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New Insights into Neoproterozoic–Cretaceous Events in the Mamfe Basin(SW Cameroon,Central Africa):Evidence from Textural Analyses,U-Th Composition,and U-Pb Zircon Geochronology from Granitic Basement

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Journal of Earth Science 2021年第6期32卷 1472-1484页

作者： Nguo S.Kanouo Arnaud P.Kouské david r.Lentz rose F.Yongué Mineral Exploration and Ore Genesis Unit Department of Mining Engineering and Mineral ProcessingFaculty of Mines and Petroleum IndustriesUniversity of MarouaMaroua Kangola 46Cameroon Department of Civil Engineering the University Institute of TechnologyUniversity of DoualaDouala 8698Cameroon Department of Earth Sciences University of New BrunswickNew BrunswickE3B 5A3Canada Department of Earth Sciences University of YaoundéYaoundé812Cameroon

Backscattered electron BSE-CL images,U-Th abundance,and U-Pb ages were obtained for zircons from the Nkogho granitic basement rocks cropping out in the Mamfe Basin(SW Cameroon).These data are used to characterize and classify each zircon,elucidate their geochemical *** were also used to formulate a model of their host composition to ascertain the source,and document any preserved postemplacement *** zircons mainly form long to short prisms that are pyramidal to dipyramidal in *** typically exhibit complex oscillatory growth zoning,as well as exhibit sector *** features are mainly compatible with igneous zircons,although a few examples have metamorphic *** U(30 ppm–6380 ppm),Th(4 ppm–1280 ppm),and Pb(12 ppm–648 ppm)contents show core to rim variations with most values fall within the range of crustal granitic *** Th/U ratios(0.08–1.23),with core to rim differences mainly encompass values typical of magmatic zircons with a few values characterizing metamorphic zircons that grew in equilibrium with an anatectic *** U-Pb ages(108.4±1.7 to 988.4±19.0 Ma)with some core and rim age differences date Early Neoproterozoic,Cryogenian–Ediacarian,Early Cambrian–Ordovician,Devonian–Carboniferous,and Aptian–Albian *** arc-like Nkogho I-type granitoid crystallized from granitic magma during Cryogenian to Ediacarian times and was later affected by post-Ediacarian Cambrian to Albian magmatic ***–Albian ages probably reflect opening of the Mamfe Basin.

关键词： Cameroon Mamfe Basin granitoid zircon U-Pb age U/Th

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real-world clinical efficacy of tofacitinib in moderate-to-severe ulcerative colitis

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World Journal of Gastroenterology 2024年第34期30卷 3929-3931页

作者： Sara r Lopes Claudio Martins Madalena Teixeira david Tomás Department of Gastroenterology Unidade Local de Saúde da Arrábida-Hospital de São BernardoSetúbal 2910-446Portugal

Tofacitinib is an oral small-molecule Janus kinase(JAK)inhibitor that preferentially inhibits JAK1 and *** efficacy in inducing and maintaining remission in ulcerative colitis(UC)as well as its safety profile has been demonstrated in multicenter,randomized,double-blind,placebo-controlled ***,real-world studies evaluating the effectiveness and adverse effects of tofacitinib have been conducted,affirming its clinical efficacy in moderate-to-severe UC.

关键词： Ulcerative colitis Tofacitinib real-world studies Inflammatory bowel disease Janus kinase inhibitor

Vegetation change as related to terrain factors at two glacier forefronts, Glacier National Park, Montana, U.S.A.

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Journal of Mountain Science 2020年第1期17卷 1-15页

作者： Callie B.LAMBErT Lynn M・rESLEr Yang SHAO david r.BUTLEr Department of Geography Virginia Tech220 Stanger StreetBlacksburgVA24061USA Texas State University Department of GeographySan MarcosTX 78666USA

Glacier recession is a globally occurring trend. Although a rich body of work has documented glacial response to climate warming, few studies have assessed vegetation cover change in recently deglaciated areas, especially using geospatial technologies. Here, vegetation change at two glacier forefronts in Glacier National Park, Montana, *** quantified through remote sensing analysis,fieldwork validation, and statistical ***, we assessed the spatial and temporal patterns of landcover change at the two glacier forefronts in Glacier National Park and determined the role of selected biophysical terrain factors(elevation, slope, aspect, solar radiation, flow accumulation, topographic wetness index, and surficial geology) on vegetation change(from nonvegetated to vegetated cover) at the deglaciated *** imagery of the study locations in 1991, 2003,and 2015 were classified and validated using visual interpretation. Model results revealed geographic differences in biophysical correlates of vegetation change between the study areas, suggesting that terrain variation is a key factor affecting spatialtemporal patterns of vegetation change. At Jackson Glacier forefront, increases in vegetation over some portion or all of the study period were negatively associated with elevation, slope angle, and consolidated bedrock. At Grinnell Glacier forefront,increases in vegetation associated negatively with elevation and positively with solar *** geospatial and field approaches to the study of vegetation change in recently deglaciated terrain are recommended to understand and monitor processes and patterns of ongoing habitat change in rapidly changing mountain environments.

