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How expensive is inflammatory bowel disease? A critical analysis

World Journal of Gastroenterology 2008年第43期14卷 6641-6647页

作者： selwyn odes Inflammatory Bowcl Diseases Unit Department of Gastroenterology and HcpatologySoroka Medical Center and Ben Gurion University of the NcgevPO Box 151Beer Sheva 84101Israel

Economic analysis of chronic diseases is required for proper allocation of resources and understanding costeffectiveness studies of new therapies. Studies on health care cost of ulcerative colitis （UC） and Crohn＇s disease （CD） are reviewed here. These studies were carried out in various countries with disparate health care systems. In the United States, data were often modeled or retrieved from large insurance schemes. Surgery and in-patient hospitalization accounted for over half the outlay on UC and CD. Fistulous disease in CD and parenteral nutrition were very costly. In Canada, overall charges were lower than in the United States, but there too, surgical costs were relatively high. In European studies, economic data were abstracted directly from patients＇ files. One pan-European study examined the outlay on UC and CD in a community-based prospective inception cohort followed for 10 years. Overall costs in Europe were lower than in the United States. Surgery, hospitalization, year of follow-up, disease phenotype in CD and ASCA-positivity impacted significantly on costs. In all studies, the cost data were right skewed, aminosalicylates were expensive drugs, and biological agents the most expensive; moreover indirect costs were not calculated. Infliximab raised costs considerably in CD, but there were no long-term followup studies, so that the cost-benefit of biological agents remains unknown. In conclusion, costs of managing UC and CD vary by country, surgery, genotype and several other factors. The most important question for further research is whether the biological therapies are cost-effective in the long-term.

关键词： Inflammatory bowel disease Ulcerative colitis Crohn's disease Cost-analysis Medical economics

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Refractory Ulcerative Proctitis—A Brief Review

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Open Journal of Gastroenterology 2016年第10期6卷 239-248页

作者： Shmuel odes Faculty of Health Sciences Ben-Gurion University of the Negev Beersheva Israel

Ulcerative proctitis (UP) is a common condition in adult patients and can be very dif-ficult to treat. This review considers critically the definition of this entity, its epidemi-ology and course, and the modes of the... 详细信息

关键词： Ulcerative Proctitis Epidemiology Therapy

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Simple pain measures reveal psycho-social pathology in patients with Crohn's disease

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World Journal of Gastroenterology 2017年第6期23卷 1076-1089页

作者： Shmuel odes Michael Friger Ruslan Sergienko Doron Schwartz Orly Sarid Vered Slonim-Nevo Terri Singer Elena Chernin Hillel Vardi Dan Greenberg Israel IBD Research Nucleus Department of Gastroenterology Faculty of Health SciencesBen-Gurion University of the Negev Department of Public Health Faculty of Health SciencesBen-Gurion University of the Negev Department of Gastroenterology and Hepatology Soroka Medical CenterSoroka Medical Center Spitzer Department of Social Work Ben-Gurion University of the Negev Department of Health Systems Management Faculty of Health Sciences Ben-Gurion University of the Negev 不详

To determine whether pain has psycho-social associations in adult Crohn’s disease (CD) *** completed demographics, disease status, Patient Harvey-Bradshaw Index (P-HBI), Short Form Health Survey (SF-36), Short Inflammatory Bowel Disease Questionnaire (SIBDQ), and five socio-psychological questionnaires: Brief Symptom Inventory, Brief COPE Inventory, Family Assessment Device, Satisfaction with Life Scale, and Work Productivity and Activity Impairment Questionnaire. Pain sub-scales in P-HBI, SF-36 and SIBDQ measures were recoded into 4 identical scores for univariate and multinomial logistic regression analysis of associations with psycho-social *** cohort comprised 594 patients, mean age 38.6 ± 14.8 years, women 52.5%, P-HBI 5.76 ± 5.15. P-HBI, SF-36 and SIBDQ broadly agreed in their assessment of pain intensity. More severe pain was significantly associated with female gender, low socio-economic status, unemployment, Israeli birth and smoking. Higher pain scores correlated positively with psychological stress, dysfunctional coping strategies, poor family relationships, absenteeism, presenteeism, productivity loss and activity impairment and all WPAI sub-scores. Patients exhibiting greater satisfaction with life had less pain. The regression showed increasing odds ratios for psychological stress (lowest 2.26, highest 12.17) and female gender (highest 3.19) with increasing pain. Internet-recruited patients were sicker and differed from hardcopy questionnaire patients in their associations with *** measures in P-HBI, SF-36 and SIBDQ correlate with psycho-social pathology in CD. Physicians should be aware also of these relationships in approaching CD patients with pain.

