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Antiviral Effect of Ribonuclease from <i>Bacillus pumilus</i>against Phytopathogenic Rna-Viruses

Agricultural Sciences 2015年第11期6卷 1357-1366页

作者： Margarita Sharipova Annett Rockstroh Nelly Balaban Ayslu Mardanova Anna Toymentseva Anastasiya Tikhonova semen vologin Zenon Stashevsky Kazan (Volga Region) Federal University Kazan Russia Tatar Research Institute of Agriculture Kazan Russia

Background: Viruses can cause different diseases in plants. To prevent viral infections, plants are treated with chemical compounds and antiviral agents. Chemical antiviral agents usually have narrow specificity, which limits their wide application. Alternative antiviral strategy is associated with the use of microbial enzymes, which are less toxic and are readily decomposed without accumulation of harmful substances. The aim of this work is to study the effect of Bacillus pumilus ribonuclease on various phytopathogenic viruses with specific focus on the ability of enzyme to eliminate them from plant explants in vitro. Materials and methods: Extracellular ribonuclease of B. pumilus is tested as an antiviral agent. To study the antiviral effect of RNase, depending on concentration and the time of application several plant-virus model systems are used. Virus detection is conducted by serological testing and RT-PCR. Results: Bacillus pumilus ribonuclease possesses antiviral activity against plant Rna-viruses RCMV (red clover mottle virus), PVX (Potato Virus X) and AMV (Alfalfa Mosaic Virus). The maximum inhibitory effect against actively replicating viruses is observed when plants are treated with the enzyme in the concentration of 100 ug/ml prior to infection. In case of local necrosis ribonuclease in the concentration of 1 ug/ml completely inhibits the development of RCMV virus on bean plants. The enzyme is able to penetrate plants and inhibit the development of viral infection, inhibiting effect for untreated surfaces decreased on average for 20%. It is also found that B. pumilus ribonuclease protects apical explants of sprouts of potato tubers from PVM and PVS viruses. Conclusion: B. pumilus ribonuclease possesses antiviral activity against plant Rna-viruses and produces viruses-free plants in the apical meristem culture.

关键词： Bacillus Pumilus Ribonuclease Phytopathogenic Rna-Viruses Inhibition Virus-Free Apical

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Study of the Laser Light Effect on Improving Sheep semen Quality

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Chinese Journal of Lasers 1995年第2期B4卷 175-179页

作者： YUE Wenbin LIU Wenzhong(Department of Animal Shanxi Agricultutal University,Shanxi, Taigu, 030801, China)HU Yueling HE Jianming(Shanxi Frozen-semen Centre, Shanxi,Taiyuan, China) Shanxi Agricultural Univ Taigu China

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关键词： Helium-Neon laser irradiation sheep semen in vitro

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Functional magnetic resonance imaging study of group independent components underpinning item responses to paranoid-depressive scale

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World Journal of Clinical Cases 2023年第36期11卷 8458-8474页

作者： Drozdstoy Stoyanov Rositsa Paunova Julian Dichev Sevdalina Kandilarova Vladimir Khorev semen Kurkin Department of Psychiatry Medical University PlovdivPlovdiv 4000Bulgaria Research Institute Medical UniversityPlovdiv 4002Bulgaria Faculty of Medicine Medical UniversityPlovdiv 4002Bulgaria Department of Psychiatry and Medical Psychology Medical UniversityPlovdiv 4002Bulgaria Baltic Center for Artificial Intelligence and Neurotechnology Immanuel Kant Baltic Federal UniversityKaliningrad 236041Russia

