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Relationship among Parkinson’s disease, constipation, microbes, and microbiological therapy

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World Journal of Gastroenterology 2024年第3期30卷 225-237页

作者： Xin-Yang Yuan Yu-sen chen Zhou Liu Department of Neurology Affiliated Hospital of Guangdong Medical UniversityZhanjiang 524000Guangdong ProvinceChina Institute of Neurology Guangdong Key Laboratory of Age-Related Cardiac and Cerebral DiseasesZhanjiang 524000Guangdong ProvinceChina

This comprehensive review elucidates the complex interplay between gut microbiota and constipation in Parkinson’s disease(PD),a prevalent non-motor symptom contributing significantly to patients’morbidity.A marked alteration in the gut microbiota,predominantly an increase in the abundance of Proteobacteria and Bacteroidetes,is observed in PD-related *** treatments,although safe,have failed to effectively alleviate symptoms,thereby necessitating the development of novel therapeutic *** interventions such as prebiotics,probiotics,and fecal microbiota transplantation(FMT)hold therapeutic *** prebiotics improve bowel movements,probiotics are effective in enhancing stool consistency and alleviating abdominal *** shows potential for significantly alleviating constipation symptoms by restoring gut microbiota balance in patients with *** promising developments,the causal relationship between changes in gut microbiota and PD-related constipation remains elusive,highlighting the need for further research in this expanding field.

关键词： Parkinson disease Constipation Gut microbiota Prebiotics Probiotics Fecal microbiota transplantation

Preparation of yttrium oxide coating with enhanced thermal shock resistance on refractories used for titanium alloy melting and casting

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Journal of Iron and Steel Research International 2024年第6期31卷 1411-1422页

作者： Ao chen Yan Ma Zhou-fu Wang Hao Liu Xi-tang Wang sen-na chen chen-xin Zhang Zi-yi Tang Wei-dong Fu Wei cheng The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina Xiangyang Juli High Technology Material Co. Ltd.Xiangyang 441705HubeiChina Xiangyang Public Inspection and Testing Center Xiangyang 441000HubeiChina

In order to enhance the service life of refractories for melting and casting of titanium alloy,preparation of yttrium oxide coatings on the refractories surface is an effective *** improvement of thermal shock stability of the coating is beneficial to its spalling resistance during the high-temperature service,and the available slurry with good performance is the *** effects of the varieties and contents of dispersant(sodium tripolyphosphate,sodium hexametaphosphate,sodium pyrophosphate,citric acid and polycarboxylate ammonium salt)and binder(aluminum dihydrogen phosphate,zirconium acetate and yttria sol)on the stability,rheological and thixotropic properties of yttrium oxide waterbased slurry were investigated,and the effects of slurry composition design on the thermal shock resistance of the coating were *** results showed that the introduction of polycarboxylate ammonium salt as dispersant significantly improved the stability of the slurry,and the varieties of the binders had significant effects on the dispersibility of the *** aluminum dihydrogen phosphate and polycarboxylate ammonium salt were used as binder and dispersant,respectively,the slurry had better stability,suitable rheological and thixotropic *** using aluminum dihydrogen phosphate as binder,the coating had good thermal shock resistance and no obvious cracks were observed for the coating after thermal shock,which was attributed to the yttrium aluminate binding phase generated in the *** effective method was provided for preparing yttrium oxide coatings with enhanced thermal shock resistance applied in the process of titanium alloy melting and casting.

关键词： Yttrium oxide-Slurry Stability Rheological property Thixotropic property-Coating Thermal shock resistance

Abnormal Innervation,Demyelination,and Degeneration of Spiral Ganglion Neurons as Well as Disruption of Heminodes are Involved in the Onset of Deafness in Cx26 Null Mice

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Neuroscience Bulletin 2024年第8期40卷 1093-1103页

作者： Yue Qiu Le Xie Xiaohui Wang Kai Xu Xue Bai sen chen Yu Sun Department of Otorhinolaryngology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Otolaryngology Nanchang UniversityNanchang 330006China

GJB2 gene mutations are the most common causes of autosomal recessive non-syndromic hereditary *** individuals suffering from severe to profound GJB2-related deafness,cochlear implants have emerged as the sole remedy for auditory *** previous studies have highlighted the crucial role of preserving cochlear neural components in achieving favorable outcomes after cochlear ***,we generated a conditional knockout mouse model(Cx26-CKO)in which Cx26 was completely deleted in the cochlear supporting cells driven by the Sox2 *** Cx26-CKO mice showed severe hearing loss and massive loss of hair cells and Deiter’s cells,which represented the extreme form of human deafness caused by GJB2 gene *** addition,multiple pathological changes in the peripheral auditory nervous system were found,including abnormal innervation,demyelination,and degeneration of spiral ganglion neurons as well as disruption of heminodes in Cx26-CKO *** findings provide invaluable insights into the deafness mechanism and the treatment for severe deafness in Cx26-null mice.

