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Gut commensal metabolite rhamnose promotes macrophages phagocytosis by activating SLC12A4 and.protects against sepsis in mice

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3068-3085页

作者： d.ngping Li Rongjuan Wei Xianglong Zhang Shenhai Gong Meijuan Wan Fangzhao Wang Jiaxin Li Meiling Chen Ruofan Liu Yantong Wan Yinghao Hong Zhenhua Zeng Peng Gu Zhang Wang Kutty selva Nand.kumar Yong Jiang Hongwei Zhou Peng Chen d.partment of Pathophysiology Guangdong Provincial Key Laboratory of ProteomicsSchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510000China d.partment of Critical Care Med.cine Nanfang HospitalSouthern Medical UniversityGuangzhou 510000China d.partment of Gastroenterology Shenzhen HospitalSouthern Medical UniversityShenzhen 518000China d.nstitute of Ecological Sciences School of Life SciencesSouth China Normal UniversityGuangzhou 510000China d.partment of Environmental and.Biosciences School of BusinessInnovation and SustainabilityKristian IV’s vag 3Halmstad UniversityHalmstad 30004Sweden Microbiome Med.cine Center Zhujiang HospitalSouthern Medical UniversityGuangzhou 510000China

Sepsis progression is significantly associated.with the d.sruption of gut ***,the mod.latory mechanisms of gut microbiota operating d.ring sepsis are still ***,we investigated.how gut commensals impact sepsis d.velopment in a pre-clinical *** ligation and.puncture(CLP)surgery was used.to establish polymicrobial sepsis in *** d.pleted.of gut microbiota by an antibiotic cocktail(ABX)exhibited.a significantly higher level of mortality than *** d.termined.by metabolomics analysis,ABX treatment has d.pleted.many metabolites,and.subsequent supplementation with L-rhamnose(rhamnose,Rha),a bacterial carbohyd.ate metabolite,exerted.profound.immunomod.latory properties with a significant enhancement in macrophage phagocytosis,which in turn improved.organ d.mage and.***,rhamnose bind. d.rectly to and.activates the solute carrier family 12(potassium-chlorid. symporter),member 4(SLC12A4)in macrophages and.promotes phagocytosis by activating the small G-proteins,Ras-related.C3 botulinum toxin substrate1(Rac1)and.cell d.vision control protein 42 homolog(Cd.42).Interestingly,rhamnose has enhanced.the phagocytosis capacity of macrophages from sepsis *** conclusion,by id.ntifying SLC12A4 as the host interacting protein,we d.sclosed.that the gut commensal metabolite rhamnose is a functional molecular that could.promote the phagocytosis capacity of macrophages and.protect the host against sepsis.

关键词： Gut microbiota Sepsis Rhamnose SLC12A4 GTP-Rac1 GTP-Cd.42 Macrophage Phagocytosis

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恶性雀斑痣和恶性雀斑痣黑色素瘤的手术边界:绘制连续切除界线的技术

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世界核心医学期刊文摘（皮肤病学分册） 2005年第2期1卷 2-3页

作者： Huilgol S.C. selva d. 刘超 Wakefield.Clinic 270 Wakefield St. Adelaide SA 5000 Australia

Objectives: To assess the margins required.for excision of lentigo maligna (LM) and.lentigo maligna melanoma (LMM) by the technique of mapped.serial excision (MSE), and.to assess the efficacy of MSE. d.sign: An interventional, prospective, noncontrolled.case series. Setting: Tertiary referral, d.rmatologic surgery unit. Patients: Consecutive patients with head.and.neck LM or LMM who und.rwent MSE between March 1, 1993, and.October 31, 2002. Intervention: The MSE of LM or LMM. Main Outcome Measures: The number of 5-mm levels for excision of LM and.LMM and.recurrence. Results: One hund.ed.sixty-one LMs or LMMs in 155 patients were treated. Thirty percent (37 of 125) of LMs required.more than 5-mm margins. For LMMs less than 1 mm in Breslow thickness, 12%(4/32) required.more than 10-mm margins. For primary tumors, 20%of LMs (18 of 91) required.more than 5-mm margins, while 10%of LMMs less than 1 mm in Breslow thickness (2 of 21) required.ore than a 10-mm margin. For recurrent tumors, 56%of LMs (19/34) required.more than a 5-mm margin. Mean follow-up of 38 months (range, 5-100 months) showed.4 recurrences (2%) after MSE. The extrapolated.recurrence at 5 years was 5.0%Conclusions: The current recommend.tions of 5-mm margins for LM and.10-mm margins for LMM less than 1 mm in Breslow thickness are often insufficient. Our results d.monstrate the importance of margin-controlled.excision, particularly in recurrent lesions. The use of MSE offers a high cure rate, in conjunction with tissue conservation.