BACKGROUND Our study expand upon a large body of evidence in the field of neuropsychiatric imaging with cognitive,affective and behavioral tasks,adapted for the functional magnetic resonance imaging(MRI)(fMRI)experimental *** is sufficient evidence that common networks underpin activations in task-based fMRI across different mental *** To investigate whether there exist specific neural circuits which underpin differ-ential item responses to depressive,paranoid and neutral items(DN)in patients respectively with schizophrenia(SCZ)and major depressive disorder(MDD).METHODS 60 patients were recruited with SCZ and *** patients have been scanned on 3T magnetic resonance tomography platform with functional MRI paradigm,comprised of block design,including blocks with items from diagnostic paranoid(DP),depression specific(DS)and DN from general interest *** performed a two-sample t-test between the two groups-SCZ patients and depressive *** purpose was to observe different brain networks which were activated during a specific condition of the task,respectively DS,DP,*** Several significant results are demonstrated in the comparison between SCZ and depressive groups while performing this *** identified one component that is task-related and independent of condition(shared between all three conditions),composed by regions within the temporal(right superior and middle temporal gyri),frontal(left middle and inferior frontal gyri)and limbic/salience system(right anterior insula).Another com-ponent is related to both diagnostic specific conditions(DS and DP)*** is shared between DEP and SCZ,and includes frontal motor/language and parietal *** specific component is modulated preferentially by to the DP condition,and is related mainly to prefrontal regions,whereas other two components are significantly modulated with the DS condition and include clusters within the default mode network such as posterior cingulate and prec

关键词： Paranoid-depressive scale Functional magnetic resonance imaging Cross-validation Group independent component analysis Schizophrenia Depression

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CFDI（中国投资）对俄罗斯经济的影响研究

CFDI（中国投资）对俄罗斯经济的影响研究

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作者： Popov semen 浙江理工大学

学位级别：硕士

俄罗斯是世界上唯一的一个横跨亚洲和欧洲两个大洲的国家,并且传承了苏联最多遗址的国家,并且,它也是世界上领土面积最大的国家同时还是联合国五个常任理事国之一,其国家有着丰富的自然资源并且具备人口稀少即地广人稀的显著特点。中国... 详细信息

俄罗斯是世界上唯一的一个横跨亚洲和欧洲两个大洲的国家,并且传承了苏联最多遗址的国家,并且,它也是世界上领土面积最大的国家同时还是联合国五个常任理事国之一,其国家有着丰富的自然资源并且具备人口稀少即地广人稀的显著特点。中国在改革开放以来的发展越来越受到全世界的关注和重视,原因之一是中国的发展速度不断加快和实力的不断提高;另外,当今世界,对于世界十大经济体并且也是常任理事国之一的中国来说,地域问题和政治问题在历史舞台上的作用显得尤为重要。,中国和俄罗斯作为发展中的两个大国就现有的环境而言具备很好的投资合作空间和条件以及具备非常可观的发展前景空间。中俄两国地域相邻,历史渊源颇深。俄罗斯盛产矿产、石油、天然气等资源能源,是世界公认的能源大国、科技大国、军事大国,科研实力雄厚,但在物流设施、金融等方面比较落后;而中国是全球最大的加工业基地,生产能力强,互联网金融与物流行业发展迅速,但资源能源匮乏,对矿产、天然气等能源的需求极大,可见,中俄两国的投资经济存在很强的互补性。所以,研究中国对俄直接投资和中俄经济的关系可以为中俄未来的投资与经贸合作的战略转型提供依据,以充分发挥两者的互补效应。分析中国直接投资对俄罗斯经济产生的影响的研究不多,从1992到2017年关于中国对俄罗斯直接投资的资料比较少,并且也没有深入分析中俄投资合作的投资规模、投资地区分布、投资行业以及投资方式这方面的资料很重要,力求在理论上丰富中国直接投资对俄罗斯经济影响这一研究领域,将为中俄投资合作提供理论支持。目前双方的投资结构和投资规模对拉动双边经贸关系的战略升级所起的作用十分有限。为此,从俄罗斯人的角度来看直接投资问题的具有现实意义。本篇论文从投资规模、投资地区分布情况、投资行业以及投资方式四个方面全面分析中国对俄罗斯直接投资存在的问题。论文对中国对俄罗斯直接投资的过去、现在延续状况,对其特点、发展变化做出判断,然后从理论上探寻中国对俄罗斯直接投资怎么影响俄罗斯经济,为实证分析做铺垫。统计数据计算分析对象,建立数学模型,实证分析怎么中国投资影响俄罗斯经济。本文选取相应的指标作为解释变量,具体选取的指标有:国内投资率、劳动力投入、人力资源、政府总体消费支出占GDP的百分比、中国对俄罗斯直接投资流入量、中国的外商直接投资与国内投资之间的交互作用、人力资本和中国外商直接投资的交互项、俄罗斯经济政策和外国直接投资的交互作用。结果表明,劳动力投入、人力资本改善、国内投资增加、中国的外商直接投资流入增加均对俄罗斯的经济发展起到正向的促进作用,政府消费支出对经济增长起到负向的影响,但这种影响并不大,这可能是由于俄罗斯的经济财政政策还不太完善,政府消费支出没能正向的对经济发展起到作用。三个交互影响的变量中,中国外商直接投资与政府消费支出对经济发展起到正向的影响,而与预测不一致的是中国外商直接投资与国内投资的交互项和中国外商直接投资与人力资本的交互项,对经济发展的影响是负的。在宏观层面上,中国直接投资对俄罗斯的经济增长产生了积极作用,以及外国直接投资对其他经济增长贡献因素产生了溢出效应,可以预测在改善俄罗斯的腐败、贸易便利化不足等各种不良影响因素的情况下,其积极作用将更为明显。因此,本文提出一些可以为俄中投资与经济关系的发展提供新动力的政策建议。