关键词： Land cover change Physical geography Glacial forefronts Vegetation change Glacier National Park Terrain factors

Novel Cryo-EM structures of the D1 dopamine receptor unlock its therapeutic potential

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Signal Transduction and Targeted Therapy 2021年第6期6卷 1634-1635页

作者： david r.Sibley Kathryn D.Luderman rBenjamin Free Lei Shi Molecular Neuropharmacology Section National Institute of Neurological Disorders and StrokeIntramural Research ProgramNational Institutes of HealthBethesdaMDUSA Computational Chemistry and Molecular Biophysics Section Molecular Targets and Medications Discovery BranchNational Institute on Drug AbuseIntramural Research ProgramNational Institutes of HealthBaltimoreMDUSA

Three recent articles published in Cell1,2 and Cell research3 have reported multiple cryo-electron microscopy(cryo-EM)structures of the D1 dopamine receptor(DrD1)bound to either dopamine,various DrD1 agonists,or a positive allosteric modulator(PAM),while in complex with the active heterotrimeric Gs *** studies describe for the first time active-state structures of the DrD1,an exciting advancement in the field that will allow for a better understanding of selective agonist binding,DrD1 activation,G protein selectivity,and the provision of multiple templates to facilitate future drug design and discovery for this important therapeutic target.

关键词： selectivity activation potential

role of polyethylene particles in peri-prosthetic osteolysis:A review

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World Journal of Orthopedics 2011年第10期2卷 93-101页

作者： Gerald J Atkins david r Haynes Donald W Howie david M Findlay Discipline of Orthopaedics and Trauma The University of AdelaideSouth Australia 5005Australia Discipline of Pathology The University of AdelaideSouth Australia 5005Australia

There is convincing evidence that particles produced by the wear of joint prostheses are causal in the periprosthetic loss of bone,or osteolysis,which,if it progresses,leads to the phenomenon of aseptic *** is important to fully understand the biology of this bone loss because it threatens prosthesis survival,and loosened implants can result in peri-prosthetic fracture,which is disastrous for the patient and presents a difficult surgical *** focus of this review is the bioactivity of polyethylene(PE)particles,since there is evidence that these are major players in the development and progression of osteolysis around prostheses which use PE as the bearing *** review describes the biological consequences of interaction of PE particles with macrophages,osteoclasts and cells of the osteoblast lineage,including *** explores the possible cellular mechanisms of action of PE and seeks to use the findings to date to propose potential nonsurgical treatments for *** particular,a nonsurgical approach is likely to be applicable to implants containing newer,highly cross-linked PEs(HXLPEs),for which osteolysis seems to occur with much reduced PE wear compared with conventional *** caveat here is that we know little as yet about the bioactivity of HXLPE particles and addressing this constitutes our next challenge.

关键词： Polyethylene Aseptic loosening Osteolysis Wear particle Peri-prosthetic

Getting physical with medical education:Exercise based virtual anatomy review classes for medical students

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World Journal of Methodology 2025年第1期15卷 20-25页

作者： Nadeesha r Samarasinghe Taniya S Nagpal Michele L Barbeau Charys M Martin Division of General Surgery Faculty of MedicineUniversity of British ColumbiaVancouver V6T 1Z3BCCanada Faculty of Kinesiology Sport and RecreationUniversity of AlbertaEdmonton T6G 2R3ABCanada Anatomy and Cell Biology University of Western OntarioLondon N6A 3K7ONCanada Department of Anatomy and Cell Biology Schulich School of Medicine and DentistryThe University of Western OntarioLondon N6A 3K7ONCanada

The benefits of regular physical activity are well ***,few studies have examined the effectiveness of integrating physical activity(PA)into curricula within a post-secondary *** investigate the incorporation of PA into medical curriculum,we developed a series of optional exercise-based review sessions designed to reinforce musculoskeletal(MSK)anatomy course *** synchronous sessions were co-taught by a group fitness instructor and an anatomy *** fitness instructor would lead students through both strength and yoga style exercises,while the anatomy instructor asked questions about relevant anatomical structures related to course material previously *** the sessions,participants were asked to evaluate the classes on their self-reported exam preparedness in improving MSK anatomy knowledge,PA levels,and mental *** participants completed surveys;a majority agreed that the classes increased understanding of MSK concepts(90.0%)and activity levels(97.7%).Many(70.0%)felt that the classes helped reduce *** majority of respondents(90.0%)agreed that the classes contributed to increased feelings of social ***,medical students saw benefit in PA based interventions to supplement MSK course *** with increasing activity levels and promoting health behaviours,integrating PA into medical curriculum may improve comprehension of learning material,alleviate stress and foster social connectivity among medical students.

