Siew Mooi Ching Navin Kumar Devaraj Maiza Tusimin Habibah Abdul Hamid Fan Kee Hoo Department of Family Medicine Faculty of Medicine and Health SciencesUniversiti Putra MalaysiaSerdang 43400SelangorMalaysia Clinical Research Centre Hospital Seberang JayaMinistry of Health MalaysiaPerai 13700PenangMalaysia Department of Psychiatry Faculty of Medicine and Health SciencesUniversiti Putra MalaysiaSerdang 43400SelangorMalaysia Department of Obstetrics and Gynaecology Faculty of Medicine and Health SciencesUniversiti Putra MalaysiaSerdang 43400SelangorMalaysia Department of Medicine Faculty of Medicine and Health SciencesUniversiti Putra MalaysiaSerdang 43400SelangorMalaysia

BACKGROUND A diagnosis of gestational diabetes mellitus(GDM)negatively influences maternal mental *** is a lack of systematic review and meta-analysis on prevalence of anxiety among GDM *** To pool data from existing literature to determine the pooled estimates for the prevalence of anxiety among women diagnosed with *** We searched multiple databases including MEDLINE,Cinahl,PubMed and Scopus to identify studies published up to 31 October 2019 with data on the prevalence of anxiety among women diagnosed with *** were extracted from published *** were pooled using random-effects *** We reviewed 19 abstracts,retrieved 10 articles and included three studies incorporating 12744 GDM women from three *** pooled prevalence of anxiety was 29.5%(95%CI:6.9,52.0)among GDM *** Prevalence of anxiety among GDM women was *** suggest that epidemiological studies on anxiety should be conducted urgently as it merits clinical *** addition,it is important to identify factors associated with anxiety among women diagnosed with GDM.

关键词： Prevalence Anxiety Gestational diabetes Psychiatry Meta-analysis Systematic review

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Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin:Creation of an unnatural analogue with improved anticancer properties

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Acta Pharmaceutica Sinica B 2024年第1期14卷 421-432页

作者： Dexiu Yan Jemma Arakelyan Teng Wan Ritvik Raina Tsz Ki Chan Dohyun Ahn Vladimir Kushnarev Tsz Kiu Cheung Ho Ching Chan Inseo choi Pui Yi Ho Feijun Hu Yujeong Kim Hill Lam Lau Ying Lo Law Chi seng Leung Chun Yin Tong Kai Kap Wong Wing Lam Yim Nikolay S.Karnaukhov Richard Y.C.Kong Maria V.Babak Yudai Matsuda Department of Chemistry City University of Hong KongHong Kong SARChina iGEM Team“VarieCure” City University of Hong KongHong Kong SARChina Department of Biomedical Engineering City University of Hong KongHong Kong SARChina Moscow Clinical Research Center Named After A.S.Loginov Moscow 111123Russian Federation

A biosynthetic gene cluster for the bioactive fungal sesterterpenoids variecolin(1)and variecolactone(2)was identified in Aspergillus aculeatus ATCC *** production of 1 and 2 was achieved in Aspergillus oryzae by expressing the sesterterpene synthase VrcA and the cytochrome P450 ***,the replacement of VrcB with homologous P450s from other fungal terpenoid pathways yielded three new variecolin analogues(5-7).Analysis of the compounds’anticancer activity in vitro and in vivo revealed that although 5 and 1 had comparable activities,5 was associated with significantly reduced toxic side effects in cancer-bearing mice,indicating its potentially broader therapeutic *** study describes the first tests of variecolin and its analogues in animals and demonstrates the utility of synthetic biology for creating molecules with improved biological activities.

关键词： Animal studies Anticancer properties Biosynthesis Natural products Sesterterpenoids Synthetic biology Terpene synthases Variecolin

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Fractionation of edible bird’s nest glycoprotein hydrolysates:characterisation and antioxidative activities of the fractions

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Food Science and Human Wellness 2022年第4期11卷 886-894页

作者： Poh Kei chong Sue Lian Mun Lee Sin Chang Abdul Salam Babji seng Joe Lim Department of Food Sciences Faculty of Science and TechnologyUniversiti Kebangsaan Malaysia43600 UKM BangiSelangorMalaysia Department of Food Science and Nutrition Faculty of Applied SciencesUCSI University Kuala LumpurNo.1Jalan Menara GadingUCSI Heights 56000 CherasKuala LumpurMalaysia Innovation Centre for Confectionery Technology(MANIS) Faculty of Science and TechnologyUniversiti Kebangsaan Malaysia43600 UKM BangiSelangorMalaysia Centre for Innovation and Technology Transfer(INOVASI-UKM) ChancelleryUniversiti Kebangsaan Malaysia43600 UKM BangiSelangorMalaysia