关键词：中国投资俄罗斯经济对外直接投资

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Neoadjuvant hyperfractionated accelerated radiotherapy plus concomitant 5-fluorouracil infusion in locally advanced rectal cancer: A phase Ⅱ study

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World Journal of Gastrointestinal Oncology 2018年第1期10卷 40-47页

作者： Zeynep Gural Sezer Saglam Serap Yucel Esra Kaytan-Saglam Oktar Asoglu Cetin Ordu Hediye Acun Rasul Sharifov semen Onder Ahmet Kizir Ethem N Oral Department of Radiation Oncology Acibadem University Medical Faculty Department of Medical Oncology Istanbul Bilim University Department of Radiation Oncology Istanbul Medical FacultyIstanbul University Department of General Surgery Academia of Clinical Science of Bogazici Department of Medical Biophysics Harran University Medical Faculty Department of Radiology Bezm-i AlemUniversity Department of Pathology Istanbul Medical FacultyIstanbul University

AIM To evaluate the efficacy and tolerability of neoadjuvant hyperfractionated accelerated radiotherapy(HART)and concurrent chemotherapy in patients with locally advanced infraperitoneal rectal cancer. METHODS A total of 30 patients with histopathologically confirmed T2-3/N0+ infraperitoneal adenocarcinoma of rectum cancer patients received preoperative 42 Gy/1.5 Gy/18 days/bid radiotherapy and continuous infusion of 5-fluorouracil(325 mg/m^2). All patients were operated 4-8 wk after neoadjuvant concomitant therapy. RESULTS In the early phase of treatment, 6 patients had grade Ⅲ-Ⅳ gastrointestinal toxicity, 2 patients had grade Ⅲ-Ⅳ hematologic toxicity, and 1 patient had grade Ⅴ toxicity due to postoperative sepsis during chemotherapy. Only 1 patient had radiotherapy-related late side effects, i.e., grade Ⅳ tenesmus. Complete pathological response was achieved in 6 patients(21%), while near-complete pathological response was obtained in 9(31%). After a median follow-up period of 60 mo, the local tumor control rate was 96.6%. In 13 patients, distant metastasis occurred. Disease-free survival rates at 2 and 5 years were 63.3% and 53%, and corresponding overall survival rates were 70% and 53.1%, *** Although it has excellent local control and complete pathological response rates, neoadjuvant HART concurrent chemotherapy appears to not be a feasible treatment regimen in locally advanced rectal cancer, having high perioperative complication and intolerable side effects. Effects of reduced 5-fluorouracil dose or omission of chemotherapy with the aim of reducing toxicity may be examined in further studies.