关键词： Crohn’s disease Psycho-social pathology Pain

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完善强化方案以提高焊接金属结构用的以钡微合金化的...

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国外钢铁钒钛 1991年第1期4卷 28-28,18页

作者： odes.,PD 梁雪平

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Inflammatory bowel disease among first generation immigrants in Israel:A nationwide epi-Israeli Inflammatory Bowel Disease Research Nucleus study

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World Journal of Methodology 2023年第5期13卷 475-483页

作者： Mira Stulman Gili Focht Yiska Loewenberg Weisband Shira Greenfeld Amir Ben Tov Natan Ledderman Eran Matz Ora Paltiel Shmuel odes Iris Dotan Eric Ian Benchimol Dan Turner The Juliet Keiden Institute of Pediatric Gastroenterology and Nutrition Shaare Zedek Medical CenterFaculty of MedicineThe Hebrew University of JerusalemJerusalem 9103102Israel Braun School of Public Health and Community Medicine Hadassah Medical OrganizationFaculty of MedicineHebrew University of JerusalemJerusalem 9574869Israel Clalit Research Institute Tel Aviv 6209804Israel Maccabi Health Services and the Sackler Faculty of Medicine Tel Aviv UniversityTel Aviv 6801296Israel Meuhedet Health Services Tel Aviv 6203854Israel Leumit Health Services Tel Aviv 6473704Israel Faculty of Health Sciences Ben-Gurion University of the NegevBeer-Sheva 84105Israel Department of Gastroenterology Rabin Medical CenterPetah Tikva 49100Israel Department of Paediatrics and Institute of Health Policy Management and EvaluationThe Hospital for Sick ChildrenUniversity of TorontoToronto M5G 1X8ONCanada SickKids Inflammatory Bowel Disease Centre Division of GastroenterologyHepatology and NutritionChild Health Evaluative SciencesThe Hospital for Sick Children and the SickKids Research InstituteToronto M5G 1X8Canada ICES Toronto M4N 3M5Canada

BACKGROUND Israel has a high rate of Jewish immigration and a high prevalence of inflammatory bowel disease(IBD).AIM To compare IBD prevalence in first-generation immigrants vs Israel-born *** Patients with a diagnosis of IBD as of June 2020 were included from the validated epi-IIRN(Israeli IBD Research Nucleus)cohort that includes 98%of the Israeli *** stratified the immigration cohort by IBD risk according to country of origin,time period of immigration,and age group as of June *** A total of 33544 patients were ascertained,of whom 18524(55%)had Crohn’s disease(CD)and 15020(45%)had ulcerative colitis(UC);28394(85%)were Israel-born and 5150(15%)were *** was more prevalent in immigrants(2717;53%)than in non-immigrants(12303,43%,P<0.001),especially in the<1990 immigration *** adjusting for age,longer duration in Israel was associated with a higher point prevalence rate in June 2020(high-risk origin:Immigration<1990:645.9/100000,≥1990:613.2/100000,P=0.043;intermediate/low-risk origin:<1990:540.5/100000,≥1990:192.0/100000,P<0.001).The prevalence was higher in patients immigrating from countries with high risk for IBD(561.4/100000)than those originating from intermediate-/low-risk countries(514.3/100000;P<0.001);non-immigrant prevalence was 528.9/*** Lending support to the environmental effect on IBD etiology,we found that among immigrants to Israel,the prevalence of IBD increased with longer time since immigration,and was related to the risk of IBD in the country of *** UC rate was higher than that of CD only in those immigrating in earlier time periods.

关键词： Epidemiology Inflammatory bowel disease Immigration Environment

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