E dible bird’s nest(EBN)hydrolysates have been proven to exhibit enhanced ***,being a macromolecule,fractions with different molecular weights would have different properties and ***,this research was aimed to determine the chemical properties and antioxidant activities of freezedried(EBN_(FD))and spray-dried EBN(EBN_(SD))hydrolysates fractionated using gel permeation chromatography(GPC).Overall,two well-separated fractions were identified(EBN_(fFD1),EBN_(fFD2),EBN_(fSD1) and EBN_(fSD2)).EBNFD demonstrated significantly higher(P≤0.05)peptide(3.6%),total carbohydrate(27.7%)and sialic acid(18.2%)contents than that of *** trend was observed in low molecular weight fractionates(EBN_(fFD2) and EBN_(fSD2)).Meanwhile,the first fractionates(EBN_(fFD1) and EBN_(fSD1))exhibited significantly higher(P≤0.05)hydroxyl radical(·OH)scavenging *** transform infrared(FTIR)spectroscopy demonstrated that all EBN fractionates have similar spectrum,except in the region of N—H(amideⅡ)and C—H alkyl *** conclusion,EBN fractionates with different molecular weights showed different chemical properties and antioxidant activities.

关键词： Fractionates Gel permeation chromatography Hydrolysates Peptide content Sialic acid

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Finite element analysis of tibio-femoral contact mechanics of a customised knee spacer

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Biosurface and Biotribology 2022年第2期8卷 121-128页

作者： Alex C.T.Choh Andy Yew seng Jin Yeo Desmond Y.R.chong Shi-Lu Chia Department of Orthopaedic Surgery Singapore General HospitalSingaporeSingapore Engineering Cluster Singapore Institute of TechnologySingaporeSingapore

With one-third of patients having osteoarthritis predominantly in one compartment of the knee,unicompartmental knee spacers have been introduced as a less invasive alternative to total knee ***,patients with the knee spacer implanted were seen to have persistent pain,resulting in high revision rates.A static finite element model of the knee and its interaction with a knee spacer implant at full extension and 90°flexion was used to investigate the tibio-femoral contact mechanics of the knee joint after a knee spacer *** different knee spacer designs(contoured,flat and C-shaped)were modelled and prescribed with cobalt-chrome,ultra-high molecular polyethylene and polyurethane material *** results suggested that a softer spacer is generally preferred as this helps in the conformity of knee spacer to the condyle,effectively distributing the load subjected to the *** spacers that result in high stresses resulting from lower contact areas should be avoided.

关键词： biomechanics contact pressure finite element analysis knee spacer

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Changes and development plans in the mountain villages of South Korea:Comparison of the first and second national surveys

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Journal of Mountain Science 2017年第8期14卷 1473-1489页

作者： Hag Mo KANG Hyun KIM Chang Heon LEE chong Kyu LEE Soo Im choi Department of Forest Environmental Science Chonbuk National University Jeollabuk-do Forest Environment Research Institute Department of Forest Resources Gyeongnam National University of Science and Technology Department of Forest Resources Sunchon National University

Owing to the geographic disadvantages of mountain villages, the social, cultural, and economic conditions of mountain villagers are inferior to those of urban dwellers in South Korea. Thus, in 1995, the The government of South Korea launched a mountain village development support program to promote agriculture and forestry, balance national land development, and preserve cultural heritage. The program was effectively implemented, improving the income, population size, and living conditions of villagers in addition to setting up a system for stable project implementation. However, concerns were raised about long-term development planning, the creation and marketing of specialty brands, facility management/operation, and follow-up support. The government conducted surveys of mountain villagers in 2003 and 2014, obtaining basic data to address these issues. This study evaluates the outcomes of these two surveys, suggesting areas requiring focusedaction, concentrating on village development projects, forest resource distribution and use, demographic trends, the economy, exchange with urban areas, green tourism, and master planning. We find that despite growth in the forest labor force, forest ownership is diminishing in terms of the number and scale of holdings. Consequently, it is necessary to commercialize forest resources, establish favorable settlement conditions, and expand government support for village-run projects. In addition, systematic forest management for older tree age classes would benefit the public and provide assets for future mountain village development. Our results are expected to provide baseline information for the establishment and efficient implementation of mountain village development policy.