关键词： Hyperfractionated accelerated radiotherapy Rectal cancer Neoadjuvant chemoradiotherapy

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Evolutionary history of mountain voles of the subgenus Aschizomys (Cricetidae, Rodentia), inferred from mitochondrial and nuclear markers

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Integrative Zoology 2020年第3期15卷 187-201页

作者： semen Yu.BODROV Vera K.VASILJEVA Innokentiy M.OKHLOPKOV Nikolai V.MAMAYEV Evgeniy S.ZAKHAROV Alexey Yu OLEINIKOV Evgeniy A.GENELT-YANOVSKIY Natalia I.ABRAMSON Zoological Institute Russian Academy of SciencesSaint PetersburgRussia Institute for Biological Problems of Cryolithozone YakutskSakha Republic(Yakutia)Russia Institute of Water and Ecological Problems KhabarovskRussia Saint-Petersburg Scientific Center RAS Saint PetersburgRussia

In this study,we present an assessment of the evolutionary history and phylogenetic relationships of Asian mountain voles of the subgenus Aschizomys,genus Alticola,based on extensive sampling and phylogenetic analyses of data from mitochondrial and nuclear *** species of this subgenus are widespread in the mountain areas of north-eastern ***,both their distribution and taxonomic borders remained questionable for more than 100 *** study showed discordance in the phylogenetic patterns between nuclear and mtDNA *** found that mtDNA in *** is paraphyletic relative to ***,but nuclear markers demonstrated reciprocal *** to species distribution modeling,ranges of *** and *** experienced a secondary contact during the Last Glacial Maximum(approximately 22 kyr BP),and thus a hybridization event seems plausible during that *** tree analyses recovered a sister group relationship between the two species of the Aschizomys subgenus,with an estimated divergence date of around 0.8 *** results provided good support for currently recognized subspecies within both *** and *** based on mitochondrial and nuclear datasets.A new,yet undescribed form,supposedly of a subspecific status within ***,was found in the Bureinskiy Range in the Khabarovsk *** finding expands the current species distribution range further to the southeast.

关键词： Asian mountain voles Aschizomys phylogeny taxonomy species tree species distribution modeling

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微棱镜逆反射材料特性分析及制作

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浙江工业大学学报 2010年第3期9卷 351-354页

作者：张明乐孜纯刘恺全必胜 PETROV Viacheslav semen Shanoylo 浙江工业大学理学院浙江杭州310032 浙江工业大学信息工程学院浙江杭州310032 乌克兰国家科学院信息记录问题研究所乌克兰基辅03113

对微棱镜逆反射材料进行了理论研究和实验制作.理论分析了微棱镜单元内光线的逆反射特性,并研究了全反射条件对入射孔径角的限制以及阵列结构的逆反射率.提出了一种新的工艺方法,用于制作大尺寸的微棱镜模版.该方法将小尺寸镍模版利用类... 详细信息

对微棱镜逆反射材料进行了理论研究和实验制作.理论分析了微棱镜单元内光线的逆反射特性,并研究了全反射条件对入射孔径角的限制以及阵列结构的逆反射率.提出了一种新的工艺方法,用于制作大尺寸的微棱镜模版.该方法将小尺寸镍模版利用类似"盖章"的方法在较大尺寸的聚碳酸酯基底上依次压制并使其紧密排列,然后再利用电铸的方法生长出大尺寸镍工作模版.最终得到了尺寸为500 mm×100 mm的模版.使用其制作的样片的逆反射系数最高大于750 cd/(lx.m2).

关键词：微棱镜逆反射模版

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Clinical and Histological Patterns of Oropharyngeal Tumors in Selected Health Institutions in North Western Nigeria

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International Journal of Otolaryngology and Head & Neck Surgery 2015年第2期4卷 55-60页

作者： Kufre Robert Iseh Mohammed Abdullahi Daniel Jiya Aliyu Stanley Amutta Stephen semen Yikawe Joseph Hassan Solomon Department of ENT Usmanu Danfodiyo University Teaching Hospital Sokoto Nigeria