关键词： Spiral ganglion neurons Gjb2 Heminode Hearing loss

KCNQ1 rs2237895 gene polymorphism increases susceptibility to type 2 diabetes mellitus in Asian populations

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World Journal of Diabetes 2024年第3期15卷 552-564页

作者： Dong-Xu Li Li-Ping Yin Yu-Qi Song Nan-Nan Shao Huan Zhu chen-sen He Jiang-Jie Sun First Clinical Medical College Anhui Medical UniversityHefei 230032Anhui ProvinceChina School of Mental Health and Psychological Sciences Anhui Medical UniversityHefei 230032Anhui ProvinceChina School of Clinical Medicine Anhui Medical UniversityHefei 230031Anhui ProvinceChina School of Health Care Management Anhui Medical UniversityHefei 230032Anhui ProvinceChina

BACKGROUND The association of single nucleotide polymorphism of KCNQ1 gene rs2237895 with type 2 diabetes mellitus(T2DM)is currently *** is unknown whether this association can be gene realized across different *** To determine the association of KCNQ1 rs2237895 with T2DM and provide reliable evidence for genetic susceptibility to *** We searched PubMed,Embase,Web of Science,Cochrane Library,Medline,Baidu Academic,China National Knowledge Infrastructure,China Biomedical Literature Database,and Wanfang to investigate the association between KCNQ1 gene rs2237895 and the risk of T2DM up to January 12,*** Manager 5.4 was used to analyze the association of the KCNQ1 gene rs2237895 polymorphism with T2DM and to evaluate the publication bias of the selected *** Twelve case–control studies(including 11273 cases and 11654 controls)met our inclusion *** the full population,allelic model[odds ratio(OR):1.19;95%confidence interval(95%CI):1.09–1.29;P<0.0001],recessive model(OR:1.20;95%CI:1.11–1.29;P<0.0001),dominant model(OR:1.27.95%CI:1.14–1.42;P<0.0001),and codominant model(OR:1.36;95%CI:1.15–1.60;P=0.0003)(OR:1.22;95%CI:1.10–1.36;P=0.0002)indicated that the KCNQ1 gene rs2237895 polymorphism was significantly correlated with susceptibility to *** stratified analysis,this association was confirmed in Asian populations:allelic model(OR:1.25;95%CI:1.13–1.37;P<0.0001),recessive model(OR:1.29;95%CI:1.11–1.49;P=0.0007),dominant model(OR:1.35;95%CI:1.20–1.52;P<0.0001),codominant model(OR:1.49;95%CI:1.22–1.81;P<0.0001)(OR:1.26;95%CI:1.16–1.36;P<0.0001).In non-Asian populations,this association was not significant:Allelic model(OR:1.06,95%CI:0.98–1.14;P=0.12),recessive model(OR:1.04;95%CI:0.75–1.42;P=0.83),dominant model(OR:1.06;95%CI:0.98–1.15;P=0.15),codominant model(OR:1.08;95%CI:0.82–1.42;P=***:1.15;95%CI:0.95–1.39;P=0.14).CONCLUSION KCNQ1 gene rs2237895 was significantly associated with susceptibility to T2DM

关键词： Type 2 diabetes mellitus KCNQ1 rs2237895 Single nucleotide polymorphism Asian populations

大型铺管船托管架疲劳损伤实时监测应用与研究

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船舶力学 2024年第6期28卷 907-916页

作者：闫宏生陈森彪贾同宇陈永訢孟祥伟天津大学水利工程仿真与安全国家重点实验室天津300072 海洋石油工程股份有限公司天津300461

托管架长期承受着交变载荷的作用,结构疲劳破坏问题不容忽视。为此,本文分别基于波浪谱和监测数据对托管架的疲劳问题进行研究。通过计算结果的对比分析,发现基于波浪谱的疲劳损伤计算,由于波浪荷载的随机性很强,导致计算结果偏于保守,... 详细信息