关键词： Forest resources management Mountain village changes Mountain village economy Support for mountain villages Urban-rural exchange

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Expression of Recombinant Human Lysozyme-tachyplesin I(hLYZ-TP I)in Pichia Pastoris and Analysis of Antibacterial Activity

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Biomedical and Environmental Sciences 2013年第4期26卷 319-322页

作者： GAO Yu ZHAO Hong Lei FENG Xin ZHAI Rui Dong ZHU seng DU chong Tao SUN Chang Jiang LEI Lian Cheng College of Animal Science and Veterinary Medicine Jilin University

Antimicrobial peptides （AMPs） are making headlines in science because they demonstrate superior microbicidal characteristics compared to synthetic and semi-synthetic antibiotics.

关键词： Design hLYZ-TP I)in Pichia Pastoris and Analysis of Antibacterial Activity Expression of Recombinant Human Lysozyme-tachyplesin I TP

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稀土氧化物修饰的富勒烯-二氧化钛复合材料光催化降解亚甲基蓝(英文)

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催化学报 2011年第9期32卷 1457-1464页

作者： choi Jong-geun PARK chong-yeon OH Won-chun Department of Advanced Materials Science & Engineering Hanseo University

Rare earth oxide-treated fullerene and titania composites (Y-fullerene/TiO2) were prepared by the sol-gel method. The products had interesting surface compositions. X-ray diffraction patterns of the composites showed that the Y-fullerene/TiO2 composites contained a single and clear anatase phase. The surface properties were observed by scanning electron microscopy, which gave a characterization of the texture on the Y-fullerene/TiO2 composites and showed a homogenous distribution of titanium particles. The energy-dispersive X-ray spectra showed the presence of C and Ti with strong Y peaks. The composite obtained was also characterized with transmission electron microscopy and UV-Vis spectroscopy. The photocatalytic results showed that the Y-fullerene/TiO2 composites had excellent activity for the degradation of methylene blue under visible light irradiation. This was attributed to both the effects on the photocatalysis of the supported TiO2 by charge transfer by the fullerene, and the introduction of yttrium to enhance photo-generated electron transfer.

关键词： fullerene yttrium titania visible light methylene blue

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Endoscopic submucosal dissection vs endoscopic mucosal resection for colorectal polyps:A meta-analysis and metaregression with single arm analysis

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World Journal of Gastroenterology 2021年第25期27卷 3925-3939页

作者： Xiong Chang Lim Kameswara Rishi Yeshayahu Nistala Cheng Han Ng Snow Yunni Lin Darren Jun Hao Tan Khek-Yu Ho Choon-seng chong Mark Muthiah Yong Loo Lin School of Medicine National University of SingaporeSingapore 117597Singapore Department of Medicine National University HospitalSingapore 119074Singapore Department of Surgery National University HospitalSingapore 119074Singapore

BACKGROUND Endoscopic submucosal dissection(ESD)has shown to be effective in management of colorectal neoplasm in the Asian countries,while its implementation in Western countries where endoscopic mucosal resection(EMR)is preferred is still *** To compare the surgical,histological,and oncological outcomes between ESD and EMR in the treatment of colorectal polyps,with subgroup analysis comparing the efficacy of ESD and EMR between Japan and the rest of the *** Embase and Medline databases were searched from inception to October 2020 in accordance with PRISMA guidelines for studies comparing en bloc,complete resection,margin involvement,resection time,need for additional surgery,complications,and recurrence rate of ESD with *** Of 281344 colorectal polyps from 21 studies were *** compared to EMR,the pooled analysis revealed ESD was associated with higher en bloc and complete resection rate,and lower lateral margin involvement and *** led to increased procedural time,need for additional surgery,and perforation *** significant difference in bleeding risk was found between the two ***-regression analysis suggested only right colonic polyps correlated with an increased perforation risk in *** including polyp size and invasion depth did not significantly influence the en bloc and complete resection rate,bleeding risk and *** subgroup analysis,Japan performed better than the rest of the world in both ESD and EMR with perforation risk of 4%and 0.0002%,respectively,as compared to perforation risk of 8%and 1%,respectively,in reports coming from rest of the *** ESD resulted in better resection outcomes and lower recurrence compared to *** appropriate training,ESD is preferred over EMR as the first-line therapy for resection of colorectal polyps,without restricting to lesions greater than 20 mm and those with high suspicion of submucosal invasion.