关键词：雀斑痣黑色素瘤皮损边缘切除范围复发性肿瘤干预性原发性肿瘤年复发率皮肤外科

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聚乳酸羟基乙酸缝线在睑板外侧条形剥离术中的应用

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世界核心医学期刊文摘（眼科学分册） 2005年第4期1卷 15-16页

作者： Hsuan J. selva d. 陈立军

To evaluate the rate of recurrence of horizontal laxity or lid.malposition and.suture- related.complications associated.with the use of an absorbable suture in the lateral tarsal strip proced.re. Prospective, interventional, consecutive case series. A prospective stud.. setting: Institutional. patient population: One hund.ed.patients with horizontal lid.laxity associated.with ectropion or entropion. Patients with paralytic ectropion or ocular prostheses were exclud.d. intervention: One hund.ed.and.five lateral tarsal strip proced.res were performed.using a 6- 0 polyglactin suture. These were combined.with full- thickness skin grafts (34), internal (55) or external (23) retractor plications, and.inverting sutures (4) as required.to correct the lid.malposition. main outcome measures: Recurrence of horizontal laxity or lid.malposition and.suture related.complications were the main outcome measures. Suture related.wound.infection was d.agnosed.clinically by the presence of pus associated.with wound.breakd.wn. One patient failed.to reach 3- month follow- up and.was exclud.d. There was one recurrence of horizontal laxity after a mean follow- up period.of 9.1 months. Four patients d.veloped.lateral canthal wound.infections, compared.with none at the other operative sites. The 95% confid.nce intervals for infections in the tarsal strip proced.re were 1.1% to 9.6% , which were significantly greater than zero (P d.res. A 6- 0 absorbable suture may be used.for the lateral tarsal strip and.d.es not lead.to a recurrence of horizontal laxity. It d.es not appear to red.ce the wound.infection rate associated.with this proced.re.

关键词：睑板聚乳酸羟基乙酸肌折叠术麻痹性睑外翻剥离术睑内翻复发率外眦部可吸收性缝线义眼

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在澳大利亚莫氏显微外科手术治疗基底细胞癌Ⅰ:10年经验

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世界核心医学期刊文摘（皮肤病学分册） 2005年第12期1卷 12-13页

作者： Leibovitch I. Huilgol S.C. selva d. 刘芯 d.. Wakefield.Clinic 270 Wakefield St Adelaide SA 5000 Australia

Background. Only a few prospective stud.es have been published.on surgical treatments for cutaneous basal cell carcinoma (BCC). Objective: Our purpose was to report the clinical find.ngs of all patients with BCC treated.with Mohs micrographic surgery (MMS) in Australia between 1993 and.2002. Method. This prospective,multicenter case series includ.d.all patients in Australia treated.with MMS for BCC, who were monitored.by the Skin and.Cancer Found.tion between 1993 and.2002. The main outcome measures were patient d.mographics, reason for referral, d.ration of tumor, site, preoperative tumor size, recurrences before MMS, histologic classification of malignancy, and.postoperative d.fect size. Results: The stud. includ.d.11,127 patients (47% females and.53% males) with a mean age of 62 years (range, 15- 98 years). In 43.8% of cases BCC was a recurrent tumor. Most of the tumors (98.3% ) were on the head.and.neck area, most commonly on the nose (39% ), cheek and.maxilla (16.5% ), periocular area (12.7% ), and.auricular region (11.4% ). The most common histologic subtypes were infiltrating (30.7% ), nod.locystic (24.2% ), and.superficial (13.6% ). Previously recurrent tumors were larger than primary tumors (P d.a larger postexcision d.fect and.more subclinical extension, and.required.more levels of excision (P d.ta were missing for some outcome measures. Conclusion: This large prospective series of BCC managed.by MMS is characterized.by a high percentage of high- risk tumors. Most tumors were located.in the mid. facial area and.the histologic subtype was mainly infiltrating or nod.locystic. That previously recurrent tumors were larger and.d.monstrated.a more extensive subclinical extension compared.with primary tumors emphasizes the importance of initial tumor erad.cation with margin control.

关键词：基底细胞癌显微外科原发肿瘤组织学恶性程度复发性肿瘤囊肿型统计学数据亚临床面中部浸润型

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莫氏显微手术治疗唇部皮肤癌:临床特征与手术结局

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世界核心医学期刊文摘（皮肤病学分册） 2006年第3期2卷 38-39页

作者： Leibovitch I. Huilgol S.C. selva d. 焦婷 d.partment of Ophthalmology and.Visual Sciences Royal Adelaide Hospital University of Adelaide Adelaide SA Australia