托管架长期承受着交变载荷的作用,结构疲劳破坏问题不容忽视。为此,本文分别基于波浪谱和监测数据对托管架的疲劳问题进行研究。通过计算结果的对比分析,发现基于波浪谱的疲劳损伤计算,由于波浪荷载的随机性很强,导致计算结果偏于保守,适用于设计阶段结构的疲劳寿命预报评估;而基于实时监测数据的疲劳损伤计算,数据相对更加准确,适用于实时评估结构当前的疲劳损伤情况,并依此提出适当的维修和保养建议。

关键词：托管架疲劳谱分析实时监测对比分析

多元组织移植在眼睑分裂痣整形外科修复中的应用

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中华整形外科杂志 2024年第3期40卷 300-306页

作者：罗思思卢晓昭杨喆马宁陈森李养群中国医学科学院北京协和医学院整形外科医院尿道下裂整形中心北京100144 天津市河东区中医院整形外科天津300000

目的探讨多元组织移植在眼睑分裂痣手术治疗的临床效果及策略。方法回顾性分析2005年1月至2022年1月,于中国医学科学院整形外科医院尿道下裂整形中心就诊的眼睑分裂痣患者临床资料。手术分为4种。(1)直接切除缝合术;(2)单纯游离植皮术:... 详细信息

目的探讨多元组织移植在眼睑分裂痣手术治疗的临床效果及策略。方法回顾性分析2005年1月至2022年1月,于中国医学科学院整形外科医院尿道下裂整形中心就诊的眼睑分裂痣患者临床资料。手术分为4种。(1)直接切除缝合术;(2)单纯游离植皮术:根据缺损大小,上睑及下睑创面以中厚或全厚皮片覆盖;(3)眼轮匝肌肌皮瓣联合游离植皮术:上睑缺损及下睑近缘处缺损以皮片移植,下睑缺损以同侧眼轮匝肌蒂颞区皮瓣修复;(4)眼轮匝肌为蒂的颞区扩张皮瓣联合游离植皮术:手术分两期,一期手术于患侧颞区置入扩张器,二期手术取出扩张器后,行眼睑病变组织切除,再形成外眦眼轮匝肌眶部为蒂的岛状皮瓣,旋转180°后覆盖下睑缺损,上睑及下睑近睑缘处缺损仍以皮片移植。通过门诊、电话及微信随访患者术后面部外观及眼部运动等情况。采用SPSS 22.0统计软件进行分析,计量资料以±s表示,组内术前及术后颜面部修复重建术后疗效评估标准建议(A&F)评分比较采用配对t检验,P0.05);单纯游离植皮术10例,术后A&F评分(5.13±1.59)分较术前(2.25±1.59)分高,差异无统计学意义(P>0.05);眼轮匝肌肌皮瓣联合游离植皮7例,术后A&F评分(5.54±1.46)分较术前(2.18±1.61)分明显提高,差异有统计学意义(P0.05)。所有患者切口均一期愈合,皮片或皮瓣成活良好,眼睑功能正常。28例患者获得8~81个月随访,其中3例术后继发下睑外翻畸形,3例切口及植皮区黑痣复发,2例植皮区色素沉着较明显,1例继发重力性上睑下垂,其余患者修复效果满意;6例因联系方式变更失访。结论眼轮匝肌肌皮瓣联合游离植皮在中到大面积眼睑分裂痣的整形外科修复中可获得更稳定的效果。上睑及下睑近睑缘处以游离植皮修复,下睑以皮瓣移植修复,更加符合上下睑的生理状态,不同的组织移植方式联合,可使面部容外形更美观。

关键词：眼睑先天性分裂痣组织移植皮瓣外科治疗

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基于改进YOLOv7的麦穗检测算法

吉林大学学报（理学版） 2024年第4期62卷 886-894页

作者：陈森徐伟峰王洪涛雷耀华北电力大学(保定)计算机系河北保定071003 河北省能源电力知识计算重点实验室河北保定071003

针对麦穗数据集中存在的检测目标密集、遮挡、各地区形态不一致现象引起的漏检、模型泛化能力弱等问题,提出一种基于改进YOLOv7的麦穗检测算法.首先,在YOLOv7网络的骨干特征提取网络引入混合注意力机制加强对位置特征的提取,缓解检测目... 详细信息