关键词： Endoscopic mucosal resection Endoscopy Colonic polyps Colorectal neoplasm Colonoscopy

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复方生肌膏用于肛瘘术后创面愈合的效果观察

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中国肛肠病杂志 2024年第6期44卷 39-41页

作者：赵晨翔王建忠卢临生师九平贾增增刘伟王鹏张迪临汾市中心医院肛肠外科山西临汾041000 天津市人民医院肛肠外科天津300122

目的:研究复方生肌膏用于肛瘘术后创面愈合的效果。方法:选择2021年1月至2023年1月,医院收治的72例肛瘘患者,依据随机数字法分为观察组和对照组,每组36例。观察组应用复方生肌膏纱条换药,对照组应用凡士林纱条换药。对比2组术后不同时... 详细信息

目的:研究复方生肌膏用于肛瘘术后创面愈合的效果。方法:选择2021年1月至2023年1月,医院收治的72例肛瘘患者,依据随机数字法分为观察组和对照组,每组36例。观察组应用复方生肌膏纱条换药,对照组应用凡士林纱条换药。对比2组术后不同时间点创面分泌物评分、肉芽组织评分、创面愈合率及愈合时间等指标。结果:观察组术后第7天创面分泌物评分和创面疼痛评分均低于对照组(P0.05)。结论:肛瘘术后应用复方生肌膏纱条换药能够减少创面分泌物,促进肉芽组织生长,减轻患者疼痛,缩短创面愈合时间,值得临床推广应用。

关键词：肛瘘复方生肌膏创面愈合

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Is colonic lavage a suitable alternative for left-sided colonic emergencies?

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World Journal of Gastrointestinal Surgery 2021年第4期13卷 379-391页

作者： Hui Yu Tham Wen Hui Lim Sneha Rajiv Jain Cheng Han Mg Snow Yunni Lin Jie Ling Xiao Fung Joon Foo Kar Yong Wong Choon seng chong Department of Surgery University Surgical ClusterNational University HospitalSingapore 11759Singapore Department of Medicine Yong Loo Lin School of MedicineNational University of SingaporeSingapore 11759Singapore Department of Colorectal Surgery Singapore General HospitalSingapore 169608Singapore Department of General Surgery Sengkang HealthSingapore 544886Singapore Colorectal Surgery Service Department of General SurgeryTan Tock Seng HospitalSingapore 308433Singapore Division of Colorectal Surgery University Surgical ClusterNational University Health SystemSingapore 119228Singapore Department of General Surgery Yong Loo Lin School of MedicineNational University of SingaporeSingapore 119228Singapore

BACKGROUND The use of intra-operative colonic lavage(IOCL)with primary anastomosis remains controversial in the emergency left-sided large bowel pathologies,with alternatives including Hartmann’s procedure,manual decompression and subtotal *** To compare the peri-operative outcomes of IOCL to other *** Electronic databases were searched for articles employing IOCL from inception till July 13,*** ratio and weighted mean differences(WMD)were estimated for dichotomous and continuous outcomes ***-arm meta-analysis was conducted using DerSimonian and Laird random *** Of 28 studies were included in this meta-analysis,involving 1142 undergoing IOCL,and 634 other *** leads to comparable rates of wound infection when compared to Hartmann’s procedure,and anastomotic leak and wound infection when compared to manual *** was a decreased length of hospital stay(WMD=-7.750;95%CI:-13.504 to-1.996;P=0.008)compared to manual decompression and an increased operating ***-arm meta-analysis found that overall mortality rates with IOCL was 4%(CI:0.03-0.05).Rates of anastomotic leak and wound infection were 3%(CI:0.02-0.04)and 12%(CI:0.09-0.16)*** IOCL leads to similar rates of post-operative complications compared to other *** extensive studies are needed to assess the outcomes of IOCL for emergency left-sided colonic surgeries.

关键词： Colon Colonic irrigation Intra-operative colonic lavage Anastomosis Emergency surgery Colonic neoplasm

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