Background. The Australian Mohs micrographic surgery (MMS) d.tabase was initiated.in 1993 by the Skin and.Cancer Found.tion Australia (SCFA) with the aim of collecting prospective d.ta, and.involved.all Mohs surgeons in the country. Objectives: To present a large series of patients with cutaneous lip tumours treated.with MMS in Australia between 1993 and.2002. Method.: This prospective multicentre case series includ.d.all patients with cutaneous lip tumours who were monitored.by the SCFA. The main outcome measures were patient d.mographics, reason for referral, d.ration of tumour, site, preoperative tumour size and.postoperative d.fect size, recurrences prior to MMS, histological subtypes, perineural invasion and.5-year recurrence after MMS. Results: There were 581 patients (66.1% women and.33.9% men, P d.age of 58 ± 15 years. The upper lip was the most common site involved.(81.1% ). Basal cell carcinoma (BCC) was d.agnosed.in 82.3% , squamous cell carcinoma (SCC) in 16.5% , Bowen s d.sease (Bd. in 0.7% and.microcystic ad.exal carcinoma (MAC) in 0.5% of cases. BCC was more common on the upper lip and.in women, whereas SCC was more common on the lower lip and.in men (P d.in women (75.4% ), whereas most lower lip tumours occurred.in men (73.6% ). SCC was associated.with a larger tumour and.postoperative d.fect size compared.with the other tumours. The 5-year recurrence for BCC was 3.0% , and.there were no cases of recurrence for SCC, Bd.or MAC. Conclusions: BCC was the most common cutaneous lip tumour managed.by MMS, and.was significantly more common on the upper lip and.in women. The low 5-year recurrence rate emphasizes the importance of margin-controlled.excision.

关键词：显微手术治疗皮肤癌手术结局临床特征唇部澳大利亚肿瘤部位术后缺损年复发率人口统计学

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在澳大利亚莫氏显微外科手术治疗基底细胞癌Ⅲ:嗜神经浸润

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世界核心医学期刊文摘（皮肤病学分册） 2005年第12期1卷 13-14页

作者： Leibovitch I. Huilgol S.C. selva d. 张莹 d.. Wakefield.Clinic 270 Wakefield St Adelaide SA 5000 Australia3

Background. Perineural invasion (PNI) is an important factor may possibly influence the aggressiveness of basal cell carcinoma (BCC). Objective: Our purpose was to evaluate the incid.nce, features, and.outcomes of BCC with PNI in patients treated.with Mohs micrographic surgery (MMS). Method. This prospective, multicenter case series includ.d.all patients in Australia treated.with MMS for BCC with PNI, who were monitored.by the Skin and.Cancer Found.tion Australia between 1993 and.2002. The parameters record.d.were patient d.mographics, reason for referral, d.ration of tumor, site, preoperative tumor size, recurrence before MMS, histologic subtypes, postoperative d.fect size, and.recurrence at 5 years after MMS. Results: Two- hund.ed.eighty- three patients were d.agnosed.with PNI. Most cases occurred.in male patients (61% ; P=.006) and.in previously recurrent tumors (60.4% ; P d.basosquamous subtypes were more likely to be associated.with PNI (P d.postoperative d.fect sizes were significantly larger in cases with PNI compared.with cases with no PNI (P d.a 5- year follow- up period.after MMS, and.6 of them (7.7% ) were d.agnosed.with ***: d.ta were missing for some outcome measures. Conclusion: PNI is an uncommon feature of BCC. When present, PNI is associated.with larger, more aggressive tumors, and.the risk of 5- year recurrence is higher. This emphasizes the importance of tumor excision with margin control and.long- term patient monitoring.

关键词：基底细胞癌显微外科神经浸润统计学数据硬斑侵袭性病例研究浸润型持续时间长期监测

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游离眼睑移植的皮瓣供区并发症研究

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世界核心医学期刊文摘（眼科学分册） 2005年第3期1卷 36-37页

作者： Leibovitch I. selva d. d.vis G. Ghabrial R. 张少娟

Purpose To d.termine if harvesting free tarsal grafts from the upper eyelid. i s associated.with significant morbid.ty. d.sign Prospective case series. Method. Consecutive patients managed.with free tarsal grafts by three of the authors (d..S., d.G., R.G.) over a 4 year period. Results Ninety one eyelid. in 75 patien ts were operated.on using the free tarsal graft for various eyelid.pathologies. Mean follow up period.was 14.83 ±8.45 months (range, 4 to 42 months). Contour peaking in d.nor upper eyelid.appeared.in two eyelid. (2.2%), lash ptosis in fo ur eyelid. (4.4%) of three patients, and.d.nor site infection in one eyelid.(1. 1%). Four patients (5.3%) complained.of a transient ocular d.scomfort. There w ere no cases of postoperative changes on the eyelid.height, entropion, or kerato pathy in the d.nor site eye. Most of the d.nor site complications were mild.or t ransient and.required.no further surgery. In three patients who und.rwent subseq uent surgery to treat preexisting ptosis or retraction of the d.nor eyelid. the results were less pred.ctable and.further proced.res were required. Conclusion F ree tarsal grafts harvested.from the upper eyelid., with preservation of at leas t 4 mm of the tarsal plate inferiorly, d. not lead.to significant d.nor site mor bid.ty. However, subsequent proced.res to alter the position of the d.nor eyelid.may be less pred.ctable.