Background: Tumors of the oropharynx affect a common pathway for deglutition, respiration and speech and therefore pose a challenge to both the patient and clinician. This paper attempts to present clinical and histologic patterns, and therapeutic challenges of oropharyngeal tumors from three selected health facilities in North Western Nigeria. Materials and Methods: The medical records of patients seen in the Usmanu Danfodiyo University Teaching Hospital, Sokoto, Federal Medi- cal Centre Birnin Kebbi and Shepherd Specialist Hospital, Sokoto with oropharyngeal tumors over a fourteen-year period were reviewed (January 2000 to December 2013). Results: A total of 36 patients were seen. Twenty (56%) were males and 16 (44%) were females, making the male:female ratio, 1.3:1, (P value of 0.004 for the null hypothesis). The age range was 3 to 80 years, with a mean age of 45.5 years. Majority of patients were in their 5th decade of life (33%). Nineteen (53%) patients presented with dysphagia, 11 (28%) with mass in the mouth (soft palate), 7 (17%) with neck swelling, while 3 patients (7%) presented with upper airway obstruction. Twenty-six patients (72%) presented at an advanced stage. Squamous cell carcinoma accounted for 31% of the cases, followed by lymphoma 14%, adenoid cystic carcinoma 8%, pleomorphic adenoma 5%, mucoepidermoid carcinoma 5%, peripheral nerve sheath tumour 3%, alveolar rhabdomyosarcoma (3%), tuberculoma (3%) and inflammatory polyp (3%). Surgery was carried out in 31 cases (86.1%) for the purpose of obtaining biopsy and removal of tumour, followed by chemotherapy (5.5%) and radiotherapy (5.5%) where histologic diagnosis was malignant. Five (13.9%) did not consent for any intervention. Conclusion: Oropharyngeal tumours are varied in presentation. Squamous cell carcinoma (31%) was the commonest histologic type followed by lymphoma (14%) and adencystic carcinoma (8%). About 72% of the cases were in advanced stages (T4). More than half of the tumours (53%) wer

关键词： Oropharyngeal Tumour Squamous Cell Carcinoma Lymphoma North Western Nigeria

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Cardiovascular risk factors and hearing loss among adults in a tertiary center of Northwestern Nigeria

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2018年第4期4卷 253-257页

作者： Stephen semen Yikawe Kufre Robert Iseh Anas Ahmad Sabir Mfon Ime Inoh Joseph Hassan Solomon Nasiru Aliyu Department of Otolaryngology Usmanu Danfodiyo University Teaching HospitalSokotoNigeria Department of Internal Medicine Usmanu Danfodiyo University Teaching HospitalSokotoNigeria

Objective:To assess the effect of cardiovascular risk factors on hearing ***:This was a cross sectional study conducted in Usmanu Danfodiyo University Teaching Hospital,Sokoto.A pretested questionnaire was used to obtain information about the biodata and medical history of participants after which,they were examined and had their hearing thresholds ***:In this study,total of 220 participants were *** these participants,112(55.5%)were females,while 98(44.5%)were *** average age of the participants was(45.2412.21)*** mean of pure tone average among the participants was(19.159.28)dB ***-six(16.4%)of the participants had some degree of hearing ***,30 of them(13.6%)had hypertension,while 23(10.5%)presented with diabetes *** addition,43 participants(19.5%)had BMI(body mass index)that was25 kg/***,9 out of the 220 participants(4.1%)had a history of cigarette *** studies indicated that hypertension,diabetes mellitus,BMI of25 kg/m2,and aging were significantly associated with the risk of hearing loss.

关键词： Hearing loss Hypertension Diabetes mellitus Cigarette smoking

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永冻层排水处理的案例研究(英文)

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黑龙江大学工程学报 2014年第3期5卷 238-241页

作者： Viktor V.Shepelev semen P.Gotovtsev 俄罗斯科学院西伯利亚分院麦尔尼科夫冻土研究所

基于3个冻土区冻土温度场变化情况,对雅库特西部钻石矿所排污水处理进行了长期的地热观察,并对结果进行了分析。该区域地表水温度动态变化为注入水对地质环境的影响评估提供了基本依据,总结了有毒矿井水对永久冻土的影响,并提出了改善... 详细信息

基于3个冻土区冻土温度场变化情况,对雅库特西部钻石矿所排污水处理进行了长期的地热观察,并对结果进行了分析。该区域地表水温度动态变化为注入水对地质环境的影响评估提供了基本依据,总结了有毒矿井水对永久冻土的影响,并提出了改善措施的标准。

关键词：永久冻土排水地下水处理长期冻土水文地质条件地热监控

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