针对麦穗数据集中存在的检测目标密集、遮挡、各地区形态不一致现象引起的漏检、模型泛化能力弱等问题,提出一种基于改进YOLOv7的麦穗检测算法.首先,在YOLOv7网络的骨干特征提取网络引入混合注意力机制加强对位置特征的提取,缓解检测目标密集导致的漏检问题;其次,在骨干特征提取网络引入能结合不同尺寸的可切换空洞卷积(switchable atrous convolution, SAC),通过增大感受野实现提取不同尺度的特征信息,可有效改善因遮挡现象引起的漏检问题;最后,在特征融合部分引入增量学习模块(example vector correction, EVC),提高模型的鲁棒性和泛化能力.实验结果表明,改进后的麦穗识别算法在全球小麦麦穗数据集的平均目标检测精度与原YOLOv7相比提高了2.11个百分点.

关键词：小麦麦穗检测混合注意力增量学习空洞卷积

基于Stacking集成和偏探索贝叶斯优化的特征选择

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山西大学学报(自然科学版) 2024年第1期47卷 93-102页

作者：孙林郭嘉琪朱雨晨陈森天津科技大学人工智能学院河南师范大学计算机与信息工程学院

针对高维基因数据集的最优特征子集不易确定，以及传统的贝叶斯优化算法容易陷入局部最优，导致无法快速筛选出最优参数等问题，本文提出了一种基于Stacking集成和偏探索贝叶斯优化的基因选择方法。首先，使用卡方过滤法剔除原始特征空... 详细信息

针对高维基因数据集的最优特征子集不易确定，以及传统的贝叶斯优化算法容易陷入局部最优，导致无法快速筛选出最优参数等问题，本文提出了一种基于Stacking集成和偏探索贝叶斯优化的基因选择方法。首先，使用卡方过滤法剔除原始特征空间中的冗余基因，获得相关性较高的基因，通过贝叶斯优化算法的采集函数进行改进，引入跳出系数，使得贝叶斯优化算法能够自适应地跳出局部最优，降低开销并加快寻优的效率；然后，使用偏探索贝叶斯优化寻找随机森林的最优参数，使用优化后随机森林模型筛选最优基因子集；最后，设计了一种Stacking集成模型框架来构建分类器，并对最优基因子集进行分类，进而构建了基于Stacking集成和偏探索贝叶斯优化的基因选择算法。在9个公开的基因表达谱数据集上进行仿真实验，结果表明所提算法可以快速筛选出最优的基因子集，且具有较高的分类精度。

关键词：基因选择 Stacking算法贝叶斯优化算法随机森林模型

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典型扭曲管内传热与流动阻力性能对比分析

过程工程学报 2024年第2期24卷 172-181页

作者：周西文陈森王旭鹏朱慧杰李修真河南科技大学建筑能源与热科学技术研究所河南洛阳471023

为对比分析典型扭曲管内传热及流动阻力性能,以指导优化设计新型扭曲管,基于实验验证,采用数值计算方法,研究了典型横截面形状的扭曲管内流体在低雷诺数时的换热特性。结果表明,扭曲管的规律性螺旋形变诱导其内流体产生周期性螺旋流动,... 详细信息

为对比分析典型扭曲管内传热及流动阻力性能,以指导优化设计新型扭曲管,基于实验验证,采用数值计算方法,研究了典型横截面形状的扭曲管内流体在低雷诺数时的换热特性。结果表明,扭曲管的规律性螺旋形变诱导其内流体产生周期性螺旋流动,在垂直主流方向上产生二次流,增强了温度梯度与速度矢量间的协同程度,使得扭曲管的传热性能强于等横截面周长的普通圆管;在雷诺数为650~1550时,对流传热系数由高到低对应的换热管依次为扭曲三角形管、扭曲矩形管、扭曲椭圆管、扭曲方形管和普通圆管,扭曲三角形管的对流传热系数和流动阻力损失分别比普通圆管增大1.94~1.97倍和2.96~3.06倍,扭曲管的综合传热性能均优于普通圆管,扭曲三角形管的综合传热性能评价因子是最高的,平均约为1.86,其余依次为扭曲矩形管、扭曲椭圆管和扭曲方形管,扭曲三角形管具有最优的对流传热性能。

关键词：强化传热流动阻力扭曲管二次流