关键词：并发症研究皮瓣供区睑内翻上睑角膜病变睑板移植术病例研究

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拉坦前列素可导致睫毛下垂

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世界核心医学期刊文摘（眼科学分册） 2005年第9期1卷 24-24页

作者： Casson R.J. selva d. 张鹏 Glaucoma Unit Department of Ophthalmology Royal Adelaide Hospital North Terrace Adelaide SA 5000 Australia

PURPOSE: To report a case of lash ptosis caused.by latanoprost. d.SIGN: Observational case report. METHOd.: Retrospective chart review. RESULTS: A 61-year-old. ocular hypertensive man who was using latanoprost OU presented.with trichomegaly and.bilateral lash ptosis. The lash ptosis had.not resolved.6 months after stopping latanoprost, and.anterior lamellar repositions were performed. At last follow-up, 8 months after surgery, the lid. were in a normal position, but the trichomegaly had.red.ced.only slightly. CONCLUSIONS: Lash ptosis should.be consid.red.as a possible complication of latanoprost therapy.

关键词：拉坦睑板高眼压位置正常位置调整观察性性图

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结膜鳞状细胞癌侵入周围神经导致患者死亡1例

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世界核心医学期刊文摘（眼科学分册） 2005年第9期1卷 46-46页

作者： Kaines A. d.vis G. selva d. 杨建刚 Oculoplastic and.Orbital Clinic Department of Ophthalmology Royal Adelaide Hospital North Terrace Adelaide SA 5000 Australia

Conjunctival squamous cell carcinoma is generally a low-grad. malignancy. A 42-year-old.man presented.with histologic evid.nce of extra-tumoral perineural invasion associated.with an incompletely excised.limbal conjunctival squamous cell carcinoma. d.spite further surgery, close observation, plaque rad.otherapy, and.eyelid.sparing orbital exenteration followed.by external beam rad.otherapy, the patient d.veloped.intracranial perineural invasion with involvement of the trigeminal and.facial nerves, ultimately resulting in d.ath. Repeated.magnetic resonance imaging with contrast failed.to d.tect perineural invasion until late in the course of d.sease. Awareness of the possibility of perineural invasion in patients with conjunctival squamous cell carcinoma and.of its aggressive nature may be life-saving. Nevertheless, even with initial aggressive tumor control, some patients will show an aggressive tumor growth with recurrences.

关键词：结膜鳞状细胞癌眶内容物剜除术低度恶性肿瘤恶性肿瘤早期神经侵犯局部放射治疗磁共振成像线束

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在澳大利亚莫氏显微外科手术治疗基底细胞癌Ⅱ:5年随访结果

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世界核心医学期刊文摘（皮肤病学分册） 2005年第12期1卷 13-13页

作者： Leibovitch I. Huilgol S.C. selva d. 张莹 d.. Wakefield.Clinic 270 Wakefield St Adelaide SA 5000 Australia

Background. Long- term follow- up is essential to evaluate the role of Mohs micrographic surgery (MMS) in the treatment for cutaneous basal cell carcinoma (BCC). Objective: Our purpose was to report the 5- year follow- up outcome of patients treated.with MMS for BCC. Method. This prospective, multicenter case series includ.d.all patients in Australia treated.with MMS for BCC, who were monitored.by the Skin and.Cancer Found.tion between 1993 and.2002. Parameters record.d.were patient d.mographics, d.ration of tumor, site, preoperative tumor size, recurrences before MMS, histologic classification of malignancy, postoperative d.fect size, and.5- year recurrence after MMS. Results: Three thousand.three hund.ed.seventy (3370)- patients (1594 female and.1776 male patients) completed.a 5- year follow- up period. Fifty- six percent of the tumors were primary and.44% were previously recurrent. Most of them (98.4% ) were located.on the head.and.neck, and.the most common histologic subtypes were nod.locystic (29.3% ) and.infiltrating (28.3% ). Recurrence at 5 years was d.agnosed.in 1.4% of primary and.in 4% of recurrent tumors. Previous tumor recurrence (P d.ration before MMS (P=.015), infiltrating histology (P=.13), and.more levels for tumor (P d.ctors for tumor recurrence after MMS. Limitation: d.ta were missing for some outcome measures. Conclusion: The low 5- year recurrence rate of BCC with MMS emphasizes the importance of margin- controlled.excision.

关键词：基底细胞癌显微外科组织学恶性程度统计学数据囊肿型复发率病例研究浸润型亚临床持续时间

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