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Hepatitis B reactivation related to everolimus

World Journal of Hepatology 2013年第1期5卷 43-45页

作者： sema sezgin gksu Serife Bilal Hasan Senol Coskun Faculty of Medicine Department of Medical OncologyAkdeniz Univercity07058 AntalyaTurkey

Reactivation of hepatitis B virus (HBV) during chemotherapy is a well known complication in patients with chronic hepatitis B and *** clinical manifestations range from subclinical elevation of liver enzymes to severe,potentially fatal fulminant *** can occur in a patient with previous inactive HBV infection;either an inactive carrier or a patient with resolved *** is a mammalian target of rapamycin (mTOR) inhibitor approved in renal cell carcinoma,neuroendocrine tumours and breast *** inhibitors are a new generation of drugs for targeted treatment;therefore,little about their side effects is ***,we report a patient with renal cell carcinoma who experienced a flare of hepatitis B infection during treatment with *** should be aware of HBV reactivation in patients who are undergoing treatment with everolimus,and screening for hepatitis B infection and prophylactic antiviral treatment should be considered.

关键词： Hepatitis B Virus reactivation Everolimus Mammalian target of rapamycin inhibitors Immunosuppressive treatment Renal cell carcinoma

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Periodontopathogen profile of healthy and oral lichen planus patients with gingivitis or periodontitis

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International Journal of Oral Science 2013年第2期5卷 92-97页

作者： Abdullah Seckin Ertugrul Ugur Arslan Recep Dursun sema sezgin Hakki Department of Periodontology Faculty of DentistryYuzuncu Yil University Department of Microbiology Selcuklu Medical FacultySelcuk University Department of Dermatology Baskent Research Hospital Department of Periodontology Faculty of DentistrySelcuk University

Oral lichen planus （OLP） is a chronic inflammatory disease that is frequently detected in oral tissues. The aim of our study was to identify the prevalence of the detection of periodontopathogenic microorganisms （Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia and Treponema denticola in OLP patients and to compare with this prevalence of periodontopathogenic microorganisms in healthy non-OLP patients. Our study included 27 （18 chronic periodontitis （OLPP） and 9 gingivitis （OLPg）） patients diagnosed with OLP along with 26 （13 chronic periodontitis （HP） and 13 gingivitis （Hg）） healthy non-OLP patients. The multiplex polymerase chain reaction （PCR）with subsequent reverse hybridization method （micro-IDent） was used for identifying periodontopathogenic microorganisms present in subgingival plaque samples. The percentages of detection for A. actinomycetemcomitans, P. gingivalis, P. intermedia, T. forsythia and T. denticola in subgingival plaque samples taken from OLP patients （OLPg and OLPP） were 18.5%, 85.1%, 81.4%, 88.8% and 74%, respectively. Meanwhile, in the non-OLP patients （Hg and HP）, these values were 7.6%, 50%, 46.1%, 73% and 57.7%, respectively. Thus, comparing the non-OLP groups with the OLP groups, the periodontopathogens＇ percentages of detection in the OLP groups were higher than those in the non-OLP groups. According to our study results, OLP patients have higher levels of infection with A. actinomycetemcomitans, P. gingivalis, P. intermedia, T. forsythia and T. denticola than non-OLP patients. We argue that the high percentages in patients with OLP may help identify the importance of periodontopathoRenic microorganisms in the progress of periodontal diseases of OLP.

关键词： Aggregatibacter actinomycetemcomitans oral lichen planus Porphyromonas gingivalis Prevotel/a intermedia Tannerel/a forsythia Treponema denticola

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