关键词： Medical education Musculoskeletal Anatomy Exercise Online learning

Particulate matter emissions and gaseous air toxic pollutants from commercial meat cooking operations

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Journal of Environmental Sciences 2018年第3期30卷 162-170页

作者： Nicholas Gysel William A.Welch Chia-Li Chen Poornima Dixit david r.Cocker Ⅲ Georgios Karavalakis Department of Chemical and Environmental Engineering University of CaliforniaRiverside Center for Environmental research and Technology University of CaliforniaRiverside

This study assessed the effectiveness of three novel control technologies for particulate matter（PM） and volatile organic compound（VOC） removal from commercial meat cooking operations. All experiments were conducted using standardized procedures at University of California, riverside＇s commercial test cooking facility. PM mass emissions collected using South Coast Air Quality Management District（SCAQMD） Method 5.1, as well as a dilution tunnel-based PM method showed statistically significantly reductions for each control technology when compared to baseline testing（i.e., without a catalyst）. Overall, particle number emissions decreased with the use of control technologies, with the exception of control technology 2（CT2）, which is a grease removal technology based on boundary layer momentum transfer（BLMT） theory. Particle size distributions were unimodal with CT2 resulting in higher particle number populations at lower particle diameters. Organic carbon was the dominant PM component（ 99%） for all experiments. Formaldehyde and acetaldehyde were the most abundant carbonyl compounds and showed reductions with the application of the control technologies. Some reductions in mono-aromatic VOCs were also observed with CT2 and the electrostatic precipitator（ESP） CT3 compared to the baseline testing.

关键词： Charbroiled meat cooking Particulate emissions Particle number Carbonyl compounds VOCs

3D tomographic analysis of equatorial plasma bubble using GNSS-TEC data from Indonesian GNSS Network

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Earth and Planetary Physics 2025年第1期9卷 127-136页

作者： Ihsan Naufal Muafiry Prayitno Abadi Teguh N.Pratama Dyah r.Martiningrum Sri Ekawati Yuandhika GWismaya Febrylian FChabibi Gatot HPramono research Center for Climate and Atmosphere Indonesian National Research and Innovation Agency(BRIN)BandungIndonesia Indonesian Geospatial Information Agency(BIG) JakartaIndonesia Dept.of Physics Faculty of ScienceUniversiti Teknologi MalaysiaJohor BahruMalaysia Dept.Earth Planet Sci. Hokkaido UniversitySapporoJapan School of Electrical Engineering Telkom UniversityBandungIndonesia

Equatorial Plasma Bubbles(EPBs)are ionospheric irregularities that take place near the magnetic *** most commonly occur after sunset during the equinox months,although they can also be observed during other *** phenomenon significantly disrupts radio wave signals essential to communication and navigation *** national network of Global Navigation Satellite System(GNSS)receivers in Indonesia(>30°longitudinal range)provides an opportunity for detailed EPB *** explore this,we conducted preliminary 3D tomography of total electron content(TEC)data captured by GNSS receivers following a geomagnetic storm on December 3,2023,when at least four EPB clusters occurred in the Southeast Asian *** and extracted TEC depletion with a 120-minute running average were then used as inputs for a 3D tomography *** 2D spatial distribution consistently captured the four EPB clusters over *** tomography results were validated through a classical checkerboard test and comparisons with other ionospheric data sources,such as the Global Ionospheric Map(GIM)and International reference Ionosphere(IrI)*** of the results demonstrates the capability of the Indonesian GNSS network to measure peak ionospheric *** findings highlight the potential for future three-dimensional research of plasma bubbles in low-latitude regions using existing GNSS networks,with extensive longitudinal coverage.

关键词： EPB Indonesian GNSS Network 3D tomography

Brains for Dementia research: The Importance of Cohorts in Brain Banking

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Neuroscience Bulletin 2019年第2期35卷 289-294页

作者： Paul T.Francis Gillian M.Hayes Helen Costello david r.Whitfield Wolfson Centre for Age-related Diseases King's College London

Background:The Historical Importance of Studies of Human Brain in Dementia research The collection of brain and related tissue has a long history(1)In terms of dementia,a more systematic examination of the relationship between brain pathology and clinical symptoms can be traced to Alois Alzheimer’s group in Munich in the early 1900s(2)The use of human brain tissue is essential to increase our understanding of dementia as it gives us the gold standard of disease pathogenesis and clues as to the molecular mechanisms that underpin the various diseases and conditions.

关键词： Importance of Cohorts Dementia research mechanisms