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Intraocular pressure measurement over soft contact lens by rebound tonometer: a comparative study

International Journal of Ophthalmology(English edition) 2015年第3期8卷 540-543页

作者： senay asik nacaroglu Emine Seker Un Mehmet Giray Ersoz Yelda Tasci Department of Ophthalmology Tepecik Traning and Research Hospital Department of Ophthalmology Akdagmadeni State Hospital

AIM: To evaluate the intraocular pressure(IOP)measurements by Icare rebound tonometer over a contact lens in comparison with Goldmann applanation tonometry(GAT). METHODS: Fifty patients using contact lens were included in this study. One of the eyes of the patients was selected randomly and their IOP were measured by rebound tonometer with and without contact lens(RTCL,RT respectively) and by GAT, as well as their central corneal thickness(CCT) by optical pachymeter. The results of both methods were compared by correlation analysis, general linear method repeated measure and Bland-Altman ***: Mean IOP values measured by RTCL, RT and GAT were 15.68 ±3.7, 14.50 ±3.4 and 14.16 ±2.8(P <0.001), respectively. Mean IOP by RTCL was significantly higher than the measurements implemented by RT and GAT(P <0.001), while there was no difference between the measurements by GAT and RT(P =0.629). There was a good level of positive correlation between GAT and RTCL as well as RT(r =0.786 P <0.001, r =0.833 P <0.001, respectively). We have observed that CCT increase did not show any correlation with the differences of the measurements between RTCL and RT(P =0.329), RTCL and GAT(P =0.07) as well as RT and GAT(P =0.189) in linear regression ***: The average of the measurements over contact lens by rebound tonometer was found to be higher than what was measured by GAT. Although this difference is statistically significant, it may be clinically negligible in the normal population.

关键词： contact lens intraocular pressure rebound tonometer

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Protective effect of pomegranate juice on retinal oxidative stress in streptozotocin-induced diabetic rats

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International Journal of Ophthalmology(English edition) 2017年第11期10卷 1662-1668页

作者： Betul Tugcu senay asik nacaroglu Asuman Gedikbasi Mehmet Uhri Nur Acar Hakan Ozdemir Department of Ophthalmology Faculty of Medicine Bezmialem University Istanbu134093 Turkey Department of Ophthalmology Bagcilar Training and Research Hospital Istanbu134200 Turkey Department of Biochemistry Bakirkoy Dr. Sadi Konuk Training and Research Hospital Istanbu134147 Turkey Department of Pathology Kanuni Sultan Suleyman Training and Research Hospital Istanbu134303 Turkey Department of Ophthalmology Acibadem University School of Medicine Istanbu134457 Turkey

AIM： To investigate the effect of pomegranate juice（PJ） intake on overall oxidation status in retinas of diabetic ***： Twenty-seven rats were divided into four groups as control（CO）, diabetic（DM）, control treated with PJ（CO-PJ）, and diabetic treated with PJ（DM-PJ）.The retina tissues were used to determine 8-hydroxy-2＇-deoxyguanosine（8 OHd G）, malondialdehyde（MDA）, reduced glutathione（GSH） levels, and the enzyme activities of superoxide dismutase（SOD） and glutathione peroxidase（GSH-Px）. RESULTS： The levels of 8 OHdG and MDA were significantly increased in the retina of DM group compared to CO group（P=0.001, P〈0.001 respectively）. Both 8 OHd G and MDA levels were decreased in PJ-DM group compared to DM group（P=0.004, P〈0.001 respectively）. The activities of antioxidant enzymes GSH, SOD, and GDH-Px were significantly decreased in the retina of DM group compared to CO group（P≤0.01）. GSH and GSH-Px activities were higher in PJ-DM group compared with DM group（P=0.010, P=0.042, respectively） but SOD activity was not statistically different（P=0.938）. CONCLUSION： PJ intake is found to be effective in decreasing oxidative end products, and in increasing the activities of antioxidant enzymes in diabetic retinas of rats, which suggests it may be effective against oxidative stress in diabetic retinas.

关键词： antioxidant enzymes diabetic retinopathy immunohistochemical staining oxidative stress pomegranate juice

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